HIV-1-INFECTION

This early-stage study tested the safety and immune response of a new experimental HIV vaccine in healthy adults. Twenty participants received either the new DNA-based vaccine alone or in combination with another vaccine shot. The main goal was to see if the vaccines were safe an…

This study looked back at the health records of 800 people with HIV to compare two different treatment plans. It aimed to see if a two-drug regimen works as well as a standard three-drug regimen at keeping the virus under control for 48 weeks. The research focused on people in th…

This completed study tested whether a specific blend of six plant extracts and vitamin C could help protect and increase levels of important immune cells (CD4+ T and B lymphocytes) in people living with HIV. The goal was to see if this natural formula could reduce the virus's dam…

This large, completed Phase 3 study tested a new once-daily pill (doravirine/islatravir) for people newly diagnosed with HIV-1. It directly compared this new combination to a standard HIV treatment to see if it was as good or better at suppressing the virus and if it was safe. Th…

This study looked at how safe it is for people with well-controlled HIV to switch from getting treatment through injections every two months to taking a daily pill instead. It involved 33 participants who wanted to change from the injection regimen, often due to side effects or i…

This study tested a combination of two lab-made antibodies, TMB-365 and TMB-380, given by IV infusion. The goal was to see if these infusions could safely maintain control of HIV for 24 weeks in people who stopped their standard daily pill regimen. Researchers first checked the s…

This study tested the safety of a new gene therapy for people living with HIV who also have a high-risk type of lymphoma (a blood cancer). Researchers collected a patient's own blood cells, modified them with a gene designed to resist HIV, and then gave them back after a stem cel…

This study tested an experimental drug called PRO 140 in combination with other HIV medications for people whose current treatments were no longer working well. It involved 6 adults with HIV who had developed resistance to multiple classes of standard drugs. Researchers measured …

This study tested if people with well-controlled HIV could switch from taking daily pills to a new weekly combination of two drugs, islatravir and ulonivirine. The goal was to see if the weekly treatment was safe and tolerable. However, the trial was stopped early because partici…

This study tested whether a common HIV medication (dolutegravir) works safely alongside anti-rejection drugs in people who have received organ transplants. Researchers followed 19 HIV-positive transplant patients to see if the HIV treatment remained effective without interfering …

This small pilot study tested whether taking capsules containing healthy donor stool (fecal microbiota transplantation) could help repair gut damage and reduce harmful inflammation in people living with HIV. Twenty participants whose HIV was well-controlled by medication but who …

This study tested the safety of a new combination treatment for HIV. It involved 20 women who were already on successful HIV medication. Researchers gave them two long-acting antibodies and an immune system booster, then carefully paused their regular pills to see if the new trea…

This study tested if an existing HIV medication, Trogarzo, could be given in simpler ways. Researchers wanted to see if a very quick 30-second IV push or a simple injection into the muscle was safe and worked as well as the standard longer IV infusion. The goal was to make treatm…

This large Phase 3 trial tested whether a stronger, intensified tuberculosis (TB) treatment regimen could save more lives than standard TB treatment in HIV patients hospitalized with TB and severely weakened immune systems (CD4 ≤ 100 cells/μL). It enrolled 1,330 adults and adoles…

This study tested a cell phone app called START, designed to help men who use stimulants like methamphetamine stick to their HIV medication. The goal was to help control their HIV and improve their overall well-being. Researchers enrolled 286 men who have sex with men, are living…

This study tested whether a 4-week group program could help older adults (age 50+) living with HIV build resilience and better manage daily stress. Researchers enrolled 106 participants who had recent challenges with their HIV care. The program aimed to teach skills like positive…

This study aimed to understand how much HIV medication passes from a mother to her baby through breastmilk. Researchers measured drug levels in the blood and breastmilk of 16 mothers with HIV who chose to breastfeed while on treatment. The goal was to gather data to help make bre…

This study aimed to understand how drinking alcohol affects brain inflammation and the immune system in people living with HIV. Researchers recruited healthy individuals and people with well-controlled HIV, gave them either an alcoholic or non-alcoholic drink, and then took blood…