TUBERCULOSIS

This study tests whether a 2-month combination of four drugs can cure tuberculosis (TB) in children under 10 as safely and effectively as the current 4- to 6-month treatment. About 860 children with drug-susceptible TB will take either the shorter or standard regimen. If successf…

This study tests a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults living with or without HIV in South Africa. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will be monitored for side effects and their immune ce…

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can help preserve lung function and reduce heart problems in adults with active pulmonary TB. About 150 participants will receive either doxycycline or a placebo for 8 weeks alongsi…

This study in Uganda tests whether having trained peers lead education and counseling sessions can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults will take part. The goal is to see if this approach boosts TB cure rates and keeps people wi…

This study tests whether a simpler two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people starting HIV treatment while also being treated for tuberculosis. About 150 participants will be randomly assigned to one of three treatme…

This study tests whether adding the common cholesterol-lowering drug atorvastatin to standard tuberculosis (TB) medication can improve cure rates and reduce side effects. About 440 adults and teens with newly diagnosed, drug-sensitive TB in Nigeria will receive either standard tr…

This study tests whether people with tuberculosis (TB) who have no symptoms can be treated in a shorter time—17 weeks instead of the usual longer course. About 426 adults in China will receive either the standard regimen or a shortened one. The goal is to see if the shorter treat…

This study tests a new program called QUIT-AD that combines existing methods to help people with HIV or TB quit smoking. The program will be offered to 86 adults in Cape Town, South Africa who smoke daily. Researchers will check if the program is practical, well-liked, and helps …

This study tests a new medicine (JDB0131) combined with other drugs to treat a tough form of tuberculosis that doesn't respond to the usual antibiotic rifampin. About 60 adults with this drug-resistant TB will receive different treatment combinations for 8 weeks. The main goal is…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can help more people reach effective drug levels in their blood. The goal is to improve treatment success and reduce the risk of drug resistance. The trial involves 200 adults and chi…

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB) in children under 15. Every year, about 230,000 children die from TB, often because current tests are slow or hard to use. Researchers will enroll 2,100 children with TB symptoms to see how we…

This study tests a new skin test called EEC to see if it can accurately diagnose tuberculosis (TB) infection in people aged 3 and older. About 1,784 participants will be enrolled, including people with TB, healthy volunteers, and those with other lung diseases. The goal is to see…

This study tests whether a smartphone app can tell the difference between a tuberculosis (TB) cough and other coughs by analyzing the sound. Researchers will collect cough recordings from 1,751 people with a prolonged cough and use machine learning to build a quick, non-invasive …

This study tests new, faster, and cheaper ways to diagnose tuberculosis (TB) at the point of care. It will involve 1,350 adults with a cough or TB risk factors. The goal is to find better tests that can help identify the millions of people with TB who are currently missed.

This study aims to see if a new CRISPR-based blood test can accurately diagnose tuberculosis (TB) in children. TB is hard to detect in kids because standard tests often miss the infection. The study will enroll 1,220 children in Bolivia to compare the new test with current method…

This study is testing a new blood and urine test that looks for DNA from the bacteria that cause tuberculosis (TB). The goal is to see if this test can quickly and accurately diagnose active TB, including hard-to-detect cases in children or outside the lungs, and also monitor how…

This study aims to find better, faster, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have r…

This study tests if giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can stop them from getting infected. About 647 kids will either get the medicine immediately or wait to see if they test positive first. The goal is to see…

This study tests whether a 1-month, ultra-short TB prevention regimen works as well as the standard 3-month treatment for school students and staff who have been in close contact with someone with active TB. About 3,520 participants aged 13 and older will be enrolled. If successf…

This study tests whether adding balloon-blowing exercises to standard breathing techniques helps children with tuberculosis cough up mucus, feel less short of breath, and walk farther. About 34 kids aged 8 to 14 will be split into two groups: one doing breathing exercises alone, …

This study is testing simple checklists and guides (called Treatment Decision Algorithms) to help doctors at local clinics and hospitals in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children under 15. The goal is to see if these tools help more sick kid…

This study looks at how certain immune cells (monocytes and macrophages) behave in people with sarcoidosis, a disease that causes inflammation and lumps called granulomas. Researchers will compare these cells in sarcoidosis patients to those in tuberculosis patients. The goal is …

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, a condition called a paradoxical reaction. Researchers will follow 140 adults on TB therapy, with or without these reactions, using blood tests, urine samples, and PET/CT scans over 6 …

This study tests whether combining better sputum tests, chest X-rays with computer help, and non-sputum samples (like stool and mouth swabs) can find more tuberculosis (TB) cases in clinics in Guinea-Bissau and Ethiopia. About 1,584 adults with TB symptoms will take part. The goa…

This study aims to learn more about tuberculosis (TB) by collecting blood and other samples from people with active or latent TB. Researchers want to better understand how the disease works and how it affects the body. Participants will provide samples and may receive treatment f…

This study enrolls 750 people who have finished standard TB treatment to see if new blood or sputum tests can predict whether their TB will come back within a year. Current methods for predicting TB recurrence are not very accurate, making it hard to test new treatments. By findi…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a blood test to improve TB detection. They will also compare different support methods to help patient…

This study looks at how the immune systems of people being treated for tuberculosis respond to COVID-19 vaccines compared to healthy people. About 108 adults (54 with TB and 54 healthy) will receive one or two doses of a standard COVID-19 vaccine. Researchers will measure antibod…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will track about 6,770 participants, including those with HIV, using advanced genetic tools to see if asymptomatic TB cases cause new infections. The…