Can a cheap diuretic boost kidney protection in ADPKD?
NCT ID NCT05373264
First seen Mar 12, 2026 · Last updated May 13, 2026 · Updated 8 times
Summary
This study tests whether adding hydrochlorothiazide (a water pill) to the standard drug tolvaptan can better slow kidney function loss and reduce side effects like frequent urination in people with autosomal dominant polycystic kidney disease (ADPKD). About 300 adults on stable tolvaptan will receive either hydrochlorothiazide or a placebo. The goal is to improve both treatment effectiveness and quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Amsterdam University Medical Center
RECRUITINGAmsterdam, Netherlands
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Charité University Hospital
RECRUITINGBerlin, Germany
Contact
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Cliniques Universitaires Saint-Luc
RECRUITINGBrussels, Belgium
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Erasmus University Medical Center
RECRUITINGRotterdam, Netherlands
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Fundación Puigvert
RECRUITINGBarcelona, Spain
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Hospital La Cavale Blanche
RECRUITINGBrest, France
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La Fundación Jiménez Díaz
RECRUITINGMadrid, Spain
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Med. Klinik und Poliklinik III, Universitätsklinikum Dresden.
RECRUITINGDresden, Germany
Contact
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Necker-Enfants Malades Hospital
RECRUITINGParis, France
Contact
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University Hospital Cologne
RECRUITINGCologne, Germany
Contact
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University Hospital Leuven
RECRUITINGLeuven, Belgium
Contact
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University Medical Center Groningen
RECRUITINGGroningen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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