University Medical Center Groningen

This study compares two drugs, vicadrostat and spironolactone, both given with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two com…

This study tests whether patiromer, a drug that lowers potassium levels, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and…

This study tests whether adding hydrochlorothiazide (a water pill) to the standard drug tolvaptan can better slow kidney function loss and reduce side effects like frequent urination in people with autosomal dominant polycystic kidney disease (ADPKD). About 300 adults on stable t…

This study compares two common heart procedures—bypass surgery (CABG) and stents (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and imp…

This study tests if giving donor kidneys a 6-hour warm bath with nutrients (normothermic machine perfusion) before transplant helps them work better. 240 people receiving a kidney from a donor aged 50+ will be randomly assigned to standard cold storage or the extra warm treatment…

This study tests a new type of shoe (LEEF-shoe) designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the LEEF-shoe and standard custom-made orthopedic shoes for several weeks. Researchers will measure foot pressure, how often th…

This pilot study tests whether giving a higher dose of proton therapy to the lung tumor is safe for people with stage III non-small-cell lung cancer who are also receiving chemotherapy. About 87 participants will receive the higher dose during the same number of treatment visits …

This study tests whether giving fluids and blood pressure medicines based on each person's heart response improves care for sepsis patients. Sepsis is a life-threatening infection reaction that can cause organ failure. 188 adults in the emergency department will be randomly assig…

This study tests whether a new decision-making tool, which includes a quick blood test for inflammation, helps general practitioners better decide which children with belly pain need to go to the hospital for possible appendicitis. About 566 children aged 4 to 18 will take part. …

This study tests a special imaging agent (89Zr-DF-Crefmirlimab) that helps PET scans show where immune cells called CD8 T-cells are in the body. About 30 adults with advanced solid tumors will receive this agent before and during standard immunotherapy. The goal is to see if the …

This study tests a new way to find early signs of esophageal cancer in people with Barrett's esophagus. Participants will drink or have a topical solution containing two fluorescent dyes that attach to cancer cells, making them glow during a special endoscopy. The goal is to see …

This study tests whether a simple at-home taste and smell training program can improve taste function in cancer patients who experience taste changes from tyrosine kinase inhibitors (TKIs). About 90 adults from 12 Dutch hospitals will either do the training or receive standard ca…

This study tests whether using a breathing machine (CPAP or BiPAP) can reduce tumor movement during radiation therapy for people with advanced lung cancer, esophageal cancer, or lymphoma. The goal is to see if these devices help keep the tumor still, which could make treatment mo…

This study tests a new virtual reality (VR) therapy for people who hear voices that others cannot hear, a common symptom in mental illness. The therapy uses computer avatars to represent the voices, aiming to reduce how distressing and frequent they are. Researchers will enroll 1…

This study is testing a new virtual reality (VR) version of a therapy exercise for adults aged 18-65 with psychiatric disorders. The goal is to see if talking to VR avatars representing different emotional 'modes' is a feasible and helpful way to reduce self-criticism and improve…

This study tests a home-based taste steering tool to help cancer patients enjoy food more when chemotherapy alters their taste and smell. About 201 adults with specific cancers will either use the tool or receive standard care. Researchers will measure food enjoyment, quality of …

This study tests a small, hands-free device called the PEP-buddy that helps people with COPD breathe easier during sudden episodes of breathlessness. The device works by creating gentle pressure when you breathe out. Researchers will study 25 adults with COPD to see if using the …

This small pilot study tests whether EMDR therapy can reduce nausea and vomiting that some cancer survivors continue to experience long after chemotherapy ends. Researchers will enroll 20 adults who have had cancer and still suffer from these symptoms for more than two months. Th…

This study looks at different types of fluid buildup (congestion) in people hospitalized for acute heart failure. Researchers will use ultrasound and other tests to group patients by their congestion pattern and see how each group responds to standard treatment. The goal is to be…

This study looks at whether a test called the Hinting Task can pick up on social thinking problems in people with Huntington's disease. Social thinking helps us understand hints and read between the lines in conversations. Researchers will compare results from 52 people with Hunt…

This study explores how a lung treatment called endobronchial valves (EBV) changes leg muscle function in people with severe emphysema. Researchers will measure muscle energy and structure before and 6 months after valve placement using MRI scans and small muscle samples. The goa…

This study is creating a large database of 10,000 lung cancer patients who received radiotherapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the best tre…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study tests whether a special PET scan can detect a protein called SSTR2 on nasopharyngeal cancer tumors. Ten adults with EBV-related nasopharyngeal cancer will get the scan before and after starting chemotherapy or chemoradiation. The goal is to see if this imaging method c…

This study looks at how a treatment called bronchoscopic lung volume reduction with endobronchial valves changes oxygen use during daily activities in people with severe COPD. About 20 patients scheduled for this treatment will perform simple tasks while wearing a portable oxygen…

This study looks at a program that helps nurses from refugee and migrant backgrounds adjust to working in the Netherlands. Researchers will ask participants and supervisors about their experiences to find out what works and what can be improved. The goal is to make the workplace …

This study tests whether eating dried chicory root (a high-fiber prebiotic) for 6 weeks can change gut bacteria and immune cells in 20 people who had surgery for stage II melanoma. Researchers will measure short-chain fatty acids in stool and map gut microbes. The goal is to lear…

This study looks at how a 7-day low iodine diet changes the amount of radioactive iodine absorbed by the body in people who have had their thyroid removed due to thyroid cancer. Twenty-five adults will have their iodine uptake measured before and after the diet. The goal is to un…