TUBERCULOSIS

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccin…

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study tests whether people with asymptomatic tuberculosis (TB) can be treated effectively with a shorter course of standard antibiotics—17 weeks instead of the usual 6 months. Researchers will compare the shorter regimen to standard treatment in 426 participants in China. Th…

This study tests a new drug called JDB0131, combined with other TB medications, in 60 people with rifampin-resistant tuberculosis. Participants will receive one of two doses of JDB0131 or a standard drug (delamanid) for 8 weeks. The goal is to see which combination clears the bac…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorte…

This study looks at whether a higher dose of the TB medicine rifampicin is safe and works well in children with both HIV and TB. Twenty children will take their usual HIV and TB drugs, but for two weeks the rifampicin dose will be increased. Researchers will measure drug levels i…

This study tests whether adding atorvastatin, a widely used cholesterol-lowering drug, to standard tuberculosis (TB) antibiotics can help clear the infection faster and reduce lung damage. About 440 adults with pulmonary TB will receive either standard treatment alone or with dif…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a cough lasting at least two weeks, then use machine learning to build a quick screeni…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have …

This study is testing whether measuring TB DNA in blood and urine can help diagnose tuberculosis and track treatment progress. Current TB tests can be slow or require invasive procedures. The trial will enroll 85 people with active TB, latent TB, or no TB to see how accurate the …

This study is testing whether a special PET scan tracer called 18F-FAPI-74 can detect scarring (fibrosis) in the lungs of people with active tuberculosis. About 30 adults with confirmed TB will get the tracer and a whole-body PET/CT scan during and after treatment. The goal is to…

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

Every year, millions of people with tuberculosis (TB) go undiagnosed. This study tests new, faster diagnostic tools that use a simple tongue swab instead of the usual sputum sample. Researchers will enroll 1,350 adults with cough or TB risk factors to see how accurate these point…

This study is testing a new blood test called CRISPR-TB to diagnose tuberculosis (TB) in children more accurately. Current tests often miss TB in kids because they have fewer bacteria. The study will enroll 1,220 children in Bolivia to see if this test can detect TB better than s…

This Phase 3 trial is testing a new skin test called EEC to see how well it detects tuberculosis (TB) infection in people aged 3 and older. The study will compare EEC to existing tests like EC, TB-PPD, and IGRA in about 1,784 participants, including TB patients, healthy people, a…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests whether adding balloon blowing to standard breathing exercises helps children with tuberculosis cough up mucus, reduce shortness of breath, and improve their ability to walk. Thirty-four children aged 8 to 14 will be randomly assigned to either breathing exercise…

This study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…

This study will follow 2000 adults in France who are starting treatment for tuberculosis. Researchers will collect health data and samples like blood, urine, and breath over two years to see how well treatments work. The goal is to learn more about TB care and build a biobank for…

This study looks at how different types of mycobacterial infections, including drug-resistant tuberculosis and nontuberculous mycobacteria, change the body's immune response. Researchers will collect blood and other samples from 120 participants, including healthy people and thos…

This study aims to understand why some people with tuberculosis (TB) experience a paradoxical reaction, where they initially improve on treatment but then suddenly get worse. Researchers will follow 140 adults with TB, with or without signs of this reaction, using blood tests, ur…

This study compares the immune response to COVID-19 vaccines between people being treated for tuberculosis (TB) and healthy individuals. About 133 participants in the Thailand-Myanmar border area will receive one of three vaccines (Pfizer, AstraZeneca, or Janssen). Researchers wi…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study looks at 750 people who have finished treatment for drug-sensitive tuberculosis. Researchers will test new sputum and blood-based methods to see if they can predict whether the disease will come back within a year. The goal is to find better ways to measure treatment s…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study aims to find more tuberculosis (TB) cases by improving diagnostic tools already available in local health clinics. About 1,584 adults with TB symptoms in Guinea-Bissau and Ethiopia will be randomly assigned to either standard care or an enhanced testing approach that i…