Water pill could boost kidney Drug's power and cut side effects
NCT ID NCT05373264
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a common water pill (hydrochlorothiazide) to the standard drug tolvaptan can slow kidney function decline and reduce side effects like frequent urination in people with autosomal dominant polycystic kidney disease (ADPKD). About 300 adults on a stable dose of tolvaptan will receive either hydrochlorothiazide or a placebo. The goal is to improve both treatment effectiveness and quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Amsterdam University Medical Center
RECRUITINGAmsterdam, Netherlands
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Charité University Hospital
RECRUITINGBerlin, Germany
Contact
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Cliniques Universitaires Saint-Luc
RECRUITINGBrussels, Belgium
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Erasmus University Medical Center
RECRUITINGRotterdam, Netherlands
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Fundación Puigvert
RECRUITINGBarcelona, Spain
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Hospital La Cavale Blanche
RECRUITINGBrest, France
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La Fundación Jiménez Díaz
RECRUITINGMadrid, Spain
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Med. Klinik und Poliklinik III, Universitätsklinikum Dresden.
RECRUITINGDresden, Germany
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Necker-Enfants Malades Hospital
RECRUITINGParis, France
Contact
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University Hospital Cologne
RECRUITINGCologne, Germany
Contact
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University Hospital Leuven
RECRUITINGLeuven, Belgium
Contact
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University Medical Center Groningen
RECRUITINGGroningen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••