HIV pill combo simplifies treatment for patients over 45

NCT ID NCT02212379

Completed Disease control Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a two-drug combination of raltegravir and etravirine in 170 adults with HIV who were at least 45 years old and already had the virus well-controlled. Participants switched from a standard three-drug regimen to this simpler two-pill combo. After 96 weeks, over 98% still had undetectable virus levels, suggesting this approach could be a safe and effective option for older adults living with HIV.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: raltegravir and etravirine (oral tablets)
What this could lead to: If successful, this could offer a simpler, two-drug option for older adults with HIV, reducing pill burden and side effects while keeping the virus suppressed.
What could go wrong: This was a small, single-arm phase II study with no comparison group. Results may not apply to all patients, and long-term risks or resistance are still unknown.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

CHU Hôtel Dieu

Nantes, 44093, France
Hospital Clinic

Barcelona, 08036, Spain
Hospital de Bellvitge

Barcelona, 08000, Spain
Hospital de la santa Creu i San Pau

Barcelona, 08025, Spain
Hôpital Avicenne

Bobigny, 93000, France
Hôpital Bichat Claude Bernard

Paris, 75018, France
Hôpital Bicêtre

Le Kremlin-Bicêtre, 94275, France
Hôpital Bretonneau

Tours, 37044, France
Hôpital Cochin

Paris, 75014, France
Hôpital Croix Rousse

Lyon, 69317, France
Hôpital Européen Georges Pompidou

Paris, 75908, France
Hôpital Gui de Chauliac

Montpellier, 34000, France
Hôpital Jean Verdier

Bondy, 93140, France
Hôpital Necker

Paris, 75015, France
Hôpital Pitié-Salpétrière

Paris, 75013, France
Hôpital Saint André

Bordeaux, 33076, France
Hôpital Saint Louis

Paris, 75010, France
Hôpital Sainte marguerite

Marseille, 13009, France
Hôpital de l'Archet

Nice, 06202, France

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