University Medical Center Groningen

This study looks at 720 people with a weakened heart muscle (non-ischemic dilated cardiomyopathy) and a low pumping ability. Researchers want to see if using an MRI to find heart scarring can help decide who benefits most from getting an implantable defibrillator (ICD) to prevent…

This study tests a weekly injection called survodutide in 120 adults with chronic kidney disease and high protein in their urine. The goal is to see if it can safely lower urine protein levels and protect kidney function over 36 weeks. Participants must already be on standard blo…

This study looks at whether reducing the number of kidney function tests during heart failure treatment helps patients reach higher, more effective medication doses without safety risks. It involves 344 adults with heart failure and reduced pumping ability. Researchers will compa…

This study looks at how to best replace thyroid hormones after radioiodine treatment for high-risk thyroid cancer. About 40 participants will receive either a combination of two hormones (L-T3 and L-T4) or the standard single hormone (L-T4) for two weeks. The goal is to see which…

This study tests whether combining two drugs—dapagliflozin and SC0062—can better protect the kidneys in adults with type 1 diabetes and chronic kidney disease. About 36 participants will try each drug alone and together to see if the combo reduces protein in urine and prevents fl…

This study tests whether a special fluorescent dye, given before a bronchoscopy, can help doctors see lung tumors more clearly. About 20 adults with a suspicious lung nodule or lymph node will receive the dye and then undergo a bronchoscopy with a special camera. The goal is to s…

This study tests whether early, symptom-guided therapy can help people recover faster from mild traumatic brain injury. About 655 adults will receive either physical/occupational therapy, phone counseling, or usual care. The goal is to reduce long-term complaints like headaches, …

This pilot study will use brain scans (fMRI) to see how a mild electrical stimulation treatment called TENS affects brain activity in 30 people with Multiple Sclerosis who have fatigue and walking problems. The goal is to understand how TENS works in the brain, not to test it as …

This study tests whether two fluorescent dyes attached to common IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. About 30 adults with ulcerative colitis or Crohn's disease will receive the dyed drugs before a routine colonoscopy. The goal is to see…

This study looks at a dental procedure where a tooth is replaced with an implant and a temporary crown is placed on the same day. The temporary crown is made before the surgery using digital planning. Researchers will check how well the implant and crown hold up, how the bone aro…

This study looks at people who got dental implants with a special denture (overdenture) in their upper jaw 15 years ago because their regular dentures didn't fit well. Researchers want to see how the bone around the implants has changed, how many implants are still working, and h…

This study looks at how the drug canagliflozin spreads through the body of people on dialysis. The goal is to see if it can still protect the heart and kidneys even when kidney function is very low. Ten adults on dialysis will receive the drug and undergo PET scans to track where…

This study compares two ways of doing a therapy exercise: using imagination or using virtual reality (VR). Healthy student volunteers will try both versions and report how they feel. The goal is to see if VR makes the exercise easier or more effective, especially for people who h…

This early-stage study tests a new imaging method called fluorescence endoscopy to see if immunotherapy targets (PD-1 and PD-L1 proteins) are present in esophageal cancer. Fifteen participants will receive two fluorescent tracers before a routine endoscopic exam. The goal is to l…