University Medical Center Groningen

This study follows 261 people with persistent, recurrent, or metastatic cervical cancer who are taking pembrolizumab (Keytruda) with or without bevacizumab (Avastin). Some participants may choose to stop pembrolizumab early if their tumor shrinks or disappears, while others conti…

This early-stage trial explores whether injecting the immunotherapy drug nivolumab directly into lymph nodes before standard surgery is feasible and safe for people with cervical cancer. The study involves 12 participants and aims to see if this targeted approach can shrink tumor…

This study compares two different drugs, vicadrostat and spironolactone, both taken with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. The trial involves 100 adults with chronic kidney disease and heart disease or heart failure. Part…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and i…

This study tests a new type of shoe, called the LEEF-shoe, designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the LEEF-shoe and standard orthopedic shoes for several weeks to compare how well they relieve pressure on the feet.…

This study tests whether adding a common water pill (hydrochlorothiazide) to the standard drug tolvaptan can slow kidney function decline and reduce side effects like frequent urination in people with autosomal dominant polycystic kidney disease (ADPKD). About 300 adults on a sta…

This pilot study tests whether giving a higher dose of proton therapy to the lung tumor is safe for people with stage III non-small-cell lung cancer who are also getting chemotherapy. About 87 participants will receive the higher radiation dose along with standard chemo drugs. Re…

This study tests whether giving a donor kidney a 4-6 hour warm bath on a machine (normothermic machine perfusion) right before transplant helps it work better a year later. The trial includes 240 adults receiving a kidney from a donor aged 50 or older. Half get the standard cold …

This study tests whether patiromer, a drug that lowers potassium, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and lower …

This study tests whether giving fluids and blood pressure medicines based on each patient's heart response can improve sepsis care. 188 adults with sepsis in the emergency department will be randomly assigned to either personalized treatment or standard care. The goal is to see i…

This study looks at whether a routine MRI scan of the brain is helpful for people newly diagnosed with stage IV non-small cell lung cancer that has spread but does not yet cause brain symptoms. One hundred participants will get a brain MRI, and doctors will assess how the results…

This study tests a new way to find early signs of esophageal cancer in people with Barrett's esophagus. Participants will receive two fluorescent dyes (bevacizumab-800CW and cetuximab-800CW) either by mouth or directly on the esophagus before a standard endoscopy. The goal is to …

This study tests a special imaging agent (89Zr-DF-Crefmirlimab) that helps PET scans show immune cells called CD8 T-cells inside tumors. About 30 adults with advanced solid tumors will receive this agent before and during standard immunotherapy (anti-PD-1). The goal is to see if …

This study tests whether a simple checklist plus a finger-prick blood test can help family doctors decide which children with belly pain need to go to the hospital for possible appendicitis. About 566 children aged 4 to 18 will take part. If it works, fewer kids without appendici…

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the prob…

This study tests whether early, symptom-guided therapy can prevent long-term complaints after mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, psychoeducation by phone, or usual care. The goal is to reduce post-concussion…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study tests a small, hands-free device called PEP-buddy that creates gentle pressure when you breathe out. It is designed to quickly relieve sudden shortness of breath in people with COPD. Researchers will have 25 participants use the device for 4 weeks to measure if it redu…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests whether EMDR therapy can reduce nausea and vomiting that some cancer survivors continue to experience long after chemotherapy ends. About 20 adults who have finished cancer treatment and still have these symptoms will receive EMDR sessions. The goal is to see if …

This study tests whether a 12-week at-home taste and smell training program can improve taste function in cancer patients who experience taste changes from tyrosine kinase inhibitors. Ninety participants across 12 Dutch hospitals will be randomly assigned to the training or stand…

This study tests whether a home-based 'taste steering' program can improve food enjoyment for cancer patients undergoing chemotherapy. 201 adults with metastatic triple negative breast cancer, metastatic testicular cancer, or stage II-IV diffuse large B cell lymphoma will be rand…

This study tests a new virtual reality therapy for people who hear voices that others cannot hear. The therapy uses computer-generated avatars to represent the voices, helping patients learn to cope. Researchers will compare this VR therapy plus usual care to usual care alone in …

This study looks at how mindfulness and fantasizing affect repetitive negative thinking in 100 adults whose depression is in remission. Participants will try both techniques and researchers will measure changes in thinking patterns, heart activity, and brain waves. The goal is to…

This study is watching 5,000 adult ICU patients to understand why some develop more severe organ failure than others. Researchers will track patients' health and quality of life for a year. The goal is to find new clues that could one day lead to better treatments for critical il…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

This study tests whether doing a therapy exercise in virtual reality feels different from doing it with imagination alone. Thirty healthy students will try both versions and report how they feel. The goal is to see if VR can make therapy more concrete and accessible.

This study is testing a new technique called diamond magnetometry to measure free radicals in individual sperm cells and blood. Free radicals are natural but can damage sperm if out of balance. Researchers will also look at the bacteria in semen and how lifestyle and diet affect …

This study examines how a minimally invasive lung valve treatment changes leg muscle function in people with severe emphysema. Researchers will use MRI scans and small muscle samples to measure energy use and muscle structure before and after treatment. The goal is to understand …

This study follows 20 people with severe emphysema who are scheduled to receive endobronchial valves. Researchers will measure how much oxygen patients use during everyday activities before and six months after the procedure. The goal is to see if the treatment reduces the physic…

This study is creating a large database of 10,000 lung cancer patients who received radiation therapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the bes…

This study examines a program designed to help nurses from refugee or migrant backgrounds adjust to working in the Netherlands. Researchers will interview participants and supervisors to see what works and what can be improved. The goal is to make the program better and create a …

This study looks at how a 7-day low-iodine diet changes the amount of radioactive iodine taken up by the body in people who have had their thyroid removed due to thyroid cancer. Researchers will measure iodine uptake before and after the diet in 25 adults. The goal is to understa…

This study looks at whether a test called the Hinting Task can pick up on social thinking difficulties in people with Huntington's disease. Social thinking helps us understand hints and other people's perspectives, and problems with it can affect daily life. Researchers will comp…

This study looks at the long-term health of children (16 years and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's transplant or medications.…

This study tests whether eating dried chicory root (a high-fiber prebiotic) every day for 6 weeks can change gut bacteria and immune cells in 20 people who had surgery for stage II melanoma. Researchers want to see if it increases helpful substances called short-chain fatty acids…

This study tests whether a special PET scan can show how much of a certain protein (SSTR2) is present in nasopharyngeal cancer tumors. Ten adults with EBV-related nasopharyngeal cancer will get the scan before and after starting chemotherapy or chemoradiation. The goal is to see …

This study observes 270 adults hospitalized with acute heart failure to identify different patterns of fluid buildup (congestion). Researchers will use ultrasound, liver scans, and urine tests to see how these patterns relate to treatment response and outcomes like rehospitalizat…