Persistent atrial fibrillation

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This global trial compares two ablation strategies for people with persistent atrial fibrillation (AF) that hasn't responded to medication. One group gets standard ablation of the pulmonary veins and back wall of the left atrium. The other group gets ablation guided by a special …

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This study is testing the FARAPULSE Pulsed Field Ablation system in 376 people with persistent atrial fibrillation (AFib) who have already had a prior ablation. The device uses electrical pulses to destroy the heart tissue causing the abnormal rhythm. The goal is to see if it is …

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study is testing a new device called the FARAFLEX system, which uses targeted electrical pulses to treat atrial fibrillation, a common heart rhythm problem. About 250 adults with persistent or paroxysmal atrial fibrillation will take part. The goal is to see if the device is…

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to…

This study tests whether adding extra scar lines in the heart, along with the standard vein isolation procedure, helps people with persistent atrial fibrillation stay in normal rhythm longer. About 640 adults aged 18–80 with symptomatic, drug-resistant persistent AFib will be ran…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This study tests a new system (VARIPULSE catheter and TRUPULSE generator) with updated software for treating persistent atrial fibrillation, a long-lasting irregular heartbeat. About 50 adults aged 18-75 who have not responded to medication will undergo a heart ablation procedure…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see …

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study tests whether Qidong Yixin Granules, an herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to receive either the…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard procedure called ablation, but with the CoreMap system guiding the treatment. The…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests whether a heart procedure called catheter ablation can slow down memory loss in people with mild cognitive impairment who also have a common heart rhythm problem called atrial fibrillation. 120 participants will be randomly assigned to get either the ablation plu…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This pilot study tests whether using a noninvasive global mapping system to guide catheter ablation can improve outcomes for people with persistent atrial fibrillation. Thirty participants will receive standard pulmonary vein isolation plus personalized ablation of up to three ad…

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where…

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (AF), a type of irregular heartbeat. The catheter can switch between a large 'petal' shape for quick vein isolation and a small 'bud' shape for precise linear ablation. Forty a…

This study tests a new device that uses pulsed electric fields to treat persistent atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 people to see if the procedure is safe and can restore normal heart rhythm. The goal is to offer a more precise and l…

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat catheter ablation for atrial fibrillation (AFib) can lower the chance of AFib coming back. About 250 people with high blood pressure and AFib who need a second ablation will be randomly assig…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study looks at whether a lower daily dose of the heart medication amiodarone can keep the heart in a normal rhythm as well as the standard dose, but with fewer side effects. About 312 adults with persistent atrial fibrillation who have had a successful electrical shock to re…

This study tests whether adding a kidney nerve-zapping procedure (renal artery denervation) to the standard heart ablation procedure can better control persistent atrial fibrillation (AF). About 50 adults with persistent AF and controlled or no high blood pressure will be randoml…

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two p…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This trial compares three different catheter ablation strategies for people with persistent atrial fibrillation (AFib), a heart rhythm problem. Sixty adults aged 18-80 will be randomly assigned to one of three approaches using a special catheter that can switch between two energy…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study is testing whether a machine learning algorithm can accurately detect heart murmurs that point to structural heart disease. Researchers will record heart sounds from 125 adults using two different digital stethoscopes and compare the algorithm's findings to standard ec…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study compares electrical cardioversion—a procedure that delivers a shock to restore normal heart rhythm—to a sham version where no shock is given. Researchers want to see if the real procedure truly improves quality of life in people with persistent atrial fibrillation, a c…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study compares two types of supervised exercise programs—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care alone in 132 adults with persistent or permanent atrial fibrillation. Participants will exercise twice weekly for…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This registry is collecting information from 8,000 people undergoing heart or chest surgery. The goal is to see how factors before and during surgery relate to serious complications like death, shock, or infection. By analyzing this data, researchers hope to find ways to improve …

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This Stanford study looks at 200 people with persistent atrial fibrillation (AF) who are scheduled for ablation or Maze surgery. Researchers will map the heart's electrical activity to see if the size of organized areas predicts whether the procedure works. The goal is to better …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study tracks 150 adults in cardiac rehab to see if men and women differ in how much they move during and up to 6 months after the program. Participants wear activity trackers and complete fitness tests at three visits over 10 months. The goal is to understand barriers to sta…

This study at St Bartholomew's Hospital is enrolling 160 people with persistent atrial fibrillation (AFib) who are scheduled for their first catheter ablation. Researchers will create detailed 3D electrical maps of the heart during the procedure to understand why AFib persists an…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…