Atrial fibrillation

This study tests whether adding extra scar lines in the heart, along with the standard vein isolation procedure, helps people with persistent atrial fibrillation stay in normal rhythm longer. About 640 adults aged 18–80 with symptomatic, drug-resistant persistent AFib will be ran…

This study is tracking 1000 people with atrial fibrillation who receive the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to prevent blood clots from causing strokes. The goal is to see how safe and effective the device is in everyday medical practi…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This pilot study tests whether a left-sided stellate ganglion block using bupivacaine can lower the rate of atrial fibrillation after esophagectomy, pneumonectomy, or lobectomy. 48 adults aged 18-85 undergoing these surgeries will receive either the nerve block or a saline placeb…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This early study tests a new balloon device that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm disorder. 75 people with short-duration AF who haven't had prior ablation will receive the procedure and be followed for one year. The goal is to see i…

This trial tests whether combining a minimally invasive heart valve repair (TEER) with an electrical shock to restore normal heart rhythm (cardioversion) can improve outcomes for people with severe mitral regurgitation and atrial fibrillation. Participants who have already had a …

This trial asks whether people with permanent atrial fibrillation (AF) can continue drinking caffeinated coffee without worsening their heart rate control. Half of the participants will keep their usual coffee habit, while the other half will switch to decaf for a month, then swa…

This Phase 2 trial tests an oral drug called PKN605 in 165 adults with atrial fibrillation. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor their doctors know which they get. The main goal is to see if PKN605 reduces the amount of …

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study is checking the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants who have symptoms and haven't respon…

This study looks at a new way to treat an irregular heartbeat (atrial fibrillation) that can happen after heart surgery. It uses low-energy electrical shocks and special pacing to try to restore a normal rhythm. The goal is to see if this approach is safe and effective, and if it…

This study tracks 500 Chinese patients with paroxysmal atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system as part of their normal care. Researchers will monitor safety and effectiveness for up to three years. The goal is to see how well the device…

This study tests a telemedicine program for people aged 65-80 with both atrial fibrillation and heart failure living in rural China. Village clinics are randomly assigned to offer either standard care or a program that includes a digital health system, a smartwatch for monitoring…

This study is testing the FARAPULSE Pulsed Field Ablation system in 376 people with persistent atrial fibrillation (AFib) who have already had a prior ablation. The device uses electrical pulses to destroy the heart tissue causing the abnormal rhythm. The goal is to see if it is …

This trial investigates whether isolating the superior vena cava, in addition to the standard pulmonary vein isolation, improves success rates for treating atrial fibrillation. Using a newer, safer energy source called pulsed field ablation, the study compares the two procedures …

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This trial tests whether a new high-power short-duration radiofrequency ablation technique (90 watts for 4 seconds) is safer and more effective than the standard low-power approach (35 watts for 10-15 seconds) for treating atrial fibrillation. The study includes adults with parox…

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This study is testing a new device called the FARAFLEX system, which uses targeted electrical pulses to treat atrial fibrillation, a common heart rhythm problem. About 250 adults with persistent or paroxysmal atrial fibrillation will take part. The goal is to see if the device is…

This trial investigates whether cardiac ablation — a procedure that destroys tiny areas of heart tissue causing irregular rhythms — can improve exercise capacity in endurance athletes with atrial fibrillation. One hundred athletes who train at least four hours per week will have …

This trial compares two catheter ablation strategies for people with persistent atrial fibrillation (AF). One group receives standard pulmonary vein isolation using pulsed-field ablation; the other receives radiofrequency ablation followed by additional map-guided targeting of ab…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This study tests doing two heart procedures at the same time for people with atrial fibrillation. First, doctors use pulsed field energy to fix the heart's rhythm. Then, they implant a small device to close off a part of the heart where clots can form. The goal is to see if this …

This study compares two pacemaker methods for people with a slow heart rate: standard right ventricular pacing and a newer 'physiological pacing' that targets the heart's natural conduction system. Researchers will track 2,600 participants over time to see which method better pre…

This study follows 200 people with paroxysmal atrial fibrillation (AF) who undergo a procedure using a freezing catheter to isolate the pulmonary veins. The goal is to see how many remain free from AF, atrial flutter, or atrial tachycardia for up to 3 years, and to track safety e…

This study tests whether a filter device called the Sentinel Cerebral Protection System can prevent stroke and brain injury during ablation for atrial fibrillation (an irregular heartbeat). The device is placed in the arteries to catch debris that might break loose during the pro…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This study looks at whether pulsed field ablation (PFA), a standard treatment for atrial fibrillation, creates lasting changes in the heart's electrical pathways. Researchers will check this during a follow-up procedure to close the left atrial appendage, and may do extra ablatio…

This trial tests whether the position of the electrodes on the chest — front-to-back versus front-to-side — and applying manual pressure to the electrodes improve the success of electrical cardioversion for atrial fibrillation. About 1750 adults scheduled for non-urgent cardiover…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard procedure called ablation, but with the CoreMap system guiding the treatment. The…

This study compares two ablation methods for people with persistent atrial fibrillation (AFib), a heart rhythm problem. One group gets standard treatment (isolating the pulmonary veins), while the other gets that plus extra ablation on the back wall of the heart and a nearby vein…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This study tests a monthly injection called abelacimab to prevent strokes in about 1,900 people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. Participants will receive either the drug or a placebo, and researchers will trac…

This registry tracks 20,000 people with atrial fibrillation or ventricular arrhythmias who undergo catheter ablation using advanced CARTO mapping technologies. The goal is to see how safe and effective these procedures are in everyday medical practice. Researchers will monitor he…

This pilot study tests whether using a noninvasive global mapping system to guide catheter ablation can improve outcomes for people with persistent atrial fibrillation. Thirty participants will receive standard pulmonary vein isolation plus personalized ablation of up to three ad…

This study tests a new system (VARIPULSE catheter and TRUPULSE generator) with updated software for treating persistent atrial fibrillation, a long-lasting irregular heartbeat. About 50 adults aged 18-75 who have not responded to medication will undergo a heart ablation procedure…

This study tests a new device called CLAAS that is placed in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1600 participants will be randomly assigned to get either the new device or one of two already-approved devices. The goal i…

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optim…

This study tests a new mapping catheter and software to help doctors treat atrial fibrillation, a common heart rhythm problem. About 200 Chinese patients will receive a standard ablation procedure, but doctors will use the new tools to guide them. The goal is to see if the new de…

This study is tracking 10,000 people with atrial fibrillation who are having a heart ablation procedure. The goal is to see how well the procedure works and how safe it is in everyday medical practice. Researchers will measure how much AF burden patients have 6 months after the p…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This pilot study is testing whether the anti-inflammatory drug colchicine can lower inflammation and reduce the risk of atrial fibrillation (an irregular heartbeat) after coronary artery bypass surgery. 24 adults scheduled for bypass surgery will be randomly assigned to receive e…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study will test an AI software called Volta AF-Xplorer II during catheter ablation for atrial fibrillation. About 150 adults will be treated in real-world clinics, and researchers will track how well the AI helps guide the procedure. The goal is to see if the AI improves saf…

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes and major bleeding. Participants must already be…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a new way to guide catheter ablation for atrial fibrillation (AF), a common heart rhythm problem. The technique uses unipolar voltage mapping to find specific electrical signals (QS potentials) that may help keep AF going. Researchers will compare this personaliz…

This study looks at people with heart devices that detect short bursts of irregular heartbeats (atrial high-rate episodes lasting 6 minutes to 24 hours) but no diagnosed atrial fibrillation. It tests whether starting rhythm-control drugs early, along with managing heart risk fact…

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This study is testing a small, leadless pacemaker placed in the heart's upper chamber (atrium) for people with sinus node dysfunction, a condition where the heart's natural pacemaker doesn't work properly. Participants receive the Aveir AR pacemaker and a loop recorder to track h…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several we…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This early study tests a new device called the LAmbre™ II, designed to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who are at high risk for stroke. The goal is to prevent blood clots from forming there, potentially reducing …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful catheter ablation procedure. About 3,160 adults who have been free of AF for 6 to 12 months after ablation will be randomly assigned to either continue or sto…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study looks at whether it is safer to stop or continue taking direct oral anticoagulants (blood thinners) during planned heart procedures like angiography or stent placement. About 1,270 adults with atrial fibrillation and coronary artery disease will be randomly assigned to…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study compares a new procedure called pulsed field ablation (PFA) to standard treatment for atrial fibrillation, a common heart rhythm problem that raises stroke risk. About 1,574 adults who need catheter ablation will be randomly assigned to receive PFA or standard care. Th…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests whether a short course of amiodarone can reduce the return and burden of atrial fibrillation (AF) in 400 adults who develop new AF after heart surgery. Participants receive either standard care or amiodarone for 4 weeks. The goal is to see if this approach is pra…

This early study tests a new device called the Append System in 15 adults with atrial fibrillation (a type of irregular heartbeat). The device is threaded through a blood vessel to close off a small pouch in the heart called the left atrial appendage, where clots often form. The …

This study looks at whether it's safe to wait 5-9 days before treating a sudden episode of atrial fibrillation or flutter, instead of treating it right away in the emergency room. About 500 patients who are stable enough to go home will be randomly assigned to either immediate tr…

This study tests a new, faster method for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 150 adults will receive a heart ablation using very high power for short durations, aiming to reduce procedure time. The goal is to see if this approach is as …

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see …

This study compares a new pulsed field ablation (PFA) catheter to standard heat or cold ablation for atrial fibrillation (AF). About 136 adults with AF will be randomly assigned to one of the two methods. Researchers will check if the new approach is as good at preventing irregul…

This study tests whether enavogliflozin, a drug originally for diabetes, can prevent atrial fibrillation (AF) from returning after a catheter ablation procedure in people with AF and heart failure. About 390 adults will receive either the drug or a placebo daily for a year. The m…

This study looks at people with paroxysmal atrial fibrillation (a type of irregular heartbeat) that came back after a previous treatment. It compares two approaches during a repeat procedure: isolating the superior vena cava alone versus also adding ethanol (alcohol) infusion int…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single antic…

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation have an irregular heartbeat. About 209 adults with AF will use a home sleep test device and a Fitbit smartwatch to track their …

This study compares two approaches to taking blood thinners after a common heart procedure for atrial fibrillation. One group takes blood thinners every day as usual, while the other takes them only when a small implanted monitor detects an irregular heartbeat. The goal is to see…

This study tests a new device called MAGiC that uses magnets to help doctors treat abnormal heart rhythms. About 150 adults who need a standard heart ablation procedure will take part. The goal is to see if the device is safe and works well, both right after the procedure and ove…

This study tests a new device called the CellFX nsPFA catheter, which uses short electrical pulses instead of heat to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if it is safe and effective at restoring normal rhythm in 215 adults who …

This study tests a new device called the CellFX Nano-PFA 360 catheter, which uses very short electrical pulses to treat atrial fibrillation (an irregular heartbeat). About 60 adults aged 18 to 75 with paroxysmal atrial fibrillation will receive this procedure. The goal is to see …

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study compares two approaches for treating atrial tachycardia that occurs after atrial fibrillation ablation or heart surgery. One group gets standard ablation targeting all abnormal heart circuits, while the other gets a more focused ablation guided by a new ultra-high-dens…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study compares a new, tailored ablation approach to the standard treatment for people with paroxysmal atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with AFib will be randomly assigned to either standard pulmonary vein isolation or a procedure th…

This study looks at whether keeping magnesium at a higher or lower level helps critically ill patients live longer and have fewer heart rhythm problems. About 3,250 adults in intensive care will be assigned to one of two magnesium replacement protocols. No extra tests or tasks ar…

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study is testing a new type of heart pacing lead that is placed in the left bundle branch area, a key part of the heart's electrical system. The goal is to see if this approach is safe and works better than standard pacing for people with bradycardia (slow heart rate) or hea…

This study compares two blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults who need to start blood thinners will take one of the two drugs. The goal is to find which medicatio…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study looks at people with an irregular heartbeat (atrial fibrillation) who have had a brain bleed. Doctors are unsure if blood thinners are safe for them. The trial compares two options: the blood thinner apixaban or a procedure to close a part of the heart (left atrial app…

This study compares two procedures—pulsed field ablation and cryoballoon ablation—for treating atrial fibrillation (an irregular heartbeat). About 104 people having their first ablation will be randomly assigned to one method. The goal is to see which technique creates better sca…

This study tests whether Qidong Yixin Granules, an herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to receive either the…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 adults with both conditions will wear a heart monitor and complete quality-of-life surveys. The goa…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests doing two heart procedures at the same time for people with atrial fibrillation (AFib) who cannot take long-term blood thinners. The first procedure uses pulse field ablation to fix the heart's faulty electrical signals. The second closes off a small pouch in the…

This study tests whether adding an AI-powered heart mapping system (vMap) to the standard ablation procedure helps treat atrial fibrillation (AF) better than ablation alone. About 423 adults with persistent or recurrent AF will be randomly assigned to either standard treatment or…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study compares two ways of placing a pacemaker lead in people who need frequent pacing. One method (left bundle branch pacing) aims to activate the heart more naturally than the standard method. The goal is to see if it reduces the time the heart spends in fast, irregular rh…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults aged 18-80 who have been on blood thinners for at least 2 months after ablation and have no signs of AF recurrenc…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study is testing a device called LambrE that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to prevent strokes in patients who cannot take blood thinners due to ble…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study compares two types of pacemaker placement after a procedure called AV node ablation for people with atrial fibrillation and normal heart function. One method uses standard right ventricular pacing, while the other targets the left bundle branch area. The goal is to see…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study tests two ways to manage atrial fibrillation in people with heart failure: using a procedure called catheter ablation to restore normal rhythm, or using medications to control heart rate. About 84 participants will be randomly assigned to one of these approaches. The g…

This study tests a new device called the SpherePVI catheter, which uses heat to isolate the veins that trigger atrial fibrillation. About 100 adults with symptomatic AF who haven't responded to medication will be enrolled. The main goals are to see if the procedure is safe and ca…

This study tests a new catheter system called SpherePVI that uses heat to destroy tiny areas of heart tissue causing atrial fibrillation (an irregular heartbeat). About 150 people with symptomatic atrial fibrillation will undergo the procedure. The goal is to see if the device ca…

This study looks at 60 adults with rapid atrial fibrillation who already have a pacemaker and recently had a heart ablation procedure. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps patients exercise better compared to standard …

This study compares two types of repeat catheter ablation for people with symptomatic atrial fibrillation (AF) whose first treatment didn't work. 200 participants will be randomly assigned to receive either dual-energy ablation or standard contact force-guided ablation. The goal …

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study compares reprocessed (cleaned and re-sterilized) ablation catheters to brand-new ones in 200 adults with atrial fibrillation undergoing pulmonary vein isolation. The goal is to see if the reused catheters are just as safe and effective, while also being cheaper and bet…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study tests whether ondansetron, a drug usually used to prevent nausea from cancer treatment, can help people with atrial fibrillation (AFib). Researchers believe ondansetron may block a specific heart current that contributes to AFib. Eighty adults scheduled for AFib ablati…

This study tests a new device that uses short bursts of energy (pulsed field ablation) to treat atrial fibrillation, a common heart rhythm problem. The device maps the heart and then delivers energy to specific areas to correct the rhythm. Researchers will enroll 175 people to se…

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life afte…

This study tests whether a heart procedure called catheter ablation can slow down memory loss in people with mild cognitive impairment who also have a common heart rhythm problem called atrial fibrillation. 120 participants will be randomly assigned to get either the ablation plu…

This study tests a new circular-shaped catheter that uses pulsed field energy to treat atrial fibrillation and atrial flutter. About 150 adults will receive the procedure, guided by ultrasound inside the heart. The goal is to see if the catheter safely and effectively blocks abno…

This study tests a device called AtriLASH that closes a small heart pouch (the left atrial appendage) during planned heart surgery in 200 people with atrial fibrillation. The goal is to prevent blood clots that cause strokes, potentially reducing the need for blood-thinning medic…

This study tests a telemedicine-based care model for heart failure patients who are frequently readmitted to hospital and cannot join standard rehab. Researchers will provide on-demand video and chat support from cardiologists to general practitioners and community health workers…

This study tests whether blood thinners (NOACs) can prevent stroke in people who develop atrial fibrillation only during stressful events like surgery or serious illness. About 2,270 participants will be randomly assigned to take a blood thinner or not, and researchers will track…

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (an irregular heartbeat) during heart surgery. About 30 adults aged 18 to 85 who need heart surgery and have a history of atrial fibrillation will take part. The device aims to create sca…

This study tests four different drugs (norepinephrine, epinephrine, phenylephrine, and vasopressin) in ICU patients with shock that doesn't improve with fluids. The goal is to see which drug causes fewer dangerous heart rhythm problems and improves survival. About 836 adults will…

This phase 2 study at the Cleveland Clinic will test whether the weight-loss drug tirzepatide (Zepbound) can help people with obesity and atrial fibrillation (AFib). About 100 participants will receive weekly injections of tirzepatide or a placebo for up to 12 months. The main go…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (an irregular heartbeat) while patients undergo other heart surgery. About 135 adults aged 18-85 with a history of AFib will participate. The goal is to see if the device safely restores normal…

This study looks at whether doing a heart procedure called ablation early after diagnosis can help prevent strokes, heart-related deaths, and heart failure hospitalizations in people with atrial fibrillation (an irregular heartbeat) who also have other health issues like high blo…

This study compares a new pacing technique (His bundle pacing) to standard right ventricular pacing in 100 adults with symptomatic atrial fibrillation and heart failure who are having AV node ablation. The goal is to see if the new method helps them walk farther, feel better, and…

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (AF), a type of irregular heartbeat. The catheter can switch between a large 'petal' shape for quick vein isolation and a small 'bud' shape for precise linear ablation. Forty a…

This study tests whether adding a special pacing test during heart ablation can lower the chance of atrial fibrillation coming back. About 240 adults with paroxysmal AF (short, self-stopping episodes) will be randomly assigned to standard ablation or standard ablation plus extra …

This study looks at whether a lower daily dose of the heart medication amiodarone can keep the heart in a normal rhythm as well as the standard dose, but with fewer side effects. About 312 adults with persistent atrial fibrillation who have had a successful electrical shock to re…

This study tests whether adding a kidney nerve-zapping procedure (renal artery denervation) to the standard heart ablation procedure can better control persistent atrial fibrillation (AF). About 50 adults with persistent AF and controlled or no high blood pressure will be randoml…

This study tests whether a mobile app that provides education, medication reminders, and risk factor management can help people with atrial fibrillation stay free of heart rhythm problems after a new type of heart procedure called FARAPULSE pulse field ablation. The study will in…

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two p…

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AFib) in people who are overweight or have obesity. About 200 adults aged 18-75 with AFib and a BMI of 30 or higher will receive semaglutide plus standard AFib care. Res…

This study looks at the long-term safety and effectiveness of a device called QDOT MICRO, used with VISITAG SURPOINT, to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. About 250 adults who have symptoms that don't get better with medication will be fol…

This observational study is tracking 678 people with atrial fibrillation who are getting a Watchman device implanted to close off the left atrial appendage and reduce stroke risk. The study focuses on centers where a single doctor performs eight or more of these procedures in one…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study compares newer blood thinners (DOACs) to the standard drug warfarin in patients who need anticoagulation after open-heart surgery. About 3500 adults with atrial fibrillation will be randomly assigned to receive either a DOAC or warfarin for 30 days. The main goal is to…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study tests whether dapagliflozin, a drug typically used for diabetes, can prevent atrial fibrillation from coming back after a procedure called cardioversion (an electric shock to restore normal heart rhythm). About 1600 adults with AF will take either dapagliflozin or no e…

This study tests a device called CoolCryo that freezes small areas of heart tissue to stop atrial fibrillation (an irregular heartbeat). It is being used in 20 people who are already having mitral valve surgery. The goal is to see if the freezing treatment can keep the heart in n…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This trial compares three different catheter ablation strategies for people with persistent atrial fibrillation (AFib), a heart rhythm problem. Sixty adults aged 18-80 will be randomly assigned to one of three approaches using a special catheter that can switch between two energy…

This study tests a new approach for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). It combines two procedures: pulsed-field ablation to isolate the pulmonary veins, plus targeted thermal ablation of a nerve cluster near the heart. The goal is to see if a…

This study compares two ways to perform a heart ablation for atrial fibrillation: one using only X-ray guidance, and the other adding a 3D mapping system. Researchers want to see if the simpler X-ray-only method is just as effective at isolating the pulmonary veins, which is key …

This study tests a new catheter called OPTRELL™ to map and treat persistent atrial fibrillation (AF), a type of irregular heartbeat that is harder to treat. The device helps doctors identify and target the specific areas in the heart causing the problem. The trial will enroll 80 …

This study is testing whether a combination of a special pacemaker (conduction system pacing) and a targeted heart ablation can help people with both heart failure and permanent atrial fibrillation. About 334 participants will be randomly assigned to either receive the procedure …

This study tests whether the anti-inflammatory drug colchicine, combined with a special surgical technique, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. Researchers will compare 70 patients receiving colchicine plus the new…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

This trial tests whether a machine-learning algorithm can detect atrial fibrillation (AF) early by analyzing pulse wave signals from a wearable sensor. The study involves 200 adults with heart failure, comparing the algorithm's readings against standard ECG results. If it works, …

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study tests whether a special CT scan done in the emergency department can quickly check for blood clots in people with atrial fibrillation or atrial flutter. If no clot is found, doctors can proceed with a procedure to restore normal heart rhythm (cardioversion) right away.…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing whether a special blood pressure monitor can accurately detect atrial fibrillation, a common heart rhythm disorder. Researchers will compare the monitor's readings with standard diagnostic methods in 392 adults, some with and some without AF. If it works, th…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study tests whether a smartwatch (Withings ScanWatch) can diagnose atrial fibrillation that occurs after heart surgery better than standard monitoring. About 324 adults who had on-pump heart surgery will either use the smartwatch or receive usual care. The goal is to catch s…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests whether a smartwatch algorithm can detect atrial fibrillation (AF), an irregular heartbeat that often goes unnoticed and raises stroke risk. Researchers will enroll 500 stroke survivors who will wear a standard heart monitor and a study-provided smartwatch for 30…

This study is testing whether an AI-enhanced 12-lead ECG can better identify people at risk for atrial fibrillation (AF), a major cause of stroke and heart failure. Researchers will enroll 350 adults with AF or atrial tachycardia who are in normal rhythm at the time of ECG record…

This study is testing whether certain heart ultrasound findings can identify people who might have hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. Researchers will enroll 3000 participants with abnormal ultrasound results and randomly assig…

This study tests whether an artificial intelligence (AI) system can help doctors spot hidden atrial fibrillation (AF) — a common heart rhythm disorder that raises stroke risk — by flagging suspicious electrocardiograms (ECGs). About 14,700 patients will be randomly assigned to ha…

This Stanford study is testing computer algorithms to better map the heart's electrical activity in people with atrial fibrillation (AF), a common heart rhythm disorder. Researchers will compare different methods to see which best identifies problem areas in the heart. The study …

This study tests whether a telemedicine program, led by village doctors and supported by wearable devices and remote specialists, can prevent heart failure in older adults (65-80) with atrial fibrillation living in rural China. About 1,268 participants will be assigned to either …

This trial investigates whether a short course of atorvastatin, a widely used statin, can prevent atrial fibrillation—a rapid, irregular heartbeat—in adults aged 60 and older undergoing lung surgery. Participants are randomly assigned to receive either atorvastatin or a placebo f…

This trial tests whether making a small opening in the sac around the heart (posterior pericardiotomy) during heart surgery can prevent a common complication called atrial fibrillation. About 650 adults in China having surgery on the heart's valves, coronary arteries, or aorta wi…

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This large study tests whether a smartphone app can help prevent strokes by detecting atrial fibrillation (an irregular heartbeat) early. Adults aged 65 and older in Austria are randomly assigned to use the 'Pulskontrolle' app for pulse checks or to receive usual care. If the app…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether using a special clamp (EnCompass) to create a scar line in the heart and a clip (AtriClip) to close off a small pouch can prevent new atrial fibrillation after heart surgery. The trial will enroll 960 people aged 65 or older who are having planned heart s…

This study tests whether the blood thinner rivaroxaban can prevent strokes, heart attacks, and death in people with hypertrophic cardiomyopathy (HCM) who have early signs of atrial damage but normal heart rhythm. About 532 adults aged 40-80 with HCM and reduced left atrial strain…

This study tests whether giving the drug amiodarone after minimally invasive esophageal cancer surgery can prevent a common complication called atrial fibrillation (an irregular, often rapid heart rhythm). About 90 adults having this surgery will be randomly assigned to receive e…

This study tests whether a concentrated grape powder, taken for three days before heart surgery, can prevent a common complication called post-operative atrial fibrillation (POAF). POAF is an irregular heartbeat thought to be triggered by inflammation after surgery. The trial wil…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This study involves 600 adults having their first open-heart surgery. Doctors will use a temporary pacemaker to test if the heart is prone to atrial fibrillation (AFib) during the operation. Those who show risk will be randomly assigned to receive the drug amiodarone or standard …

This study looks at whether closing a small pouch in the heart (the left atrial appendage) during open-heart surgery can help prevent strokes in people with atrial fibrillation. Researchers will analyze heart tissue, blood, and ECG recordings from 1000 participants to find out wh…

This study tests whether placing a biodegradable patch soaked with the drug amiodarone on the heart during surgery can prevent atrial fibrillation (a common irregular heartbeat) afterward. About 500 adults having elective heart surgery will be randomly assigned to get either the …

This study tests whether giving magnesium through an IV can prevent new-onset atrial fibrillation (a type of irregular heartbeat) in critically ill patients in the intensive care unit. Researchers will enroll 200 adults and randomly assign them to receive either magnesium or a pl…

This trial is testing whether a mild sedation combination of remimazolam and fentanyl can be used instead of general anesthesia during a pulsed-field ablation procedure for atrial fibrillation. The study will enroll 20 adults with paroxysmal or persistent AF and monitor how well …

This study looks at whether a procedure called catheter ablation can improve quality of life for people aged 80 and older who have a heart rhythm problem called atrial fibrillation. Half of the 182 participants will get the real procedure, and half will get a fake one (sham) to s…

This study compares electrical cardioversion—a procedure that delivers a shock to restore normal heart rhythm—to a sham version where no shock is given. Researchers want to see if the real procedure truly improves quality of life in people with persistent atrial fibrillation, a c…

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can improve mental well-being in patients who are more vulnerable due to low income or education. About 290 participants will either receive usual care or be paired with a mentor for 16…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests whether a smartwatch and text message system can encourage people with paroxysmal atrial fibrillation (a type of irregular heartbeat) to be more physically active. The trial has two phases: first, a small group will help design the messages and test the smartwatc…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether using a brain activity monitor (BIS) to guide sedation during a procedure that shocks the heart back to normal rhythm leads to faster recovery and fewer side effects. About 60 adults with atrial fibrillation will be randomly assigned to receive sedation g…

This study is testing a mobile app called Cardio2U for people with atrial fibrillation or heart failure. The app helps patients track their condition, learn about their disease, and communicate with their care team. Researchers will check if patients find the app easy to use and …

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study looks at whether helping patients have realistic expectations before a catheter ablation for atrial fibrillation can improve their quality of life in the first three months after the procedure. About 60 adults with symptomatic atrial fibrillation will take part. The go…

This study tests if using a camera inside the heart (intracardiac echocardiography) is as safe and effective as the standard throat camera (transesophageal echocardiography) for guiding a procedure to close a heart pouch. The goal is to prevent strokes in people with an irregular…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study compares a new guidewire (AccuSafe) to the standard needle used to cross the heart wall during catheter ablation for atrial fibrillation. The goal is to see if the guidewire is safer and more effective, especially when done without X-ray guidance. 80 patients will be r…

This study compares a new second-generation catheter (FARAWAVE Nav) used without a pre-procedure CT scan to the standard approach with a CT scan for treating atrial fibrillation. The goal is to see if the new method reduces radiation exposure and procedure time. 58 adults with at…

This study compares two types of supervised exercise programs—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care alone in 132 adults with persistent or permanent atrial fibrillation. Participants will exercise twice weekly for…

This study tests a special closure device (VASCADE MVP) to stop bleeding after a heart ablation for atrial fibrillation. The goal is to see if it helps patients get up and walk sooner compared to standard manual compression. One hundred adults undergoing ablation will be randomly…

This trial compares two defibrillators—one delivering a maximum of 200 joules and the other 360 joules—to see which is better at restoring normal heart rhythm in people with persistent atrial fibrillation. About 376 adults scheduled for elective cardioversion will be randomly ass…

This study tests whether a 12-week digital MediYoga program—combining deep breathing, gentle yoga, and meditation—can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get …

This study tests whether a 4-week program of exercise and psychological education before catheter ablation for atrial fibrillation can improve heart fitness and reduce arrhythmias after the procedure. About 100 adults aged 18-70 scheduled for their first ablation will be randomly…

This study tests whether giving magnesium through an IV can safely slow a rapid heart rate in people with atrial fibrillation or flutter. Researchers will compare two different doses of magnesium to a placebo. The goal is to see if magnesium helps control heart rate within the fi…

This study tests whether a heart ultrasound method called Intracardiac Echocardiography (ICE) works as well as the standard method (TEE) for placing the Watchman device in people with atrial fibrillation. The Watchman device helps prevent strokes by closing off a part of the hear…

This registry is following 1,950 people with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to correct irregular heartbeats. Researchers are tracking how well the procedure prevents AFib from coming back and how often ser…

This study looks at whether certain fat molecules in the blood, called lipids and ceramides, are linked to atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from people with atrial fibrillation to those with other heart conditions but no a…

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study tracks 400 people who had a procedure to close a patent foramen ovale (PFO), a small hole between the heart's upper chambers that can raise stroke risk. Researchers want to see how often strokes or mini-strokes return, whether a residual shunt persists, and what factor…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This observational study investigates whether blood clotting markers and heart ultrasound measurements can help assess stroke risk in people with device-detected atrial fibrillation—a brief, symptomless irregular heart rhythm picked up by pacemakers or similar implants. Researche…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This observational study looks at why women with atrial fibrillation (AF) tend to have higher recurrence rates after standard ablation. Researchers will map the heart's electrical activity in 100 patients right after routine pulmonary vein isolation to find extra trigger spots th…

This study investigates whether certain proteins or chemical changes in the blood can predict who will develop atrial fibrillation (AF), a condition that can lead to strokes. Researchers will follow 500 people with implanted pacemakers or defibrillators for up to 11 years, using …

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

This observational study will follow 8,000 people with irregular heartbeats (arrhythmias) who are scheduled for a standard catheter ablation procedure using Biosense Webster devices. Researchers will track safety issues and how well the procedure works in everyday hospital practi…

This study uses wearable EKG patches to track heart rhythms in 150 adults having elective open-heart surgery. The goal is to find out how often atrial fibrillation occurs after surgery and what factors increase the risk. Researchers hope this will lead to better prediction and pr…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward impacts their quality of life. Participants fill out surveys about their physical and mental health, as well as any treatments they receive. The goal is to better understand…

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This pilot study at Tulane University is testing whether obstructive sleep apnea (OSA) can cause scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use a special MRI with contrast dye to measure scarring in 60 adults wi…

This registry is collecting data from 3,000 adults with atrial fibrillation who undergo a procedure to close off a part of the heart called the left atrial appendage. The goal is to track how well the procedure works to prevent strokes and to identify any complications. Hospitals…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This study looks at whether scarring (fibrosis) in the heart's upper chambers can predict who will develop an irregular heartbeat after heart surgery. Researchers will track 50 adults aged 40+ with no prior irregular heartbeat who are scheduled for heart surgery. The goal is to s…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study looks at whether a person's genetic makeup can help spot undiagnosed atrial fibrillation (AF), an irregular heartbeat that raises stroke risk. About 800 adults with symptoms or risk factors will wear a heart monitor for 7 days and use a handheld ECG device at home for …

This study will use a special X-ray technique called fluoroscopy to check how often the diaphragm becomes temporarily paralyzed after pulsed field ablation, a newer treatment for atrial fibrillation. Researchers will monitor 250 adults before and after the procedure to detect any…

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study is a registry that will follow 4,000 people in China who are having a procedure called catheter ablation to treat atrial fibrillation or ventricular tachycardia. The goal is to see how well the procedure works over the long term and how safe it is. Participants will be…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study compares two catheters used during a common heart procedure for atrial fibrillation. The goal is to see if one catheter can confirm that the treatment worked faster than the current method. Thirty adults with persistent atrial fibrillation or atrial flutter will be enr…

This study looks at whether measuring the function of the right upper heart chamber using ultrasound can help predict a common irregular heartbeat (atrial fibrillation) that often occurs after heart surgery. About 334 adults scheduled for bypass surgery will have their heart func…

This study will follow 2,500 elderly people (ages 65-80) in rural China who have atrial fibrillation, a common heart rhythm problem. Researchers will screen them for heart failure using blood tests and heart ultrasounds, then check on them every three months to see how their cond…

This study is testing whether a Samsung smartwatch and heart MRI scans can detect early signs of heart muscle damage (atrial myopathy) in 360 people with atrial fibrillation or at high risk for heart disease. Participants wear the watch for up to 9 months while researchers track …

This study investigates whether certain genetic variations make some people with atrial fibrillation more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 participants, including those with AF-related cardiomyopathy and control g…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This observational study looks at 200 adults with early-onset atrial fibrillation and certain genetic variants. Researchers will use cardiac MRI and electrophysiologic mapping during scheduled heart procedures to find who is at high risk for ventricular tachycardia, a dangerous h…

This registry is tracking 2,000 people with atrial fibrillation who are taking blood thinners for a long time. The goal is to see how often serious bleeding or clotting events happen. Researchers will also look at genetic factors that might affect risk. This is an observational s…

This study follows 750 people with atrial fibrillation (an irregular heartbeat) who are getting a procedure called catheter ablation. The main goal is to learn why the heart rhythm problem returns in up to 45% of patients within a year after the procedure. Researchers will track …

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study follows 1,200 people in China with atrial fibrillation who are getting a new type of procedure called pulsed field ablation. Researchers want to see if early heart rhythm problems after the procedure can predict if the condition will come back later. Participants will …

This study is looking at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called catheter ablation. The goal is to see if more scarring means a higher chance of AF coming back or needing hospit…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in 50 people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use ultrasound images taken during the procedure to measure changes in heart f…

This study tracks 774 adults who develop a new type of irregular heartbeat (atrial fibrillation) while hospitalized for a heart attack. Researchers will use continuous electronic monitoring to measure how much time patients spend in this abnormal rhythm. The goal is to see if the…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation for atrial fibrillation. Researchers will use a special catheter to measure pressure in the abdomen while patients are under different types of anesthesia. The goal is to see if t…

This study watches 800 adults with nonvalvular atrial fibrillation (a type of irregular heartbeat) who are starting the blood thinner apixaban for the first time. Researchers will track how often serious or minor bleeding occurs and how well patients stick to their medication sch…

This study follows 50 adults with paroxysmal atrial fibrillation (AFib) who are scheduled for catheter ablation. Researchers will use exercise tests, heart MRIs, and echocardiograms to measure how well the heart's left atrium works during exercise before and 5-6 months after the …

This study is a registry that will collect information on how a new balloon-in-basket device (VOLT PFA) is used in real-world hospitals to treat atrial fibrillation (AFib). Researchers will track procedure details, safety, and how well it stops abnormal heart rhythms. About 1,000…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This pilot study aims to see if certain blood markers that indicate clotting increase when atrial fibrillation (AFib) is more active. Researchers will take blood samples from 20 adults before, during, and up to 90 days after a catheter ablation procedure. The goal is to better un…

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to see how often AF returns and whether the cause (heart surgery, other surgery, …

This study looks at 350 adults with transfusion-dependent beta-thalassemia to find differences between those who have atrial fibrillation (a type of irregular heartbeat) and those who do not. Researchers will compare clinical tests, lab results, and imaging to better understand t…

This Stanford study looks at 200 people with persistent atrial fibrillation (AF) who are scheduled for ablation or Maze surgery. Researchers will map the heart's electrical activity to see if the size of organized areas predicts whether the procedure works. The goal is to better …

This study is testing whether a special heart ultrasound can predict who will develop atrial fibrillation after heart surgery. Researchers will measure how well the heart's upper chambers work together before surgery in 138 patients. They will then track patients during recovery …

This study looks at how well the Micra AV2 pacemaker can detect atrial fibrillation (AFib) in people who already have a history of paroxysmal AFib. Researchers will monitor 50 patients using the pacemaker's signals and a special Holter monitor. The goal is to understand how often…

This study tests whether a connected watch can better detect returning atrial fibrillation (an irregular heartbeat) in 106 adults who had heart surgery and developed a temporary irregular rhythm. Participants will wear the watch for 12 months, and doctors will compare how well it…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study looks at whether a night of disrupted sleep can lead to extra heartbeats or atrial fibrillation the next day. Researchers will ask 100 adults with sleep apnea to either use or not use their sleep device on different nights, then monitor their heart rhythms. The goal is…

This study watches 40 adults with atrial fibrillation who get a new type of heart treatment called pulsed field ablation. The goal is to see if the procedure causes tiny, symptom-free brain spots that show up on MRI scans. Researchers want to know how often these spots happen and…

This study follows 1,125 adults with atrial fibrillation who have had or will have a catheter ablation procedure. Over one year, participants use a smartphone app to report symptoms, lifestyle habits, and quality of life, and provide ECG readings. The goal is to identify factors …

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study follows 250 atrial fibrillation patients who received a left atrial appendage closure device to prevent strokes. The procedure blocks a small pouch in the heart where clots often form, allowing patients to avoid long-term blood thinners. Researchers will track how many…

This observational study enrolls 5,000 adults hospitalized with acute coronary syndrome in Italy. Researchers will track how often doctors follow European quality indicators, like timely artery-opening procedures and proper discharge medications. Participants are followed for 12 …

This study compares a 7-day AI-enhanced single-lead ECG patch against routine 12-lead ECGs to detect new atrial fibrillation in 15,360 adults aged 60+ in rural China. The goal is to see if longer, smarter monitoring catches more cases and reduces deaths, strokes, and heart failur…

This study is a registry that collects information on 2,000 people with atrial fibrillation who have heart surgery to treat it. The goal is to see how well the surgery works in everyday medical practice and what complications occur. No new treatment is being tested; instead, rese…

This study looks at whether avoiding alcohol reduces the chance of an atrial fibrillation (AFib) episode in people with paroxysmal AFib. One hundred participants will be randomly assigned each day to either avoid or be allowed to drink alcohol. They will wear heart monitors, fitn…

This study is watching 400 US patients who have a procedure to fix atrial fibrillation (a type of irregular heartbeat). Doctors will use an AI system to help guide the procedure. The goal is to see if using AI leads to better outcomes, like fewer heart rhythm problems after treat…

This study follows 198 people with symptomatic atrial fibrillation (AF) who decided not to join a larger trial comparing aggressive risk management plus ablation versus ablation alone. Researchers will track their hospital visits, emergency department stays, and AF episodes over …

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …

This study looks at how well and how safely a new catheter (Varipulse) works for treating a type of irregular heartbeat called atrial fibrillation. About 50 adults with this condition will receive the procedure. Researchers will check if the treatment successfully blocks faulty e…

This study at St Bartholomew's Hospital is enrolling 160 people with persistent atrial fibrillation (AFib) who are scheduled for their first catheter ablation. Researchers will create detailed 3D electrical maps of the heart during the procedure to understand why AFib persists an…

This Stanford study is testing whether machine learning can help predict which patients with atrial fibrillation will benefit from a heart ablation procedure. Researchers will collect data from 120 people undergoing ablation and use it to train an algorithm that forecasts success…

This study looks at how two different catheters used to treat atrial fibrillation (a type of irregular heartbeat) affect the temperature of the esophagus (the tube connecting the mouth to the stomach) and the risk of injury to it. About 30 adults with paroxysmal atrial fibrillati…

This registry will follow 540 people with atrial fibrillation who are treated with the Affera ablation device. Researchers want to see how well the device stops irregular heart rhythms and how safe it is in everyday medical practice. The study is observational, meaning patients g…

This study watches how well a small heart monitor (BIOMONITOR III) works in routine medical care for 1400 people. It tracks how quickly the device finds hidden heart rhythm problems like atrial fibrillation or fainting spells. The goal is to learn about the device's real-life per…

This registry collects information from 1,000 patients who have had or will have a heart rhythm procedure at University Hospital Düsseldorf. The goal is to track safety and success of these standard procedures in everyday care. No new treatments are being tested; instead, researc…

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems continuously for up to 5 years. The goal is to lea…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…

This study will follow 30,000 people aged 60 and older in rural China for up to 10 years. Researchers want to see if a comprehensive program—including medication, lifestyle changes, health education, and regular check-ups with a 7-day heart monitor—can lower the number of heart a…