Pacemaker vs. pills: which works better for irregular heartbeat and heart failure?
NCT ID NCT06299514
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optimized heart failure drugs. The goal is to see which approach reduces deaths, heart failure events, and improves quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pacemaker and ablation procedure (conduction system pacing with AV node ablation) versus standard heart failure medications
What this could lead to
If successful, this could show that a pacemaker plus ablation is a better option than medication for controlling heart rate and improving quality of life in people with atrial fibrillation and heart failure.
What could go wrong
This is a large trial, but it is not yet complete. The pacemaker procedure carries risks like infection or bleeding, and it may not prove to be better than medication for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Hospitalier de L'Université de Montréal (CHUM)
RECRUITINGMontreal, Quebec, H2X0A9, Canada
Contact
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Hamilton Health Sciences Corporation
RECRUITINGHamilton, Ontario, L8L2X2, Canada
Contact
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Hôpital Fleurimont
RECRUITINGSherbrooke, Quebec, J1H5N4, Canada
Contact
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Institut universitaire de cardiologie et de pneumologie Québec - Université Laval (IUCPQ-ULaval)
RECRUITINGQuébec, Quebec, G1V4G5, Canada
Contact
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London Health Sciences Centre - University Hospital
RECRUITINGLondon, Ontario, N6A5A5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Montreal Heart Institute
RECRUITINGMontreal, Quebec, Canada
Contact
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Nova Scotia Health Authority
RECRUITINGHalifax, Nova Scotia, B3S0H6, Canada
Contact
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Ottawa Heart Institute Research Corporation
RECRUITINGOttawa, Ontario, K1Y4W7, Canada
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Southlake Regional Health Centre
RECRUITINGNewmarket, Ontario, Canada
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, Canada
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Victoria Cardiac Arrhythmia Trials
RECRUITINGVictoria, British Columbia, Canada
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Waterloo Wellington Cardiovascular Research Institute
RECRUITINGKitchener, Ontario, N2G1G3, Canada
Contact