Pacemaker vs. pills: which works better for irregular heartbeat and heart failure?

NCT ID NCT06299514

Recruiting now Disease control Sponsor: Habib Khan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optimized heart failure drugs. The goal is to see which approach reduces deaths, heart failure events, and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pacemaker and ablation procedure (conduction system pacing with AV node ablation) versus standard heart failure medications
What this could lead to: If successful, this could show that a pacemaker plus ablation is a better option than medication for controlling heart rate and improving quality of life in people with atrial fibrillation and heart failure.
What could go wrong: This is a large trial, but it is not yet complete. The pacemaker procedure carries risks like infection or bleeding, and it may not prove to be better than medication for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation cardiac rhythm disease heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMIA ATRIAL ATRIAL FIBRILLATION HEART FAILURE PACEMAKER

Contacts and locations

Locations

Centre Hospitalier de L'Université de Montréal (CHUM)
RECRUITING

Montreal, Quebec, H2X0A9, Canada
Hamilton Health Sciences Corporation
RECRUITING

Hamilton, Ontario, L8L2X2, Canada
Hôpital Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H5N4, Canada
Institut universitaire de cardiologie et de pneumologie Québec - Université Laval (IUCPQ-ULaval)
RECRUITING

Québec, Quebec, G1V4G5, Canada
London Health Sciences Centre - University Hospital
RECRUITING

London, Ontario, N6A5A5, Canada
Montreal Heart Institute
RECRUITING

Montreal, Quebec, Canada
Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, B3S0H6, Canada
Ottawa Heart Institute Research Corporation
RECRUITING

Ottawa, Ontario, K1Y4W7, Canada
Southlake Regional Health Centre
RECRUITING

Newmarket, Ontario, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, Canada
Victoria Cardiac Arrhythmia Trials
RECRUITING

Victoria, British Columbia, Canada
Waterloo Wellington Cardiovascular Research Institute
RECRUITING

Kitchener, Ontario, N2G1G3, Canada

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