Can a cholesterol drug keep atrial fibrillation at bay after ablation?
NCT ID NCT07752758
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the procedure, while the other half receives standard care. The main goal is to see if ezetimibe lowers the chance of atrial arrhythmia recurrence within six months, potentially offering a simple way to improve long-term outcomes after ablation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ezetimibe, an oral cholesterol-lowering drug, taken as 10 mg once daily for 6 months after catheter ablation.
- What this could lead to
- If effective, ezetimibe could become a simple, low-cost addition to post-ablation care, potentially reducing the need for repeat procedures and improving long-term heart rhythm control.
- What could go wrong
- This is a small pilot study, so results may not be conclusive. Ezetimibe is generally well-tolerated but can cause muscle or liver side effects, and its benefit for AF recurrence is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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