New scan could reveal hidden lung damage in TB survivors

NCT ID NCT07077213

Recruiting now Diagnosis Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a special PET scan tracer called 18F-FAPI-74 can detect scarring (fibrosis) in the lungs of people with active tuberculosis. About 30 adults with confirmed TB will get the tracer and a whole-body PET/CT scan during and after treatment. The goal is to see if this scan can spot fibrosis better than standard imaging, which could help doctors understand and manage long-term lung damage from TB.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-FAPI-74 (a radioactive tracer for PET scans)
What this could lead to: If successful, this could lead to a better way to detect and monitor lung scarring in tuberculosis patients, helping doctors assess long-term lung damage.
What could go wrong: This is a small, early-phase study with only 30 participants. The tracer may not clearly show scarring, and results may not apply to all TB patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

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