Heart fix may shield brain: FALCON trial tests ablation for memory loss
NCT ID NCT05790707
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a heart procedure called catheter ablation can slow down memory loss in people with mild cognitive impairment who also have a common heart rhythm problem called atrial fibrillation. 120 participants will be randomly assigned to get either the ablation plus heart-rhythm drugs, or the drugs alone. The main goal is to see if the ablation group has better scores on a memory and thinking test after 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
catheter ablation (a procedure using heat or cold to destroy heart tissue causing irregular rhythm) plus antiarrhythmic drugs
What this could lead to
If it works, this could point toward a way to preserve memory and thinking in people with both atrial fibrillation and mild cognitive impairment.
What could go wrong
This is a small, early-stage study (120 people) and the main outcome is a questionnaire score, not a hard endpoint. The procedure carries risks like bleeding, infection, or heart damage, and the cognitive benefit is uncertain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU Angers
RECRUITINGAngers, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Grenoble
RECRUITINGGrenoble, France
Contact Phone: •••-•••-••••
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Centre Cardiologique du Nord
NOT_YET_RECRUITINGSaint-Denis, France
Contact
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La Timone
RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital
RECRUITINGBrest, France
Contact
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University Hospital
RECRUITINGCaen, France
Contact
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University Hospital
RECRUITINGDijon, France
Contact
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University Hospital
RECRUITINGPoitiers, France
Contact