Could inhaled TB drugs curb the spread of Drug-Resistant tuberculosis?
NCT ID NCT07708779
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This phase 1 study tests whether inhaling high doses of the antibiotic isoniazid is safe and tolerable for people with tuberculosis. Eight adults with known drug-sensitive TB will receive single inhaled doses of 200, 600, and 1200 mg, plus one intravenous dose for comparison. Researchers will monitor lung function and side effects to determine if this approach can deliver high drug concentrations directly to the lungs, potentially reducing how long patients remain contagious.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- isoniazid inhalation
- What this could lead to
- If successful, this approach could allow high-dose isoniazid to be delivered directly to the lungs, potentially shortening the contagious period and reducing the spread of tuberculosis, including drug-resistant strains.
- What could go wrong
- This is a very early, small phase 1 study with only 8 participants, focused on safety and tolerability. It does not yet test effectiveness, and inhaled antibiotics can cause side effects like coughing or shortness of breath.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TUBERCULOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University Medical Center Groningen
RECRUITINGGroningen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can new tests predict who will develop active TB?
- Could a 3-Month TB cocktail replace the standard 6-Month regimen?
- Could a simple blood test ensure the right TB dose for kids?
- Community-Driven TB screening aims to reach vulnerable immigrants
- New TB vaccine aims to prevent active lung disease in adults
- Blood test aims to unmask hidden TB infections before they turn deadly