TUBERCULOSIS

This study is testing a new tuberculosis (TB) vaccine called MTBVAC to see if it is safe and if it triggers a good immune response. It involves 276 adolescents and adults in South Africa, including people living with and without HIV. Participants receive a single injection of eit…

This early-stage study is testing a new experimental vaccine designed to protect against tuberculosis (TB). It will involve 36 healthy adults aged 18-49 to check if the vaccine is safe and if it triggers a protective immune response. Participants will receive either one of two do…

This study aims to improve tuberculosis treatment by personalizing drug doses. Researchers will use a simple urine test to check if patients are getting enough of a key TB drug (rifampin) and adjust their dose if needed. The trial involves 200 adults and children in Tanzania who …

This study is testing if adding atorvastatin, a common cholesterol-lowering drug, to the standard tuberculosis (TB) treatment helps patients get better faster and more completely. It will involve 440 people with active lung TB to see if the combination clears the infection from t…

This study is testing if a shorter, 2-month treatment plan can cure drug-susceptible tuberculosis (TB) in children as well as the current standard 4-6 month plan. It will enroll 860 children under 10 years old to compare the safety and effectiveness of the two regimens. The goal …

This study is testing a new step-by-step guide and digital tool to help health workers at local clinics and hospitals in Mozambique and Zambia better identify and treat tuberculosis (TB) in children. It aims to see if this tool helps find more TB cases and leads to faster, more a…

This study aims to see if the standard 6-month treatment for asymptomatic tuberculosis can be safely shortened to 4 or even 3 months. It will enroll 426 people in China who have TB but no symptoms. Participants will be randomly assigned to receive either the standard treatment or…

This study is testing whether having trained peers provide education and counseling helps people in Uganda complete their tuberculosis (TB) treatment and stay on their HIV medication. It will involve about 1,920 adults who are starting TB treatment, some of whom also have HIV. Th…

This study is testing a new drug, JDB0131, combined with other medicines to treat tuberculosis that is resistant to standard antibiotics. It will involve 60 patients with this hard-to-treat form of TB to see if the new combination is effective and safe over 8 weeks. The main goal…

This study is testing a new support program designed to help people in South Africa who have HIV and/or tuberculosis (TB) quit smoking. The program, called QUIT-AD, combines counseling and support to help people stop smoking and also stick to their important HIV or TB medications…

This study is testing if a simpler, two-drug HIV treatment works as well as the standard three-drug treatment for people who are also taking medicine for tuberculosis (TB). It will enroll 150 adults with both HIV and TB who are starting HIV treatment for the first time. The goal …

This study is testing whether adding alcohol reduction counseling to regular TB and HIV medical care can help patients drink less and improve their health. Researchers will work with 450 adults in India who have tuberculosis, HIV, or both, and who report unhealthy drinking. Parti…

This study is testing if adding a common antibiotic called doxycycline to standard tuberculosis (TB) treatment can protect patients' lungs and heart from long-term damage. It will involve 150 adults with active TB who have just started treatment. The goal is to see if this extra …

This study aims to find better, faster, and cheaper ways to diagnose tuberculosis (TB) in children under 15. It will test new, simple diagnostic tools that don't rely on hard-to-get sputum samples, which are a major hurdle for diagnosing kids. The goal is to speed up diagnosis an…

This study aims to find better, faster, and less expensive ways to diagnose tuberculosis (TB) at local clinics. It will test new diagnostic tools on people with TB symptoms or risk factors in countries where TB is common. The goal is to see how accurate and easy-to-use these new …

This trial is testing a new skin test called EEC to see if it can accurately diagnose tuberculosis (TB) infection. It will involve over 1,700 people aged 3 and older, including healthy individuals, TB patients, and people with other lung diseases. The main goal is to see if EEC w…

This study aims to find and test new, simpler tools to diagnose tuberculosis (TB) faster and at a lower cost. It will involve over 26,000 people with TB symptoms or risk factors across 10 countries. Researchers will check how accurate and easy-to-use these new tests are compared …

This study aims to evaluate a new blood test designed to improve the diagnosis of tuberculosis (TB) in children. It will enroll 1,220 children in Bolivia who have symptoms of respiratory illness and are suspected of having TB. The test looks for tiny pieces of TB bacteria in the …

This study aims to find more people with tuberculosis (TB) in high-risk areas of Ethiopia and Guinea-Bissau. It tests a package of improved methods, including better sputum collection instructions, AI analysis of chest X-rays, and new sample types like saliva and stool. The goal …

This study is testing if a new, much shorter one-month tuberculosis (TB) prevention treatment works as well as the standard three-month treatment. It involves over 3,500 students and school staff in China who have been exposed to someone with active TB at school but do not have t…

This study is testing if giving tuberculosis (TB) preventive medicine immediately after a household member is diagnosed can stop children and teenagers from catching the infection. Researchers will compare kids who get the medicine right away to those who follow standard care, wh…

This study aims to understand why some tuberculosis patients unexpectedly get worse after starting treatment, a problem called a paradoxical reaction. Researchers will observe 140 adults being treated for TB, with and without these reactions, using scans and blood tests over 6-18…

This study aims to learn more about how tuberculosis (TB) behaves in the body over time. Researchers will follow 150 people, aged 2 and older, who have either active TB or a latent (hidden) TB infection. They will collect blood and other samples to study the bacteria and the body…

This large study aims to find out if people who have tuberculosis (TB) but show no symptoms can still pass the disease to others. Researchers will follow over 6,700 people with HIV and their close contacts in Mozambique for a year, using advanced genetic testing to track how the …

This research study aims to better understand how the immune system works in sarcoidosis, a disease that causes inflammation and lumps called granulomas. Researchers will compare blood and tissue samples from 100 people with sarcoidosis to samples from people with tuberculosis, w…

This study aims to find better ways to predict if tuberculosis (TB) will come back after a person finishes treatment. Researchers will follow 750 people who have completed standard TB treatment for one year, checking their blood and sputum for biological markers. The goal is to i…

This study aims to find better ways to detect, prevent, and treat tuberculosis (TB) in people living with HIV. It will test new screening tools, compare different preventive treatment delivery methods, and analyze costs to improve care for 6,500 participants. The goal is to gener…