Major trial aims to shield failing kidneys and hearts

NCT ID NCT05374291

Summary

This large study is testing whether the drug dapagliflozin can help protect the heart and kidneys in people with very severe chronic kidney disease, including those on dialysis or with a kidney transplant. About 1,750 participants will take either dapagliflozin or a placebo daily to see if it reduces the combined risk of death, kidney failure, or hospitalization for heart failure. The goal is to find a new, effective treatment for a high-risk group with very few proven options.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AZ Glorieux

    Ronse, Belgium

  • AZ Groeninge

    Kortrijk, Belgium

  • Admiraal de Ruyter Ziekenhuis

    Goes, Zeeland, Netherlands

  • Albert Schweitzer ziekenhuis

    Dordrecht, South Holland, Netherlands

  • Alrijne

    Leiderdorp, South Holland, Netherlands

  • Amphia Ziekenhuis

    Breda, North Brabant, Netherlands

  • Amsterdam UMC

    Amsterdam, North Holland, Netherlands

  • Bernhoven

    Uden, Netherlands

  • Box Hill Hospital (Eastern Health)

    Melbourne, Australia

  • Bravis ziekenhuis

    Roosendaal, Netherlands

  • Canberra Health Services

    Canberra, Australian Capital Teritory, Australia

  • Catharina Ziekenhuis Eindhoven

    Eindhoven, Netherlands

  • Charité

    Berlin, 10117, Germany

  • Clínica Universidad de Navarra

    Pamplona, Spain

  • Concord Repatriation General Hospital

    Sydney, New South Wales, Australia

  • Deventer Ziekenhuis

    Deventer, Netherlands

  • Diakonessenhuis Utrecht

    Utrecht, Netherlands

  • Dialyse Centrum Groningen

    Groningen, Provincie Groningen, Netherlands

  • Dialysecentrum Dianet (Amsterdam)

    Amsterdam, Netherlands

  • Dialysecentrum Dianet (Utrecht)

    Utrecht, Netherlands

  • Dialysecentrum Tergooi

    Hilversum, Netherlands

  • Dialysezentrum Heilbronn - Überörtliche Berufsausübungsgemeinschaft für Nephro und Dialyse (ÜBAG)

    Heilbronn, 74076, Germany

  • East Metro Health Services (Royal Perth Hospital and Armadale Health Services)

    Perth, Western Australia, Australia

  • Erasmus Medisch Centrum

    Rotterdam, South Holland, Netherlands

  • Flevoziekenhuis

    Almere Stad, Flevoland, Netherlands

  • Franciscus Gasthuis en Vlietland

    Rotterdam, Netherlands

  • Gelre Ziekenhuizen

    Apeldoorn, Gelderland, Netherlands

  • Haaglanden Medisch Centrum

    The Hague, South Holland, Netherlands

  • HagaZiekenhuis

    The Hague, South Holland, Netherlands

  • Hospital Arnau de Vilanova

    Lleida, Spain

  • Hospital Clinico Universitario de Valencia

    Valencia, Spain

  • Hospital Universitari Germans Trias i Pujol

    Barcelona, Spain

  • Isala Ziekenhuis

    Zwolle, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, Netherlands

  • John Hunter Hospital

    New Lambton Heights, New South Wales, Australia

  • Laurentius Ziekenhuis

    Roermond, Limburg, Netherlands

  • Leiden UMC

    Leiden, Netherlands

  • Liverpool Hospital

    Sydney, New South Wales, Australia

  • Maasstad Ziekenhuis

    Rotterdam, South Holland, Netherlands

  • Maastricht UMC+

    Maastricht, Netherlands

  • Martini Ziekenhuis

    Groningen, Netherlands

  • Maxima Medisch Centrum

    Eindhoven, Netherlands

  • Meander Medisch Centrum

    Amersfoort, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Netherlands

  • Medizinische Klinik und Poliklinik I der Universitätsklinik WürzburgSchwerpunkt Nephrologie

    Würzburg, 697080, Germany

  • Nephrologisches Zentrum Villingen/Schwenningen

    Villingen-Schwenningen, 678052, Germany

  • Niercentrum aan de Amstel

    Amstelveen, Netherlands

  • Nierenzentrum Heidelberg

    Heidelberg, 69120, Germany

  • Nierenzentrum Wiesbaden

    Wiesbaden, 2365191, Germany

  • Noordwest Ziekenhuisgroep Alkmaar

    Alkmaar, Netherlands

  • OLVG

    Amsterdam, North Holland, Netherlands

  • Praxis für Dialyse und Nierenkrankheiten

    Berlin, 12627, Germany

  • Prince of Wales Hospital

    Sydney, New South Wales, Australia

  • Radboud UMC

    Nijmegen, Netherlands

  • Reinier de Graaf Ziekenhuis

    Delft, Netherlands

  • Royal Adelaide Hospital

    Adelaide, South Australia, Australia

  • Royal Brisbane and Womens Hospital

    Brisbane, Queensland, Australia

  • Royal Melbourne Hospital

    Parkville, Victoria, Australia

  • Royal North Shore Hospital

    Sydney, New South Wales, Australia

  • Royal Prince Alfred Hospital

    Sydney, New South Wales, Australia

  • Saxenburgh Medisch Centrum

    Hardenberg, Overijssel, Netherlands

  • Singapore General Hospital

    Singapore, Singapore

  • Spaarne Gasthuis

    Hoofddorp, Netherlands

  • St George Hospital

    Sydney, New South Wales, Australia

  • St. Antonius Ziekenhuis

    Nieuwegein, Netherlands

  • St. Jansdal ziekenhuis

    Lelystad, Netherlands

  • Sunshine Coast Hospital and Health Services

    Birtinya, Queensland, Australia

  • Townsville University hospital

    Douglas, Queensland, Australia

  • UMC Utrecht

    Utrecht, Netherlands

  • UMCG

    Groningen, Provincie Groningen, Netherlands

  • UZ Brussel

    Brussels, Belgium

  • UZ Leuven

    Leuven, Belgium

  • Universitätsklinikum Düsseldorf

    Düsseldorf, 40225, Germany

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum Halle (Saale) Innere Medizin 2

    Halle, 06120, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, Germany

  • Universitätsklinikum JenaKlinik für Innere Medizin III

    Jena, 07747, Germany

  • Universitätsklinikum RegensburgAbteilung für Nephrologie

    Regensburg, 93053, Germany

  • Universitätsklinikum Tübingen Medizinische Klinik IV

    Tübingen, 72076, Germany

  • Universitätsklinikum Ulm, Klinik für Innere Medizin I, Nephrologie

    Ulm, 89081, Germany

  • Universitätsmedizin Mainz

    Mainz, 55131, Germany

  • Vall d'Hebron University Hospital

    Barcelona, Spain

  • VieCuri Medisch Centrum

    Venlo, Netherlands

  • Western Health

    Melbourne, Victoria, Australia

  • Westmead Hospital

    Sydney, New South Wales, Australia

  • Wilhelmina Ziekenhuis Assen

    Assen, Drenthe, Netherlands

  • Wollongong Hospital

    Wollongong, New South Wales, Australia

  • Zentrum fuer Nieren-, Hochdruck- und Stoffwechselerkrankungen Hannover

    Hanover, 30625, Germany

  • Ziekenhuisgroep Twente

    Almelo, Overijssel, Netherlands

  • Zuyderland Medisch Centrum

    Sittard, Limburg, Netherlands

Conditions

Explore the condition pages connected to this study.