University Medical Center Groningen

This study tests whether giving the immunotherapy drug pembrolizumab before standard hysterectomy can shrink tumors in people with a specific type of uterine cancer (MMRd). Twelve participants will receive 9 cycles of pembrolizumab before their surgery. The main goal is to see ho…

This study tests whether the drug finerenone can lower protein in the urine (a sign of kidney damage) better than a placebo in 180 adults with chronic kidney disease who are not taking certain blood pressure medicines. Participants will take finerenone or a dummy pill for 6 month…

This study compares two treatment approaches for people with high-risk rectal cancer. The experimental group gets a short course of radiation (5 days) followed by several weeks of chemotherapy before surgery, while the standard group gets the usual longer radiation with chemo. Th…

This study tests whether dapagliflozin, a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalizations in 1,750 people with severe chronic kidney disease, including those on dialysis or with a kidney transplant. Participants will …

This study looks at why some people lose more weight than others after bariatric surgery. Researchers will use brain scans (PET) to measure changes in the brain's reward system, specifically dopamine receptors, in 30 adults who had surgery 2-3 years ago. The goal is to understand…

This study tests a new type of PET scan that looks for a protein called PD-L1 in people with large B-cell lymphoma receiving CAR T-cell therapy. The goal is to see if this scan can predict whether the treatment will work and help tell the difference between active cancer and infl…

This study aims to find out why certain cancer drugs cause serious heart or lung side effects in some patients. Researchers will take skin or blood cells from 20 people who had extreme reactions to chemotherapy and turn them into stem cells to study the heart damage in a lab. The…

This study looks at why testicular cancer survivors may have a higher risk of heart disease. Researchers will study nearly 1,000 men who had testicular cancer between 1976 and 2007, focusing on how their cancer treatment (like chemotherapy) might affect their heart health over ti…

This study looks at how the immune system in the gut changes when people with cancer receive immunotherapy. Researchers will take small tissue samples from the gut and blood samples before and during treatment. The goal is to learn more about the body's response, not to test a ne…