Cardiac rhythm disease

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optim…

This study tests a new mapping catheter and software to help doctors treat atrial fibrillation, a common heart rhythm problem. About 200 Chinese patients will receive a standard ablation procedure, but doctors will use the new tools to guide them. The goal is to see if the new de…

This study tracks 500 Chinese patients with paroxysmal atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system as part of their normal care. Researchers will monitor safety and effectiveness for up to three years. The goal is to see how well the device…

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This global trial compares two ablation strategies for people with persistent atrial fibrillation (AF) that hasn't responded to medication. One group gets standard ablation of the pulmonary veins and back wall of the left atrium. The other group gets ablation guided by a special …

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This study is testing the FARAPULSE Pulsed Field Ablation system in 376 people with persistent atrial fibrillation (AFib) who have already had a prior ablation. The device uses electrical pulses to destroy the heart tissue causing the abnormal rhythm. The goal is to see if it is …

This study tests a new device called CLAAS that is placed in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1600 participants will be randomly assigned to get either the new device or one of two already-approved devices. The goal i…

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study is testing a new device called the FARAFLEX system, which uses targeted electrical pulses to treat atrial fibrillation, a common heart rhythm problem. About 250 adults with persistent or paroxysmal atrial fibrillation will take part. The goal is to see if the device is…

This study is tracking 10,000 people with atrial fibrillation who are having a heart ablation procedure. The goal is to see how well the procedure works and how safe it is in everyday medical practice. Researchers will measure how much AF burden patients have 6 months after the p…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This study tests two ways to treat a slow heart rate caused by overactive nerves, without using a permanent pacemaker. One method uses freezing (cryoablation) and the other uses burning (radiofrequency) to calm the nerves. Sixty adults aged 18 to 60 with symptoms like fainting or…

This study is tracking 1000 people with atrial fibrillation who receive the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to prevent blood clots from causing strokes. The goal is to see how safe and effective the device is in everyday medical practi…

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study tests whether adding an implantable cardioverter defibrillator (ICD) to standard medication helps people with variant angina who have survived a sudden cardiac arrest. About 140 adults will be randomly assigned to get either an ICD plus medication or medication alone. …

This study tests doing two heart procedures at the same time for people with atrial fibrillation. First, doctors use pulsed field energy to fix the heart's rhythm. Then, they implant a small device to close off a part of the heart where clots can form. The goal is to see if this …

This pilot study is testing whether the anti-inflammatory drug colchicine can lower inflammation and reduce the risk of atrial fibrillation (an irregular heartbeat) after coronary artery bypass surgery. 24 adults scheduled for bypass surgery will be randomly assigned to receive e…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study will test an AI software called Volta AF-Xplorer II during catheter ablation for atrial fibrillation. About 150 adults will be treated in real-world clinics, and researchers will track how well the AI helps guide the procedure. The goal is to see if the AI improves saf…

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes and major bleeding. Participants must already be…

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to…

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether adding extra scar lines in the heart, along with the standard vein isolation procedure, helps people with persistent atrial fibrillation stay in normal rhythm longer. About 640 adults aged 18–80 with symptomatic, drug-resistant persistent AFib will be ran…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study is testing a new device called the Sphere-9 catheter, used with the Affera mapping system, to treat ventricular tachycardia (VT) — a fast, dangerous heart rhythm. The procedure uses heat to destroy small areas of scarred heart tissue that cause the abnormal rhythm. The…

This trial tests a new way to treat typical atrial flutter, a heart rhythm problem. Instead of the standard linear ablation, doctors use a special catheter with tiny sensors to map and target only the high-voltage areas causing the flutter. The goal is to see if this approach is …

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a leg can reduce brain damage in people who survive a cardiac arrest outside the hospital. The procedure, called remote ischemic post-conditioning (RIPOST), is started within 4 hours after the he…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a new way to guide catheter ablation for atrial fibrillation (AF), a common heart rhythm problem. The technique uses unipolar voltage mapping to find specific electrical signals (QS potentials) that may help keep AF going. Researchers will compare this personaliz…

This study looks at people with heart devices that detect short bursts of irregular heartbeats (atrial high-rate episodes lasting 6 minutes to 24 hours) but no diagnosed atrial fibrillation. It tests whether starting rhythm-control drugs early, along with managing heart risk fact…

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This study is testing a small, leadless pacemaker placed in the heart's upper chamber (atrium) for people with sinus node dysfunction, a condition where the heart's natural pacemaker doesn't work properly. Participants receive the Aveir AR pacemaker and a loop recorder to track h…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several we…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This early study tests a new device called the LAmbre™ II, designed to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who are at high risk for stroke. The goal is to prevent blood clots from forming there, potentially reducing …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study tests whether using special brain monitors (near-infrared light, ultrasound, and brain wave tracking) can help doctors better manage oxygen levels in the brain for people on life support after a cardiac arrest. The goal is to see if this approach increases the number o…

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This study tests a new system (VARIPULSE catheter and TRUPULSE generator) with updated software for treating persistent atrial fibrillation, a long-lasting irregular heartbeat. About 50 adults aged 18-75 who have not responded to medication will undergo a heart ablation procedure…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful catheter ablation procedure. About 3,160 adults who have been free of AF for 6 to 12 months after ablation will be randomly assigned to either continue or sto…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study is checking the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants who have symptoms and haven't respon…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This early study tests a new device that uses a special wire with radiofrequency energy to safely cross the wall between the heart's upper chambers. This step is needed for procedures that treat heart rhythm problems or close the left atrial appendage. The study will enroll 60 ad…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This early-stage trial tests a single dose of SGT-501, a gene therapy given by IV, in 18 people with a rare inherited heart condition called CPVT that can cause dangerous fast heartbeats during exercise or stress. The main goal is to check safety and find the right dose in adults…

This study looks at whether pulsed field ablation (PFA), a standard treatment for atrial fibrillation, creates lasting changes in the heart's electrical pathways. Researchers will check this during a follow-up procedure to close the left atrial appendage, and may do extra ablatio…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study looks at whether it is safer to stop or continue taking direct oral anticoagulants (blood thinners) during planned heart procedures like angiography or stent placement. About 1,270 adults with atrial fibrillation and coronary artery disease will be randomly assigned to…

This study tests a method to sort sperm by gender (X or Y chromosome) using a density gradient. The goal is to help couples undergoing IVF or insemination have a baby of a desired sex, for medical or personal reasons. About 2000 couples will take part, and researchers will check …

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study compares a new procedure called pulsed field ablation (PFA) to standard treatment for atrial fibrillation, a common heart rhythm problem that raises stroke risk. About 1,574 adults who need catheter ablation will be randomly assigned to receive PFA or standard care. Th…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study tests a newer pacing method called Conduction System Pacing (CSP) against standard right ventricular pacing in 1,260 adults with heart block. The goal is to see if CSP reduces heart failure events, hospitalizations, and need for additional procedures, while also improv…

This study tests whether a short course of amiodarone can reduce the return and burden of atrial fibrillation (AF) in 400 adults who develop new AF after heart surgery. Participants receive either standard care or amiodarone for 4 weeks. The goal is to see if this approach is pra…

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This early study tests a new device called the Append System in 15 adults with atrial fibrillation (a type of irregular heartbeat). The device is threaded through a blood vessel to close off a small pouch in the heart called the left atrial appendage, where clots often form. The …

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study looks at whether it's safe to wait 5-9 days before treating a sudden episode of atrial fibrillation or flutter, instead of treating it right away in the emergency room. About 500 patients who are stable enough to go home will be randomly assigned to either immediate tr…

This study follows 200 people with paroxysmal atrial fibrillation (AF) who undergo a procedure using a freezing catheter to isolate the pulmonary veins. The goal is to see how many remain free from AF, atrial flutter, or atrial tachycardia for up to 3 years, and to track safety e…

This study tests a new, faster method for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 150 adults will receive a heart ablation using very high power for short durations, aiming to reduce procedure time. The goal is to see if this approach is as …

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study follows 1,805 people who already have an Aveir DR leadless pacemaker to see how safe it is over 5 years. The pacemaker helps control slow heart rhythms without wires. Researchers will track complications shortly after implant and for years afterward using real-world da…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This Phase 2 trial tests an oral drug called PKN605 in 165 adults with atrial fibrillation. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor their doctors know which they get. The main goal is to see if PKN605 reduces the amount of …

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see …

This study compares a new pacing method called conduction system pacing (CSP) to standard pacing for people with a slow heart rate and a wide QRS pattern on their ECG. The goal is to see if CSP better preserves the heart's pumping ability over one year. About 120 adults who need …

This study compares a new pulsed field ablation (PFA) catheter to standard heat or cold ablation for atrial fibrillation (AF). About 136 adults with AF will be randomly assigned to one of the two methods. Researchers will check if the new approach is as good at preventing irregul…

This study tests whether enavogliflozin, a drug originally for diabetes, can prevent atrial fibrillation (AF) from returning after a catheter ablation procedure in people with AF and heart failure. About 390 adults will receive either the drug or a placebo daily for a year. The m…

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This study looks at people with paroxysmal atrial fibrillation (a type of irregular heartbeat) that came back after a previous treatment. It compares two approaches during a repeat procedure: isolating the superior vena cava alone versus also adding ethanol (alcohol) infusion int…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single antic…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation have an irregular heartbeat. About 209 adults with AF will use a home sleep test device and a Fitbit smartwatch to track their …

This study compares two approaches to taking blood thinners after a common heart procedure for atrial fibrillation. One group takes blood thinners every day as usual, while the other takes them only when a small implanted monitor detects an irregular heartbeat. The goal is to see…

This study tests a new device called MAGiC that uses magnets to help doctors treat abnormal heart rhythms. About 150 adults who need a standard heart ablation procedure will take part. The goal is to see if the device is safe and works well, both right after the procedure and ove…

This study tests a new device called the CellFX nsPFA catheter, which uses short electrical pulses instead of heat to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if it is safe and effective at restoring normal rhythm in 215 adults who …

This study tests a new device called the CellFX Nano-PFA 360 catheter, which uses very short electrical pulses to treat atrial fibrillation (an irregular heartbeat). About 60 adults aged 18 to 75 with paroxysmal atrial fibrillation will receive this procedure. The goal is to see …

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This study compares two approaches for treating atrial tachycardia that occurs after atrial fibrillation ablation or heart surgery. One group gets standard ablation targeting all abnormal heart circuits, while the other gets a more focused ablation guided by a new ultra-high-dens…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study compares a new, tailored ablation approach to the standard treatment for people with paroxysmal atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with AFib will be randomly assigned to either standard pulmonary vein isolation or a procedure th…

This study follows 50 patients with ventricular tachycardia that hasn't responded to standard treatments. They receive a single, high-dose radiation treatment (STAR) aimed at the heart tissue causing the abnormal rhythm. Researchers will track how well the treatment controls the …

This study looks at whether keeping magnesium at a higher or lower level helps critically ill patients live longer and have fewer heart rhythm problems. About 3,250 adults in intensive care will be assigned to one of two magnesium replacement protocols. No extra tests or tasks ar…

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study is testing a new type of heart pacing lead that is placed in the left bundle branch area, a key part of the heart's electrical system. The goal is to see if this approach is safe and works better than standard pacing for people with bradycardia (slow heart rate) or hea…

This study tests a new step-by-step care plan for paramedics to use after an adult's heart is restarted following a cardiac arrest outside the hospital. The plan includes careful monitoring of oxygen, blood pressure, and fluids to prevent the heart from stopping again. About 318 …

This study tests a new approach for people with a life-threatening fast heart rhythm called ventricular tachycardia (VT) that keeps coming back after standard treatment. It compares a single, targeted radiation dose (cardiac radioablation) to a repeat catheter ablation, which is …

This study compares two blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults who need to start blood thinners will take one of the two drugs. The goal is to find which medicatio…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This study tests a newer pacing method called left bundle branch area pacing against standard pacing in people who need a pacemaker after a TAVI procedure. About 266 participants will be enrolled to see if the new method reduces heart-related deaths, hospitalizations for heart fa…

This early-stage trial tests a single intravenous dose of a gene therapy called RP-A601 in 9 adults with a genetic heart condition (PKP2-ACM) that causes dangerous heart rhythms and heart failure. The therapy delivers a working copy of the PKP2 gene to heart cells to restore prot…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study is testing a new catheter that uses real-time MRI to guide treatment for a common heart rhythm problem called type I atrial flutter. About 91 adults who need this procedure will receive radiofrequency ablation to block abnormal electrical signals. The main goals are to…

This trial tests whether a new app and device can help community first responders give better CPR during out-of-hospital cardiac arrests. The enhanced system allows two-way audio and one-way video communication with dispatchers, plus real-time feedback on chest compressions. Rese…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study looks at people with an irregular heartbeat (atrial fibrillation) who have had a brain bleed. Doctors are unsure if blood thinners are safe for them. The trial compares two options: the blood thinner apixaban or a procedure to close a part of the heart (left atrial app…

This study tests a new device that uses extreme cold (cryoablation) to treat a fast, dangerous heart rhythm called sustained monomorphic ventricular tachycardia. About 206 adults with this condition will receive the freezing treatment. The goal is to see if it safely stops the ab…

This study tests whether giving magnesium sulfate soon after a cardiac arrest can protect the brain from damage. Researchers will give 178 patients either magnesium or a saltwater solution within two hours of their heart restarting. The main goal is to see if the treatment is saf…

This study tests whether pregnant women at high risk for fetal heart block can use a home monitor to catch early signs of the condition. If detected, they receive steroids and IVIG to try to reverse the block before it becomes permanent. The goal is to prevent stillbirth and the …

This study compares two procedures—pulsed field ablation and cryoballoon ablation—for treating atrial fibrillation (an irregular heartbeat). About 104 people having their first ablation will be randomly assigned to one method. The goal is to see which technique creates better sca…

This study tests whether Qidong Yixin Granules, an herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to receive either the…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study compares two types of pacemaker settings in people who need a pacemaker after a TAVI procedure (a minimally invasive heart valve replacement). The two methods are 'physiological pacing' (which tries to mimic natural heart activation) and standard 'right ventricular pac…

This study looks at a new way to treat an irregular heartbeat (atrial fibrillation) that can happen after heart surgery. It uses low-energy electrical shocks and special pacing to try to restore a normal rhythm. The goal is to see if this approach is safe and effective, and if it…

This study tests whether adding a vein-injected alcohol treatment to the usual heart ablation procedure can better control dangerous heart rhythms in people with prior heart attacks. About 156 adults with an implanted defibrillator and recent episodes of rapid heartbeat will be r…

This study tests a monthly injection called abelacimab to prevent strokes in about 1,900 people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. Participants will receive either the drug or a placebo, and researchers will trac…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 adults with both conditions will wear a heart monitor and complete quality-of-life surveys. The goa…

This study compares two methods—DEEP mapping and activation mapping—used during catheter ablation to treat ventricular tachycardia (VT), a fast, dangerous heart rhythm. About 222 adults with an implanted defibrillator and VT will be randomly assigned to one technique. The goal is…

This study looks at people with an implanted defibrillator who had a successful first procedure to fix a dangerous fast heart rhythm (ventricular tachycardia). A few days later, they get a non-invasive heart stimulation test. If the test triggers the rhythm again, patients are ra…

This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or med…

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests doing two heart procedures at the same time for people with atrial fibrillation (AFib) who cannot take long-term blood thinners. The first procedure uses pulse field ablation to fix the heart's faulty electrical signals. The second closes off a small pouch in the…

This study tests whether adding an AI-powered heart mapping system (vMap) to the standard ablation procedure helps treat atrial fibrillation (AF) better than ablation alone. About 423 adults with persistent or recurrent AF will be randomly assigned to either standard treatment or…

This study compares a newer pacing method called left bundle branch pacing (LBBP) with standard right ventricular pacing in 1,300 people who need a pacemaker for heart block. Standard pacing can sometimes weaken the heart over time, leading to heart failure. LBBP tries to mimic t…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard procedure called ablation, but with the CoreMap system guiding the treatment. The…

This study compares two ways of placing a pacemaker lead in people who need frequent pacing. One method (left bundle branch pacing) aims to activate the heart more naturally than the standard method. The goal is to see if it reduces the time the heart spends in fast, irregular rh…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This study compares a newer pacemaker method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves the heart's pumping ability and reduces complica…

This study compares two ways to place a pacemaker in people with heart block (a condition where the heart's electrical signals slow or stop). One method uses standard right ventricular pacing, the other uses conduction system pacing (targeting the heart's natural electrical pathw…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults aged 18-80 who have been on blood thinners for at least 2 months after ablation and have no signs of AF recurrenc…

This study tests a single, precise dose of radiation to the heart to treat dangerous arrhythmias in 60 patients who haven't improved with medication or standard procedures. Researchers will monitor changes in heart rhythm events and medication use over 18 months. The goal is to s…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study is testing a device called LambrE that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to prevent strokes in patients who cannot take blood thinners due to ble…

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study tests an experimental drug called CRD-4730 in 12 adults with a rare inherited heart condition (CPVT) that can cause dangerous heart rhythms during exercise or stress. Participants will receive two different doses of the drug and a placebo in random order to see if it s…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study compares two types of pacemaker placement after a procedure called AV node ablation for people with atrial fibrillation and normal heart function. One method uses standard right ventricular pacing, while the other targets the left bundle branch area. The goal is to see…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study tests two ways to manage atrial fibrillation in people with heart failure: using a procedure called catheter ablation to restore normal rhythm, or using medications to control heart rate. About 84 participants will be randomly assigned to one of these approaches. The g…

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be ra…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests a new device called the SpherePVI catheter, which uses heat to isolate the veins that trigger atrial fibrillation. About 100 adults with symptomatic AF who haven't responded to medication will be enrolled. The main goals are to see if the procedure is safe and ca…

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study tests a new catheter system called SpherePVI that uses heat to destroy tiny areas of heart tissue causing atrial fibrillation (an irregular heartbeat). About 150 people with symptomatic atrial fibrillation will undergo the procedure. The goal is to see if the device ca…

This study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…

This study looks at 60 adults with rapid atrial fibrillation who already have a pacemaker and recently had a heart ablation procedure. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps patients exercise better compared to standard …

This study compares two types of repeat catheter ablation for people with symptomatic atrial fibrillation (AF) whose first treatment didn't work. 200 participants will be randomly assigned to receive either dual-energy ablation or standard contact force-guided ablation. The goal …

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study compares reprocessed (cleaned and re-sterilized) ablation catheters to brand-new ones in 200 adults with atrial fibrillation undergoing pulmonary vein isolation. The goal is to see if the reused catheters are just as safe and effective, while also being cheaper and bet…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study tests whether ondansetron, a drug usually used to prevent nausea from cancer treatment, can help people with atrial fibrillation (AFib). Researchers believe ondansetron may block a specific heart current that contributes to AFib. Eighty adults scheduled for AFib ablati…

This study tests a new device that uses short bursts of energy (pulsed field ablation) to treat atrial fibrillation, a common heart rhythm problem. The device maps the heart and then delivers energy to specific areas to correct the rhythm. Researchers will enroll 175 people to se…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study looks at whether a specific antibody in the blood can help diagnose and predict the course of a rare, life-threatening heart condition called short-coupled ventricular fibrillation (SCVF). Researchers will test 300 adults with SCVF for these antibodies and study how th…

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study tests whether a special CT scan done in the emergency department can quickly check for blood clots in people with atrial fibrillation or atrial flutter. If no clot is found, doctors can proceed with a procedure to restore normal heart rhythm (cardioversion) right away.…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study explores whether a quick, painless cheek swab can spot protein changes linked to inherited heart conditions that cause sudden cardiac death in young people. Researchers will collect samples from 26 patients with arrhythmic disorders or family members at risk. If the te…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study tests a new, noninvasive method to quickly determine if critically ill children need intravenous fluids. The method uses gentle abdominal pressure and a device that measures blood flow. If accurate, it could help doctors avoid giving unnecessary fluids, which can be ha…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study is testing whether a small implantable heart monitor (Reveal LINQ) can detect serious heart block in people who develop a new electrical problem (left bundle branch block) after having their aortic valve replaced (TAVI). About 80 participants will get the monitor and b…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study is testing whether a special blood pressure monitor can accurately detect atrial fibrillation, a common heart rhythm disorder. Researchers will compare the monitor's readings with standard diagnostic methods in 392 adults, some with and some without AF. If it works, th…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study tests whether a smartwatch (Withings ScanWatch) can diagnose atrial fibrillation that occurs after heart surgery better than standard monitoring. About 324 adults who had on-pump heart surgery will either use the smartwatch or receive usual care. The goal is to catch s…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether using a special clamp (EnCompass) to create a scar line in the heart and a clip (AtriClip) to close off a small pouch can prevent new atrial fibrillation after heart surgery. The trial will enroll 960 people aged 65 or older who are having planned heart s…

This study tests whether the blood thinner rivaroxaban can prevent strokes, heart attacks, and death in people with hypertrophic cardiomyopathy (HCM) who have early signs of atrial damage but normal heart rhythm. About 532 adults aged 40-80 with HCM and reduced left atrial strain…

This study tests if a nerve block called a stellate ganglion block can lower the chance of developing atrial fibrillation (a fast, irregular heartbeat) after heart surgery. About 220 adults having valve or bypass surgery will receive either the nerve block or a placebo. The goal …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests whether giving the drug amiodarone after minimally invasive esophageal cancer surgery can prevent a common complication called atrial fibrillation (an irregular, often rapid heart rhythm). About 90 adults having this surgery will be randomly assigned to receive e…

This study tests whether a concentrated grape powder, taken for three days before heart surgery, can prevent a common complication called post-operative atrial fibrillation (POAF). POAF is an irregular heartbeat thought to be triggered by inflammation after surgery. The trial wil…

This study compares two approaches for heart attack survivors with weak hearts: taking modern medications alone versus getting a defibrillator implant plus medications. The goal is to see if medication alone is as good at preventing sudden cardiac death. About 3,600 participants …

This study tests whether a newer pacemaker method (conduction system pacing) can better prevent heart muscle weakening compared to the standard method. Researchers will enroll 200 adults who need a pacemaker for a slow heart rhythm. The goal is to see which approach reduces the r…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This study involves 600 adults having their first open-heart surgery. Doctors will use a temporary pacemaker to test if the heart is prone to atrial fibrillation (AFib) during the operation. Those who show risk will be randomly assigned to receive the drug amiodarone or standard …

This study compares electrical cardioversion—a procedure that delivers a shock to restore normal heart rhythm—to a sham version where no shock is given. Researchers want to see if the real procedure truly improves quality of life in people with persistent atrial fibrillation, a c…

This study compares two ways to dilute the numbing drug bupivacaine for a nerve block used during arm surgery. Researchers want to see if using sugar water (5% dextrose) instead of salt water (0.9% saline) affects how well and how long the block works. About 90 adults having elec…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can improve mental well-being in patients who are more vulnerable due to low income or education. About 290 participants will either receive usual care or be paired with a mentor for 16…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study compares a simple nasal swab to the standard Valsalva maneuver for stopping a common rapid heartbeat condition called supraventricular tachycardia (SVT). About 60 adults with SVT in the emergency room will be randomly assigned to one of the two methods. The goal is to …

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests whether a smartwatch and text message system can encourage people with paroxysmal atrial fibrillation (a type of irregular heartbeat) to be more physically active. The trial has two phases: first, a small group will help design the messages and test the smartwatc…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether using a brain activity monitor (BIS) to guide sedation during a procedure that shocks the heart back to normal rhythm leads to faster recovery and fewer side effects. About 60 adults with atrial fibrillation will be randomly assigned to receive sedation g…

This study is testing a mobile app called Cardio2U for people with atrial fibrillation or heart failure. The app helps patients track their condition, learn about their disease, and communicate with their care team. Researchers will check if patients find the app easy to use and …

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study looks at whether helping patients have realistic expectations before a catheter ablation for atrial fibrillation can improve their quality of life in the first three months after the procedure. About 60 adults with symptomatic atrial fibrillation will take part. The go…

This study tests whether a non-invasive magnetic stimulation device can reduce dangerous heart rhythm episodes in people with ventricular tachycardia storm. About 60 adults who have had multiple episodes despite medication will receive either real or sham stimulation. The goal is…

This study tests whether a 12-week home walking program can improve daily activity and quality of life in people who have an implantable cardioverter defibrillator (ICD). Researchers will enroll 210 adults who can walk without help and have had an ICD placed to prevent sudden car…

This study tests whether a special mapping catheter (Optrell) can better locate and treat heart rhythm problems coming from the papillary muscles, which are small muscle bumps inside the heart. About 20 adults with frequent or bothersome premature ventricular contractions (PVCs) …

This study tests if using a camera inside the heart (intracardiac echocardiography) is as safe and effective as the standard throat camera (transesophageal echocardiography) for guiding a procedure to close a heart pouch. The goal is to prevent strokes in people with an irregular…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study compares a new guidewire (AccuSafe) to the standard needle used to cross the heart wall during catheter ablation for atrial fibrillation. The goal is to see if the guidewire is safer and more effective, especially when done without X-ray guidance. 80 patients will be r…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests whether pentoxyfilline, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility undergoing frozen embryo transfer. About 100 women with good-quality embryos will receive the drug or a plac…

This study tests whether using a tiny ultrasound camera inside the heart during ablation can reduce or replace X-rays. Ablation uses catheters to fix abnormal heart rhythms, and X-rays are normally used to guide them. Half of the 70 participants will get the ultrasound-guided pro…

This study tests whether tadalafil, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility. About 100 women who have good-quality frozen embryos will take tadalafil before embryo transfer. The main goal i…

This study compares a new second-generation catheter (FARAWAVE Nav) used without a pre-procedure CT scan to the standard approach with a CT scan for treating atrial fibrillation. The goal is to see if the new method reduces radiation exposure and procedure time. 58 adults with at…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study compares two types of supervised exercise programs—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care alone in 132 adults with persistent or permanent atrial fibrillation. Participants will exercise twice weekly for…

This study tests a special closure device (VASCADE MVP) to stop bleeding after a heart ablation for atrial fibrillation. The goal is to see if it helps patients get up and walk sooner compared to standard manual compression. One hundred adults undergoing ablation will be randomly…

This study looks at whether a procedure called catheter ablation can improve quality of life for people aged 80 and older who have a heart rhythm problem called atrial fibrillation. Half of the 182 participants will get the real procedure, and half will get a fake one (sham) to s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This trial compares two defibrillators—one delivering a maximum of 200 joules and the other 360 joules—to see which is better at restoring normal heart rhythm in people with persistent atrial fibrillation. About 376 adults scheduled for elective cardioversion will be randomly ass…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study follows up with people who survived a dangerous heart condition called electrical storm and were treated in the ICU. Researchers want to understand how the experience and treatments affect mental health and quality of life. Participants fill out questionnaires about PT…

This study involves 100 adults with heart rhythm problems who are already scheduled for a standard heart mapping procedure. Researchers will test new software features on the mapping system to see how well they work. The goal is to gather feedback to improve future versions of th…

This study uses a special catheter to record detailed electrical signals from the heart during a standard procedure for dangerous heart rhythms (ventricular tachycardia). Researchers aim to better understand why these rhythms start and how to pinpoint the exact trouble spots. Ten…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study uses wearable EKG patches to track heart rhythms in 150 adults having elective open-heart surgery. The goal is to find out how often atrial fibrillation occurs after surgery and what factors increase the risk. Researchers hope this will lead to better prediction and pr…

This study tests whether an artificial intelligence algorithm can predict survival and complications in people who have had a cardiorespiratory arrest and been revived. Researchers will analyze hospital records from 300 to 500 patients treated in intensive care units in France be…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward impacts their quality of life. Participants fill out surveys about their physical and mental health, as well as any treatments they receive. The goal is to better understand…

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study observes 50 adult organ donors to measure oxygen levels in the blood when the heart stops during a Maastricht III donation procedure. Researchers take blood samples at key moments to understand how low oxygen gets. The goal is to gather knowledge, not to test a treatme…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is looking at whether women with lower ovarian reserve (fewer eggs) have had more early miscarriages in the past. Researchers will measure ovarian reserve with a blood test (AMH) and an ultrasound (antral follicle count) in over 2,000 women seeking fertility care. This…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will measure how well patients sense carbon dioxide in their blood and how seizures affect breathing and heart function. 335 adults with epilepsy will be followed for up to 10 years. The…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study tracks immune-related substances in the blood of 40 women undergoing a frozen embryo transfer. Researchers want to see how these markers change before and after the transfer, and whether they relate to pregnancy success. The goal is to better understand the role of the…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This pilot study at Tulane University is testing whether obstructive sleep apnea (OSA) can cause scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use a special MRI with contrast dye to measure scarring in 60 adults wi…

This study looks at whether scarring (fibrosis) in the heart's upper chambers can predict who will develop an irregular heartbeat after heart surgery. Researchers will track 50 adults aged 40+ with no prior irregular heartbeat who are scheduled for heart surgery. The goal is to s…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This registry is collecting data from 3,000 adults with atrial fibrillation who undergo a procedure to close off a part of the heart called the left atrial appendage. The goal is to track how well the procedure works to prevent strokes and to identify any complications. Hospitals…

This study is not testing a drug or treatment. Instead, researchers are using artificial intelligence to analyze electrocardiogram (ECG) data from over 127,000 people. The goal is to create computer models that can quickly and accurately predict life-threatening heart rhythm prob…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study looks at whether a person's genetic makeup can help spot undiagnosed atrial fibrillation (AF), an irregular heartbeat that raises stroke risk. About 800 adults with symptoms or risk factors will wear a heart monitor for 7 days and use a handheld ECG device at home for …

This study will use a special X-ray technique called fluoroscopy to check how often the diaphragm becomes temporarily paralyzed after pulsed field ablation, a newer treatment for atrial fibrillation. Researchers will monitor 250 adults before and after the procedure to detect any…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

This study aims to create a North American registry of sudden unexplained death in epilepsy (SUDEP) cases. Researchers will interview family members and review medical records of people with epilepsy who died suddenly. By comparing these cases with living epilepsy patients, they …

This study is a registry that will follow 4,000 people in China who are having a procedure called catheter ablation to treat atrial fibrillation or ventricular tachycardia. The goal is to see how well the procedure works over the long term and how safe it is. Participants will be…

After a cardiac arrest, many patients remain comatose and are at risk of further brain injury. Doctors currently measure brain oxygen by drawing blood from the jugular vein and sending it to a lab, which takes time. This study tests a special catheter that can measure oxygen leve…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This observational study will follow 8,000 people with irregular heartbeats (arrhythmias) who are scheduled for a standard catheter ablation procedure using Biosense Webster devices. Researchers will track safety issues and how well the procedure works in everyday hospital practi…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study is observing 150 people who have a pacemaker with a special setting called Closed Loop Stimulation (CLS) combined with left bundle branch area pacing. The goal is to see if this setting reduces the occurrence of atrial fibrillation over two years. Participants have sin…

This study compares two catheters used during a common heart procedure for atrial fibrillation. The goal is to see if one catheter can confirm that the treatment worked faster than the current method. Thirty adults with persistent atrial fibrillation or atrial flutter will be enr…

This observational study looks at why women with atrial fibrillation (AF) tend to have higher recurrence rates after standard ablation. Researchers will map the heart's electrical activity in 100 patients right after routine pulmonary vein isolation to find extra trigger spots th…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study looks at whether measuring the function of the right upper heart chamber using ultrasound can help predict a common irregular heartbeat (atrial fibrillation) that often occurs after heart surgery. About 334 adults scheduled for bypass surgery will have their heart func…

This study will follow 2,500 elderly people (ages 65-80) in rural China who have atrial fibrillation, a common heart rhythm problem. Researchers will screen them for heart failure using blood tests and heart ultrasounds, then check on them every three months to see how their cond…

This registry is following 1,950 people with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to correct irregular heartbeats. Researchers are tracking how well the procedure prevents AFib from coming back and how often ser…

This study looks at a new, less invasive way to monitor blood flow during heart ablation procedures. Doctors will use a special device to track heart function beat-by-beat. The goal is to see if this method helps improve care for 27 adult patients having heart ablation.

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study is testing whether a Samsung smartwatch and heart MRI scans can detect early signs of heart muscle damage (atrial myopathy) in 360 people with atrial fibrillation or at high risk for heart disease. Participants wear the watch for up to 9 months while researchers track …

This study tests whether paramedics can safely place a small tube in the leg artery of people having a cardiac arrest outside the hospital. The tube allows continuous blood pressure monitoring, which may help doctors give the right amount of medication to keep the heart pumping. …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study investigates whether certain genetic variations make some people with atrial fibrillation more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 participants, including those with AF-related cardiomyopathy and control g…

This observational study looks at how signals from a left bundle branch pacing lead change during daily activities and overdrive pacing in 50 people with an ICD or CRT-D. Researchers want to see if these leads can accurately detect ventricular tachycardia or fibrillation. Partici…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study monitors how long Medtronic heart devices (like pacemakers) last and how often they have problems. It includes up to 20,000 people who have or will get one of these devices. The goal is to collect real-world data to improve future device safety and performance.

This observational study looks at 200 adults with early-onset atrial fibrillation and certain genetic variants. Researchers will use cardiac MRI and electrophysiologic mapping during scheduled heart procedures to find who is at high risk for ventricular tachycardia, a dangerous h…

This study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …

This registry is tracking 2,000 people with atrial fibrillation who are taking blood thinners for a long time. The goal is to see how often serious bleeding or clotting events happen. Researchers will also look at genetic factors that might affect risk. This is an observational s…

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study tests whether a mixed reality (MR) system called HEROS 4.0 can teach CPR as effectively as traditional instructor-led classes. 120 adults who haven't had CPR training in the last year will be split into two groups: one using MR and one using standard video and in-perso…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18–50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients and also check family members for inherited heart risks. The goal is to better understand why cardiac arres…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study follows 750 people with atrial fibrillation (an irregular heartbeat) who are getting a procedure called catheter ablation. The main goal is to learn why the heart rhythm problem returns in up to 45% of patients within a year after the procedure. Researchers will track …

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study follows 1,200 people in China with atrial fibrillation who are getting a new type of procedure called pulsed field ablation. Researchers want to see if early heart rhythm problems after the procedure can predict if the condition will come back later. Participants will …

This study tests whether improved telephone instructions for CPR can reduce the time without chest compressions when using an AED. About 80 volunteers will act as single rescuers in a simulated cardiac arrest. Half will get standard phone CPR guidance, and half will get enhanced …

This study aims to create a tool that uses stress heart MRI and routine medical data to predict which patients with dilated cardiomyopathy (a weakened, enlarged heart) are at highest risk for serious problems like heart failure or sudden cardiac death. Researchers will follow 2,0…

This study is looking at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called catheter ablation. The goal is to see if more scarring means a higher chance of AF coming back or needing hospit…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This registry is collecting information from 8,000 people undergoing heart or chest surgery. The goal is to see how factors before and during surgery relate to serious complications like death, shock, or infection. By analyzing this data, researchers hope to find ways to improve …

This study watches how hospital staff give breaths during CPR to adults whose hearts stop. It will measure the rate and volume of breaths and see which levels are linked to restarting the heart and surviving 30 days. The goal is to find the best ventilation approach during CPR.

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks at whether combining blood tests and brain ultrasound can better predict how well someone recovers from a cardiac arrest. Researchers will enroll 50 adults and check their blood for proteins linked to inflammation and use ultrasound to measure brain blood flow an…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study is looking for proteins, metabolites, and platelet changes in the blood that could predict whether a person will survive after receiving ECPR, a machine that takes over heart and lung function during cardiac arrest. Researchers will study blood samples from 130 adults …

This study is collecting cervical mucus from 476 women undergoing IVF or frozen embryo transfer. Researchers will analyze the proteins in the mucus to find markers that indicate when the uterus is most receptive to an embryo. By comparing samples from women who become pregnant wi…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in 50 people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use ultrasound images taken during the procedure to measure changes in heart f…

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study tracks 774 adults who develop a new type of irregular heartbeat (atrial fibrillation) while hospitalized for a heart attack. Researchers will use continuous electronic monitoring to measure how much time patients spend in this abnormal rhythm. The goal is to see if the…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tests whether combining detailed heart scans (MRI/CT) with electrical mapping can help doctors better target and treat scar-related ventricular tachycardia (VT), a dangerous heart rhythm. Twenty people with VT who already have an implanted defibrillator will undergo ex…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation for atrial fibrillation. Researchers will use a special catheter to measure pressure in the abdomen while patients are under different types of anesthesia. The goal is to see if t…

This study watches 800 adults with nonvalvular atrial fibrillation (a type of irregular heartbeat) who are starting the blood thinner apixaban for the first time. Researchers will track how often serious or minor bleeding occurs and how well patients stick to their medication sch…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture good-quality ECGs, which migh…

This study follows 50 adults with paroxysmal atrial fibrillation (AFib) who are scheduled for catheter ablation. Researchers will use exercise tests, heart MRIs, and echocardiograms to measure how well the heart's left atrium works during exercise before and 5-6 months after the …

This study examines whether special pacemakers can effectively treat a common type of fast heart rhythm (atrial tachycardia) in people born with heart defects. Researchers will review medical records from up to 300 patients over 10 years to see if the pacemaker reduces the need f…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study is a registry that will collect information on how a new balloon-in-basket device (VOLT PFA) is used in real-world hospitals to treat atrial fibrillation (AFib). Researchers will track procedure details, safety, and how well it stops abnormal heart rhythms. About 1,000…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…

This pilot study aims to see if certain blood markers that indicate clotting increase when atrial fibrillation (AFib) is more active. Researchers will take blood samples from 20 adults before, during, and up to 90 days after a catheter ablation procedure. The goal is to better un…

This study will implant a small heart monitor (loop recorder) in 20 young adults aged 18-60 who have a heart condition called mitral annular disjunction and mild or no symptoms. The goal is to detect hidden dangerous heart rhythms that could lead to sudden cardiac death. Particip…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study looks at how a heart rhythm treatment called catheter ablation affects the quality of life of people with ventricular tachycardia who have an implantable defibrillator. Researchers will ask 70 participants to fill out questionnaires about their health and well-being at…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study looks at why the airway sometimes closes during CPR for people who have a cardiac arrest outside the hospital. Researchers will analyze breathing data from 150 adults to see how common this closure is and whether it affects the chances of restarting the heart. The goal…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study looks at rules doctors use to decide when to stop trying to revive someone after a cardiac arrest outside the hospital. These rules were made in Western countries, and this study checks if they work for people in Asia. Researchers will study 140,000 patients to see if …

This study tests an AI system that reads blood pressure signals during CPR to tell rescuers if they are compressing the wrong part of the chest. In about half of cardiac arrest patients, standard chest compressions accidentally press on a valve in the heart, reducing blood flow. …

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to see how often AF returns and whether the cause (heart surgery, other surgery, …

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arres…

This study looks at 350 adults with transfusion-dependent beta-thalassemia to find differences between those who have atrial fibrillation (a type of irregular heartbeat) and those who do not. Researchers will compare clinical tests, lab results, and imaging to better understand t…

This Stanford study looks at 200 people with persistent atrial fibrillation (AF) who are scheduled for ablation or Maze surgery. Researchers will map the heart's electrical activity to see if the size of organized areas predicts whether the procedure works. The goal is to better …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital. The goal is to better understand what happens before, during, and after the event, so doctors can improve care and survival rates. Participants are foll…

This study is testing whether a special heart ultrasound can predict who will develop atrial fibrillation after heart surgery. Researchers will measure how well the heart's upper chambers work together before surgery in 138 patients. They will then track patients during recovery …

This study looks at how well the Micra AV2 pacemaker can detect atrial fibrillation (AFib) in people who already have a history of paroxysmal AFib. Researchers will monitor 50 patients using the pacemaker's signals and a special Holter monitor. The goal is to understand how often…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study tests whether a connected watch can better detect returning atrial fibrillation (an irregular heartbeat) in 106 adults who had heart surgery and developed a temporary irregular rhythm. Participants will wear the watch for 12 months, and doctors will compare how well it…