MILD COGNITIVE IMPAIRMENT

This study looks at whether treating a common heart rhythm problem (atrial fibrillation) with a procedure called catheter ablation can help slow down memory loss in people who already have mild thinking difficulties. About 120 adults aged 60 to 80 with both conditions will be ran…

This study tests a 12-week program for people with mild cognitive impairment (early memory loss) and their family caregivers. The program includes professional and caregiver-led sessions to improve thinking, memory, and quality of life. Researchers will also look at gut health an…

This study tests a pressure-sensor exercise mat and software designed to improve thinking and balance in older adults. About 205 people aged 65 and older will do group exercises like memory games and balance drills using the mat. Researchers will compare their results to a contro…

This study tests whether metformin, a common diabetes medicine, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give metformin or a placebo to 54 people aged 60-75 for 26 weeks. They will use brain scans a…

This study tests a new weekly injection (mazdutide) in 420 people with type 2 diabetes who also have mild cognitive impairment or early dementia. The goal is to see if the drug can slow down memory and thinking problems over 76 weeks. Participants are randomly assigned to receive…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems keep their daily living skills and delay dementia. About 1,300 participants aged 55–89 will try different combinations of cognitive training or general mental stimulation…

This study is testing whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 people aged 55 to 89 will take rapamycin for 12 months. Researchers will monitor side effects and check if the drug reaches the…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication. About 100 participants will use either the full app with reminders or just an education portal for 16 weeks. …

This early-stage study tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to see if it is safe and can slow or prevent brain cell loss in people with early Alzheimer's disease or mild cognitive impairment. The study involves 12 participa…

This study tests an experimental drug called senicapoc in people with mild or early Alzheimer's disease. The goal is to see if it can slow memory loss and reduce brain inflammation. About 55 participants will take either the drug or a placebo for one year. This is a small early-s…

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other brain diseases. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute smell test using scratch-and-s…

This study tests a new, ultra-low radiation PET scan to detect Alzheimer's disease and other dementias. Researchers aim to reduce radiation exposure by 10 to 100 times compared to current scans. About 200 adults, including healthy volunteers and those with memory problems, will r…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, and r…

This study tests whether a telerehabilitation program using a virtual reality (VR) app can improve thinking skills and social abilities in people with mild memory problems. About 480 adults aged 40-80 with subjective cognitive decline or mild cognitive impairment will use VR exer…

This study tests a program called Sense4Safety for older adults (65+) with mild cognitive impairment who are at high risk of falling. Participants get in-home sensors that detect fall risks, plus a coach who helps create a personalized safety plan. The goal is to see if this appr…

This study tests a computer-based program (CAST) to reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and to ease the burden on their care partners. About 388 pairs (patient and care partner) will take part. The program involves two sessi…

This study tests a new exercise program for people with mild cognitive impairment (early memory loss) due to Alzheimer's. The program focuses on doing two tasks at once, like walking while counting. Researchers want to see if it improves walking, balance, and thinking. About 45 a…

This study tests whether 6 months of supervised aerobic exercise (like walking or cycling) can boost fitness, reduce brain damage, and improve memory in adults 65 and older with mild cognitive impairment or early Alzheimer's. Participants will exercise regularly, have memory test…

This study tests whether a simple smell training program can improve memory, thinking, and daily function in 30 adults aged 55-89 with mild cognitive impairment (MCI), a condition that often precedes Alzheimer's disease. Participants will be randomly assigned to either smell trai…

This study tests whether a gentle, non-invasive ultrasound technique called LIFUP can increase brain activity in a memory-related area and improve memory in people with mild cognitive impairment or mild Alzheimer's. About 144 participants will receive focused ultrasound to the en…

This study tests whether eating only between 10 a.m. and 8 p.m. (14 hours of nightly fasting) can reduce sleep problems, memory loss, and disease markers in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try this eating sch…

This study tests whether a special type of tai ji quan that combines physical movement with mental tasks can reduce falls in older adults with mild cognitive impairment (MCI). Researchers will enroll 336 people aged 65 and older who have memory complaints and a history of falls o…

This study tests whether playing online games with others can help older adults (ages 50-85) feel more socially connected and less lonely. It includes people with and without mild cognitive impairment (MCI). Participants will play games remotely and report changes in loneliness, …

This study tests whether a non-invasive brain stimulation technique, called theta burst stimulation, can improve cognitive control in healthy adults and those with mild cognitive impairment. Participants play a cognitive video game while a brain-computer interface monitors their …

This study tests whether a low-carbohydrate (ketogenic) diet or a low-fat diet can improve thinking and memory in people with mild cognitive impairment. About 120 volunteers will follow one of the two diets for 16 weeks, then return to their normal eating habits. Researchers will…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve memory in healthy young adults, healthy older adults, and older adults with amnestic mild cognitive impairment (aMCI), a condition that often…

This study looks at whether over-the-counter hearing aids can improve communication for people over 60 with mild to moderate hearing loss and mild cognitive impairment or early Alzheimer's. Participants and their communication partners will try either hearing aids first or specia…

This study tests a non-invasive brain stimulation method called deep TMS in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. The treatment uses a special coil to stimulate deeper brain areas fo…

This study tests whether personalized, virtual music therapy sessions can boost memory, mood, and thinking skills in people with mild Alzheimer's or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will meas…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This early-stage study tests whether a drug called CpG 1018, which stimulates the body's natural immune system, is safe for people with mild cognitive impairment or mild Alzheimer's dementia. About 39 participants will receive one of three doses or a placebo over 8 weeks. The mai…

This study tests whether doing special visual exercises on a computer can improve attention and thinking speed in older adults with mild cognitive impairment. About 40 participants will either do these exercises or watch TV for 30 days. Researchers will compare changes in process…

This study tests whether breathing air with slightly less oxygen (intermittent hypoxia training) can safely improve memory and thinking in people aged 55-79 with mild cognitive impairment. Over 12 weeks, participants will be randomly assigned to receive the treatment or a sham (f…

This study tests whether a dental mouthpiece or a CPAP machine better improves memory and thinking in people with sleep apnea and mild cognitive issues. About 260 adults aged 45 and older will be randomly assigned to one of the two treatments for one year. The goal is to see whic…

This study tests whether a 12-week home-based strength training program, supported by technology and telehealth, is practical for adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Researchers will measure how many people complete the program and how often they…

This study tests a small device worn on the ear that sends gentle pulses to a nerve, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four adults aged 55 to 89 will use the device at home for 30 minutes each day over four…

This study looks at whether exercising before a gentle brain stimulation technique (tDCS) can improve memory in people aged 50+ with mild cognitive problems and heart or blood vessel risk factors. Participants will exercise and then receive brain stimulation, and their memory and…

This study tests whether adding an antioxidant to an NMDA-enhancing drug can improve thinking and memory more than the NMDA drug alone. It involves 80 people with early Alzheimer's or mild cognitive impairment. Participants will be followed for 24 weeks to see changes in cognitiv…

This study is testing a safe, home-based brain stimulation technique called RS-tDCS+ combined with cognitive training to improve attention in 160 active-duty service members and veterans who have had a mild traumatic brain injury. Participants will receive either real or sham sti…

This study tests a dietary supplement called Sabroxy® in 140 adults aged 40-80 who have both mild cognitive impairment (early memory loss) and insulin resistance (a pre-diabetic condition). Participants will take either the supplement or a placebo daily for 8 weeks. The goal is t…

This study tests a gentle brain stimulation method called tDCS to see if it can improve thinking and memory in people with Parkinson's disease who have mild cognitive issues. About 36 adults with Parkinson's will receive tDCS or a sham treatment, and their cognitive performance w…

This study looks at whether a 6-month home walking program can improve memory, thinking skills, and brain structure in older adults with chronic kidney disease and mild memory problems. Researchers will compare the walking group to a health education group. The goal is to find a …

This study tests whether rhythmic light therapy can improve brain function and memory in people with mild cognitive impairment. Twenty participants will each attend three one-hour sessions with different light patterns while their brain activity is recorded. The goal is to see if…

This study tests a medical device called Neuclare that is placed on the head to see if it can temporarily improve thinking and planning skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medi…

This study tests different amounts of a safe, non-invasive brain stimulation called TMS in 60 older adults (ages 60-85) who have mild memory problems and depression. The goal is to find the best dose to improve both mood and thinking, which could help prevent dementia in the futu…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—a lack of interest or motivation—is common and disabling in these conditions. The study includes 10 participa…

This study looks at whether a simple, low-intensity exercise program can improve memory and thinking in older adults who have mild cognitive impairment (MCI), a condition that raises the risk of dementia. Researchers will compare a group that does combined physical and mental exe…

This study looks at whether high-intensity interval training (HIIT) or moderate-intensity continuous exercise (like brisk walking) better improves thinking skills and physical fitness in older adults with mild cognitive impairment (MCI). Sixty-eight participants will exercise thr…

This study tests whether playing a digital navigation game can improve long-term memory in healthy older adults and those with mild cognitive impairment. About 150 participants will play either the navigation game or a control game for up to 8 weeks at home. Memory and thinking s…

This study tests whether improving deep sleep with gentle sounds can make cognitive training more effective for people with Parkinson's disease and mild memory problems. Fifty participants will do a 5-week brain-training program at home while using a sleep device that plays soft …

This small pilot study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people who have mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The study will measure change…

This study tests whether a special type of brain stimulation, combined with aerobic exercise, can improve thinking and walking in older adults who are frail and have mild memory problems. Researchers will compare different stimulation patterns to see which works best. The goal is…

This study is testing whether a non-invasive technique called transcranial ultrasound stimulation (TUS) can safely improve thinking, movement, and quality of life in people with neurodegenerative diseases like Parkinson's and Alzheimer's. Twenty adults aged 18-80 with these condi…

This study is testing whether a memory support training program is practical to offer to people with mild cognitive impairment and their care partners. Researchers will survey patients about their interest in the program and analyze implementation costs. A small group will receiv…

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve memory and brain function in older adults with mild memory problems or early Alzheimer's. About 30 participants will receive daily stimulation sessions over two 10-day periods, wit…

This study is tracking 8,000 stroke survivors to understand why some develop memory and thinking problems (dementia) after a stroke. Researchers will use brain scans, blood tests, and thinking assessments to find factors that predict cognitive decline. The goal is to help doctors…

This study looks at whether people with Mild Cognitive Impairment (MCI) have trouble hearing in noisy places compared to healthy adults. Researchers will test hearing and thinking skills in 70 volunteers aged 55-80. The goal is to see if simple hearing tests can help detect early…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis over time. The goal is to gather data, not to test a treatment, so there is no …

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study explores whether artificial intelligence can estimate a person's cognitive test scores by analyzing a short speech recording. 150 adults aged 50 and older will tell a story based on a picture while their voice is recorded. The AI's predictions will be compared to stand…

This study looks at whether mild traumatic brain injuries (mTBIs) in Veterans increase the risk of dementia. Researchers will measure memory, brain waves, brain structure, and certain proteins in 800 participants. The goal is to find early signs of brain changes related to Alzhei…

This study aims to find early signs that predict memory loss and dementia in 850 older adults, including those with mild memory issues or prediabetes. Researchers will track thinking skills, brain scans, and spinal fluid markers over time. The goal is to better understand how pro…

This study is gathering data from 1,200 older adults (ages 60-90) who are either cognitively normal, have mild memory problems, or have mild-to-moderate Alzheimer's. Researchers will compare digital tests (like smartphone tasks) and blood markers with brain scans to see if these …

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and people with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation to each person's brain networks. The …

This study follows 800 healthy adults aged 50 to 80 over four years to find early biological markers of Alzheimer's disease. Researchers will use blood tests, spinal fluid samples, and brain scans to track changes. The goal is to develop a screening tool for the general populatio…

This study looks at how mild cognitive impairment (MCI) affects the brain's ability to quickly make decisions and move. Researchers will track hand movements and brain changes in 60 adults aged 45-90, including those with MCI and healthy volunteers. The goal is to find early sign…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other similar diseases. Researchers want to see if inflammation levels are higher in these patients compared to healthy volunteers. Participants will have MRI…

This study is building a large group of 1,000 older adults (age 60+) in Tennessee to help researchers better understand Alzheimer's disease. Participants include people with normal memory, mild memory problems, or Alzheimer's. They will have yearly check-ups, brain scans, and blo…

This study looks at how a gentle, non-invasive brain stimulation technique affects brain activity and memory in healthy older adults and those with mild memory problems. Researchers will use brain scans and memory tests to see if the stimulation causes changes. The goal is to bet…

This study looks at why some people improve their thinking skills after a brain injury through computer-based brain training. Researchers will test memory, attention, and other mental abilities in 30 adults aged 25-65 who had a brain injury at least a year ago. They will also mea…

This study explores whether a 12-week program combining brain training and aerobic exercise can improve brain function in people with mild cognitive impairment (MCI), a condition that can lead to dementia. Researchers will measure changes in brain structure, blood flow, and think…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. About 90 volunteers aged 50 and older, including healthy individuals, will get PET and MRI scans. The goal is to understand how infla…

This study uses a safe, noninvasive light-based device (fNIRS) to measure brain activity in 200 adults with depression, bipolar disorder, or mild cognitive impairment. By comparing brain patterns across groups, researchers hope to better understand how these conditions affect the…

This study looks at whether special eye scans can find early signs of Alzheimer's disease and other dementias. Researchers will check for changes in blood flow and protein buildup in the retinas of 20 older adults with mild dementia, compared to healthy volunteers. The goal is to…

This study looks at whether a simple tablet-based test can help primary care doctors detect cognitive impairment, including dementia, in older adults during regular visits. The test is designed to be easy to use and automatically scores results. Researchers will compare detection…

This study is looking at whether certain substances in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 adults aged 60 and older, including those with and without memory issues, to see how well these blood ma…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study looks at whether people with Alzheimer's disease also have harmful protein clumps (amyloid) in their hearts, which can cause heart failure. Researchers will use special PET scans—normally used to see amyloid in the brain—to also scan the heart. About 15 participants wi…

This study aims to better predict how dementia will progress in individuals with mild cognitive impairment or early dementia. Researchers will collect blood samples and use computer models to track changes in thinking and memory over time. The goal is to improve prognostic confid…

This study looks at whether pharmacies can help find people with early memory problems and connect them to support. About 1,020 adults aged 60 and older with mild cognitive issues will take a digital memory test at a pharmacy. If results are concerning, they get referred to a doc…

This study looks at how stress hormones and certain genes might speed up memory loss in older adults with mild cognitive impairment. Researchers will test memory and collect blood and saliva samples after a short stressful task. Participants return after two years to see if stres…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…

This study aims to help family doctors better detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using simple blood tests and brain scans. The goal is to make accurate diagnosis easier and faster in primary c…

This study tests a web-based tool called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life wishes with a care partner. The goal is to see if the tool improves decision-making confidence and reduces anxiety for both the…

This study looks at whether time-restricted eating (eating only during a set window each day) is practical for postmenopausal women with mild cognitive impairment. The goal is to see if this simple lifestyle change could help delay Alzheimer's disease. Fifteen women will track th…

This study is testing whether new blood tests can accurately diagnose the cause of memory problems, potentially replacing the need for more invasive spinal fluid tests. Researchers will compare blood test results with spinal fluid results in 1,200 people being evaluated at a memo…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild memory problems. Researchers want to see how tau relates to thinking skills, brain activity, and the risk of future decline. About 105 people aged 55–90 who …

This study looks at whether improving deep sleep can help protect the brain in older adults at risk for Alzheimer's disease. Researchers will ask 116 people aged 65-85 with mild sleep issues to spend less time in bed to naturally deepen their sleep. They will measure changes in m…