New heart device aims to tame persistent AFib

NCT ID NCT07527299

Recruiting now Disease control Sponsor: Biosense Webster, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to reduce stroke risk. About 920 participants will be followed to see if the treatment is safe and effective over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VARIPULSE catheter system (pulsed field ablation device)
What this could lead to: If successful, this could provide a safer and more effective way to control persistent atrial fibrillation, reducing symptoms and stroke risk.
What could go wrong: This is an early-stage trial with 920 participants, so results may not apply to everyone. Risks include serious complications like stroke, heart damage, or nerve injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION

Contacts and locations

Locations

Albert Einstein College Of Medicine - Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Arizona Arrhythmia Research Group Phoenix Cardio Research Group PCRG
NOT_YET_RECRUITING

Phoenix, Arizona, 85018, United States
Arrhythmia Research Group
RECRUITING

Jonesboro, Arkansas, 72401, United States
Aurora Denver Cardiology Associates
NOT_YET_RECRUITING

Aurora, Colorado, 80012, United States
Grandview Medical Center
NOT_YET_RECRUITING

Birmingham, Alabama, 35243, United States
Hartford Hospital
NOT_YET_RECRUITING

Hartford, Connecticut, 06102, United States
Hoag Memorial Hospital
NOT_YET_RECRUITING

Newport, California, 92663, United States
Honorhealth
NOT_YET_RECRUITING

Scottsdale, Arizona, 85258, United States
Houston Methodist Sugarland
NOT_YET_RECRUITING

Sugar Land, Texas, 77479, United States
JFK Medical Center
NOT_YET_RECRUITING

Atlantis, Florida, 33462, United States
John Hunter Hospital
NOT_YET_RECRUITING

New Lambton Heights, 2305, Australia
Lindner Clinical Trial Center/Christ Hospital
NOT_YET_RECRUITING

Cincinnati, Ohio, 45219, United States
Marin General Hospital
NOT_YET_RECRUITING

Larkspur, California, 94939, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Jacksonville
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Mercy Hospital
NOT_YET_RECRUITING

Janesville, Wisconsin, 53548, United States
Monash Health Victorian Heart Hospital
NOT_YET_RECRUITING

Clayton, 3168, Australia
Oklahoma Heart Hospital
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Pacific Heart Institute Cedars Sinai Medical Center
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
Penn Presbyterian Medical Center
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Pima Heart and Vascular
RECRUITING

Tucson, Arizona, 85741, United States
Saint Elizabeth Medical Center
NOT_YET_RECRUITING

Edgewood, Kentucky, 41017, United States
The Kansas City Heart Rhythm Institute
NOT_YET_RECRUITING

Overland Park, Kansas, 66211, United States
Tucson Medical Center
WITHDRAWN

Tucson, Arizona, 85712, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Washington Regional Medical Center
NOT_YET_RECRUITING

Fayetteville, Arkansas, 72703, United States
Westmead Hospital
NOT_YET_RECRUITING

Westmead, 2145, Australia

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