Poop pills could tame HIV inflammation

NCT ID NCT06022406

Completed Disease control Sponsor: Jean-Pierre Routy Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether taking capsules containing healthy donor stool (fecal microbiota transplantation, or FMT) can reduce gut inflammation in people with HIV who are on antiretroviral therapy (ART) but have a low CD4/CD8 ratio. Twenty participants were randomly assigned to receive either FMT or placebo capsules twice, three weeks apart. Researchers measured changes in gut permeability and inflammation markers in the blood and, in a substudy, in colon biopsies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal microbiota transplantation (FMT) capsules
What this could lead to: If it works, this could point toward a way to reduce chronic inflammation in people with HIV, potentially lowering the risk of long-term health problems.
What could go wrong: This is a very small, early pilot study with only 20 participants. The treatment may not reduce inflammation, and the effects may not be lasting or generalizable to all people with HIV.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dysbiosis HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

Chronic Viral Illness Service

Montreal, Quebec, H4A 3J1, Canada

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