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Scientists probe the mysterious crash that defines ME/CFS

NCT ID NCT07715838

Recruiting now Knowledge-focused Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study investigates post-exertional malaise (PEM), the hallmark symptom of ME/CFS, where even minor activity triggers severe symptom worsening. Researchers will compare 50 ME/CFS patients with 50 healthy volunteers matched by age, sex, and activity level. Participants undergo physical and mental tasks while their heart rate, blood pressure, brain activity, muscle function, and blood markers are measured before, during, and after exertion. The goal is to uncover the biological roots of PEM and pave the way for objective diagnostic tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If this study succeeds, it could reveal the biological mechanisms behind post-exertional malaise in ME/CFS, pointing toward objective diagnostic criteria and potential treatment targets.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly help patients. The findings may be complex and not lead to immediate clinical changes.

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Conditions

The condition(s) this trial relates to.

myalgic encephalomeyelitis/chronic fatigue syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYALGIC ENCEPHALOMYELITIS / CHRONIC FATIGUE SYNDROME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UMC Groningen

    RECRUITING

    Groningen, 9713VB, Netherlands

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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