HEART FAILURE

This study tests whether having a specially trained community paramedic visit heart failure patients at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. Researchers will track days out of t…

This study tests an investigational drug called omecamtiv mecarbil in 1800 adults with severe heart failure and a very weak heart pump. The goal is to see if the drug can lower the risk of serious events like hospitalization, need for a heart pump or transplant, stroke, or death.…

This study tests whether a daily pill called enavogliflozin (a type of SGLT2 inhibitor) can reduce the risk of major heart problems or worsening heart failure in people who have already had a valve replacement (TAVR) for severe aortic stenosis and still have heart failure with pr…

This study tests whether two common supplements—coenzyme Q10 and selenium—can lower the risk of heart failure complications. About 4,044 adults with heart failure in Denmark will take either the supplements or placebos for 2-3 years. Researchers will track how many are hospitaliz…

This study tests whether adding vicadrostat to the standard drug empagliflozin helps people with heart failure who have a preserved ejection fraction (heart pumps normally but still causes symptoms). About 6000 adults with heart failure symptoms will be randomly assigned to recei…

This study tests a 12-week phone coaching program for 280 adults with mild-to-moderate heart failure. The program uses positive psychology and motivational interviewing to help patients improve their diet, exercise, and medication habits. Participants also receive text messages f…

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction. The goal is to see if this approach improves fitness and heart health better than standard advice. 336 par…

This study compares a targeted drug called acalabrutinib to other standard treatments for adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The main goal is to see if acalabrutinib causes fewer heart-related side effects. About 60 part…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in people with cardiogenic shock from heart failure can lower the risk of dying in the hospital. About 400 adults aged 18-90 with severe heart failure and shock will be enrolled. The monitor …

This study tests a new temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through a blood vessel to help the left ventricle work. The goal is to see if it is safe a…

This study tests whether Empagliflozin (Jardiance), a drug already used for heart failure, can help adults born with heart defects. About 40 participants will take the drug and be monitored for changes in heart function, exercise ability, and hospitalizations. The goal is to see …

This study tests whether a virtual ward — follow-up care via phone or video — can reduce hospital readmissions for people with heart failure. About 346 adults who were recently hospitalized for heart failure will take part. Researchers will compare readmission rates, costs, and q…

This study compares a new pacing method called His-bundle pacing (His-CRT) to standard biventricular pacing (BIV-CRT) in 120 adults with heart failure and right bundle-branch block. The goal is to see if His-CRT improves the heart's pumping ability more than the standard approach…

This study tests whether an AI-powered health coach, along with a vital sign monitor, can help 300 adults with heart disease, diabetes, or kidney disease better manage their health. Participants will use a chatbot and tracking tools to improve key health numbers and reduce hospit…

This study tests a new machine that keeps donated hearts healthy outside the body before transplant. It includes hearts from donors that might not normally be used. About 60 adults waiting for a heart transplant will take part. The goal is to see if this method is safe and helps …

This study is testing a smartphone app designed to help adults aged 55 and older who have multiple chronic conditions like heart failure, diabetes, and kidney disease. The app provides fall prevention tips, a personalized after-hospital care plan, and tools to track symptoms and …

This study tests a new remote monitoring system called SmartSignalHF for people with heart failure who have a pacemaker or defibrillator. The goal is to see if it can reduce deaths and hospitalizations compared to standard care. About 1,132 adults with moderate heart failure will…

This study tests whether temporarily blocking the splanchnic nerves can reduce congestion and improve exercise capacity in people with heart failure. About 54 adults with heart failure and reduced pumping ability will receive the nerve block or a placebo. The goal is to see if th…

This study looks at whether using smartphone health apps and receiving personalized text messages can help people with chronic heart failure manage their condition better. Researchers want to see if these tools reduce the number of days people spend in the hospital for heart prob…

This study tests whether adjusting the dose of water pills (diuretics) based on urine sodium levels helps hospitalized heart failure patients get better faster. About 600 adults with acute heart failure will be assigned to either a higher or lower urine sodium target, or standard…

This study tests whether a special heart monitor can help prevent serious problems like death, need for a heart pump, or repeat hospital stays in people who have survived a severe heart condition called cardiogenic shock. About 40 adults will be randomly assigned to get the monit…

This study looks at whether adding protein drinks to the diet can prevent muscle wasting in people with heart failure. About 120 adults with severe heart failure will be split into three groups: no extra protein, low-dose protein, or high-dose protein. Researchers will measure ch…

This study compares two types of heart procedures—convergent hybrid ablation and standard catheter ablation—in 120 adults with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. The goal is to see which approach better controls heart rhythm without …

This study tests a single low-dose radiation treatment to the whole heart in 40 adults with advanced heart failure who have not responded to standard therapies. The goal is to see if it can improve the heart's pumping ability by at least 5% over six months. Researchers will also …

This study tests whether taking a daily selenium supplement (200 micrograms) can reduce hospitalizations and heart-related deaths in people with heart failure. Researchers will compare selenium to a placebo in over 4,300 participants from Sweden and Norway. The goal is to see if …

This study tests a drug called ziltivekimab in people with heart failure and signs of inflammation. About 5600 participants will receive either the drug or a placebo as a monthly injection. The goal is to see if the drug can prevent heart failure hospitalizations, urgent visits, …

This study is testing whether using portable air purifiers at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with other heart health markers. The study involves 255 adults in India with a spec…

This study tests whether a pacemaker plus a small heart procedure works better than standard medications for controlling heart rate in 600 people with atrial fibrillation and heart failure. The pacemaker uses a newer method called conduction system pacing to regulate the heartbea…

This early study tests if electrically pacing the diaphragm (the muscle that helps you breathe) can improve heart function in people with heart failure. Ten adults already scheduled for a heart device will get temporary pacing during their procedure. Researchers will check if it'…

This study is testing a device called the Occlutech Atrial Flow Regulator in 150 people with chronic heart failure. The device is implanted to help balance pressure in the heart's chambers, potentially reducing symptoms and hospital stays. Researchers will track safety and heart-…

This study tests if the drug sacubitril/valsartan can improve heart function in people who have an artificial heart valve and heart failure with a weak pumping ability. About 220 adults will take the drug and be checked for improvement in their daily activities and symptoms. The …

This study compares two types of heart pacing—conduction system pacing and standard biventricular pacing—in 320 adults with heart failure and a wide QRS. The goal is to see which method better reduces the risk of death, heart failure hospitalization, or need for a heart transplan…

This study tests the Cardiohelp device, a heart-lung machine, in 50 children with severe heart failure to see if it is safe and works well for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. Th…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with two home-based sessions, plus education and coaching. The goal is to see if this approach helps participants become …

This study tests a nurse-led program where patients with heart failure and their care partners learn simple strategies to improve medication adherence. The goal is to reduce hospitalizations and improve quality of life. About 328 patient-care partner pairs will participate.

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom improvement between tho…

This study tests whether a quick urine sodium measurement can help doctors better adjust diuretic doses for people with chronic heart failure. About 300 participants will be assigned to either a urine-guided dosing strategy or standard care. The goal is to see if this approach im…

This study tests if briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with heart failure. About 240 adults with heart failure who need a heart catheterization will be randomly assigned to receive either the cuf…

This study compares two types of heart pacing for people with heart failure: one guided by artificial intelligence (AI) and one using the standard method. The goal is to see if the AI-guided approach improves the heart's pumping ability more. About 224 adults with heart failure w…

This study tests a small, wearable patch that measures heart function from outside the body, aiming to help doctors adjust heart failure medications remotely and on time. The patch is designed to be low-cost and safe, avoiding the need for surgical implants. Researchers will enro…

This study tests whether the drug finerenone can reduce heart failure events and deaths in people hospitalized with acute heart failure who have a mildly reduced or preserved pumping function. About 5,200 adults will receive either finerenone or a placebo to compare outcomes. The…

This study tests whether using digital checklists and reminders in cardiology clinics can increase the use of guideline-recommended heart failure medications. About 4,000 adults with heart failure and reduced ejection fraction will take part. The goal is to improve medication use…

This study tests a new medicine called CDR132L in 200 adults with heart failure and an enlarged heart. Participants will receive either the drug or a placebo for about 60 weeks to see if it improves heart structure and function. The goal is to find a new way to control heart fail…

This study looks at 70 people with heart failure, an irregular heartbeat (atrial fibrillation), and a special pacemaker (CRT) that isn't pacing enough. It compares two procedures: one that fixes the irregular heartbeat (AF ablation) and one that slows the heart's electrical signa…

This study looks at whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers, a common heart medication. About 1,300 adults with a history of heart failure and now-normal heart function will either continue or stop their …

This study tests an experimental drug called BMS-986435 in people with a type of heart failure where the heart pumps normally but is too stiff to fill properly (HFpEF). The goal is to see if the drug is safe and how the body processes it. About 208 adults with stable symptoms wil…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study compares two drugs, vicadrostat and spironolactone, both given with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two com…

This study looks at 780 adults who had a certain type of heart attack (NSTEMI) and also developed sudden heart failure. It compares getting a coronary angiogram (a special X-ray of the heart arteries) within 2 hours versus waiting until the patient is stable. The goal is to see w…

This study tests whether adding vicadrostat to the standard heart failure medicine empagliflozin can reduce heart-related deaths, hospitalizations, and urgent visits in people with chronic heart failure and a weakened heart pumping ability. About 4200 adults with symptomatic hear…

This study looks at people with heart failure whose heart function has returned to normal. It tests whether slowly reducing their daily medicines to just two is safe compared to staying on all four standard drugs. One hundred adults will be followed for two years with heart scans…

This study tests whether a preventive heart procedure (ablation) can reduce dangerous heart rhythms in people with heart failure who are getting an implantable defibrillator (ICD). About 62 high-risk participants will be randomly assigned to receive ablation within three months o…

This study tests a small implanted device that sends gentle electrical signals to the heart to help it pump better. It is for people with heart failure whose heart still pumps somewhat well (ejection fraction 40-70%). The goal is to see if the device improves walking ability and …

This study tests a device that uses 3D images of the feet and lower legs to detect early fluid buildup in people with heart failure. The goal is to see if catching these signs early can improve quality of life and reduce hospital visits or deaths. About 300 adults in the UK who h…

This study tests a personalized stem cell therapy for 10 people with advanced heart failure who already have a mechanical heart pump (LVAD). Two months after LVAD surgery, patients receive their own stem cells injected into the heart. Researchers will check if this improves heart…

This study tests a drug called vericiguat in children with heart failure caused by a weak left heart pump. About 342 kids aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks to see if it improves heart function. The goal is to find a better treatment…

This study is a large registry that will follow 5,500 people with heart failure who receive a special heart device called CCM. The goal is to see how well the device works and how safe it is over time in real-world settings. Researchers will track hospitalizations, complications,…

This study tests a 6-month program that combines exercise training, problem-solving help, and community health worker support for 210 adults with type 2 diabetes, obesity, and early heart problems. Participants must have low income and live in Baltimore or Washington County, Mary…

This study looks at whether a small sensor placed in the lung artery (the Cordella PA Sensor System) can help people with chronic heart failure by reducing deaths and hospital stays. About 2,150 people will be tracked for two years, comparing those who get the sensor to those who…

This study tests a newer heart pacing method (left bundle branch pacing) against the standard approach (biventricular pacing) in 60 adults with chronic heart failure and reduced pumping ability. The goal is to see if the newer method improves heart structure, reduces deaths, and …

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will take part to see if this device is as safe and effective as a…

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This study is testing a new wireless heart device (WiSE CRT System) combined with a small internal pacemaker to help the heart beat in sync without using traditional wires. It involves 40 people with heart failure who meet specific criteria. The goal is to see if this approach is…

This study tests whether using a device called Bioimpedance Analysis (BIA) can help doctors better manage fluid levels in heart failure patients admitted to the hospital. About 255 adults will be randomly assigned to either BIA-guided treatment or standard care. The goal is to se…

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study tests a device that automatically tracks leg swelling (edema) in people with chronic heart failure. The goal is to see if early alerts from the device can help doctors adjust treatment and reduce hospital stays. About 1,500 adults with a history of leg swelling will us…

This study tests whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive either standard care alone or standard care plus stem cells g…

This study tests whether a small sensor implanted in the lung artery can help doctors better manage heart failure and reduce hospital visits. About 1000 adults with a history of heart failure will be followed to compare outcomes between those who get the sensor and those who do n…

This study looks at people whose heart failure has gotten better, with their heart's pumping ability back to normal. It tests whether slowly reducing two common heart medications (RAS blockers or beta blockers) is safe compared to staying on all meds. About 150 adults will be ran…

This study tests a small sensor placed in the lung artery to monitor heart pressure in people with heart failure. The sensor sends daily readings to doctors, helping them adjust treatment early to prevent worsening symptoms. About 1,750 adults with mild to moderate heart failure …

This study tests a special machine that keeps donor hearts cool and oxygenated during transport, which may help more hearts be usable for transplant. About 20 adults waiting for a heart transplant will receive a heart preserved this way. The goal is to see if the method is safe a…

This study compares two common heart procedures—bypass surgery (CABG) and stents (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and imp…

This study looks at whether older adults (70+) with heart failure can skip getting an implantable defibrillator (ICD) and just take heart failure medications. The goal is to see if medication alone is as good as medication plus an ICD at helping people live longer. About 730 part…

This study tests a new medicine called CDR132L in 200 adults with heart failure and thickened heart muscle. Participants receive either the drug or a placebo for about 60 weeks to see if it improves heart structure and function. The goal is to control the disease and ease symptom…

This study tests a hospital-wide treatment plan for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the plan helps doctors identify who will benefit most from a minimally invasive valve repair procedure called MitraClip. …

This study tests whether a potassium-lowering drug (SZC) can help elderly patients (70+) with heart failure and chronic kidney disease safely increase their doses of RAASi medications, which are often limited by high potassium levels. About 94 participants will be randomly assign…

This study tests whether injecting lab-grown heart muscle cells (HiCM-188) into the heart can help people with severe heart failure (NYHA class III-IV). About 80 adults aged 18-75 with weak hearts (LVEF ≤35%) will receive the cells during bypass surgery. The main goal is to see i…

This large Phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the chance of heart failure or heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. About 11,300 adults aged 40 an…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,100 adults with heart failure and a weak heart pump. The goal is to see if the newer method improves quality of life, reduces hospital stay…

This study tests a patch of lab-grown heart muscle made from stem cells, implanted onto the heart to help it pump better. It is for 53 people with advanced heart failure who have no other options. The goal is to see if the patch is safe and can improve heart function.

This study tests whether social prescribing—a program that connects patients to community resources like housing, transportation, or mental health support—can help women with heart failure take their medications as prescribed and improve their quality of life. About 200 women wit…

This study tests whether the drug sotagliflozin can slow kidney function loss in 150 people with type 1 diabetes and moderate to severe kidney disease. Participants will take either the drug or a placebo daily for 3 years, while following a plan to prevent a serious side effect c…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein near the heart to help the valve close better. The goal is to see if it improves symptoms, walking ability, and reduces ho…

This study tests a new device called the Supira System in 45 people with heart failure and low heart function who need a high-risk heart procedure. The device is designed to help pump blood during and after the procedure, potentially reducing complications. The goal is to see if …

This study is testing a new way to pace the heart called left bundle branch area pacing (LBBAP) in 200 people with conditions like slow heartbeat, heart failure, or atrial fibrillation. The goal is to see if this method is safe and works better than standard pacing over 6 months.…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Recipients will take antiviral medication to prevent infection. The goal is to expand the donor pool and improve survival for people with heart failure.

This study tests a smart scale that measures fluid buildup in people with heart failure. The goal is to help doctors and patients catch problems early and adjust treatment before symptoms get worse. 50 adults with heart failure will use the scale at home, and their doctors will g…

This study tests a device called Aortix, placed inside the body to help the heart pump and remove excess fluid, in people hospitalized for worsening heart failure. It compares the device plus standard care to standard care alone (diuretics) in 320 patients who are not responding …

This study looks at whether opening narrowed kidney arteries with a small mesh tube (stent) helps high-risk patients with resistant high blood pressure, worsening kidney function, or heart failure. About 80 participants will either get the stent procedure or a sham procedure, whi…

This study tests a wearable monitoring system (Sensinel CPM) for people with chronic heart failure. The goal is to see if using the system reduces hospital visits and healthcare costs compared to standard care. About 1,200 participants with moderate to severe heart failure will b…

This study looks at whether cancer survivors who had heart damage from their cancer treatment, but whose heart function has since recovered, can safely stop taking heart failure medications. About 335 adults who finished cancer therapy at least 6 months ago and are currently on h…

This study tests whether using a heart failure registry to identify patients who need treatment adjustments can improve care. Researchers will screen 500 patients and refer them for medication changes, iron deficiency tests, or device therapy, then compare outcomes with 500 patie…

This study looks at whether a low-sodium (cardiac) diet is truly necessary for better health in people who have had heart failure. Researchers will track 500 adults hospitalized for heart failure to see how sodium intake affects hospital stay length and the chance of being readmi…

This study tests whether a one-year program led by heart failure nurses, using online lessons and a mobile app, can help people with heart failure avoid repeat hospital stays and feel better. About 200 adults who were recently hospitalized for worsening heart failure will either …

This study tests if a special heart pacing method followed by a targeted ablation (a procedure to destroy a small area of heart tissue) can help people with both heart failure and a type of irregular heartbeat called permanent atrial fibrillation. The goal is to see if this appro…

This study tests whether a special alert system in implanted heart devices can improve outcomes for people with heart failure. About 1,428 adults who already have a compatible pacemaker or defibrillator will be randomly assigned to have the alert feature turned on or off. The goa…

This study tests a device implanted in the heart that measures pressure and creates a small shunt to help manage chronic heart failure. It is for people with reduced heart pumping function (ejection fraction 40% or less) who still have symptoms despite standard treatments. The go…

This study tests a special pacing method called high-intensity his bundle pacing in 34 people with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help this group, but this new approach may improve heart function and quality of life. Participants will…

This study is for people with end-stage heart failure who need a total artificial heart while they wait for a heart transplant. It will check how well the Aeson artificial heart works and how safe it is in everyday hospital use. About 95 participants will be followed to see survi…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study looks at people with heart failure who are admitted to the hospital. It compares those who were already taking a medicine called ARNI before coming to the hospital with those who were not. The goal is to see if prior use of ARNI leads to fewer heart or kidney problems …

This study is testing whether sending personalized text messages can help older adults with heart failure take better care of themselves. Researchers will enroll 30 participants who will either receive about 5 supportive texts per week for 12 weeks or be in a comparison group. Th…

This study tests whether artificial intelligence can help doctors use heart ultrasound (echocardiography) to diagnose heart failure and valve disease in rural and remote Australia. About 612 adults over 45 with exercise problems or heart risks will take part. The goal is to see i…

This study tests whether an artificial intelligence (AI) system, called Willem, can help doctors spot heart failure earlier by analyzing electrocardiograms (ECGs). About 1,968 adults with possible heart failure or high heart risk will be randomly assigned to have their ECGs read …

This study tests a portable device that detects early lung congestion in heart failure patients by measuring chest fluid levels. Researchers want to see if it matches standard imaging methods. If successful, it could help patients manage their condition at home and avoid hospital…

This study tests a new imaging method (XTR003 injection with a standard PET scan) to see which parts of the heart are still alive in people with heart failure due to blocked arteries. About 40 to 60 adults with weak hearts will get this scan, then have heart surgery to restore bl…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study is testing whether an artificial intelligence program can analyze a single-lead ECG from devices like the Apple Watch to detect low heart pumping function (ejection fraction) and other heart structure problems. Researchers will enroll 5,000 adults at five hospitals in …

This study tests a new device called UHF-ECG that uses ultra-high frequency signals to check if the heart's lower chambers are beating in sync. It involves 360 adults who need a pacemaker or heart failure treatment. The goal is to see if this new method is safer and more accurate…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 100 women will receive either dapagliflozin or a placebo daily during their chemo. Researchers will monitor heart funct…

This study tests a heart failure screening and prevention strategy for people with type 2 diabetes. Researchers will use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then help doctors prescribe proven preventive medications. The goal is to see if this…

This study tests whether a combination of heart-protecting medications and exercise can prevent heart failure in people over 50 who have had COVID-19. Researchers will measure changes in exercise capacity and watch for signs of heart failure. The goal is to find a practical way t…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to coach people on managing blood pressure and other risk factors. About 364 adults with high blood pressure or early signs of heart failure will receive support to …

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early during a hospital stay for acute heart failure helps patients recover better. About 40 adults with stable heart failure will take part. The goal is to see if early rehab impro…

This study tests whether a 12-week smartphone-assisted cardiac rehabilitation program, led by a case manager, can help heart failure patients exercise more and feel better compared to usual care. About 150 adults with stable heart failure will take part. The goal is to see if the…

This study tests whether training the muscles used for breathing can improve exercise ability and blood flow in people with heart failure. Researchers at Mayo Clinic will enroll 68 adults who are already on standard heart failure medications. Participants will undergo inspiratory…

This study tests whether a drug called anakinra can reduce inflammation and help the heart respond better to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. About 20 adults on stable inotrope therapy will receive anakinra for 3 mon…

This study tests a new medicine called ziltivekimab in people with heart failure and signs of inflammation. The goal is to see if it can reduce symptoms like shortness of breath and fatigue, and improve physical function. About 680 adults will receive either the drug or a placebo…

This study tests whether a sensor-controlled digital game can motivate adults with heart failure to regularly check their weight and stay active. About 200 participants will either get the game plus sensors or just the sensors alone. The goal is to see if the game helps people st…

This study tests a 12-week telephone program where veterans with heart failure work with a nurse to solve problems related to their health. The goal is to improve self-care, reduce symptoms of heart failure, and ease depression and anxiety. Researchers will follow participants fo…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in older adults with heart failure who also have sarcopenia (age-related muscle loss). Researchers will also explore how the program affects symptoms and qual…

This study tests whether a 12-week chair yoga program is practical and helpful for 20 heart failure patients aged 55 and older living in rural areas. Researchers will work with patients and community members to design the program and gather feedback. The goal is to see if yoga ca…

This study tests whether adjusting a pacemaker to a personalized, optimal heart rate can improve symptoms and quality of life in people with heart failure and a slow heartbeat. About 106 participants will be randomly assigned to either the new optimized pacing strategy or standar…

This study tests a new medicine called NNC0537-1482 in people with heart failure to see if it is safe and how the body handles it. About 36 adults aged 40-75 will be randomly assigned to receive either the drug or a placebo. The study lasts up to 64 days, plus a screening period.…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can sometimes weaken the heart, and exercise might help. Researchers will compare a structured exercise program to a stretch…

This study tests whether a low dose of colchicine, a drug usually used for gout, can help people with a certain type of heart failure (HFpEF) and inflammation exercise more easily. About 60 adults aged 50 and older will take either colchicine or a placebo for 3 months. Researcher…

This study tests whether taking potassium nitrate (a natural compound found in vegetables like beets) can improve leg muscle power and overall exercise ability in people with heart failure. Researchers will give 75 adults either the nitrate or a placebo daily for 6 weeks, measuri…

This study looks at whether eccentric resistance training (a type of exercise that focuses on lengthening muscles) can improve heart function and exercise ability in people with stable chronic heart failure. Researchers will compare this training to standard resistance and aerobi…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. About 320 adults in the UK will take either the drug or a placebo for 4 months, and researchers will measure changes in symptoms like b…

This study tests whether a home-based exercise program, guided by a smartphone and activity tracker, can help people who have a new heart pump (LVAD) become more active and improve their quality of life. About 100 adults with a newly implanted HeartMate 3 LVAD will either follow …

This study tests a 6-week WeChat-based group program called SOCIAL_HF for elderly heart failure patients who feel socially frail. Participants join weekly video chats, do health check-ins, and access online resources. Researchers want to see if this improves social connections, s…

This study looks at whether wetting the skin or wearing a water-soaked T-shirt can help people with heart failure keep their body temperature down and reduce stress on the heart during heat waves. About 88 adults with and without heart failure will be exposed to simulated hot, dr…

This study looks at whether using a simple bedside ultrasound (POCUS) can help doctors better manage fluids in patients hospitalized with worsening heart failure. About 66 adults will be randomly assigned to either ultrasound-guided care or standard care. The main goal is to see …

This early study tests a procedure called pulmonary artery denervation in 50 people with heart failure and a type of lung hypertension (Group 2). The goal is to see if it can improve quality of life by reducing pressure in the lung arteries. Participants must have stable heart fa…

This study looks at whether a cardiac tele-rehabilitation program done at home can improve exercise capacity in adults with chronic heart failure. Participants will use wearable devices and a remote monitoring platform for an 8-week program. Researchers will compare their progres…

This study tests whether taking L-Carnitine by mouth can improve symptoms, heart function, and quality of life in people with heart failure who also have kidney problems. About 20 adults will take the supplement and be monitored for side effects and benefits. The goal is to see i…

This study looks at whether exercising in your community or at home can improve how well your heart and lungs work. Researchers will compare people who exercise regularly with those who don't. The goal is to find a safe and effective way for people with conditions like heart dise…

This study tests whether giving a ketone supplement through a feeding tube is safe and doable for people with severe heart failure. The goal is to see if the body can reach helpful ketone levels without causing side effects like vomiting or liver problems. The study involves 12 p…

This study looks at whether listening to music during a treadmill or bike test can improve how well the heart and lungs work in people with heart failure. About 40 adults with heart failure will be tested with and without music. The goal is to see if music makes exercise easier a…

This early study tests a device that creates a small opening between the upper chambers of the heart to relieve pressure and improve symptoms in people with heart failure. About 20 adults with moderate to severe heart failure will receive the procedure. The main goal is to check …

This study looks at whether adding ertugliflozin (a diabetes drug) or metolazone to standard water pills can better control fluid buildup and improve symptoms in people with chronic heart failure. About 60 adults with heart failure who already take daily water pills will be rando…

This study is testing a phone-based system that helps people with heart failure monitor their symptoms and get real-time coaching on how to manage them at home. The goal is to see if this approach improves patients' ability to care for themselves and recognize warning signs. Rese…

This pilot study tests a simple daily weight tracking tool called 'Wake and Weigh' to see if it helps older adults (55+) with heart failure improve their self-care and quality of life. Participants will use the tool in the hospital and at home for four weeks. The study aims to se…

This study tests whether personalized support from a sport and health professional after cardiac rehab helps people with heart failure stay physically active longer. About 90 adults with stable heart failure will either get this personalized coaching or usual care. The goal is to…

This study tests whether mindfulness training can help people with both heart failure and mild memory problems improve their self-care and thinking skills. About 176 adults will take part. The goal is to see if learning to focus on the present moment helps them manage their condi…

This study is for adults with heart failure who have too much fluid in their body. Instead of going to the hospital for treatment, participants will receive a medication called Lasix (furosemide) through a small needle under the skin at home. The goal is to see if this approach i…

This study tests whether nurse-led education can help people with chronic heart failure and their caregivers better manage the condition. Researchers will enroll 280 patients and their caregivers in Greece. The goal is to see if this education improves patients' quality of life, …

This study tests an experimental oral medicine (PF-07328948) in 620 adults with heart failure. Participants will be randomly assigned to receive the drug or a placebo for 36 weeks. The goal is to see if the drug improves walking distance, heart failure symptoms, and quality of li…

This study looks at whether adding core muscle exercises (like Pilates) to standard cardiac rehab helps people recovering from heart attacks or heart failure. Sixty adults will be split into three groups: core training only, aerobic exercise only, or both combined. The goal is to…

This study tests a digital program called TPA4You that uses a Fitbit to help older adults (50+) who care for a family member with heart failure become more active. The goal is to see if the program is practical and can improve daily activity, reduce sitting time, and ease caregiv…

This study is tracking 30,000 people aged 60 and older in rural China to see if a comprehensive program—combining medication, lifestyle advice, education, and heart monitoring—can lower the risk of heart attacks, strokes, and heart-related deaths. Participants will be followed fo…

This study is testing whether a robot can perform heart ultrasounds (echocardiograms) from a distance as accurately as a standard in-person ultrasound. The goal is to improve access to heart failure care for people living on remote islands in Guadeloupe. About 50 adults with hear…

This study is testing whether a special wearable shirt and home devices can safely monitor children (ages 8-18) with heart failure. The goal is to see if this approach is practical and acceptable for families, especially those living far from hospitals or with limited resources. …

This study looks at how social factors like race, income, and where you live affect whether heart failure is caught early. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in diagnosis and medication use. The goal is to ma…

This study aims to create a tool that uses heart MRI scans and basic health information to predict which patients with dilated cardiomyopathy are at higher risk for serious problems like heart failure or sudden cardiac death. Researchers will follow 2000 participants over time to…

This study is looking at whether early heart ultrasound results can help predict which patients with worsening heart failure are more likely to be readmitted to the hospital or die. Researchers will study 76 adults admitted for heart failure and track their health over time. The …

This study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart's arteries during a controlled fast pacing in 70 adults already scheduled for a heart cathe…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study is a registry that will follow about 320 people with heart failure who receive the WiSE System, a device that helps the heart pump better. The goal is to see how safe and effective the device is in real-world use by tracking side effects and heart function improvements…

This study looks at whether people with stable heart failure whose heart function has improved can safely stop taking a specific medication called a mineralocorticoid antagonist (MRA). About 90 participants will either continue their usual medication or receive a placebo for 24 w…

This study looks at why some people with heart failure develop high blood pressure in their lungs (pulmonary hypertension). Researchers will follow 150 patients for one year, using blood tests, heart imaging, and tissue samples to study a specific cell signaling pathway (BMPR2-ac…

This study aims to test a new, non-invasive way to measure how well the heart and blood vessels work in adults, both with and without heart failure. Participants will squeeze a handgrip device for two minutes while their heart activity and blood pressure are monitored. The goal i…

This study is for people who need a pacemaker because of a slow heartbeat (bradycardia) or heart failure. During the pacemaker implant procedure, doctors will take extra measurements of the heart's electrical activity to see how a specific pacing method called His bundle pacing a…

This study tests a noninvasive light sensor placed on the thumb to measure oxygen levels in children with heart failure. Researchers will temporarily stop blood flow to the hand and watch how oxygen levels change, then release the pressure to see how quickly oxygen returns. The g…

This study tests a new type of PET/CT scan (68Ga-FAPI) to see if it can detect active scarring in the heart muscle of people with heart failure. Researchers will compare this scan with standard MRI to find out if it can spot early or ongoing fibrosis that current methods miss. Th…

This study looks at whether a pharmacist-led program can help people with heart failure get the right medications, especially those who have trouble accessing healthcare. About 40 patients will be split into two groups: one gets extra help from a pharmacist and easy-to-understand…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study gathers medical and genetic information from 100 children with a rare genetic condition called RASopathy that causes severe heart thickening. The goal is to create a detailed dataset that can be used as a comparison group in future drug trials. No new treatments are te…

This study will use wearable digital health devices to collect heart data from 5,000 adults with chronic heart conditions like heart failure, high blood pressure, and aortic stenosis. The goal is to observe how these conditions progress over time. No new treatments or medications…

This study looks at fat cells around the heart arteries in 60 patients getting a heart transplant. Researchers want to see if the size of these fat cells is linked to heart disease. No treatment is given; the goal is to learn more about how fat tissue affects heart health.

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at how diabetes changes the way heart cells use energy, which may lead to heart failure. Researchers will examine heart tissue and use imaging tests in 500 adults with heart failure, with or without type 2 diabetes. The goal is to better understand the disease an…

This study will follow 10,000 people with heart conditions (like heart failure, heart attack, or bypass surgery) who are going through cardiac rehab at a clinic in Davos, Switzerland. Researchers will collect health data, blood samples, and patient reports to learn what helps peo…

This study is not testing any new drugs. Instead, it brings together doctors, nurses, pharmacists, and patients who have recently been in the hospital for heart failure. They will discuss which treatments to study in a future trial, what doses to use, and how to measure success. …

This study looks at whether people with heart failure can safely drink as much fluid as they want instead of limiting it. About 326 participants will either follow a restricted fluid plan or drink freely. The goal is to see if free drinking is safe and improves quality of life wi…

This study looks at how lower extremity arterial disease (LEAD) might affect the heart's pumping ability. Researchers will use special ultrasound techniques to measure heart function in 162 participants with and without LEAD. The goal is to find early signs of heart trouble and u…

This study looks at whether problems with mitochondria—the energy factories inside heart cells—are linked to how heart failure progresses. Researchers will take small heart tissue samples and blood from 45 to 60 people with heart failure and blocked arteries who are having bypass…

This study is re-examining 1,400 adults in Stockholm who were part of a larger national health study. Researchers are using advanced imaging, blood tests, and questionnaires to find risk factors for heart, lung, and liver diseases. The goal is to better understand what causes the…

This study aims to improve how doctors predict heart disease risk by using advanced MRI scans (T1 mapping) of the heart. Researchers will enroll 6,000 adults without known heart disease, including people with Long COVID, to establish normal ranges and see if these scans can detec…

This study examines the deposits and biological material that build up on Impella heart pumps after they are used in patients with heart failure. Researchers will analyze pumps from 200 patients to see if these deposits are linked to the patient's medical history or blood test re…

This study looks at how the body reacts during severe heart failure complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure markers of inflammation and blood vessel health in 26 adults to better understand t…

This study aims to understand how chronic breathlessness differs in people with cancer, COPD, or heart failure by using brain scans (fMRI) and virtual reality. Sixteen adults with persistent breathlessness will undergo an fMRI while experiencing virtual reality, and report their …

This study looks at whether adding a medicine called acetazolamide (often used for glaucoma) can help people with heart failure who still have fluid buildup despite taking standard water pills. Researchers will measure how much salt and water the body releases over 24 hours after…

This study follows 2,000 people with chronic heart failure to see how their daily physical activity, measured by step counters, relates to heart-related hospitalizations and survival. Participants wear their own pedometers and answer activity questionnaires every six months. The …

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study enrolls 300 people with heart failure who do not have standard heart devices like ICDs or CRTs. Researchers use the BIOMONITOR IV, a small implant that tracks heart activity, breathing, and fluid levels remotely. The goal is to learn how often irregular heartbeats occu…

This study is testing whether a simple chatbot that asks patients about their symptoms can help doctors detect early signs of heart failure worsening. About 120 people with heart failure will answer questions regularly via a chatbot. The goal is to see if changes in their answers…

This study aims to create a computer-based tool that can predict which cancer patients are at high risk of heart damage from certain treatments. Researchers will follow 600 patients in France for one year, collecting health data to train a machine learning model. The goal is to h…

This study tests a risk calculator that predicts who is likely to develop heart failure before they have any symptoms. Researchers will recruit 600 people aged 50 and older with conditions like diabetes or high blood pressure. The goal is to see if this tool can be used in GP cli…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track inflammation, heart energy use, and thinking skills over time. The goal is to find early warning signs of heart failure and memory decline, so doctors can pers…

This study is creating a live registry to track heart failure patients across the Yale New Haven Health System. Researchers will monitor hospitalizations and use of recommended treatments in up to 40,000 participants. The goal is to better understand and improve heart failure car…

This study is testing whether monitoring a substance in the blood called sST2 can help doctors adjust treatment for people with acute heart failure. The goal is to see if this approach reduces hospital readmissions and improves quality of life. About 710 adults hospitalized for h…

This study looks at how a special breathing method (negative pressure ventilation) affects the heart's right side in people who have a left ventricular assist device (LVAD). About 30 adults who recently had LVAD surgery and are stable will try both standard and negative pressure …

This study aims to validate and check the reproducibility of laboratory tests, equipment, and techniques used in research on chronic diseases like obesity, diabetes, and heart disease. Researchers will compare old and new testing methods to ensure results are accurate and consist…

This study looks at why people with heart failure choose to take part in two different care programs after leaving the hospital: a home support program (PRADO-IC) and remote monitoring via telemedicine. Researchers will follow 700 patients in France to see what factors—like age, …

This study watches 24 heart failure patients who have a cardiac implantable device to see if their physical activity changes with the seasons. Participants wear an activity tracker for a week each season and answer a questionnaire. The goal is to understand how weather and season…

This study is for adults with advanced heart failure who are on the waiting list for a heart transplant. Researchers want to see how the drug dapagliflozin affects the link between the heart and kidneys over 6 months. They will measure a protein called suPAR in the blood to track…

This study looks at whether a smartphone app that records your voice can help detect changes in blood pressure in the lungs for people with heart failure. About 60 adults with a special implanted pressure sensor will record a short passage daily for 3 months. Researchers will lat…

This study looks at how often blood vessel problems happen after a kidney transplant and whether a balloon treatment can help. Researchers will follow 60 kidney transplant patients in Denmark to check kidney function and blood pressure. The goal is to find better ways to diagnose…

This study looks at whether a person's genetic makeup can predict how well beta-blocker medication works for heart failure with mildly reduced pumping function. Researchers will enroll 10 adults aged 18-89 and use MRI scans to measure changes in heart size and function. The goal …

This study tests a program called FRAME that helps heart failure patients discuss mental health with their doctors and loved ones. About 7,300 adults with heart failure or at risk for it will take part in clinics across Ontario, Canada. The goal is to see if the program is practi…

This study aims to understand how a 12-week exercise program (cardiac rehab) changes thousands of proteins in the blood of people with heart failure. By comparing these changes to those in patients who delay exercise, researchers hope to identify key proteins that could be target…

This study looks at why standard heart failure medications may not completely block the hormone aldosterone, which can affect salt and water balance. Researchers will give 20 people with stable heart failure either the drug spironolactone or a placebo, then measure how their bodi…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part. The goal is to see if this screening is practical and effective in a nursing home…

This study follows 20,000 people who have or will receive a Medtronic heart device (like a pacemaker or defibrillator) to see how long the devices last and how often problems occur. Participants have conditions such as irregular heartbeat, slow heart rate, or heart failure. The g…

This study looks at 160 people with heart failure who are scheduled for coronary artery bypass surgery. Researchers want to see if a blood marker called GDF-15 can help predict serious heart events like heart attack or stroke in the year after surgery. Participants will be follow…

This study uses a special MRI technique to look at the microscopic structure of the heart muscle in people at risk for heart failure. Researchers want to understand how heart muscle fibers change over time, which could help explain why some people develop heart failure. The study…

This study looks at the electrical signals inside the heart during different pacemaker settings and body positions in 75 adults who already have a left bundle branch area pacing (LBBAP) pacemaker. The goal is to gather data that could help create a new algorithm to better detect …

This study is testing a small, skin-based device that records heart signals in people with heart failure. The goal is to find patterns that could warn doctors when a patient's condition is getting worse, so they can step in early. About 70 adults hospitalized for heart failure wi…

This study looks at how heart failure may cause brain volume loss. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the link between heart health and brain …

This study looks at whether a structured education program helps heart failure patients and their families learn about the condition, self-care, and emergency signs. About 1,000 adults hospitalized or treated for heart failure will take part. The program includes a one-hour sessi…

This study is a registry that will follow 4,000 adults in the UK who have been recently diagnosed with heart failure and have a weakened heart pump (ejection fraction below 50%). Researchers will collect information on their health outcomes, such as hospital stays and deaths, to …

This study is not testing a new treatment. Instead, it will follow 101 adults with chronic heart failure for up to 10 years to understand how the disease progresses. Researchers will collect health information and check survival rates at 1, 5, and 10 years after diagnosis. The go…

This study tests a new way to adjust pacemakers in 25 heart failure patients. Doctors use a special imaging technique to measure how fast the heart's chambers activate and then try different pacemaker settings to find the best one. The goal is to improve heart function without an…

This study looks at a new alert system called HeartInsight that uses data from implanted heart devices to predict when heart failure might get worse, up to 42 days early. About 100 people with heart failure and a compatible device will be followed for 12 months. The goal is to se…

This study looks at whether using a 7-day heart monitor can find hidden atrial fibrillation (an irregular heartbeat) in people with higher levels of a heart stress marker called NT-proBNP. About 4,000 adults aged 40 and older without known AF will be split into two groups: one ge…

This study looks at heart failure, a condition where the heart can't pump enough blood, causing shortness of breath and tiredness. Researchers will collect data from 1,000 adults, including heart images and blood tests, to find different types of heart failure. The goal is to hel…

This study aims to understand how obesity leads to a type of heart failure called HFpEF, where the heart becomes stiff. Researchers will enroll 250 people with obesity and use heart ultrasounds, blood tests, and fat tissue samples to look for early signs of heart problems. Partic…

This study aims to understand the symptom burden and quality of life in cancer patients who also have heart failure. Researchers will use questionnaires to assess symptoms like fatigue and shortness of breath. The study does not provide any treatment, but will help doctors better…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This study aims to create a large collection of medical information, DNA, blood, and tissue samples from 15,000 people with and without heart conditions. Researchers will use this biobank to better understand diseases like aortic aneurysm, heart failure, and bicuspid aortic valve…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study looks at 200 adults aged 50–70 with COPD to see how many also have a type of heart failure called HFpEF. Researchers will track their health for about a year, noting hospital visits, heart problems, and survival. The goal is to better understand the link between these …

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…

This study looks at whether exercising before a blood test called AlloSure can make it better at spotting early signs of heart transplant rejection. Researchers will test 27 heart transplant recipients, both with stable and active immune responses. The goal is to see if a simple …

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, or heart failure. Researchers will measure blood flow and blood pressure in up to 420 volunteers, including healthy young and older adults, as well as patient…

This study looks at how well the right side of the heart works in people with severe heart valve disease. Researchers will use a thin tube (catheter) to get precise measurements and compare them with non-invasive imaging tests like echocardiograms. The goal is to see if simpler t…

This study aims to better understand heart failure by using advanced testing (like genetic and protein analysis) and remote monitoring. Researchers will track 100 people with heart failure to see if these tools can predict who is at risk for serious problems like hospitalization …

This study looks at whether monitored exercise can improve heart health and oxygen delivery in veterans with heart failure with preserved ejection fraction (HFpEF). Four participants will exercise three times a week for 12 weeks and have blood draws and heart tests. The goal is t…

This study is not testing a new treatment. Instead, it will follow about 400 adults with advanced heart failure who already need a mechanical heart pump. Researchers will track survival rates and complications over five years to learn how well these pumps perform in real-world us…

This study looks at how heart rate and pumping strength are linked to metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to study these connections. The goal is to learn more about heart-mus…

This study looks at whether giving a special nutritional shake (Ensure Surgery) to heart failure patients before they get a heart pump (LVAD) can improve their gut health, reduce inflammation, and lower the risk of infections and other complications. About 50 hospitalized adults …

This study looks at heart tissue from 180 adults with a type of heart failure called HFpEF. Researchers will take tiny samples of heart muscle during a standard procedure to find changes that could lead to new treatments. The goal is to understand the disease better, not to test …

This study looks at people with heart failure not caused by blocked arteries. It uses MRI scans to find scarring in the heart muscle. Half of the 2,500 participants will get an implantable defibrillator (ICD), and half will not. The goal is to see if using MRI scars to decide who…