HIV resistance study seeks answers on dolutegravir failure

NCT ID NCT06762054

Recruiting now Knowledge-focused Sponsor: University of Nairobi Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study follows 6,600 people with HIV who have developed resistance to the drug dolutegravir. Researchers want to see if continuing the same medication with extra counseling can still suppress the virus. The goal is to learn more about how resistance develops and how to manage it effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dolutegravir (DTG)
What this could lead to: If successful, this study could provide evidence on whether continuing DTG-based therapy with enhanced counseling is effective for managing resistance, potentially simplifying treatment guidelines.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all populations, and resistance patterns could limit viral suppression.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

Bomu Hospital
NOT_YET_RECRUITING

Mombasa, Kenya
Butha-Buthe District Hospital
RECRUITING

Butha-Buthe, Lesotho
CS Machava II
NOT_YET_RECRUITING

Maputo, Mozambique
CS Ndlavela
NOT_YET_RECRUITING

Maputo, Mozambique
CS Ponta Gea
NOT_YET_RECRUITING

Beira, Sofala, Mozambique
Jaramogi Oginga Odinga Teaching and Referral Hospital
RECRUITING

Kisumu, Kenya
Kenyatta National Hospital
RECRUITING

Nairobi, 00100, Kenya
MUHAS Clinical Trial Unit
NOT_YET_RECRUITING

Dar es Salaam, Tanzania
Mokhotlong District Hospital
RECRUITING

Mokhotlong, Lesotho

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