HEART FAILURE

This study tests whether social prescribing—connecting patients with community resources like housing, transportation, or mental health support—can help women with heart failure stick to their medications and improve their quality of life. About 200 women at high risk for not tak…

This study tests whether a wearable monitoring system called Sensinel CPM can reduce heart failure-related hospital visits and costs. About 1,200 adults with advanced chronic heart failure will use the system at home, and their outcomes will be compared to standard care. The goal…

This study tests a new machine that keeps donor hearts healthy outside the body before transplant. It focuses on hearts from donors who may not usually qualify, aiming to safely increase the number of available hearts. About 60 adults waiting for a heart transplant will take part…

This study tests a personalized stem cell therapy for 10 people with advanced non-ischemic heart failure who already have a mechanical heart pump (LVAD). After two months of recovery and medication optimization, each patient receives their own stem cells injected directly into th…

This study tests a patch made from stem cells that is designed to strengthen the heart muscle in people with end-stage heart failure who cannot have a heart transplant. About 53 participants will receive the patch to see if it is safe and can improve heart function. The goal is t…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospitalizations, complications, and deaths over 6…

This study looks at whether adding protein supplements to the diet can prevent or reverse muscle wasting in people with heart failure. About 120 adults with severe heart failure will be randomly assigned to receive no protein, a low dose, or a high dose of a protein drink (Ensure…

This study tests if a small sensor placed in the lung artery can help doctors manage heart failure better. About 1000 adults with heart failure will be followed for two years. The goal is to see if using the sensor reduces hospital stays and improves survival.

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and heart health in adults with low socioeconomic status, type 2 diabetes, and obesity. Participants will be randomly assi…

This study compares two ways to control heart rate in people with both atrial fibrillation (an irregular heartbeat) and heart failure. One approach uses medications, while the other involves implanting a special pacemaker and doing a small procedure to block the heart's faulty el…

This study is a large registry that will follow about 5,500 people with heart failure who receive a special heart device called CCM. The goal is to see if the device safely reduces hospital stays and improves health over several years. Participants will be monitored for complicat…

This study tests whether Empagliflozin (Jardiance), a drug already used for heart failure, can help adults with congenital heart disease whose heart function has recently declined. About 40 participants will take the drug and be monitored for changes in heart pumping strength, ex…

This study tests a 12-week phone coaching program for 280 adults with heart failure. The program uses positive psychology and motivational interviewing to help patients follow their diet, exercise, and medication plans. Participants also receive text messages for up to 24 weeks. …

This study tests whether adding vicadrostat to the standard drug empagliflozin helps people with heart failure who have a preserved ejection fraction (LVEF ≥40%). About 6000 adults with symptoms will be randomly assigned to receive either the combination or a placebo plus empagli…

This study tests a device called Aortix, which is a small pump placed in the body to help the heart and kidneys remove excess fluid. It is for people hospitalized with worsening heart failure who still have fluid buildup despite taking strong water pills. About 320 participants w…

This study tests a small, wearable patch that measures heart function from outside the body in people with heart failure. The goal is to help doctors adjust medications remotely and reduce the need for emergency hospital visits. About 200 adults with moderate to severe heart fail…

This study tests a temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through the skin to help the left ventricle work better. The goal is to see if it's safe and c…

This study tests a new device that uses 3D images of the feet and lower legs to detect early fluid buildup in people with heart failure. The goal is to see if catching these signs early can improve quality of life and reduce emergency visits or hospital stays. About 300 adults in…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. Participants will do one supervised session at a center and two home-based workouts each week, plus receive coaching and education. The goal is to see if this approach helps them be…

This study tests a new way to manage heart failure using a special scale that tracks fluid buildup. 50 adults with heart failure will use the Bodyport Cardiac Scale at home, and their doctors will get alerts if fluid levels change. The goal is to see if this helps doctors adjust …

This study looks at whether heart failure patients aged 70 and older can do just as well with medication alone as with medication plus an implanted defibrillator (ICD) to prevent sudden cardiac death. About 730 participants with weak hearts will be randomly assigned to one of two…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with blocked arteries and a weak heart pump (ejection fraction 40% or less). The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and impr…

This study looks at whether cancer survivors who had heart damage from their cancer treatment, but whose heart function has since recovered, can safely stop taking heart failure medications. About 335 adults who finished cancer therapy at least 6 months ago and are currently on h…

This study looks at whether a quick urine sodium test can help doctors decide the right dose of water pills (diuretics) for people with chronic heart failure. About 300 adults with heart failure who already take diuretics will be split into groups based on their congestion level.…

This study tests a new medicine called CDR132L to see if it can improve heart structure and function in people with heart failure. About 200 adults aged 40-84 with stable heart failure will be randomly assigned to receive either CDR132L or a placebo. The study lasts about 60 week…

This study tests a drug called finerenone in about 5,200 adults hospitalized for heart failure with mildly reduced or preserved pumping function. Participants receive either finerenone or a placebo to see if the drug reduces heart failure events and cardiovascular death. The goal…

This study tests whether a one-year program led by heart failure nurses, using a smartphone app and online training, can help people with heart failure avoid repeat hospital stays and feel better. About 200 patients who were recently hospitalized for severe heart failure will eit…

This study looks at whether ertugliflozin, a diabetes drug, can help people with chronic heart failure manage fluid buildup better than standard treatments. About 60 adults on daily water pills will receive either ertugliflozin, metolazone, or a placebo. Researchers will measure …

This study tests an investigational drug called omecamtiv mecarbil in 1800 adults with severe heart failure and a very weak heart pump. The goal is to see if the drug can lower the chance of heart failure worsening, needing a heart transplant, or death. Participants will receive …

This study tests a new device called the SATURN system that can repair a leaky mitral valve without open-heart surgery. It is for people aged 65 and older with severe symptoms who are at high risk for traditional surgery. The goal is to see if the device is safe and can reduce th…

This study tests whether a special alert system in heart devices (called HeartLogic) can help doctors manage heart failure better. About 1,428 adults who already have a compatible heart device will be randomly assigned to have the alerts turned on or off. The goal is to see if us…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by a common type of chemotherapy (anthracycline) in women with breast cancer. About 100 participants will take either dapagliflozin or a placebo daily during their chemo. Researchers…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Participants will take antiviral medication (sofosbuvir/velpatasvir) to prevent infection. The goal is to expand the donor pool for heart failure patients awaiti…

This study tests whether taking a daily 200-microgram selenium pill, on top of standard heart failure treatments, can reduce hospitalizations and deaths from heart problems. About 4,300 adults with heart failure in Sweden and Norway will take either selenium or a placebo for seve…

This study tests a nurse-led program that uses simple language and family involvement to help heart failure patients take their medications as prescribed. The goal is to improve medication adherence, reduce hospitalizations, and enhance quality of life. The study enrolls 328 pati…

This study looks at whether the Cordella PA Sensor System, a small implant that monitors pressure in the lung artery, helps people with chronic heart failure live longer and avoid hospital stays. About 2,150 people will be tracked for two years, comparing those with the sensor to…

This study tests whether a monthly injection called ziltivekimab can reduce heart-related deaths, hospitalizations, and urgent visits in people with heart failure and high inflammation. About 5,600 participants will receive either the drug or a placebo for up to 4 years, using a …

This study tests whether digital checklists and reminders can help doctors prescribe recommended heart failure medications to more patients. Researchers will enroll 4,000 adults with heart failure and reduced ejection fraction. The goal is to improve use of guideline-directed med…

This study tests whether adding vicadrostat to standard heart failure medication (empagliflozin) can reduce deaths, hospital visits, and symptom worsening in people with chronic heart failure and a weak heart pump. About 4200 adults with symptomatic heart failure and an ejection …

This study tests whether the drug sacubitril/valsartan can improve heart function in people who have an artificial heart valve and heart failure with reduced pumping ability. About 220 adults will take the drug, and doctors will check if their symptoms improve by at least one lev…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the new pump or an existing one to see if the new …

This study compares two different drugs, vicadrostat and spironolactone, when taken with empagliflozin, to see which better protects kidney function in people with chronic kidney disease and heart disease or heart failure. About 100 participants will take one of the two drug comb…

This study tests whether a virtual ward — follow-up care via phone or video — can reduce hospital readmissions for people with heart failure. About 346 adults who were recently hospitalized for heart failure will take part. Researchers will compare virtual ward care to standard c…

This study looks at whether a new monitoring system called SmartSignalHF can help people with heart failure who have a pacemaker or defibrillator. About 1,100 adults aged 18-85 with moderate heart failure will be split into two groups: one gets standard remote monitoring, the oth…

This study tests whether a daily pill called enavogliflozin (a type of diabetes drug) can reduce the risk of major heart problems or worsening heart failure in people who have already had a valve replacement for severe aortic stenosis and also have heart failure with preserved pu…

This study tests whether blocking certain nerves in the abdomen (splanchnic nerves) can improve symptoms and exercise ability in people with heart failure. The idea is that these nerves cause blood to shift from the belly to the lungs, making congestion worse. About 54 adults wit…

This study compares a heart pacing procedure (conduction system pacing) followed by a targeted ablation to standard heart-rate-controlling medications in 334 adults with permanent atrial fibrillation, mild heart failure (ejection fraction over 40%), and a recent heart failure hos…

This study tests whether a special heart monitor can help prevent serious problems in people who have survived a severe heart condition called cardiogenic shock. About 40 adults will be randomly assigned to receive the monitor or standard care, and researchers will track deaths, …

This study looks at a new way to pace the heart called left bundle branch area pacing (LBBAP) for people with conditions like slow heartbeat, heart failure, or atrial fibrillation. About 200 adults will get a special pacemaker lead, and researchers will track safety issues like i…

This study looks at 780 adults with a type of heart attack (NSTEMI) who also have sudden heart failure (fluid in the lungs). Half will get a coronary angiogram (X-ray of heart arteries) within 2 hours of diagnosis, and the other half will wait until their breathing improves. The …

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, aiming to reduce symptoms and hospital stays. Participants are randomly assigned to get th…

This study tests whether pharmacist-led medication adjustments and simple educational materials can help patients with heart failure and limited access to care get the right medications. About 40 adults with heart failure and reduced ejection fraction will be randomly assigned to…

This study tests whether a mechanical heart pump called HeartMate 3 helps people with advanced heart failure live longer and avoid serious problems like stroke or worsening heart failure. About 850 participants will either receive the pump or continue standard medical therapy. Th…

This study tests whether a preventive heart ablation procedure, done soon after implanting a defibrillator (ICD), can reduce dangerous heart rhythms in people with heart failure and weak heart muscle. About 62 high-risk participants will be randomly assigned to either receive the…

This study tests a new medicine called CDR132L to see if it can improve heart structure and function in people with heart failure. About 200 adults aged 40-84 with stable heart failure will receive either CDR132L or a placebo for around 60 weeks. The goal is to measure changes in…

This study looks at whether opening narrowed kidney arteries with a small balloon and stent, plus standard medications, works better than medications alone for high-risk patients. About 80 participants with severe kidney artery narrowing and either hard-to-control high blood pres…

This study tests whether two common supplements—coenzyme Q10 and selenium—can lower the risk of heart failure complications. About 4,044 adults with heart failure in Denmark will take either the supplements or placebos for 2-3 years. Researchers will track how many are hospitaliz…

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction. The goal is to see if this approach improves fitness and heart health better than standard advice. 336 par…

This study compares a targeted drug called acalabrutinib to other standard treatments for adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The main goal is to see if acalabrutinib causes fewer heart-related side effects. About 60 part…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in people with cardiogenic shock from heart failure can lower the risk of dying in the hospital. About 400 adults aged 18-90 with severe heart failure and shock will be enrolled. The monitor …

This study compares a new pacing method called His-bundle pacing (His-CRT) to standard biventricular pacing (BIV-CRT) in 120 adults with heart failure and right bundle-branch block. The goal is to see if His-CRT improves the heart's pumping ability more than the standard approach…

This study looks at whether using smartphone health apps and receiving personalized text messages can help people with chronic heart failure manage their condition better. Researchers want to see if these tools reduce the number of days people spend in the hospital for heart prob…

This study compares two types of heart procedures—convergent hybrid ablation and standard catheter ablation—in 120 adults with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. The goal is to see which approach better controls heart rhythm without …

This study tests a single low-dose radiation treatment to the whole heart in 40 adults with advanced heart failure who have not responded to standard therapies. The goal is to see if it can improve the heart's pumping ability by at least 5% over six months. Researchers will also …

This study is testing whether using portable air purifiers at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with other heart health markers. The study involves 255 adults in India with a spec…

This early study tests if electrically pacing the diaphragm (the muscle that helps you breathe) can improve heart function in people with heart failure. Ten adults already scheduled for a heart device will get temporary pacing during their procedure. Researchers will check if it'…

This study is testing a device called the Occlutech Atrial Flow Regulator in 150 people with chronic heart failure. The device is implanted to help balance pressure in the heart's chambers, potentially reducing symptoms and hospital stays. Researchers will track safety and heart-…

This study compares two types of heart pacing—conduction system pacing and standard biventricular pacing—in 320 adults with heart failure and a wide QRS. The goal is to see which method better reduces the risk of death, heart failure hospitalization, or need for a heart transplan…

This study tests the Cardiohelp device, a heart-lung machine, in 50 children with severe heart failure to see if it is safe and works well for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. Th…

This study tests if a newer heart pacing method (LOT-CRT) works better than the standard one (BiVP) for people with heart failure and a specific type of heart block. About 86 adults with weak hearts (LVEF ≤35%) and wide QRS will be followed for at least 6 months. The goal is to s…

This study is testing a new device called the Supira System in 45 people with heart failure and weak hearts who need high-risk angioplasty. The device is a temporary heart pump that provides support during the procedure and for a short time after, if needed. The goal is to see if…

This study tests a small sensor placed in the lung artery to monitor heart pressure in people with heart failure. The goal is to see if daily pressure readings help doctors and patients manage the condition better, reducing hospital stays and improving quality of life. About 1,75…

This study tests a new wireless system that helps the heart beat in sync for people with heart failure. About 40 participants will receive a leadless pacemaker and a small electrode placed inside the heart. The goal is to see if this approach is safe and can improve heart functio…

This study tests an experimental drug, BMS-986435/MYK-224, in 208 adults with a type of heart failure where the heart pumps normally but is too stiff. The goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo, and…

This study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the risk of heart failure or heart-related death in people with type 2 diabetes, heart disease, and high blood pressure. About 11,300 adults aged 40 and older will take either the combo or a p…

This study looks at people whose heart failure has improved so much that their heart function is now normal. It asks whether they can safely stop taking beta-blockers, a common heart medication that can cause side effects and reduce quality of life. About 1,300 participants will …

This study tests a medicine called vericiguat in children with heart failure caused by a weak left heart pump. About 342 kids aged 28 days to 18 years will take either vericiguat or a placebo for 16 weeks. The goal is to see if the drug lowers a heart stress marker (NT-proBNP) an…

This study tests whether colchicine, a drug used for gout, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive colchicine or a placebo for 6 months. The goal is to see if the drug reduces heart fai…

This study tests whether having a specially trained community paramedic visit heart failure patients at home can reduce hospital stays and emergency visits compared to standard care. About 75 adults with worsening heart failure will take part. Researchers will track days out of t…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom improvement between tho…

This study tests if briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with heart failure. About 240 adults with heart failure who need a heart catheterization will be randomly assigned to receive either the cuf…

This study compares two types of heart pacing for people with heart failure: one guided by artificial intelligence (AI) and one using the standard method. The goal is to see if the AI-guided approach improves the heart's pumping ability more. About 224 adults with heart failure w…

This study looks at 70 people with heart failure, an irregular heartbeat (atrial fibrillation), and a special pacemaker (CRT) that isn't pacing enough. It compares two procedures: one that fixes the irregular heartbeat (AF ablation) and one that slows the heart's electrical signa…

This study looks at people with heart failure whose heart function has returned to normal. It tests whether slowly reducing their daily medicines to just two is safe compared to staying on all four standard drugs. One hundred adults will be followed for two years with heart scans…

This study tests a small implanted device that sends gentle electrical signals to the heart to help it pump better. It is for people with heart failure whose heart still pumps somewhat well (ejection fraction 40-70%). The goal is to see if the device improves walking ability and …

This study tests a newer heart pacing method (left bundle branch pacing) against the standard approach (biventricular pacing) in 60 adults with chronic heart failure and reduced pumping ability. The goal is to see if the newer method improves heart structure, reduces deaths, and …

This study is testing whether a heart medication called sacubitril-valsartan is tolerable and feasible for young adult cancer survivors (diagnosed at or before age 39) who have early-stage heart failure (Stage B) without symptoms. The goal is to see if the drug can help prevent t…

This study tests whether using a device called Bioimpedance Analysis (BIA) can help doctors better manage fluid levels in heart failure patients admitted to the hospital. About 255 adults will be randomly assigned to either BIA-guided treatment or standard care. The goal is to se…

This study tests a device that automatically tracks leg swelling (edema) in people with chronic heart failure. The goal is to see if early alerts from the device can help doctors adjust treatment and reduce hospital stays. About 1,500 adults with a history of leg swelling will us…

This study tests whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive either standard care alone or standard care plus stem cells g…

This study looks at people whose heart failure has gotten better, with their heart's pumping ability back to normal. It tests whether slowly reducing two common heart medications (RAS blockers or beta blockers) is safe compared to staying on all meds. About 150 adults will be ran…

This study tests a special machine that keeps donor hearts cool and oxygenated during transport, which may help more hearts be usable for transplant. About 20 adults waiting for a heart transplant will receive a heart preserved this way. The goal is to see if the method is safe a…

This study tests a hospital-wide treatment plan for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the plan helps doctors identify who will benefit most from a minimally invasive valve repair procedure called MitraClip. …

This study tests whether a potassium-lowering drug (SZC) can help elderly patients (70+) with heart failure and chronic kidney disease safely increase their doses of RAASi medications, which are often limited by high potassium levels. About 94 participants will be randomly assign…

This study tests whether injecting lab-grown heart muscle cells (HiCM-188) into the heart can help people with severe heart failure (NYHA class III-IV). About 80 adults aged 18-75 with weak hearts (LVEF ≤35%) will receive the cells during bypass surgery. The main goal is to see i…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,100 adults with heart failure and a weak heart pump. The goal is to see if the newer method improves quality of life, reduces hospital stay…

This study tests whether the drug sotagliflozin can slow kidney function loss in 150 people with type 1 diabetes and moderate to severe kidney disease. Participants will take either the drug or a placebo daily for 3 years, while following a plan to prevent a serious side effect c…

This study tests whether using a heart failure registry to identify patients who need treatment adjustments can improve care. Researchers will screen 500 patients and refer them for medication changes, iron deficiency tests, or device therapy, then compare outcomes with 500 patie…

This study tests a device implanted in the heart that measures pressure and creates a small shunt to help manage chronic heart failure. It is for people with reduced heart pumping function (ejection fraction 40% or less) who still have symptoms despite standard treatments. The go…

This study tests a special pacing method called high-intensity his bundle pacing in 34 people with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help this group, but this new approach may improve heart function and quality of life. Participants will…

This study is for people with end-stage heart failure who need a total artificial heart while they wait for a heart transplant. It will check how well the Aeson artificial heart works and how safe it is in everyday hospital use. About 95 participants will be followed to see survi…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study tests a new device called UHF-ECG that takes a more detailed reading of the heart's electrical activity. It aims to see if it can better detect when the heart's lower chambers are out of sync compared to a standard ECG. The study involves 360 adults with slow heartbeat…

This study tests whether an AI tool can help doctors find undiagnosed heart failure in people with type 2 diabetes. About 800 participants will have their heart ultrasound results analyzed by AI, and doctors will receive alerts suggesting preventive medications. The goal is to st…

This study tests whether an artificial intelligence (AI) system can help primary care doctors detect heart failure more accurately by reading electrocardiograms (ECGs). About 1,968 adults with heart failure symptoms or high risk will be randomly assigned to get either AI-assisted…

This study tests a new imaging method using a special dye (XTR003) combined with a standard sugar scan (FDG) to see which parts of the heart are still alive in people with heart failure from blocked arteries. About 40 to 60 adults with weak hearts will get this scan before and af…

This study is testing whether an artificial intelligence program can analyze a single-lead ECG from devices like the Apple Watch to detect low heart pumping function (ejection fraction) and other heart structure problems. Researchers will enroll 5,000 adults at five hospitals in …

This study tests a portable device that uses electrical signals to detect early fluid buildup in the lungs of heart failure patients. The goal is to see if the device works as well as standard imaging methods like ultrasound. If successful, it could help patients manage their con…

This study tests whether artificial intelligence can help doctors use heart ultrasound (echocardiography) to diagnose heart failure and valve disease in rural and remote Australia. About 612 adults over 45 with exercise problems or heart risks will take part. The goal is to see i…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients and then start them on proven preventive medications. The goal is to see if this approach reduces heart failur…

This study tests whether a combination of heart-protecting medications and exercise can prevent heart failure in people over 50 who have had COVID-19. Researchers will measure changes in exercise capacity and watch for signs of heart failure. The goal is to find a practical way t…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to coach people on managing blood pressure and other risk factors. About 364 adults with high blood pressure or early signs of heart failure will receive support to …

This study looks at whether giving a special ketone drink through a nose tube is safe and doable for people with severe heart failure. The goal is to see if it can help the heart use energy better. Only 12 people with very weak hearts will take part, and the study will check for …

This study tests whether ziltivekimab, an experimental drug, can improve symptoms and daily function in people with heart failure who also have signs of inflammation. About 680 participants will receive either the drug or a placebo for up to 16 months. The main goal is to see if …

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who have had breast cancer treatment. Chemotherapy can sometimes weaken the heart and body, and this research compares structured exercise to a stretching-yoga program. T…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in people aged 50 and older with heart failure and sarcopenia (age-related muscle loss). Researchers will also explore how the program affects symptoms and qu…

This study looks at whether exercising in a community or home setting can improve exercise ability in people aged 18 to 85 with heart or lung conditions. Participants will do 40-60 minutes of exercise, like walking or cycling, five times a week for eight weeks. The goal is to see…

This study tests a 6-week WeChat-based program called SOCIAL_HF for elderly heart failure patients who feel socially frail. Participants join weekly video chats, do tasks, and access resources. Researchers want to see if it improves social connections, self-care, and support comp…

This study tests a 12-week smartphone-assisted cardiac rehabilitation program for adults with stable heart failure. Participants use a phone app guided by a case manager to exercise safely at home. The goal is to see if this approach improves exercise capacity and quality of life…

This study looks at whether a specific kind of strength training (eccentric resistance training) can improve how well the heart pumps and how much exercise people with stable chronic heart failure can do. About 84 adults with heart failure will be assigned to different exercise p…

This study tests a daily tablet called sotagliflozin in 320 people with type 1 diabetes and heart failure. The goal is to see if it improves symptoms like breathlessness and tiredness, and boosts quality of life. Participants take either the real tablet or a placebo for 4 months,…

This early-stage study tests a new drug, NNC0537-1482, in 36 adults with heart failure to see if it is safe and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo. The study lasts up to 64 days, plus a screening period. It focuse…

This study tests a digital program called TPA4You that uses a Fitbit to help older adults (50+) who care for a family member with heart failure become more physically active. The goal is to see if the program is practical and can improve daily activity, reduce sitting time, and e…

This study tests whether taking potassium nitrate (a natural salt) can help people with heart failure exercise better and feel stronger. Researchers will give 75 adults either the nitrate or a placebo daily for 6 weeks, measuring muscle power and oxygen use during treadmill tests…

This study tests whether personalized text messages can help older adults (age 50+) with heart failure improve their self-care, like taking medications correctly and following a heart-healthy diet. Participants will be randomly assigned to receive either usual care or usual care …

This study looks at whether personalized support from a sport and health professional can help people with heart failure stay physically active for a full year after completing a cardiac rehab program. About 90 adults with stable heart failure will either receive this tailored co…

This study tests whether adjusting the dose of water pills (diuretics) based on urine sodium levels helps hospitalized heart failure patients get better faster. About 600 adults with acute heart failure will be assigned to either a higher or lower urine sodium target, or standard…

This study tests whether training the muscles used for breathing can improve exercise ability and blood flow in people with heart failure. Researchers at Mayo Clinic will enroll 68 adults who are already on standard heart failure medications. Participants will undergo inspiratory…

This study tests whether a drug called anakinra can reduce inflammation and help the heart respond better to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. About 20 adults on stable inotrope therapy will receive anakinra for 3 mon…

This study tests whether a sensor-controlled digital game can motivate adults with heart failure to regularly check their weight and stay active. About 200 participants will either get the game plus sensors or just the sensors alone. The goal is to see if the game helps people st…

This study tests a 12-week telephone program where veterans with heart failure work with a nurse to solve problems related to their health. The goal is to improve self-care, reduce symptoms of heart failure, and ease depression and anxiety. Researchers will follow participants fo…

This study tests whether adjusting a pacemaker to a personalized, optimal heart rate can improve symptoms and quality of life in people with heart failure and a slow heartbeat. About 106 participants will be randomly assigned to either the new optimized pacing strategy or standar…

This study tests whether a 12-week chair yoga program is practical and helpful for 20 heart failure patients aged 55 and older living in rural areas. Researchers will work with patients and community members to design the program and gather feedback. The goal is to see if yoga ca…

This study tests simple cooling methods—like wetting the skin or wearing a water-soaked T-shirt—to see if they can keep body temperature down and reduce heart strain during heat waves. About 88 adults with heart failure and healthy volunteers will sit in a hot, dry room while res…

This study tests whether a home-based exercise program, guided by a smartphone and activity tracker, can help people who have just received a mechanical heart pump (LVAD) become more active, stronger, and have a better quality of life. About 100 adults with a new HeartMate 3 LVAD…

This early study tests a device that creates a small opening between the upper chambers of the heart to help relieve pressure in heart failure patients. About 20 adults with moderate to severe heart failure will be enrolled to see if the procedure is safe. The device is removed a…

This study looks at whether listening to music during a treadmill or bike test can improve how well the heart and lungs work in people with heart failure. About 40 adults will be tested once with music and once without. The goal is to see if music makes exercise easier and more e…

This pilot study tests a simple daily weight tracking tool called 'Wake and Weigh' to see if it helps older adults (55+) with heart failure improve their self-care and quality of life. Participants will use the tool in the hospital and at home for four weeks. The study focuses on…

This study is testing a phone-based system that helps people with heart failure monitor their symptoms and get real-time coaching on how to manage their condition at home. Researchers will enroll 50 adults with heart failure who are being discharged home and have access to a tele…

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early during a hospital stay for acute heart failure helps patients recover better. About 40 adults with stable heart failure will take part. The goal is to see if early rehab impro…

This study tests whether a low dose of colchicine, a drug usually used for gout, can help people with a certain type of heart failure (HFpEF) and inflammation exercise more easily. About 60 adults aged 50 and older will take either colchicine or a placebo for 3 months. Researcher…

This study looks at whether using a simple bedside ultrasound (POCUS) can help doctors better manage fluids in patients hospitalized with worsening heart failure. About 66 adults will be randomly assigned to either ultrasound-guided care or standard care. The main goal is to see …

This early study tests a procedure called pulmonary artery denervation in 50 people with heart failure and a type of lung hypertension (Group 2). The goal is to see if it can improve quality of life by reducing pressure in the lung arteries. Participants must have stable heart fa…

This study looks at whether a cardiac tele-rehabilitation program done at home can improve exercise capacity in adults with chronic heart failure. Participants will use wearable devices and a remote monitoring platform for an 8-week program. Researchers will compare their progres…

This study tests whether taking L-Carnitine by mouth can improve symptoms, heart function, and quality of life in people with heart failure who also have kidney problems. About 20 adults will take the supplement and be monitored for side effects and benefits. The goal is to see i…

This study tests whether mindfulness training can help people with both heart failure and mild memory problems improve their self-care and thinking skills. About 176 adults will take part. The goal is to see if learning to focus on the present moment helps them manage their condi…

This study is for adults with heart failure who have too much fluid in their body. Instead of going to the hospital for treatment, participants will receive a medication called Lasix (furosemide) through a small needle under the skin at home. The goal is to see if this approach i…

This study tests whether nurse-led education can help people with chronic heart failure and their caregivers better manage the condition. Researchers will enroll 280 patients and their caregivers in Greece. The goal is to see if this education improves patients' quality of life, …

This study tests an experimental oral medicine (PF-07328948) in 620 adults with heart failure. Participants will be randomly assigned to receive the drug or a placebo for 36 weeks. The goal is to see if the drug improves walking distance, heart failure symptoms, and quality of li…

This study looks at whether adding core muscle exercises (like Pilates) to standard cardiac rehab helps people recovering from heart attacks or heart failure. Sixty adults will be split into three groups: core training only, aerobic exercise only, or both combined. The goal is to…

This study looks at whether exercising before a blood test called AlloSure can make it better at spotting heart transplant rejection. Researchers will test 27 heart transplant recipients to see if exercise changes the test's accuracy. The goal is to find the best time to take the…

This study looks at whether a simple chatbot questionnaire can help detect early signs of heart failure getting worse. About 120 people with heart failure will regularly answer questions about their health via a chatbot. The goal is to see if changes in their answers can predict …

This study is testing a small, skin-based device that records heart signals in people with heart failure. The goal is to find early warning signs that a patient's condition is getting worse, so doctors can step in sooner. About 70 adults hospitalized for heart failure will wear t…

This study looks at whether a person's genetic makeup can predict how well they respond to beta-blocker medication for heart failure. Researchers will enroll 10 adults with mild heart failure and use a polygenic score (a genetic tool) to see if it relates to changes in heart func…

This study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart arteries of 70 people already scheduled for a heart catheter procedure. They want to see if…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study looks at whether a low-sodium (cardiac) diet is truly needed for better health in people who have had heart failure. Researchers will track 500 adults hospitalized for heart failure to see how sodium intake affects hospital stay length and readmission within 30 days. T…

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and loved ones. About 7,300 patients in Ontario, Canada will take part. The goal is to see if the program is practical and improves mental health awareness, not t…

This study will follow 5,000 adults with heart conditions like heart failure, high blood pressure, or valve disease. Participants wear a small patch that tracks heart rate, breathing, and rhythm. The goal is to learn how these conditions change over time, not to test a new treatm…

This study tests whether an AI tool can detect early signs of fluid buildup in the lungs by analyzing changes in a person's voice, cough, and breathing sounds. Researchers will enroll 250 adults with advanced heart failure to develop and refine the AI algorithm. The goal is to gi…

This study aims to improve how doctors predict heart disease risk by using a special MRI technique called T1 mapping. Researchers will scan 6000 adults without known heart disease, including people with Long COVID, to find early signs of heart problems. The goal is to better iden…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with chronic obstructive pulmonary disease (COPD). Researchers will follow 200 hospitalized COPD patients aged 50–70 to compare their health outcomes, including death and hospita…

This study looks at whether people with stable heart failure whose heart function has improved can safely stop taking a type of medication called a mineralocorticoid antagonist (MRA). Researchers will compare patients who continue the drug with those who receive a placebo over 24…

This study looks at whether adding a medicine called acetazolamide helps people with heart failure who still have fluid buildup despite standard treatments. Researchers will measure how much salt and water the body gets rid of over 24 hours. The study involves 64 adults admitted …

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part, and researchers will track how often heart failure flares up or leads to unplanne…

This study is re-examining 1,400 adults in Stockholm who were part of a larger national health study. Researchers are using advanced imaging, blood tests, and questionnaires to find new risk factors for heart disease, lung disease, and fatty liver disease. The goal is to better u…

This study aims to learn more about what happens in the body during severe heart failure complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure markers of inflammation and blood vessel health in 26 adults. …

This study looks at whether a special heart MRI can help predict serious problems like heart failure or sudden cardiac death in people with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers will follow 2,000 participants over time, combining MR…

This study looks at whether giving a special nutritional shake (Ensure Surgery) to heart failure patients before they get a mechanical heart pump (LVAD) can improve their gut health, reduce inflammation, and lower the risk of infections and other complications after surgery. Abou…

This study tests a new type of PET/CT scan (68Ga-FAPI) to see if it can find active scarring in the heart muscle of people with heart failure. Researchers will compare this scan to standard MRI to check if it can detect early or ongoing fibrosis. The goal is to improve how doctor…

This study aims to understand how a 12-week exercise program (cardiac rehab) changes thousands of proteins in the blood of people with heart failure. By comparing these changes to those in patients who delay exercise, researchers hope to identify key proteins that could be target…

This study follows 2,000 people with chronic heart failure to see how their daily physical activity levels relate to heart-related hospitalizations and survival. Participants wear a pedometer or smartwatch and answer activity questionnaires every six months. The goal is to learn …

This study watches how physical activity changes with the seasons in 24 adults with heart failure who have a cardiac implantable device. Participants wear an activity tracker for a week each season and answer questionnaires. The goal is to understand seasonal patterns to help imp…

This study looks at whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants. The goal is to see if home ho…

This study is a registry that collects information on how the WiSE System performs in people with heart failure. It does not test a new treatment but observes safety and outcomes in up to 320 participants who already receive the device. The goal is to better understand the device…

This study looks at whether a special breathing machine that uses negative pressure (like a vacuum) can improve heart function in people who have a mechanical heart pump. Researchers will measure how the right side of the heart works during this type of breathing compared to stan…

This study looks at how the brain processes breathlessness in people with advanced cancer, COPD, or heart failure. Researchers will use brain scans (fMRI) and virtual reality to see if different diseases have unique breathlessness patterns. The goal is to test if this approach is…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study looks at how special pacing methods (His bundle and left bundle area pacing) affect the heart's electrical signals in people with bradycardia (slow heartbeat) or heart failure. About 80 adults who are already scheduled for a pacemaker or similar device will have extra …

This study tests a non-invasive imaging method to find the best pacemaker settings for people with heart failure. About 25 participants will have their heart activation times measured under 16 different device settings. The goal is to improve how well the pacemaker works, but thi…

This study compares two approaches to fluid intake in people with heart failure: drinking freely versus limiting fluids. The goal is to see if drinking freely is safe and can improve quality of life and reduce thirst. About 326 adults with heart failure will participate, and rese…

This study looks at 140 adults with heart failure who are admitted to the hospital. It compares those who were already taking a medicine called ARNI before coming in to those who were not. Researchers will check medical records for heart and kidney events and hospital stay length…

This study looks at how the drug dapagliflozin affects the heart and kidneys in people with advanced heart failure who are waiting for a heart transplant. Researchers will measure a protein called suPAR in the blood to track kidney damage over 6 months. About 103 adults will take…

This study looks at whether monitored exercise during cardiac rehabilitation can help veterans with heart failure with preserved ejection fraction (HFpEF). Researchers want to see if the facility can support a larger study and if exercise shows clear benefits without harm. Partic…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to learn how to predict these problems and develop perso…

This study looks back at the medical records of 100 people with a rare genetic heart condition called RAS-CM. The goal is to gather detailed health and genetic information that can be used as a comparison group in future drug trials. Participants must have a confirmed genetic dia…

This study tests a new, non-invasive method to measure how well the heart and blood vessels work in adults with and without heart failure. Participants will have a single 20-minute visit where they squeeze a handgrip device while wearing sensors. The goal is to see if this simple…

This study aims to describe and compare the symptoms and quality of life of cancer patients who also have heart failure. Researchers will use questionnaires to measure fatigue, shortness of breath, sleep problems, and overall well-being. The goal is to better understand the chall…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study is looking at whether early heart ultrasound results can help predict which patients with worsening heart failure are more likely to be readmitted to the hospital or die. Researchers will study 76 adults admitted for heart failure and track their health over time. The …

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study looks at why some people with heart failure develop high blood pressure in their lungs (pulmonary hypertension). Researchers will follow 150 patients for one year, using blood tests, heart imaging, and tissue samples to study a specific cell signaling pathway (BMPR2-ac…

This study tests a noninvasive light sensor placed on the thumb to measure oxygen levels in children with heart failure. Researchers will temporarily stop blood flow to the hand and watch how oxygen levels change, then release the pressure to see how quickly oxygen returns. The g…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study looks at fat cells around the heart arteries in 60 patients getting a heart transplant. Researchers want to see if the size of these fat cells is linked to heart disease. No treatment is given; the goal is to learn more about how fat tissue affects heart health.

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at how diabetes changes the way heart cells use energy, which may lead to heart failure. Researchers will examine heart tissue and use imaging tests in 500 adults with heart failure, with or without type 2 diabetes. The goal is to better understand the disease an…

This study will follow 10,000 people with heart conditions (like heart failure, heart attack, or bypass surgery) who are going through cardiac rehab at a clinic in Davos, Switzerland. Researchers will collect health data, blood samples, and patient reports to learn what helps peo…

This study is not testing any new drugs. Instead, it brings together doctors, nurses, pharmacists, and patients who have recently been in the hospital for heart failure. They will discuss which treatments to study in a future trial, what doses to use, and how to measure success. …

This study looks at how lower extremity arterial disease (LEAD) might affect the heart's pumping ability. Researchers will use special ultrasound techniques to measure heart function in 162 participants with and without LEAD. The goal is to find early signs of heart trouble and u…

This study looks at whether problems with mitochondria—the energy factories inside heart cells—are linked to how heart failure progresses. Researchers will take small heart tissue samples and blood from 45 to 60 people with heart failure and blocked arteries who are having bypass…

This study looks at 160 people with heart failure who are scheduled for coronary artery bypass surgery. Researchers want to see if a blood marker called GDF-15 can help predict serious heart problems like heart attack, stroke, or death within the next year. Participants are follo…

This study aims to create a computer model that can predict which cancer patients are at high risk for heart damage from certain chemotherapy drugs. Researchers will follow 600 patients for one year, collecting data to build and test the model. The goal is to help doctors identif…

This study is looking at whether screening people with a high NT-proBNP level (a sign of possible heart strain) using a 7-day heart monitor can find hidden atrial fibrillation and lower the risk of stroke and death. About 4,000 adults aged 40 and older who have never been diagnos…

This study follows 400 adults with severe heart failure who receive a mechanical heart pump (ventricular assist device). Researchers will track survival rates and complications over five years to understand how well these devices work in real-world settings. The goal is to gather…

This study is testing a smart alert system called HeartInsight in 100 people with heart failure who have a special implanted heart device. The system monitors the heart and gives early warnings up to 42 days before a serious heart failure event. The goal is to see if doctors can …

This study looks at heart tissue from 180 people with a type of heart failure called HFpEF. During a heart catheterization, doctors will take a tiny sample of heart muscle to study its structure and function. The goal is to find clues that could lead to new treatments for heart f…

This study is a registry that collects information from people with chronic heart failure to understand how the disease changes over time. Researchers will track health outcomes, including death rates, at 1, 5, and 10 years after diagnosis. The goal is to gather accurate data, no…

This study aims to understand how obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and struggles to fill with blood. Researchers will follow 250 people with obesity for two years, using heart ultrasounds and blood tests to detect early signs…

This study is testing whether monitoring a blood marker called sST2 can help doctors better manage heart failure and reduce repeat hospital visits. Researchers will compare costs and quality of life between patients whose treatment is guided by sST2 levels and those receiving usu…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic interventions. The goal is to understand how these treatments affect…

This study looks at how well the right side of the heart works in people with severe heart valve problems. Researchers will use a thin tube (catheter) to get exact measurements and compare them to non-invasive imaging like ultrasound. The goal is to make imaging tests more reliab…

This study uses a special MRI technique to look at the tiny structure of the heart muscle in people at risk for heart failure. Researchers want to see how the heart's fibers change over time in patients who have had a heart attack or have a thickened heart muscle. The goal is to …

This study is tracking 30,000 people aged 60 and older in rural China to see if a comprehensive program—combining medication, lifestyle advice, education, and heart monitoring—can lower the risk of heart attacks, strokes, and heart-related deaths. Participants will be followed fo…

This study is testing whether a robot can perform heart ultrasounds (echocardiograms) from a distance as accurately as a standard in-person ultrasound. The goal is to improve access to heart failure care for people living on remote islands in Guadeloupe. About 50 adults with hear…

This study is testing whether a special wearable shirt and home devices can safely monitor children (ages 8-18) with heart failure. The goal is to see if this approach is practical and acceptable for families, especially those living far from hospitals or with limited resources. …

This study looks at how social factors like race, income, and where you live affect whether heart failure is caught early. Researchers will follow 1,000 adults at risk for heart failure to see if these factors lead to differences in diagnosis and medication use. The goal is to ma…

This study examines the deposits and biological material that build up on Impella heart pumps after they are used in patients with heart failure. Researchers will analyze pumps from 200 patients to see if these deposits are linked to the patient's medical history or blood test re…

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study enrolls 300 people with heart failure who do not have standard heart devices like ICDs or CRTs. Researchers use the BIOMONITOR IV, a small implant that tracks heart activity, breathing, and fluid levels remotely. The goal is to learn how often irregular heartbeats occu…

This study tests a risk calculator that predicts who is likely to develop heart failure before they have any symptoms. Researchers will recruit 600 people aged 50 and older with conditions like diabetes or high blood pressure. The goal is to see if this tool can be used in GP cli…

This study is creating a live registry to track heart failure patients across the Yale New Haven Health System. Researchers will monitor hospitalizations and use of recommended treatments in up to 40,000 participants. The goal is to better understand and improve heart failure car…

This study looks at why people with heart failure choose to take part in two different care programs after leaving the hospital: a home support program (PRADO-IC) and remote monitoring via telemedicine. Researchers will follow 700 patients in France to see what factors—like age, …

This study looks at whether a smartphone app that records your voice can help detect changes in blood pressure in the lungs for people with heart failure. About 60 adults with a special implanted pressure sensor will record a short passage daily for 3 months. Researchers will lat…

This study looks at how often blood vessel problems happen after a kidney transplant and whether a balloon treatment can help. Researchers will follow 60 kidney transplant patients in Denmark to check kidney function and blood pressure. The goal is to find better ways to diagnose…

This study looks at why standard heart failure medications may not completely block the hormone aldosterone, which can affect salt and water balance. Researchers will give 20 people with stable heart failure either the drug spironolactone or a placebo, then measure how their bodi…

This study follows 20,000 people who have or will receive a Medtronic heart device (like a pacemaker or defibrillator) to see how long the devices last and how often problems occur. Participants have conditions such as irregular heartbeat, slow heart rate, or heart failure. The g…

This study looks at the electrical signals inside the heart during different pacemaker settings and body positions in 75 adults who already have a left bundle branch area pacing (LBBAP) pacemaker. The goal is to gather data that could help create a new algorithm to better detect …

This study looks at how heart failure may cause brain volume loss. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the link between heart health and brain …

This study looks at whether a structured education program helps heart failure patients and their families learn about the condition, self-care, and emergency signs. About 1,000 adults hospitalized or treated for heart failure will take part. The program includes a one-hour sessi…

This study is a registry that will follow 4,000 adults in the UK who have been recently diagnosed with heart failure and have a weakened heart pump (ejection fraction below 50%). Researchers will collect information on their health outcomes, such as hospital stays and deaths, to …

This study looks at heart failure, a condition where the heart can't pump enough blood, causing shortness of breath and tiredness. Researchers will collect data from 1,000 adults, including heart images and blood tests, to find different types of heart failure. The goal is to hel…

This study aims to create a large collection of medical information, DNA, blood, and tissue samples from 15,000 people with and without heart conditions. Researchers will use this biobank to better understand diseases like aortic aneurysm, heart failure, and bicuspid aortic valve…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, or heart failure. Researchers will measure blood flow and blood pressure in up to 420 volunteers, including healthy young and older adults, as well as patient…

This study aims to better understand heart failure by using advanced testing (like genetic and protein analysis) and remote monitoring. Researchers will track 100 people with heart failure to see if these tools can predict who is at risk for serious problems like hospitalization …

This study looks at how heart rate and pumping strength are linked to metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to study these connections. The goal is to learn more about heart-mus…

This study looks at people with heart failure not caused by blocked arteries. It uses MRI scans to find scarring in the heart muscle. Half of the 2,500 participants will get an implantable defibrillator (ICD), and half will not. The goal is to see if using MRI scars to decide who…