TUBERCULOSIS

This study tests whether a 2-month combination of four drugs can cure tuberculosis (TB) in children under 10 as safely and effectively as the current 4- to 6-month treatment. About 860 children with drug-susceptible TB will take either the shorter or standard regimen. If successf…

This study tests a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults living with or without HIV in South Africa. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will be monitored for side effects and their immune ce…

This early-stage study tests a new vaccine called Ad5-105K to see if it is safe and triggers an immune response against tuberculosis (TB). It involves 36 healthy adults aged 18 to 49 who have been exposed to TB but have not developed the disease. Participants receive either the v…

This study tests whether people with tuberculosis (TB) who have no symptoms can be treated in a shorter time—17 weeks instead of the usual longer course. About 426 adults in China will receive either the standard regimen or a shortened one. The goal is to see if the shorter treat…

This study tests whether trained peer educators can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults in Uganda will take part. The goal is to see if peer-led counseling improves TB cure rates and keeps people with HIV on their medications.

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study tests a new medicine (JDB0131) combined with other drugs to treat a tough form of tuberculosis that doesn't respond to the usual antibiotic rifampin. About 60 adults with this drug-resistant TB will receive different treatment combinations for 8 weeks. The main goal is…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can help more people reach effective drug levels in their blood. The goal is to improve treatment success and reduce the risk of drug resistance. The trial involves 200 adults and chi…

This study is testing whether adding the cholesterol-lowering drug atorvastatin to the usual antibiotics for tuberculosis (TB) can help clear the infection faster and reduce lung damage. About 440 adults with newly diagnosed, drug-sensitive pulmonary TB in Nigeria will receive ei…

This study tests a simpler, two-drug HIV treatment (dolutegravir/lamivudine) against the standard three-drug regimen in people who have both HIV and tuberculosis (TB). About 150 participants who have never taken HIV medication will be followed for 48 weeks. The goal is to see if …

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study is testing a new blood test that uses CRISPR technology to find tuberculosis (TB) in children more accurately than current methods. The test looks for tiny bits of TB DNA in the blood, which is easier to get than the samples usually needed. Researchers will enroll abou…

This study tests a new skin test called EEC to see if it can better diagnose tuberculosis (TB) infection in people aged 3 and older. About 1,784 volunteers will take part, including people with TB, healthy people, and those with other lung diseases. The goal is to see if EEC is a…

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a cough lasting at least two weeks, then use machine learning to build a quick screeni…

This study aims to find better, faster, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have r…

This study aims to find better ways to diagnose tuberculosis (TB) in children under 15. Every year, about 230,000 children die from TB, often because current tests are slow or hard to use. Researchers will test new, faster, and simpler diagnostic tools on 2,100 children with TB s…

This study is testing a new blood and urine test that looks for tiny bits of TB bacteria's DNA (called cell-free DNA) to see if it can quickly and accurately diagnose active tuberculosis (TB) and monitor how well treatment is working. The test is non-invasive, unlike current meth…

Every year, over 3 million people with TB go undiagnosed and 1 million die. This study tests new, faster, and cheaper TB tests that can be used at a clinic or bedside. About 1350 adults with a cough lasting 2 weeks or TB risk factors will take part to see if these tests work bett…

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can stop them from getting infected. About 647 kids aged 5 to 17 will be split into two groups: one gets the medicine immediately, the other gets stan…

This study tests whether a one-month course of TB prevention pills works as well as the standard three-month course for teenagers and school staff who have been exposed to active tuberculosis. About 3,520 participants will be randomly assigned to either the short or standard regi…

This study tests whether adding balloon-blowing exercises to standard breathing techniques helps children with tuberculosis cough up mucus, feel less short of breath, and walk farther. About 34 kids aged 8 to 14 will be split into two groups: one doing breathing exercises alone, …

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines existing methods to support smoking cessation and improve HIV/TB treatment outcomes. Researchers will enroll 86 da…

This study aims to learn more about tuberculosis (TB) by collecting blood and other samples from people who have active or latent TB. Researchers want to better understand how the disease works and how it affects the body. Participants will provide samples and may receive treatme…

This study looks for better ways to find and prevent tuberculosis (TB) in people living with HIV, especially children and teens. Researchers will test a new screening method and a blood test to improve TB detection. They will also compare different support methods to help patient…

This study enrolls 750 people who have completed standard TB treatment to find blood or sputum markers that predict whether TB will return within a year. Researchers will test how accurately these markers identify recurrence risk. The goal is to make future TB treatment trials fa…

This study tests if using better tools—like chest X-rays with computer help and multiple sample types—can find more tuberculosis cases in clinics in Guinea-Bissau and Ethiopia. About 1,584 adults with TB symptoms will be split into two groups: one gets standard care, the other ge…

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, even though they initially improved. Researchers will follow 140 adults on TB therapy, with or without these paradoxical reactions, using blood tests, urine samples, and PET/CT scans t…

This study looks at how the immune systems of people being treated for tuberculosis respond to COVID-19 vaccines compared to healthy people. About 108 adults (54 with TB and 54 healthy) will receive one or two doses of a standard COVID-19 vaccine. Researchers will measure antibod…

This study will test new decision-making tools to help doctors at district hospitals and health centers in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children. The study will involve over 30,000 children under 15, including those with HIV or severe malnu…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will track about 6,770 participants, including those with HIV, using advanced genetic tools to see if asymptomatic TB cases cause new infections. The…

This study looks at how certain immune cells (monocytes and macrophages) behave in people with sarcoidosis, a disease that causes inflammation and lumps called granulomas. Researchers will compare these cells in sarcoidosis patients to those with tuberculosis. The goal is to lear…