MILD COGNITIVE IMPAIRMENT

This Phase 2 study tested ABvac40, a vaccine designed to help the immune system target and clear a protein called amyloid-beta 40, which builds up in the brains of people with Alzheimer's. The trial included 134 adults aged 55-80 with mild cognitive impairment or very mild Alzhei…

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain tra…

This study tested whether the antiviral drug valacyclovir (Valtrex) could slow brain changes linked to Alzheimer's in 50 people with mild cognitive impairment who also had herpes simplex virus antibodies. Participants took either valacyclovir or a placebo for 52 weeks. The goal w…

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This study tested whether a nasal insulin spray and a diabetes pill called empagliflozin, alone or together, could improve memory and brain function in 47 adults aged 55-85 with mild cognitive impairment or early Alzheimer's disease. The goal was to see if these treatments are sa…

This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect …

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI learned to spot patterns linked to cognitive decline. …

This study tested whether an automated speech analysis tool called AcceXible can help detect mild cognitive impairment or dementia early. Researchers analyzed speech patterns from 273 adults aged 55 and older, including healthy individuals and those with memory concerns. The goal…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, compared to the current standard of testing spinal fluid. Researchers measured specific proteins in the blood of 342 adults visiting memory clinics. The goal was to see if these blood markers c…

This study tested whether a simple, non-invasive brain wave test (EEG) can help diagnose Alzheimer's disease at different stages. Researchers collected EEG data from 29 people, including those with mild cognitive impairment, Alzheimer's at various stages, dementia with Lewy bodie…

This study looked at whether measuring certain proteins in the blood (amyloid peptides) can help diagnose Alzheimer's disease or predict its progression. Over 1,000 older adults with mild cognitive impairment or Alzheimer's were followed for two years. Researchers compared blood …

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested whether taking a daily chicken extract or a peptide supplement for two years could help prevent memory and thinking problems in healthy older adults aged 55 to 75. A total of 276 participants were randomly assigned to receive one of the two supplements or a plac…

This study tested whether lithium, a drug used for mood disorders, can prevent Alzheimer's dementia in older adults with mild cognitive impairment (MCI). 83 participants took either lithium or a placebo for a period, and researchers measured memory, thinking skills, and brain cha…

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tested two virtual, 8-week programs (Active Brains 1 and 2) in 267 older adults with chronic pain and early cognitive decline. Both programs taught skills like relaxation, cognitive training, and positive psychology to help manage symptoms. Researchers measured changes…

This study tested a virtual reality (VR) program designed to stimulate thinking skills in 45 people with mild cognitive impairment. Participants used VR headsets to do tasks like virtual shopping and recipe sequencing over 8 sessions. The goal was to see if the VR program was eas…

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This study looked at whether high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) can improve thinking skills and physical fitness in older adults with mild cognitive impairment (MCI). Sixty-eight participants exercised three times a week for e…

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This pilot study tested a 12-month lifestyle program (PRISEM) for 45 older adults with mild cognitive impairment. The program included group and individual activities focused on health education, nutrition, exercise, and stress management. The main goal was to see if the program …

This study tested whether adding virtual reality (VR) to standard computer-based cognitive training could improve memory, attention, and thinking skills in older adults with mild cognitive impairment. 70 participants completed a 12-week program of cognitive exercises, with one gr…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested whether weekly Kundalini yoga classes with daily meditation could improve memory and thinking in 81 older adults with mild cognitive impairment. Participants were split into two groups: one did yoga and meditation, the other did memory training exercises. The go…

This small study tested a virtual reality game called Hometown Bound in 9 adults with mild cognitive impairment after cancer or ICU stay. Participants played the game three times a week for four weeks. Researchers measured memory and thinking skills before and after using standar…

This study tested whether an 8-week program of social video chats could improve quality of life and reduce loneliness in older adults, including those with mild memory problems. 99 participants aged 65 and older were randomly assigned to either start the video chats right away or…

This pilot study tested a 12-week mobile health program designed to help people with mild cognitive impairment and their caregivers increase daily physical activity. The program uses behavior change techniques like goal setting and problem-solving, all delivered remotely. Sixteen…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested a 3-month walking program for Spanish-speaking Latinos aged 55 and older with mild cognitive impairment. Participants walked in groups twice a week, then received motivational phone calls for another 3 months. Researchers measured changes in physical activity, t…

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and reminders. The goal was to help them stay independent in daily life. 68 older adults took part, and rese…

This study tested whether computerized brain-training activities could improve thinking skills and depression symptoms in older adults who were already taking antidepressants. Thirty-eight participants completed the program, and researchers measured changes in mental flexibility,…

This study tested a 12-week online program called Brain Health Together for older adults with mild cognitive decline. Participants joined live-streaming exercise and education classes, plus individual coaching, all from home. The goal was to see if the program could improve think…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This pilot study tested whether combining a gentle brain stimulation technique called HD-tDCS with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main goal was to see i…

This study tested a multi-ingredient nutraceutical kit in 23 older adults (ages 50-80) with mild age-related decline. The goal was to see if it could improve muscle function, thinking skills, and immune health. Participants took the supplement and were measured on walking distanc…

This study tested whether a painless, non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's disease. Researchers used MRI…

This study tested whether combining aerobic exercise (like brisk walking and yoga) with cognitive training (memory and problem-solving games) can improve thinking skills and quality of life in older adults with mild cognitive impairment. Forty-four participants aged 60 and older …

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested whether giving insulin through the nose can help people with mild memory problems. Thirteen participants received either 20 or 40 units of insulin via a nasal device. Researchers measured how much insulin reached the fluid around the brain and checked memory wit…

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study looked at whether learning to play Go or Chess can improve thinking skills in people with mild cognitive impairment or subjective cognitive decline. 80 participants were split into groups that played Go, Chess, both, or neither for 12 weeks. The researchers measured ch…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study looked at whether different types of exercise can improve thinking and memory in older adults with mild cognitive impairment, a condition that can lead to dementia. 226 participants did aerobic training, resistance training, or both for six months. The goal was to see …

This study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…

This study tested a computer-based program that combines mental exercises and relaxation techniques for people with mild cognitive impairment (MCI). The goal was to see if this approach is practical and acceptable for improving thinking and memory. The study involved 32 participa…

This study tested whether a program called Strategy Training can help older adults with mild cognitive impairment (MCI) manage everyday tasks like shopping, paying bills, and taking medication. The training, delivered by occupational therapists, teaches goal-setting, scheduling, …

This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed s…

This study tested whether a personalized computer program (PEP) could improve attitudes toward technology and engagement with cognitive training in 49 older adults with mild cognitive impairment living in senior communities. Participants first used PEP or a control activity for 4…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study tested three online wellness programs—Tai Chi, a gentle mindful movement class called PLIE, and health education—in 77 adults aged 55 and older with mild memory or cognitive difficulties. The goal was to see if these programs could improve thinking skills, physical fun…

This study tested whether a special turmeric supplement (MERIVA®) could improve memory and thinking in older adults with metabolic syndrome. 85 people took either the supplement or a placebo for 6 months. Researchers measured changes in cognitive tests to see if turmeric helped p…

This study tested a non-invasive electrical stimulation device on the scalp in 80 adults aged 50+ with mild cognitive impairment. Participants learned word pairs while receiving either real or sham stimulation. Their memory was tested right after, and again at 7 and 28 days. The …

This study tested whether a digital program called Sleepio, which provides cognitive behavioural therapy for insomnia, could be used by people with mild cognitive impairment or mild dementia. Thirty participants were enrolled to see if the program was acceptable and easy to use. …

This pilot study tested a program called Sleep-SMART for veterans aged 60 and older who have both mild cognitive impairment (MCI) and insomnia. The program combines standard insomnia therapy with memory-support strategies to help participants learn and stick with the treatment. R…

This small pilot study tested whether a non-invasive brain stimulation technique called iTBS rTMS could improve memory in 25 adults with mild cognitive impairment (MCI). The main goal was to see if the treatment was feasible and acceptable, while also checking for any memory bene…

This study tested a new, drug-free approach to help older adults with mild cognitive impairment or Alzheimer's disease. The method combined gentle electrical brain stimulation, cognitive training, and near-infrared light therapy delivered through the nose. The goal was to see if …

This study tested whether gentle reminders (nudges) to doctors and caregivers could help reduce risky medications in people with dementia. Researchers enrolled 250 patients and their primary care providers. The goal was to see if this approach is practical and can be measured in …

This study tested whether daily singing of personally meaningful songs can boost memory and language in people with Alzheimer's disease or mild cognitive impairment. One hundred participants worked with a music therapist and sang a 'song of kin' at home for 12 months. Researchers…

This study tested whether a daily drink of perch essence can improve cognitive function in people with mild cognitive impairment. Fifty-four adults aged 45 and older took either perch essence or a placebo fish stock twice a day for 24 weeks. Researchers measured changes in memory…

This completed pilot study tested whether a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve attention and working memory in 56 active-duty service members who had a mild traumatic brain injury at least 6 months earlier.…

This study tested whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory and thinking problems. Twenty-five participants took either the drug or a placebo daily for one year. The main goal was to check safety and tolerability, wi…

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see …

This study tested a cognitive training software called SUPERBRAIN DEX in 140 people aged 50–85 with mild cognitive impairment (MCI), a condition that can lead to dementia. Participants used the software for 15–30 minutes daily, while a control group received an educational bookle…

This study looked at whether a whey protein called alpha-lactalbumin, which is high in the amino acid tryptophan, could improve mood and thinking in healthy older adults with mild memory problems. 59 participants took part. The idea is that this protein might help the brain make …

This study tested whether a tailored light intervention could improve thinking, sleep, and metabolism in 25 people with mild cognitive impairment or mild Alzheimer's disease. Participants received either active or placebo lighting at home. The goal was to see if light exposure co…

This study tested an in-home technology system that uses sensors and wearable devices to monitor people with dementia and alert their caregivers about worrisome behaviors like falls or wandering. The goal was to see if this system could reduce caregivers' anxiety, burden, and dep…

This study tested an in-home technology system designed to help Spanish-speaking caregivers of people with dementia, Alzheimer's, or mild cognitive impairment. The system uses sensors and intelligent bots to detect worrisome behaviors like falls or wandering and sends alerts to t…

This study tested a drug called SAGE-718 in 174 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The goal was to see if the drug could improve cognitive performance, like processing speed and everyday task ability. Participants took either SAGE-7…

This study tested a multimodal program combining cognitive training, physical exercise, and healthy lifestyle education in 120 older adults (ages 50-75) with mild cognitive impairment or normal cognition. Participants were randomly assigned to the program or health education alon…

This study tested whether a noninvasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas or a placebo tre…

This study looked at whether a time-restricted eating plan (fasting for 16 hours, 2-3 days a week) is feasible and acceptable for older adults aged 65-80 who have mild cognitive impairment and obesity. 33 participants completed the 12-week program, working with a psychologist to …

This study tested whether rhythmic light therapy can improve brain activity and memory in 20 people with mild cognitive impairment. Participants sat through three one-hour sessions with different light patterns while their brain waves were recorded. The goal was to see if certain…

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This study tested a program called Patient Priorities Care in 178 people with dementia or mild cognitive impairment. Participants received a packet before their clinic visit and could talk with a trained facilitator about their personal healthcare goals. The study aimed to see if…

This study looked at 150 people with mild memory problems to see if a special MRI scan (pCASL) could give similar information to a standard PET scan. Participants had both scans, plus a spinal tap and yearly memory tests for three years. The goal was to see if the MRI could help …

This study tested whether an AI platform can detect mild cognitive impairment and early dementia by analyzing people's speech. Researchers compared language patterns from speaking tasks with standard memory and thinking tests in 196 older adults. The goal was to see if speech cha…

This completed study measured levels of two substances (IGF-I and IGFBP-3) in the blood of 693 older adults: some with Alzheimer's disease, some with mild cognitive impairment, and some with normal memory. The goal was to see if these levels differ between groups and relate to th…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This completed study followed over 6,000 Medicare patients with memory problems to see if a special brain scan (amyloid PET) helps doctors make better care decisions. The study included a diverse group of participants to ensure findings apply to everyone. It did not test a new dr…

This study looked at 81 people with mild memory problems who were getting a heart valve replacement (TAVR). Researchers tested their thinking and memory with a 5-minute quiz before the procedure and again 30 days and 6 months after. The goal was to see if fixing the heart valve c…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study tested a program called Keeping on Course for people with mild cognitive impairment (MCI) and their care partners. The program teaches communication skills to help them cope better together. 29 couples participated in the study, which measured how acceptable and useful…

This study looked at whether people with mild cognitive impairment or Alzheimer's-type dementia can understand and decide about receiving their PET scan results for amyloid and tau proteins. Researchers educated 152 participants and their care partners, then assessed their abilit…

This completed study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers analyzed samples from 95 people with mild cognitive impairment or Alzheimer's, comparing them to healthy older adults. The goal was to find biomarkers…

This pilot study tested a new online program called the Brain Health Support Program (BHSP) designed to teach people about dementia and how to lower their risk through lifestyle changes like diet, exercise, and social connection. Twenty adults with mild memory concerns or a famil…

This study tested a Spanish version of the Frail'BESTest, a balance assessment tool, in 83 frail elderly people over 60 with mild cognitive impairment living in care homes. The goal was to see if the tool is valid and reliable for identifying balance issues that could lead to fal…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild memory problems. Fifty-three volunteers aged 60 and over took part in the training. The goal was to see if this creative activity cou…

This study looked at whether a simple, home-based exercise program (the Otago Exercise Program) could lower fall risk in older adults who have both mild cognitive impairment (mild memory problems) and a recent hip fracture from a fall. Sixty participants aged 65 and older were fo…

This pilot study tested whether remote smartphone tests of thinking, memory, and motor function can identify older adults who may be vulnerable to cognitive problems after spine surgery. 34 participants completed the tests before surgery, and researchers tracked who developed pos…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study tested a special device that sprays insulin into the nose to see how much gets into the brain. Twenty people with mild memory problems or normal thinking took part. The goal was to measure insulin levels in spinal fluid and check if it helps memory. This is an early st…

This small study tested whether real-time neurofeedback—a technique where people learn to control their own brainwaves—could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see i…

This study looked at whether text message reminders help people over 55 with normal thinking skills follow a daily morning light routine. The light is meant to help reset the body's internal clock. Twenty healthy adults took part, and researchers measured their light exposure and…