HEART FAILURE

This study aims to improve care for people with a specific type of heart failure by using a national patient registry to find those who are not receiving the best available medications or device therapies. Researchers will identify 500 patients who may need medication changes, de…

This study is testing whether a specific type of heart pacing, called high-intensity His bundle pacing, can improve heart function in patients with heart failure who have a 'narrow QRS' on their ECG. Researchers will implant a special pacemaker/defibrillator in about 34 participa…

This study is testing whether a medication called sacubitril-valsartan is safe and effective for people with heart failure. It will involve 60 patients who will take the drug for three months. Researchers will check if the drug improves heart function and reduces serious heart-re…

This study is testing a new drug called BMS-986435/MYK-224 in adults with a specific type of heart failure where the heart pumps normally but still causes symptoms. The main goals are to check the drug's safety, how well people tolerate it, and how it behaves in the body. About 2…

This study is testing an 8-week exercise and education program designed to help people living with HIV improve their heart health. The program combines supervised gym sessions with home workouts and coaching to help participants become more physically active. Researchers want to …

This study aims to find the best time to perform a coronary angiography (a procedure to image the heart's arteries) in patients who have a specific type of heart attack that also causes sudden, severe heart failure. Researchers will compare doing the procedure immediately (within…

This study is testing whether people with heart failure can safely drink more fluids than typically recommended. Researchers are comparing two groups: one following standard fluid restrictions and another allowed to drink freely. The goal is to see if less restriction improves qu…

This early-stage study is testing whether stem cells from donor bone marrow can help improve heart function in cancer survivors who developed heart damage from certain chemotherapy drugs. Researchers will compare two different methods of delivering the stem cells (through an IV o…

This pilot study is testing a new home monitoring system for people with heart failure. It uses a special scale and an alert guide to help manage fluid buildup, a common problem that leads to hospital visits. The goal is to see if this system can be smoothly added to a patient's …

This study is testing if a simple, at-visit urine test can help doctors more precisely adjust the dose of water pills (diuretics) for people with chronic heart failure. The goal is to see if using the test to guide treatment leads to better symptom control and fewer hospital visi…

This study tests whether repeatedly inflating and deflating a blood pressure cuff on the arm before heart procedures can protect patients' kidneys from damage. Researchers are enrolling 240 people with heart failure who need coronary angiography or stents. The goal is to see if t…

This study is testing whether a 12-week exercise program guided by a case manager and supported by a smartphone app can help people with heart failure. Researchers want to see if this approach improves patients' fitness, walking ability, and quality of life compared to standard c…

This study is testing a 16-week education and support program designed for heart failure patients and their primary caregivers. The program aims to teach them how to work together to better manage symptoms, diet, and medication after a hospital stay. Researchers want to see if th…

This trial is testing a small, implanted heart device called an Optimizer. It delivers CCM therapy, which uses electrical pulses to help the heart pump more effectively. The study aims to see if this device can help people with certain types of heart failure walk farther, feel be…

This study is testing whether using a special mobile app with health devices or receiving personalized text messages can help people with chronic heart failure take better care of themselves. The goal is to see if these tools help patients stay healthier at home and reduce trips …

This study is testing the safety and performance of two specific heart pacing leads when placed in a particular area of the heart's electrical system. Researchers will follow 200 adult patients for 6 months after implant to check for complications like infection, lead movement, o…

This nationwide Italian study is observing how well modern mechanical heart pumps (called VADs) work for adults with severe, medication-resistant heart failure. It will track over 400 patients to see how many survive in the hospital and at 1 and 5 years after getting the pump, wh…

This study is testing if a small sensor implanted in the lung artery can help manage patients recovering from severe heart failure shock. The device sends pressure data to doctors, aiming to catch problems early and prevent hospital readmissions. The trial will compare outcomes o…

This study tests whether extra support from pharmacists can help patients with heart failure get the right medication doses when they have limited access to healthcare. Forty patients in Denver will either get these special pharmacist visits with easy-to-understand education or r…

This study is testing whether a medication called ertugliflozin helps people with chronic heart failure manage their body fluid levels better than a standard water pill or a placebo. Researchers will compare how these treatments, when added to a patient's usual diuretic, affect b…

This study is testing a home monitoring device that automatically checks for leg swelling, a sign of worsening heart failure. It aims to see if sending alerts to a patient's care team when swelling is detected can help manage the condition better and prevent hospital visits. The …

This trial is testing a new treatment for severe heart failure where a patch of lab-grown heart muscle, made from human stem cells, is surgically attached to the patient's weakened heart. The goal is to see if this 'biological patch' can help the heart pump better and improve pat…

This large, late-stage study is testing whether adding a new drug called vicadrostat to an existing heart failure medicine (empagliflozin) is better at controlling the disease. It will involve about 4,200 adults with chronic heart failure who have reduced heart pumping function. …

This study is testing a small, temporary heart pump called Aortix against standard diuretic medications for people hospitalized with severe heart failure who are not responding well to drugs. The goal is to see if the device can help remove excess fluid from the body more effecti…

This early-stage study is testing whether a new drug called NNC0537-1482 is safe for people with heart failure. Researchers will give the drug or a placebo to 36 participants to see how their bodies handle it and check for side effects. The main goal is to understand the drug's s…

This study aims to find out if heart failure medication alone is just as good as medication plus an implanted defibrillator for preventing sudden cardiac death in people aged 70 and older. It will enroll 730 patients in France and follow them for four years to compare survival ra…

This study is testing a small sensor that is permanently implanted in the lung artery to monitor pressure. The goal is to see if giving patients and doctors daily access to this data helps manage heart failure better, preventing serious events and hospital stays. It will involve …

This study is testing a new temporary heart pump device called the Supira System. It aims to see if the pump is safe and can effectively support patients with weak heart function during and after a high-risk procedure to open blocked heart arteries. The device is inserted through…

This study is monitoring a small, permanently implanted device called the Atrial Flow Regulator in people with chronic heart failure. The device creates a tiny, controlled opening between the heart's upper chambers to help relieve pressure. Researchers will follow 150 patients fo…

This trial is testing if implanting a mechanical heart pump (HeartMate 3) early can help people with advanced heart failure live longer and have a better quality of life compared to staying on strong medications alone. It will enroll about 850 adults whose heart failure is worsen…

This early study is testing a new device called the NORM™ System in people with heart failure. The device is a small sensor placed in a major vein to monitor fluid levels and send data to doctors. The main goal is to see if the sensor is safe to use and works properly to collect …

This study is testing if starting a supervised exercise and breathing program early during a hospital stay for severe heart failure helps patients recover faster. Researchers will measure if patients can walk farther, breathe better, and have a shorter hospital stay. The goal is …

This study compares two approaches for people with heart failure and chronic irregular heartbeat (atrial fibrillation). One group will receive optimized medication to control heart rate, while the other will undergo a procedure to implant a special pacemaker and disable a small p…

This study is testing whether a leukemia drug called acalabrutinib is safe for people who also have moderate to severe heart problems. Researchers will compare it to other standard treatments to see which causes fewer heart-related side effects. The trial will enroll 60 adults wi…

This study is testing whether a newer, two-part 'hybrid' heart procedure works better than the standard catheter procedure for people who have both a long-lasting irregular heartbeat (persistent atrial fibrillation) and heart failure. About 120 participants will be randomly assig…

This study tests whether special heart imaging software can help doctors find the best settings for pacemakers used in heart failure patients. Researchers will create 3D computer models of patients' hearts using MRI scans to measure electrical activity. They'll test 16 different …

This study tests whether a special heart protection program can prevent heart failure in COVID-19 survivors over age 50. Participants will receive either the program (including exercise guidance, heart monitoring, and medication review) or usual care for two years. Researchers wa…

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing whether a one-year, web-based support program guided by a specialized heart failure nurse can help people recently hospitalized for heart failure. The program includes online education, an app for tracking health, and connections to support networks. Researc…

This study is testing whether a single, low-dose radiation treatment to the whole heart can help people with advanced heart failure. Researchers want to see if this approach can improve heart function by at least 5% over six months in 40 participants who haven't responded well to…

This study is testing whether an 8-week exercise program done at home or in the community can improve fitness and quality of life for adults with reduced heart or lung function. Researchers will compare 200 participants who do the exercise program to those who do not. The program…

This study is a large, long-term registry that will follow 5,500 people with heart failure who have received a special implanted device called CCM therapy. The main goal is to see how safe the device is and if it helps reduce hospital stays and improve patients' health over at le…

This study is testing whether a program using an AI chatbot health coach and remote vital sign monitoring can help people better manage their interconnected chronic conditions. It aims to reduce serious health events like heart attacks, kidney failure, and hospitalizations. The t…

This study is testing if personalized follow-up support from a sports and health professional helps people with chronic heart failure maintain the benefits of their cardiac rehabilitation program. It will compare 90 patients who receive this personalized coaching for a year after…

This study is testing whether a daily-use chest-worn device can help manage chronic heart failure. About 1,200 participants will either use the monitoring device alongside their normal care or receive standard care alone for six months. Researchers will compare how often people i…

This study is testing if a medical procedure is better than standard medications for people with a specific type of heart failure and a permanent irregular heartbeat (atrial fibrillation). The procedure involves implanting a special pacemaker and then using a minor ablation to re…

This early study is testing a new catheter-based procedure that aims to calm overactive nerves around the lung arteries. It is for people with heart failure who have also developed high blood pressure in their lungs, a condition with no approved treatments. The goal is to see if …

This early study is testing a new heart procedure that creates a small opening between the upper heart chambers to relieve pressure buildup. The procedure uses a special device but leaves no permanent implant behind. Researchers want to see if this approach is safe and might help…

This study is testing a new temporary heart pump device for patients experiencing cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. The research aims to see if the device is safe and effective at stabilizing patients' blood pressure…

This study looks at whether taking a specific heart failure medicine (ARNI) before being admitted to the hospital affects a patient's short-term health. It will compare the hospital stays of two groups: those already on the medicine and those who were not. The goal is to see if s…

This trial is testing if adding a once-daily pill called enavogliflozin to standard care can help prevent major heart problems in people who have had a minimally invasive heart valve replacement and also have a specific type of heart failure. The study will enroll about 1,040 par…

This study looks back at medical records to see if adding a diabetes drug (SGLT2 inhibitor) to a standard heart failure medication (ARNI) works better than the standard medication alone. It focuses on patients with weakened hearts and a leaky mitral valve. The goal is to see whic…

This study is testing a new system to preserve and transport donor hearts that are currently considered higher risk or 'extended criteria.' The goal is to see if this method is safe and effective, potentially making more hearts available for transplant. It will involve up to 60 a…

This study is testing whether education sessions led by nurses can help people with chronic heart failure and their family caregivers manage the condition better. It will involve 280 participants in Greece who will receive either standard care or one of two education programs. Th…

This study is testing if using a special catheter (a thin tube) to closely monitor heart pressures right away can help patients survive a dangerous condition called cardiogenic shock. It will compare this early, detailed monitoring to the current standard care, which often uses t…

This study is testing whether people with worsening heart failure can safely receive fluid-reducing medication at home instead of in the hospital. Researchers are evaluating a small injection device called Lasix ONYU that patients or caregivers can use themselves. The goal is to …

This study is testing if adding a pill called an SGLT2 inhibitor (a type of diabetes drug) to standard hospital care is safe and helps patients who are hospitalized with both worsening heart failure and sudden kidney injury. Researchers will enroll 130 adults and randomly give th…

This study is testing if a quick, non-invasive body scan can help doctors better manage fluid levels in people hospitalized with worsening heart failure. Researchers will compare patients whose fluid treatment is guided by the scan results to those receiving standard care. The ma…

This study is testing whether drinking a special nutrition shake before getting a heart pump (LVAD) can help patients recover better. Researchers want to see if the shakes improve gut health, reduce body-wide inflammation, and lower the risk of serious infections after surgery. T…

This large study in Denmark is testing whether a special alert system in heart devices can help manage heart failure better. Over 1,400 patients with implanted heart devices will be randomly assigned to either have their care guided by remote alerts from the device or to receive …

This study is testing a smart alert system built into heart devices that warns doctors about potential heart failure problems weeks before they become serious. About 100 patients in Italy with special heart devices will be followed for one year to see if these alerts help doctors…

This study is testing whether exercise can help protect the hearts of older breast cancer survivors. Many survivors face increased risk of heart problems after chemotherapy. Researchers will compare a 12-week exercise program to a gentle stretching program in 60 survivors over ag…

This study is testing a smartphone app designed to help older adults with multiple chronic conditions like heart failure, diabetes, and kidney disease manage their care after leaving the hospital. The goal is to see if the app can reduce complications and readmissions by providin…

This study is testing a new, step-by-step treatment plan for people with heart failure and a specific leaky heart valve. It aims to see if this plan helps doctors better identify which patients are most likely to benefit from a minimally invasive procedure called MitraClip. The s…

This study compares two methods for placing heart pacing wires in people with heart failure. Researchers want to see if using artificial intelligence (AI) to guide the placement works better than the standard method. The goal is to improve heart function and reduce hospital visit…

This study is testing whether sending personalized text messages can help older adults with heart failure take better care of themselves. Researchers will enroll 30 participants aged 50+ and randomly assign half to receive about 5 text messages per week for 12 weeks, with reminde…

This large UK study aims to determine if implantable defibrillators help patients with severe heart failure not caused by blocked arteries. Half of the 2,500 participants will receive the device while the other half won't, and researchers will compare survival rates over 3-10 yea…

This study is testing whether a smartphone game can help adults with heart failure stick to important daily health routines. 200 participants aged 45+ who've been hospitalized for heart failure in the past year will use sensors to track their weight and activity. Half will play a…

This large study is testing whether a newer pacemaker technique (His or Left Bundle Branch Pacing) works better than the standard method (Biventricular Pacing) for people with heart failure and a weak heart pump. It will enroll over 2,100 adults to see which method is more effect…

This study is testing a new, completely wireless pacemaker system for people with heart failure. The goal is to see if this leadless approach is safe and can help the heart pump more effectively. It will involve about 40 participants who need a special type of pacing therapy.

This study is testing a newer heart pacing method called left bundle branch pacing (LBBP) against the standard biventricular pacing for people with chronic heart failure. The goal is to see if LBBP is more effective at improving heart function, reducing hospital stays, and improv…

This large Phase 3 trial is testing whether adding a new drug called baxdrostat to an existing diabetes medication (dapagliflozin) can better prevent heart failure and heart-related death in people with type 2 diabetes who are at high risk. The study will enroll about 11,300 part…

This study is testing a small heart implant called the Carillon Mitral Contour System. It is for people with heart failure who also have a leaky mitral valve. The goal is to see if the device can safely reduce the leak, improve heart function, and help people feel better and walk…

This study is testing whether a 14-week home exercise program using elastic resistance bands can help improve muscle loss (sarcopenia) in older adults with heart failure. Researchers want to see if this simple training can strengthen muscles, improve physical function, and ease s…

This study is testing whether adding core muscle training to standard cardiac rehabilitation exercises helps people recover better from a heart attack or heart failure. It will compare three different exercise programs over eight weeks in 60 stable patients. The main goal is to s…

This study is testing whether a new oral medicine, PF-07328948, is safe and can help control heart failure in adults who are already on standard treatments. About 620 participants will take either the study medicine or a placebo pill daily for 36 weeks. Researchers will measure i…

This study aims to see if a small, implanted sensor that monitors heart pressure from home works better than standard medications alone for people with chronic heart failure. It will follow over 2,000 patients for two years to compare how many die or are hospitalized. The goal is…

This study is testing whether a comprehensive village-based management program can help elderly people with chronic heart conditions live longer and healthier lives. The program combines medication, lifestyle changes, education, and regular heart monitoring for up to 10 years. Re…

This study is testing a new idea to help people with heart failure. Researchers want to see if gently pacing the main breathing muscle (the diaphragm) can improve how well the heart pumps. They will test this in 10 patients who are already scheduled to get a special heart device,…

This study is testing whether a structured education program can help people with heart failure better understand and manage their condition. About 1,000 patients and their family members will voluntarily attend a one-hour interactive class led by doctors and nurses. Researchers …

This study is testing whether a monthly injection called ziltivekimab can help people with a common type of heart failure who also have body-wide inflammation. About 5,600 participants will receive either the real medicine or a placebo (dummy injection) for up to four years to se…

This study is testing whether a genetic score can help doctors predict which heart failure patients will benefit most from beta-blocker medications. It focuses on patients with a specific, common type of heart failure where treatment guidance is currently limited. The goal is to …

This study is testing if a home-based heart rehabilitation program using wearable devices and video calls is as good as, or better than, traditional in-hospital rehab for adults with chronic heart failure. Researchers will compare the fitness, heart function, and quality of life …

This study aims to find out which of two heart procedures works better for people who have both heart failure and atrial fibrillation (an irregular heartbeat). Seventy participants will be randomly assigned to receive either a procedure to restore normal heart rhythm or one to co…

This early-stage study is testing whether a drug that blocks inflammation (anakinra) can make patients with very advanced heart failure more sensitive to their current heart-stimulating medications (inotropes). The goal is to see if patients can use lower, safer doses of these ri…

This study is testing a 6-month support program designed to prevent heart failure in adults with type 2 diabetes and obesity who have limited income and resources. The program combines exercise training at a local YMCA with problem-solving coaching and regular check-ins from a co…

This study is testing whether a pill called sotagliflozin can slow down kidney damage in 150 people who have both type 1 diabetes and moderate to severe kidney disease. Participants will take either the real pill or a placebo (inactive pill) daily for three years, while following…

This small, early-phase study is testing whether a personalized stem cell therapy can help the heart muscle recover in people with severe, chronic heart failure. The 10 participants all have a mechanical heart pump (LVAD) implanted. Researchers will collect a patient's own stem c…

This study is testing whether an investigational medicine called CDR132L can improve the structure and function of the heart in people with chronic heart failure. About 200 participants will be randomly assigned to receive either CDR132L or a placebo over a 60-week period. The ma…

This study is testing if using a bedside ultrasound machine can help doctors better manage fluid levels in hospitalized heart failure patients. About 66 patients will be randomly assigned to receive either ultrasound-guided care or standard care. The main goal is to see if this a…

This study is testing if a medication called sacubitril/valsartan can help people who have both an artificial heart valve and heart failure with a weakened heart pump. It will involve 220 participants to see if the drug improves their heart failure symptoms and functional class. …

This study is testing whether using a specific blood marker (called sST2) to guide treatment decisions helps people with acute heart failure. It aims to see if this approach reduces hospital readmissions, controls costs, and improves patients' quality of life over two years. Abou…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into patients without hepatitis C. After transplant, patients receive antiviral medication to treat the hepatitis C infection they receive from the donor heart. The goal is to expand the pool …

This study is testing whether a heart failure medication called Empagliflozin (Jardiance) can help adults who were born with heart defects. Researchers want to see if taking this once-daily pill for one year improves heart function, reduces hospital visits, and eases symptoms lik…

This large Danish study is testing whether two common nutritional supplements—coenzyme Q10 and selenium—can help people with heart failure. About 4,000 participants will take these supplements or placebo pills for 2-3 years to see if they reduce hospital stays or death from heart…

This study is testing if a drug that reduces inflammation (anakinra) can prevent heart failure in people who have just had a heart attack. Researchers believe the body's inflammatory response to the heart attack may contribute to future heart weakness. About 84 participants will …

This study aims to see if training hospital doctors on the latest heart failure medication guidelines leads to better treatment for patients. It will observe about 438 patients with a specific type of heart failure to see if they receive the recommended drug combinations when lea…

This study is testing a new magnetically levitated heart pump called the BrioVAD System for people with advanced heart failure that hasn't improved with standard treatments. Researchers will compare it to an existing heart pump to see if it's at least as safe and effective. The t…

This study is testing if 'social prescribing' can help women with heart failure take their medications and feel better. Social prescribing connects patients with a 'link worker' who helps them find community services for needs like transportation, housing, or loneliness. Research…

This study is testing an artificial heart device for people with severe heart failure who are waiting for a heart transplant. The device is designed to keep patients alive and improve their quality of life while they wait for a donor heart. Researchers will track how long patient…

This study is testing if a drug called Lokelma (SZC), which lowers potassium, can help elderly patients with both heart failure and chronic kidney disease safely take higher, more effective doses of their standard heart medications. Many patients cannot take the full recommended …

This study is testing whether placing pacemaker wires in a specific area of the heart's natural electrical system can improve heart rhythm and function. It involves 80 adults with heart failure or very slow heart rates who are already scheduled to get a pacemaker. Researchers wil…

This large, late-stage trial is testing whether a daily pill called finerenone can help people with a common type of heart failure live longer and stay out of the hospital. It will involve 5,200 adults who were recently hospitalized for heart failure but whose hearts still pump a…

This study is testing whether an experimental medicine called CDR132L can improve the structure and function of the heart in people with a specific type of heart failure. About 200 participants will be randomly assigned to receive either CDR132L or a placebo over a 60-week period…

This study is testing if adding a drug called acetazolamide helps hospitalized heart failure patients who still have significant fluid buildup despite receiving standard diuretic medications. Researchers will measure how much extra salt and fluid patients' bodies release over 24-…

This study is testing whether a medicine called vericiguat can help children and teenagers with heart failure. Researchers will compare the drug to a placebo (an inactive substance) to see if it improves a key blood marker of heart strain and is safe for young patients. The goal …

This study is testing if a heart medication called sacubitril/valsartan is safe and practical to use in young adult cancer survivors who have early signs of heart damage from their past cancer treatments. It will involve about 53 participants who had cancer before age 40 and now …

This study is testing if a specific type of strength training, called eccentric resistance training, can improve heart function and fitness in people with stable chronic heart failure. Researchers will compare it to a standard combination of strength and aerobic exercise. The goa…

This large, late-stage trial is testing whether a new drug called omecamtiv mecarbil can help people with severe heart failure. It aims to see if the drug reduces the risk of serious events like hospitalization, needing a heart device or transplant, or death. About 1,800 particip…

This UK study is testing whether a new home device can help people with heart failure stay healthier and avoid hospital visits. The device takes daily 3D pictures of the feet to spot early signs of fluid build-up, a common problem that can lead to serious complications. About 300…

This study aims to determine if heart failure patients whose heart pumping function has returned to normal can safely stop taking beta-blocker medications. Researchers will compare 1,300 patients who either continue their current medications or gradually stop beta-blockers while …

This study is testing a special 6-month heart health program for young cancer survivors who are at risk for heart problems due to their past cancer treatments. The program combines supervised and home-based exercise with lifestyle coaching and is compared against standard advice.…

This study is testing if a procedure to open a narrowed kidney artery with a small stent helps high-risk patients more than just taking the best available medications. It will compare the effects on blood pressure, kidney function, and hospital visits for heart failure. Some pati…

This study is testing whether using portable air purifiers at home can help people with heart failure feel better and be more active. Researchers in India will give air filters to about 255 adults with a specific type of heart failure to see if cleaning the air improves how far t…

This study is testing a small device implanted in the heart wall that monitors pressure and creates a tiny opening between heart chambers. It aims to help people with chronic heart failure who still have symptoms despite standard medications. Researchers want to see if this impla…

This study is testing if a newer, more precise pacemaker technique (His-CRT) works better than the standard method (BIV-CRT) for people with heart failure and a specific electrical problem in their heart. About 120 participants will be randomly assigned to receive one of the two …

This study aims to find out if cancer survivors can safely stop taking heart failure medications after their heart function has returned to normal following cancer treatment side effects. Researchers will compare two groups: one that continues medications and one that stops them,…

This study aims to test the safety and effectiveness of a heart-lung support machine called the Cardiohelp System in children with life-threatening heart failure. It will also compare two different blood thinners used with the device. The goal is to gather enough evidence for the…

This large Phase 3 trial is testing whether adding a new drug called vicadrostat to an existing heart failure medication (empagliflozin) is more effective at preventing serious heart problems. The study will enroll 6,000 adults with symptomatic heart failure but preserved heart p…

This study is testing whether offering routine heart ultrasound screenings to nursing home residents can help reduce emergency hospital visits for heart problems. Researchers will compare nursing homes that offer the screenings to those that provide usual care, following 1,050 re…

This study is testing a new portable device that measures chest electrical signals to detect early fluid buildup in the lungs of people with heart failure. Researchers want to see if the device's readings match those from standard lung ultrasounds and CT scans. If accurate, this …

This study is testing whether an artificial intelligence (AI) system can help doctors detect heart failure more accurately and earlier than standard methods. It involves nearly 2,000 people over 65 who either have symptoms or are at high risk for heart failure. Doctors in some cl…

This study is testing if having heart transplant patients exercise before a special blood test makes the test better at detecting early signs of organ rejection. Researchers want to see if the stress of exercise causes more donor DNA to appear in the blood when there is a problem…

This study is testing a new risk calculator designed to identify people at high risk for developing heart failure before they are actually diagnosed. Researchers will work with 600 adults in Greater Manchester who are aged 50+ and have at least two other health conditions like di…

This study is testing a new, more detailed heart rhythm monitor (UHF-ECG) to see if it can better identify electrical coordination problems in the heart's lower chambers. It will compare this new test to the standard 12-lead ECG in 360 adults who have a slow heart rate or heart f…

This study is testing whether artificial intelligence can help improve access to heart scans in rural and remote Australian communities. Researchers want to see if AI-guided ultrasound machines can help detect heart problems earlier in people at risk, even when heart specialists …

This study is testing a new type of PET scan to see if it can accurately identify which areas of damaged heart muscle are still alive and could recover after a procedure to restore blood flow. About 40-60 adults with heart failure caused by blocked arteries will receive the exper…

This study is testing a small, wearable chest patch that measures heart vibrations and electrical activity. The goal is to see if this simple, external sensor can detect early signs of worsening heart failure, which could help doctors adjust medications sooner and prevent hospita…

This study is testing whether a robotic heart scan performed remotely is as accurate as a standard in-person scan for diagnosing heart problems. It aims to improve access to specialized heart care for people living on remote islands in Guadeloupe where cardiologists are rarely av…

This study is testing whether a drug called dapagliflozin can protect the heart from damage caused by a common type of breast cancer chemotherapy. About 100 women receiving anthracycline chemotherapy will take either dapagliflozin or a placebo pill daily during treatment. Researc…

This study aims to prevent heart failure in Detroit residents who are at risk due to high blood pressure. Researchers are testing a program that sends mobile health units into communities and uses community health workers to connect people with care and resources. The goal is to …

This study is testing if a 7-day heart monitor patch can help prevent strokes. It will enroll 4,000 people who have a high level of a specific blood marker but no known heart rhythm problems. Half will wear the monitor to check for a hidden irregular heartbeat (AFib); if found, t…

This study is testing a new system to prevent heart failure in people with type 2 diabetes. It uses a simple blood test and a risk score to identify patients at high risk. When a high risk is found, the system alerts the patient's doctor to start proven preventive medications ear…

This study is testing a digital exercise program designed to help older family members who care for someone with heart failure. Participants will use a Fitbit activity tracker and receive coaching to increase their physical activity. The goal is to see if this approach reduces ca…

This study is testing if a low dose of an anti-inflammatory drug called colchicine can help people with a specific type of chronic heart failure (HFpEF) who also have body-wide inflammation. For 3 months, 60 participants will take either the drug or a placebo pill to see if it im…

This study is testing a simple paper tool to help people with heart failure track their weight daily. The goal is to see if this easy-to-use tool, taught by nurses, helps patients manage their condition better and feel better in their daily lives. Researchers will enroll 42 older…

This study is testing whether drinking protein shakes can help prevent or reverse muscle loss in people with severe heart failure. Researchers will compare three groups: one getting no extra protein, one getting a low dose, and one getting a high dose. They want to see if more pr…

This study is testing whether a new program called FRAME helps people with heart failure talk about and get support for mental health issues like stress, anxiety, and depression. About 7,300 patients at clinics in Ontario, Canada, will use the FRAME tool and answer surveys before…

This study is testing a phone-based system designed to help people with heart failure manage their symptoms at home. The system calls patients daily to check their symptoms and provides automated coaching advice. Researchers want to see if this approach helps patients feel better…

This study is testing a 12-week telephone support program for US veterans living with heart failure. Participants will work with a nurse over 8 phone sessions to learn problem-solving skills for managing their condition at home. The goal is to see if this program improves daily s…

This study is testing whether an investigational drug called ziltivekimab can improve daily symptoms and physical abilities in people with a common type of heart failure who also have body-wide inflammation. About 680 participants will be randomly assigned to receive either the d…

This study is testing whether a guided home exercise program, monitored through a smartphone app and a smartwatch, can help people who have recently received a mechanical heart pump. Researchers want to see if this program helps patients walk farther, get stronger, and feel bette…

This study is testing whether mindfulness training delivered over the phone can help people who have both heart failure and mild memory problems. Researchers want to see if learning mindfulness improves participants' ability to manage their heart health day-to-day and if it affec…

This study is testing whether a 6-week online group program on WeChat can help older adults with heart failure feel less socially isolated and improve their self-care. Researchers will compare the chat-based program, which includes video meetings and daily check-ins, to giving pa…

This study is testing if listening to upbeat music can help people with heart failure exercise longer and more effectively. Researchers will recruit 40 adults with heart failure who are already scheduled for a special exercise test. During the test, half will listen to music thro…

This study is testing whether a special breathing exercise program can help people with a specific type of heart failure. Researchers want to see if strengthening the breathing muscles improves blood flow to muscles during exercise and helps people exercise longer. The study will…

This study is testing if simple cooling methods, like wearing a wet T-shirt or having wet skin, can help people with heart failure stay cooler and reduce stress on their hearts during hot weather. Researchers will compare these methods to no cooling in a simulated heat wave. The …

This study is testing a new type of PET/CT scan to see if it can better detect active scar tissue (fibrosis) in the hearts of people with heart failure. Researchers will compare the new scan to the current standard MRI in 30 participants. The goal is to find a better way to monit…

This study aims to understand how heart failure affects brain structure. Researchers will use MRI scans to measure brain volume changes in 100 people with heart failure compared to those with normal heart function. The goal is to learn more about the connection between heart heal…

This study aims to see if a simple blood test taken before heart bypass surgery can help predict which patients are at higher risk for future heart problems. Researchers will follow 160 patients with heart failure for one year after their surgery to track their health. The goal i…

This large observational study aims to collect real-world information on how patients with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease are currently managed. It will enroll 35,000 adults from many countries to track their treatments, doctor …

This study aims to check the accuracy and consistency of various laboratory tests and research procedures used to study chronic diseases like obesity, diabetes, and heart failure. It will enroll up to 100 adults, both healthy and with certain conditions, to perform tests multiple…

This study aims to understand why people with type 2 diabetes are more likely to develop heart failure. Researchers will observe 500 participants with heart failure, some with and some without diabetes, to see how their heart cells produce energy. The goal is to gather knowledge …

This study aims to learn more about the tiny bits of cells and proteins that stick to Impella heart pumps after they are used to support patients with severe heart failure. Researchers will analyze 200 used pumps to see what kinds of deposits form and try to connect those finding…

This study aims to improve how doctors assess the right side of the heart in people with serious heart valve problems. Researchers will compare detailed, invasive pressure measurements (the current gold standard) with standard, non-invasive heart imaging scans like echocardiogram…

This study aims to learn more about irregular heartbeats in people with heart failure who do not have a pacemaker or defibrillator. Researchers will use a small, implanted heart monitor called the BIOMONITOR IV to track heart activity remotely for a long time. The goal is to see …

This study aims to gather detailed medical history from about 100 infants diagnosed with a rare and severe genetic heart condition called RAS-CM. By looking back at past patient records, researchers want to understand the typical course of this disease. This information is crucia…

This study aims to understand if being more physically active helps people with chronic heart failure stay out of the hospital and live longer. It will follow 2,000 participants for several years, tracking their daily steps and activity levels using devices like smartwatches or p…

This study aims to learn what helps people recover best after serious heart events like heart attacks, surgery, or heart failure. Researchers will observe 10,000 patients during their cardiac rehabilitation program, collecting health data over many years. The goal is to find patt…

This study aims to create a better tool to predict which cancer patients might develop heart problems from certain powerful chemotherapy drugs. Researchers will use a computer program (machine learning) to analyze data from 600 patients receiving treatment. The goal is to identif…

This study is testing a skin-based sensor device to collect detailed heart data from 70 hospitalized patients with heart failure. The goal is to build a database of heart signals to see how they change when a patient's condition worsens or improves. Researchers hope this data wil…

This study aims to understand how often a specific type of heart failure occurs in people with Chronic Obstructive Pulmonary Disease (COPD) and how it affects their health. Researchers will observe 200 hospitalized COPD patients in Russia, checking their heart and lung function a…

This study uses a special type of MRI scan to look at the tiny structure of heart muscle in people at risk for heart failure. Researchers want to understand how the heart's internal architecture changes before symptoms develop. The study includes both healthy adults and people wh…

This study is not testing treatments. Its purpose is to plan a future, larger clinical trial for people hospitalized with heart failure. Researchers are asking doctors, nurses, and patients for their opinions to decide which extra treatments to test, what doses to use, and how to…

This study is creating a registry to track the long-term health of people with chronic heart failure. Researchers will follow 101 patients for up to 10 years to understand how the disease progresses over time. The main goal is to collect detailed information to see how patients f…

This study is creating a large UK registry to track 4000 adults newly diagnosed with a common type of heart failure. It aims to understand how well current treatments and guidelines work in everyday clinical practice, outside of controlled trials. Researchers will follow patients…

This study aims to see if a special heart ultrasound, done right when a patient is admitted to the hospital for worsening heart failure, can predict who is most likely to be re-hospitalized or die later. Researchers will scan 76 patients before they receive their main IV treatmen…

This study aims to understand why the heart muscle weakens at higher heart rates in people with heart failure and diabetes. Researchers will collect small samples of fat, muscle, and blood from 160 patients during their scheduled pacemaker or defibrillator surgery. By analyzing t…

This study aims to understand how often people with psoriasis have hidden heart problems and what puts them at risk. Researchers will follow 1,000 adults with psoriasis, checking their blood for specific markers and performing detailed heart scans. The goal is to find early signs…

This study aims to understand how two different methods of helping patients breathe affect heart function in people who have received a mechanical heart pump (LVAD). Researchers will compare standard breathing support with a newer external method in 30 stable patients. The main g…

This registry study aims to collect real-world information about how well the WiSE heart pacing system works and how safe it is for people with heart failure. Researchers will follow 320 patients who receive this already-approved device to track their health outcomes and any side…

This study aims to understand if problems with tiny energy-producing parts inside heart cells, called mitochondria, are linked to how heart failure progresses. Researchers will enroll 45-60 patients with heart failure who are scheduled for heart bypass surgery. They will take sma…

This study aims to monitor how well Medtronic heart rhythm devices like pacemakers and defibrillators perform over many years. It will track 20,000 patients who already have or are getting these devices to see how long they last and identify any complications. This is an observat…

This study aims to better understand why some heart failure patients do worse than others by analyzing their detailed molecular profiles over time. Researchers will collect blood samples and health data from 100 participants to identify patterns that predict who is at highest ris…

This study is creating a live registry using the health records of 40,000 heart failure patients within the Yale New Haven Health System. Its purpose is to monitor patients in real-time to identify gaps in recommended treatments and understand patterns in hospital readmissions. T…

This study aims to understand if a standard low dose of a common heart failure drug (spironolactone) fully blocks the effects of a harmful hormone called aldosterone. Researchers will give 20 stable heart failure patients infusions of this hormone and the drug in different combin…

This study aims to see if it's possible to use brain scans to understand how people with serious illnesses like cancer, COPD, or heart failure experience chronic breathlessness. Researchers will use functional MRI scans and immersive virtual reality with 16 participants to see if…

This study is exploring whether daily voice recordings analyzed by artificial intelligence can detect pressure changes in the lungs of people with heart failure. Researchers are enrolling 60 participants who already have implanted pressure sensors to compare their daily voice rec…

This study aims to understand how taking many different medications affects the health of older adults living with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will follow 2,000 participants aged 65 and older for two years, asking them to co…

This study aims to understand if a simple, non-invasive finger sensor can measure oxygen levels in the tissue of children with heart failure. Researchers will test 130 participants under 25 years old, comparing those with heart failure to healthy children. The goal is to see if t…

This study aims to understand how a drug called dapagliflozin affects the interaction between the heart and kidneys in people with very advanced heart failure who are waiting for a transplant. Researchers will measure a specific blood protein (suPAR) and other health markers over…

This study aims to understand how exercise helps people with heart failure by looking at changes in their blood proteins. Researchers will compare protein levels in 90 patients before and after a 12-week cardiac rehab program against patients who delay rehab. The long-term goal i…

This study aims to see if a special type of MRI scan can better predict who is at risk for future heart problems like heart failure or heart attacks. It will enroll 6,000 adults who are generally healthy and have no known heart disease. Researchers will use the MRI scans to look …

This is a large follow-up study to understand how different factors in the body are connected. Researchers are re-examining 1,400 people in Stockholm to see if things like gum health, sleep patterns, and body inflammation are linked to future risks of heart, lung, and liver disea…

This study aims to understand how inflammation spreads between fat tissue surrounding heart arteries and the artery walls themselves. Researchers will analyze tissue samples from 60 patients with severe heart failure who are undergoing heart transplantation. By comparing fat cell…

This study aims to understand how poor circulation in the legs (peripheral artery disease) affects heart function. Researchers will use detailed heart scans and blood tests to measure subtle heart changes in 162 participants. The goal is to learn how these conditions are connecte…

This study aims to understand how blood flow to muscles is controlled in healthy people and in those with conditions like COPD, heart failure, and high blood pressure. Researchers will measure blood flow in the arms and legs before and after giving specific drugs or having partic…

This study aims to find early signs that predict which people with type 2 diabetes are most at risk for developing heart failure or memory problems. Researchers will follow 600 adults with diabetes over time, measuring their heart function, inflammation, and thinking skills. The …

This study aims to better understand how chronic heart conditions progress in daily life. It will enroll 5,000 adults in the U.S. who have conditions like heart failure or high blood pressure. Participants will wear special sensor patches to collect health data like heart rate an…

This study aims to better understand the electrical signals produced by a specific type of pacemaker therapy called Left Bundle Branch Area Pacing (LBBAP). Researchers will measure these signals in 75 patients who already have this type of pacemaker, under different settings and …

This study aims to understand and compare the symptom burden and quality of life in people who have both cancer and heart failure. Researchers will enroll 100 participants who have completed cancer treatment within the last three years and have a confirmed heart failure diagnosis…