Can higher doses and steroids beat TB in HIV patients?

NCT ID NCT04738812

Completed Disease control Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a steroid and a deworming pill. The goal was to see if the stronger regimen reduced deaths over 48 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: higher doses of rifampicin and isoniazid, plus prednisone and albendazole
What this could lead to: If successful, this could lead to a more effective TB treatment for people with advanced HIV, potentially reducing deaths.
What could go wrong: The trial is completed but results are not yet widely confirmed. Higher drug doses may increase side effects, and the approach may not work for all patients.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease immunodeficiency disease tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION IMMUNO-DEFICIENCY TUBERCULOSIS

Contacts and locations

Locations

Ignace Deen Hospital

Conakry, Guinea
Jamot Hospital

Yaoundé, Cameroon
MACHAVA Hospital

Maputo, Mozambique
Mbarara Regional Referral hospital

Mbarara, Uganda
National Center for HIV/AIDS, Dermatology and STD (NCHADS)

Phnom Penh, Cambodia
University Teaching Hospital

Lusaka, Zambia

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