University Medical Center Groningen

This study is testing whether combining two existing drugs (dapagliflozin and SC0062) provides better protection for the kidneys than either drug alone in adults with type 1 diabetes who have early signs of kidney damage. The trial will involve 36 participants who will try differ…

This study is testing if a weekly injection called survodutide can help protect the kidneys in people with chronic kidney disease (CKD). It will involve 120 adults with CKD who have high levels of protein in their urine, a sign of kidney damage. The main goal is to see if the tre…

This study aims to find out if a special heart MRI scan can better identify which patients with a weakened heart muscle are at high risk for sudden cardiac death and would benefit from an implanted defibrillator (ICD). It will enroll 720 patients who have a weakened heart not cau…

This study aims to find the best way to restart thyroid hormone medication after treatment for high-risk thyroid cancer. Researchers will compare two approaches: a standard single hormone versus a combination of two hormones. They want to see which helps patients feel better fast…

This study aims to see if doctors can safely check kidney function less often while increasing heart failure medications to their best doses. It will involve 344 adults with a specific type of heart failure who are not yet on the full recommended doses of their key medicines. The…

This study is testing if starting therapy early can prevent common, lasting symptoms after a mild head injury. Adults who go to the emergency room within 24 hours of their injury will be randomly assigned to receive either physical/occupational therapy, phone-based education, or …

This study compares two common heart procedures—bypass surgery (CABG) and stent placement (PCI)—for people with weakened heart pumps and multiple clogged arteries. Researchers will follow 358 patients for 4 years to see which approach leads to better survival, fewer heart problem…

This study is testing whether a daily pill called finerenone can help protect kidney function in people with chronic kidney disease who are not using standard RAS inhibitor medications. It will involve 180 adults who will take either finerenone or a placebo pill for about 6 month…

This study aims to compare how two different drugs, vicadrostat and spironolactone, affect kidney function and proteins in the blood and urine of people who have both chronic kidney disease and heart disease or heart failure. About 100 participants will take one of the drugs alon…

This study is developing and testing a virtual reality (VR) version of a therapy exercise for adults with psychiatric disorders. Researchers want to see if using VR to practice dialogues with virtual characters is a helpful and acceptable way to work on difficult emotions, self-c…

This study is looking back at the dental records of 50 patients to see how well a specific technique works. The technique involves placing a dental implant and a pre-made temporary crown on the same day, all planned digitally. The goal is to see if this approach leads to fewer pr…

This study is testing whether using virtual reality (VR) makes a specific therapy exercise more effective than just using imagination. Healthy student volunteers will try both methods—one where they imagine talking to different parts of themselves, and one where they use a VR hea…

This study looks back at patients who received dental implants and a special denture (overdenture) in their upper jaw 15 years ago. Researchers will check X-rays to see how much bone has changed around the implants over time. They will also see how many implants and dentures are …

This study aims to develop a tool to predict if inflammatory bowel disease (IBD) treatments will work for a patient. Researchers will give patients fluorescent versions of two common IBD drugs and use special cameras to see where the drugs go in the gut. The goal is to understand…

This study is testing a new imaging technique to help doctors predict which esophageal cancer patients will respond to immunotherapy. Researchers will use special 'glow-in-the-dark' tracers and a camera during an endoscopy to look for specific proteins in the tumor. The goal is t…

This study aims to understand how a common therapy called TENS (transcutaneous electrical nerve stimulation) affects the brain in people with Multiple Sclerosis (MS). Researchers will use MRI brain scans to measure activity while 15 people with MS and 15 healthy volunteers receiv…