MILD COGNITIVE IMPAIRMENT

This study tested whether simple electronic reminders could help doctors and caregivers safely reduce unnecessary or risky medications for people with dementia. Researchers sent automated messages to both doctors and patients' caregivers before appointments, suggesting they discu…

This study tested if a 12-week time-restricted eating plan was practical and acceptable for older adults with mild memory problems and obesity. Participants worked with a psychologist to fast for 16 hours on 2-3 days each week. Researchers measured changes in memory, thinking ski…

This completed Phase 2 study tested whether the drug XPro1595 could help slow cognitive decline in people with early Alzheimer's disease who show signs of brain inflammation. 208 participants with mild Alzheimer's or mild cognitive impairment received either the drug or a placebo…

This study tested whether computer-based brain training exercises could improve thinking skills and reduce depression in older adults who were already taking antidepressants. Researchers enrolled 38 older adults with mild to major depression, some with mild memory concerns, and r…

This study tested whether a non-invasive brain stimulation technique could improve thinking skills in veterans with mild cognitive impairment or early dementia. Researchers used magnetic pulses on the forehead to stimulate brain areas involved in memory and decision-making. They …

This study tested whether a nasal insulin spray and a diabetes pill (empagliflozin), alone or together, could help people with early memory loss or Alzheimer's disease. It involved 47 adults aged 55-85 who showed early signs of Alzheimer's. The main goal was to check if the treat…

This study tested if a personalized, detailed treatment plan works better than standard care for people with early memory loss or mild dementia. For 9 months, one group followed a plan tailored to their specific test results, focusing on diet, exercise, and other lifestyle factor…

This study tested whether lithium, a medication long used for mood disorders, could help slow or prevent Alzheimer's dementia in older adults with mild memory problems. 83 participants with mild cognitive impairment were randomly assigned to take either lithium or a placebo pill …

This study tested whether an old, common blood pressure drug called spironolactone is safe and tolerable for older African American adults who have early memory and thinking problems. The goal was to see if the drug could help slow the decline in memory skills. A small group of 2…

This study tested a special nasal spray device designed to deliver insulin directly to the brain. Researchers wanted to see if this method could increase insulin levels in the fluid surrounding the brain and potentially improve memory. The study involved 20 people, some with mild…

This study tested whether wearing a nicotine skin patch daily for two years could improve memory, thinking, and daily function in older adults with mild cognitive impairment. Researchers enrolled 348 participants aged 55-90 who were experiencing early memory problems but not full…

This study tested a program to help reduce unnecessary or risky medications for people with dementia. A pharmacist met with patients and their caregivers via video call to review all medications based on the patient's personal health goals. The goal was to see if this approach sa…

This small pilot study tested whether combining physical exercise with a mild, non-invasive brain stimulation technique could help improve memory in people with mild cognitive impairment or early Alzheimer's disease. Researchers wanted to see if stimulating the brain during exerc…

This study tested whether a gentle, non-invasive form of brain stimulation could help people with early Alzheimer's disease. Researchers used a device to deliver a specific electrical frequency to the brain, hoping it would reduce the buildup of harmful proteins linked to memory …

This study tested whether a dietary supplement called citicoline could improve sleep and affect biological markers linked to Alzheimer's disease. It involved 100 older adults who had mild cognitive impairment (early memory problems) and poor sleep. Participants were randomly assi…

This study tested whether a special daily light treatment at home could help people with early memory loss or mild Alzheimer's disease. Researchers wanted to see if the light could improve sleep, reduce body inflammation, help the body process sugar better, and slow cognitive dec…

This study tested whether a training program called Strategy Training could help older adults with mild cognitive impairment (early memory problems) maintain their ability to perform daily tasks like shopping and managing medications. It compared the training to standard care in …

This study tested whether a liquid supplement made from perch fish could help improve or maintain thinking skills in people with mild cognitive impairment (MCI), an early stage of memory concerns. For 24 weeks, 54 participants either took the fish essence or a look-alike fish bro…

This study tested whether a computer program called SUPERBRAIN DEX could help people with mild cognitive impairment (MCI), an early stage of memory and thinking problems. Researchers compared the software against a control group in 140 older adults to see if it safely improved co…

This study tested whether a high dose of the antiviral drug valacyclovir, commonly used for herpes, could slow down early memory loss linked to Alzheimer's disease. It involved 50 older adults who had mild memory problems, tested positive for herpes simplex virus, and showed earl…

This study tested whether a 12-week program of brain training, physical exercise, and healthy lifestyle coaching could help improve or maintain thinking skills in older adults. 120 participants, aged 50-75 with normal memory or mild memory concerns, were randomly assigned to eith…

This study tested whether different types of exercise could help control cognitive decline in older adults with mild memory problems. Researchers compared aerobic exercise, strength training, a combination of both, and basic balance exercises over six months. They measured change…

This study tested a combination of three non-drug therapies to see if they could help improve memory, thinking, and quality of life in older adults with mild cognitive impairment or Alzheimer's disease. Thirty-three participants received either the active treatment or a sham (pla…

This study tested whether a computer program that analyzes speech patterns can help detect early signs of memory problems and dementia. Researchers compared the AI's analysis of how people talk with results from standard paper-and-pencil memory tests. The goal was to see if speec…

This study tested whether specific proteins in the blood can accurately diagnose Alzheimer's disease. Researchers compared blood test results from 342 patients with results from the current standard spinal fluid test and clinical assessments. The goal was to see if a less invasiv…

This study tested whether a simple, non-invasive brain wave recording (EEG) could help identify Alzheimer's disease at various stages. Researchers collected EEG data from 29 people, including those with no symptoms but at genetic risk, mild memory problems, and different stages o…

This study tested whether a special type of MRI scan (which doesn't use radiation) could work as well as a standard PET scan (which does) for spotting early brain changes in people with mild memory problems. Researchers compared the two scans in 150 people with mild cognitive imp…

This study aimed to see if measuring certain proteins in the blood could help doctors predict Alzheimer's disease. Researchers followed over 1,000 people with either mild memory problems or early Alzheimer's to see if their blood test results could forecast who would get worse or…

This study tested whether taking a special turmeric supplement for six months could help protect brain function in older adults with metabolic syndrome, a condition that increases the risk of memory problems and Alzheimer's disease. Researchers gave 85 participants either the tur…

This study tested whether a 24-week home-based program of physical activity and brain training could prevent or delay memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older who were at high risk for memory decline. They compared different …

This small pilot study tested an online educational program designed to teach people about dementia and lifestyle changes that may help prevent it. The study involved 20 adults who were at increased risk for dementia but did not have it yet. Researchers wanted to see if the onlin…

This study tested whether daily supplements made from chicken extract could help prevent cognitive decline in older adults who were not yet diagnosed with dementia. Over two years, 276 participants aged 55-75 either took the supplement, a related peptide, or a placebo. Researcher…

This study tested whether a simple home exercise program could help prevent future falls in older adults who have memory concerns and recently broke a hip from a fall. Researchers compared the exercise program to usual care in 60 participants over six months. The goal was to see …

This study tested a new in-home technology system designed to help family members caring for loved ones with dementia or memory loss. The system uses sensors, smart devices, and apps to monitor safety and provide support, aiming to reduce the caregiver's stress, anxiety, and feel…

This study tested whether a special brain training technique could help improve memory in older veterans. Researchers used a wearable headset that gives real-time feedback about brainwaves during memory tasks. The goal was to see if veterans could learn to adjust their brain acti…

This small pilot study tested whether a combination of gentle, non-invasive brain stimulation and computer-based memory training was a practical approach for people with mild cognitive impairment (MCI). Eight participants aged 50-90 with early memory loss completed the study. The…

This study tested whether having a special conversation about personal care priorities could help people with mild memory loss or dementia. 178 patients received information before a clinic visit and could talk with a trained helper about what matters most to them. Researchers th…

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically processing speed, in people with early-stage Alzheimer's disease or mild cognitive impairment. 174 participants were randomly assigned to receive either the drug or…

This small, early-stage study tested a new computer-based program designed to help people with mild memory problems. The program combined gentle movement, acupressure, and relaxation techniques. Researchers primarily wanted to see if people could stick with the program and if it …

This study tested whether magnetic stimulation applied to the front of the brain could improve apathy—a severe loss of motivation—in older Veterans with mild memory problems. Participants received either real or fake stimulation over 20 sessions to see if it could restore motivat…

This study tested a 6-week virtual program designed to help couples where one partner has mild cognitive impairment (MCI). The program taught communication skills and coping strategies to help both partners feel more in control and less stressed. Researchers measured whether coup…

This small, completed study tested whether a non-invasive brain stimulation technique could improve memory in people with mild cognitive impairment (MCI). Researchers wanted to see if it was practical to run this type of trial and to gather early data on whether stimulating diffe…

This study tested whether learning to play the board games Go or Chess could help improve thinking skills in people with early memory problems. 80 participants were assigned to learn one game, both games, or be in a control group for 12 weeks. Researchers measured changes in memo…

This study tested whether participating in arts activities like theater, dance, music, or museum visits could improve mental health. Over 500 adults in Greece with conditions like depression, anxiety, or schizophrenia were randomly assigned to either join weekly arts sessions for…

This study tested whether an existing injectable medication called tesamorelin could improve memory and thinking skills in older adults living with HIV who were experiencing mild cognitive problems. Researchers enrolled 73 participants who also had excess abdominal fat, as this i…

This study tested whether a single drink containing a special milk protein (alpha-lactalbumin) could improve mood and thinking skills in healthy older adults, including some with mild memory concerns. Researchers compared the effects of this protein to other proteins by measuring…

This study tested a smart home system designed to help Spanish-speaking caregivers of people with dementia or memory problems. The system uses sensors and internet-connected devices to monitor the person being cared for and provide support to reduce caregiver stress, anxiety, and…

This study tested whether a friendly robot could help people with dementia or memory problems feel more socially connected and engaged. For three weeks, residents, their families, and staff in an assisted living community tried using a robot that led activities like trivia and ga…

This small, completed pilot study tested whether a personalized program combining talk therapy, brain training exercises, and lifestyle advice is practical and helpful for people with thinking problems from conditions like brain injury, multiple sclerosis, or mild memory loss. Th…

This study tested whether an 8-week program of social video calls could improve quality of life for older adults, including those with mild memory concerns. About 100 participants aged 65+ were randomly assigned to either start the video social groups immediately or wait 8 weeks.…

This study tested whether an online sleep improvement program is practical and acceptable for people with mild memory problems or early-stage dementia who also have trouble sleeping. Researchers enrolled 30 older adults to try the digital program, which teaches techniques to impr…

This study tested whether a gentle, non-invasive electrical stimulation on the neck could help people with early memory problems (mild cognitive impairment) remember things better over weeks. 80 participants aged 50+ were randomly assigned to receive either the real stimulation o…

This study tested whether regular music therapy sessions focused on singing could help improve memory, language, and quality of life for people with Alzheimer's disease or mild cognitive impairment. Over 100 participants were assigned to different schedules of music therapy for a…

This study tested a new sleep therapy program designed for older veterans who have both memory problems and trouble sleeping. The program combines standard sleep therapy with special memory support strategies to help participants follow the treatment better. Researchers wanted to…

This study tested whether three different online wellness programs could help improve thinking skills and brain connections in older adults experiencing memory problems. Seventy-seven participants aged 55 and older were randomly assigned to take part in either online Tai Chi, a m…

This study tested whether a gentle electrical stimulation applied to the scalp could help improve memory and thinking in people with mild cognitive impairment or early Alzheimer's disease. Researchers gave different amounts of stimulation to 269 participants while using brain sca…

This study tested whether a noninvasive brain stimulation technique could improve memory in people with mild cognitive impairment (MCI), an early stage of memory loss. 69 participants were randomly assigned to receive either active stimulation to one of two brain areas or a place…

This study tested whether a gentle, non-invasive brain stimulation technique, combined with mental exercises, could help improve concentration and memory problems in active-duty military members who had a past mild concussion. 56 participants were randomly assigned to receive eit…

This study tested whether a special, tailored lighting treatment could help people with Alzheimer's or dementia sleep better and improve their mood and thinking. Researchers compared the active light treatment to a placebo light for six months in 101 participants. They measured c…

This study tested a new way to help older adults with mild memory problems get more benefit from computer brain training. Researchers wanted to see if first making computers more enjoyable and personal for participants would help them engage better with the training that followed…

This study aimed to understand if and how a common heart valve replacement procedure (TAVR) affects memory and thinking skills in patients who already have mild cognitive impairment. Researchers followed 81 patients, testing their memory before the procedure, then 30 days and 6 m…

This study aims to understand if the community of bacteria in the gut is different in people with early Alzheimer's disease or mild cognitive impairment compared to healthy adults. Researchers will observe 44 participants, including those with memory issues and healthy volunteers…

This study aimed to discover chemical markers in blood and urine that could help detect Alzheimer's disease earlier. Researchers analyzed samples from 95 people with different levels of memory problems, from normal aging to severe Alzheimer's. The goal was to find patterns that d…

This study aimed to understand if certain proteins in the blood (IGF-I and IGFBP-3) are linked to Alzheimer's disease and memory problems. Researchers compared these protein levels in three groups: people with Alzheimer's, people with mild memory issues, and healthy elderly indiv…

This study explored how people with mild memory problems or early Alzheimer's disease understand and emotionally handle learning the results of their brain scans. Researchers educated 152 participants about brain proteins linked to Alzheimer's, then shared their personal scan res…

This small pilot study tested whether a smartphone app could measure thinking and memory skills in older adults before major spine surgery. The goal was to see if these remote tests could help identify patients who might be at higher risk for developing confusion (delirium) after…

This study looked at whether a special brain scan (amyloid PET) helps doctors make better care decisions for people with memory problems or dementia. It followed over 6,000 Medicare patients from diverse backgrounds to see if the scan results changed their treatment plans and hea…

This study tested a Spanish version of a balance assessment tool designed for frail seniors living in nursing homes who have mild memory problems. Researchers wanted to see if this specific test is a reliable and valid way to measure balance issues in this vulnerable group. The g…

This small study tested whether daily text message reminders help people with early Alzheimer's or mild memory problems stick to a morning light therapy routine. Researchers enrolled 20 healthy older adults to see if the reminders improved their compliance. They measured particip…

This early-stage study tested whether baricitinib, a drug approved for rheumatoid arthritis, can get into the spinal fluid and reduce signs of brain inflammation in people with Alzheimer's disease, ALS, or early memory concerns. Seventeen participants took the pill daily for 24 w…

This study explored whether taking music improvisation classes could help improve self-regulation and thinking skills in older adults. Researchers enrolled 53 adults aged 60 and over, some with mild memory concerns and some without, to test the new training program. The goal was …