New HIV pill STP0404 shows promise in small trial

NCT ID NCT05869643

Completed Disease control Sponsor: ST Pharm Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2a trial tested a new experimental drug called STP0404 (Pirmitegravir) in 25 adults with HIV-1 who had never taken HIV medications before. Participants received either a low, medium, or high dose of STP0404 or a placebo once daily for 10 days. The study measured how well the drug lowered the amount of virus in the blood and checked for any side effects. The goal is to see if STP0404 can be a safe and effective new option for controlling HIV.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: STP0404 (Pirmitegravir)
What this could lead to: If successful, this could lead to a new daily pill to control HIV-1, offering another treatment option for people living with HIV.
What could go wrong: This is a small, early-phase trial (25 people) testing short-term effects over 10 days. It may not show strong enough antiviral activity or could have side effects. Larger studies are needed to confirm safety and effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

Atrium Health Wake Forest Baptist Medical Center - PPDS

Winston-Salem, North Carolina, 27157, United States
Be Well Medical Center

Berkley, Michigan, 48072, United States
Kaiser Permenente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Midway Immunology and Research Center

Ft. Pierce, Florida, 34982, United States
North Shore University Hospital

Manhasset, New York, 11030-3816, United States
North Texas Infectious Diseases Consultants, P.A.

Dallas, Texas, 75246, United States
Orlando Immunology Center

Orlando, Florida, 32803, United States
Ruane Clinical Research, Inc.

Los Angeles, California, 90036, United States
Saint Michael's Medical Center

Newark, New Jersey, 07102, United States
Schiff Center for Liver Diseases/University of Miami

Miami, Florida, 33136-2107, United States
South Jersey Infectious Disease

Somers Point, New Jersey, 08244, United States
St Hope Foundation, Inc

Bellaire, Texas, 77401, United States
USF Health South Tampa Center for Advanced Healthcare

Tampa, Florida, 33602-3511, United States

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