MILD COGNITIVE IMPAIRMENT

This study tested a vaccine called ABvac40 in 134 people with very mild Alzheimer's or mild cognitive impairment. The vaccine aims to train the immune system to attack a specific protein (Aβ40) linked to Alzheimer's. The main goal was to check safety and immune response over 24 m…

This study tested whether a nasal insulin spray combined with the diabetes drug empagliflozin can safely improve memory and thinking in people with early Alzheimer's or mild cognitive impairment. 47 adults aged 55-85 with signs of Alzheimer's in their brain took part. The goal wa…

This study tested whether a common antiviral drug, valacyclovir, can slow memory decline in people with mild cognitive impairment (MCI) who also carry the herpes simplex virus. Fifty adults aged 50-95 with MCI and positive for herpes antibodies took either the drug or a placebo f…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve thinking, memory, and daily function compared to a placebo over 24 weeks. The study also che…

This early-phase study tested baricitinib, an anti-inflammatory drug, in 17 people with Alzheimer's disease, ALS, mild cognitive impairment, or genetic risk for ALS. The goal was to see if the drug reaches the brain and lowers certain inflammatory markers. Participants took baric…

This study tested whether a personalized, precision medicine approach—using extensive lab tests to create an individual treatment plan—could improve memory better than standard care in people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part o…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, instead of the usual spinal fluid test. Researchers tested 342 adults visiting memory clinics. They measured certain proteins in the blood and compared results to standard diagnostic methods. T…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI was trained to spot differences between healthy indivi…

This study tested whether an AI tool that analyzes speech can help detect early signs of dementia or mild cognitive impairment. Researchers recorded the speech of 273 adults aged 55 and older, including healthy volunteers and those with memory concerns. The goal was to see if cha…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict how fast it will progress. Researchers followed over 1,000 older adults, some with mild cognitive impairment and some with Alzheimer's, to see …

This study looked at whether a home-based physical activity program and computer-based cognitive training, alone or together, could prevent memory loss in older women with heart disease. 253 women aged 65 and older with cardiovascular disease but no regular exercise or cognitive …

This study looked at whether lithium, a medication already used for mood disorders, could delay or prevent Alzheimer's in 83 older adults with mild cognitive impairment (MCI). Participants took lithium and were monitored with memory tests, brain scans, and blood markers over time…

This study tested a painless, non-invasive brain stimulation technique called rTMS in 97 older adults with mild memory problems or genetic risk for Alzheimer's. The goal was to see if personalized stimulation could boost brain connections and slow or prevent memory decline. Parti…

This study tested whether a daily chicken extract and peptide supplement could prevent or slow cognitive decline in older adults without dementia. Over 2 years, 276 participants aged 55-75 with normal cognition or mild memory issues took either the supplement or a placebo. The st…

This study tested a new way to help active duty service members who had a mild traumatic brain injury (concussion) at least 6 months ago and still have trouble concentrating or remembering things. Researchers used a gentle brain stimulation technique called tDCS combined with cog…

This study tested whether a non-invasive magnetic brain stimulation technique (TMS) can reduce apathy—a severe lack of motivation—in older Veterans with mild memory problems. About 100 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS coul…

This small pilot study tested whether a combination of gentle brain stimulation (called HD-tDCS) and computer-based memory exercises could improve thinking skills in people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main …

This early-phase study tested a non-invasive brain stimulation method called tACS in 17 people with mild to moderate Alzheimer's. The goal was to see if daily sessions over 2-4 weeks could safely reduce harmful amyloid and tau proteins in the brain and possibly improve thinking a…

This study tested if computer-based cognitive fitness activities could improve thinking and depression in 38 older adults who were already taking antidepressants. Participants did brain training exercises, and researchers measured changes in their mental flexibility, memory, and …

This study tested whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) could improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or early dementia. Participants received rTMS sessions, and researchers measured …

This study tested whether a mix of cognitive training, physical exercise, healthy lifestyle advice, and computer-based activities could help older adults with or at risk for mild cognitive impairment (MCI). 120 people aged 50-75 took part, with half receiving the multi-component …

This study tested whether a daily nicotine skin patch could improve memory, thinking, and daily function in people with mild cognitive impairment (MCI). About 348 participants wore either a nicotine patch or a placebo patch for 2 years. The goal was to see if nicotine, known to a…

This study tested whether a dietary supplement called citicoline could improve sleep and thinking in 100 older adults with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's disease. Participants took citicoline or a placebo for several months. Researchers …

This study tested a non-drug training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to help participants better recognize time, place, and people. 126 older adults took part, with some receiving the training three times…

This study tested a combination of nutrients (a kit) in 23 adults aged 50-80 to see if it could improve muscle strength, thinking skills, and immune function. Participants took the supplement and were measured on walking distance, leg strength, and cognitive tests. The goal was t…

This pilot study tested a specially adapted sleep therapy program, called Sleep-SMART, for 30 older veterans who have both mild cognitive impairment (MCI) and chronic insomnia. The program combines standard insomnia treatment with memory-support strategies to help veterans learn …

This study tested whether music therapy singing sessions can improve memory and language in people with Alzheimer's disease or mild cognitive impairment. Over 12 months, 100 participants met with a licensed music therapist and were assigned to different music experiences or pleas…

This study tested whether a special light treatment could help with thinking, sleep, and metabolism in people with mild cognitive impairment or early Alzheimer's disease, including those with type 2 diabetes. Twenty-five participants living at home took part. The goal was to see …

This study tested whether a daily drink made from perch essence could help improve thinking and memory in people with mild cognitive impairment. 54 adults aged 45 and older with early memory problems took part. For 24 weeks, half drank perch essence twice a day, while the other h…

This small study looked at whether a non-invasive brain stimulation technique called iTBS rTMS is practical and can help improve memory in 25 adults with mild cognitive impairment (MCI). Participants received magnetic pulses to specific brain areas. The main goals were to see if …

This study tested whether levetiracetam, a drug used for epilepsy, can reduce overactive brain signals and improve thinking in people with early Alzheimer's disease. 58 adults aged 50-90 with mild Alzheimer's or mild cognitive impairment took the drug or a placebo. Researchers me…

This study tested whether a program combining cognitive behavioral therapy, cognitive rehabilitation, and lifestyle coaching is practical and helpful for people with mild cognitive impairment, traumatic brain injury, multiple sclerosis, or long COVID. Fifteen participants receive…

This study looked at three different online wellness programs to see if they could help improve memory, thinking, and brain health in adults aged 55 and older who were having mild memory problems. A total of 77 people took part. The goal was to find out which program worked best …

This study tested a new in-home technology designed to help Spanish-speaking caregivers of people with Alzheimer's, dementia, or mild cognitive impairment. The goal was to see if the system could reduce caregiver anxiety, burden, and loneliness. Six caregivers used the technology…

This study tested whether combining exercise with a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve memory in people with mild cognitive impairment or Alzheimer's disease. Sixty adults aged 50 and older with mild memory problem…

This study looked at whether learning to play Go or Chess can help people with mild memory issues think better and feel better. 80 adults with early cognitive decline were split into groups that played Go, Chess, both, or neither for 12 weeks. Researchers measured changes in thin…

This study tested whether a special turmeric supplement (MERIVA®) could improve memory and thinking in 85 older adults with metabolic syndrome. Participants took the supplement or a placebo for 6 months. Researchers measured changes in cognitive tests to see if turmeric helped re…

This study looked at whether a protein called alpha-lactalbumin, found in whey, could help improve mood and memory in healthy older adults with mild cognitive impairment. Researchers gave 59 participants a special drink and measured changes in brain function and metabolism. The g…

This study tested whether a noninvasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain ar…

This study tested whether taking part in arts activities can improve mental health and well-being in adults with conditions like anxiety, depression, or schizophrenia. Over 500 people receiving mental health care were randomly assigned to either an arts program or a waitlist. The…

This study looked at whether spironolactone, a blood pressure medication, is safe and tolerable for older African Americans with mild memory loss or early dementia. Twenty-five participants took either the drug or a placebo for one year. Researchers tracked side effects and measu…

This study looked at whether an 8-week program of social video chats could help older adults (65+) with or without mild memory problems feel less isolated and lonely. About 99 participants were split into two groups: one started the video chats right away, and the other waited. T…

This study tested whether a digital cognitive behavioral therapy program for insomnia (Sleepio) is practical and helpful for people aged 50+ with mild cognitive impairment or mild dementia who also have sleep problems. Thirty participants were enrolled to see if they would stick …

This study looked at whether combining mental exercises with aerobic workouts can improve thinking skills and quality of life in older adults with mild cognitive impairment (MCI). 44 participants aged 60 and older with mild memory issues took part. The goal was to see if this dua…

This study looked at whether a non-drug approach called Strategy Training can help older adults with mild cognitive impairment (MCI) stay independent in daily activities like shopping, paying bills, and managing medications. About 105 participants with MCI were taught strategies …

This study tested a live-streaming group program called Brain Health Together for older adults with mild cognitive decline. The program aimed to help participants improve brain health through lifestyle changes. 208 people took part, and the researchers measured changes in thinkin…

This study tested a computer-based program that combines mental exercises and relaxation techniques for people with mild cognitive impairment (MCI), a condition that can lead to dementia. The goal was to see if the program is practical and liked by users. 32 participants complete…

This study tested an experimental drug called SAGE-718 in 174 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The goal was to see if the drug could improve thinking skills, like processing speed, compared to a placebo. The trial is now complete,…

This study tested whether tesamorelin, a drug that raises growth hormone levels, could improve memory and thinking in 73 adults aged 40+ with HIV and mild cognitive impairment. Participants also used a text-messaging app to stay motivated. The goal was to see if the combination c…

This study tested a computer program called SUPERBRAIN DEX to see if it can improve memory and thinking in people with mild cognitive impairment (MCI), a condition that can lead to dementia. 140 adults aged 50-85 took part. The program aims to ease symptoms by training the brain …

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and lists. The goal was to help them stay independent longer. Sixty-eight older adults took part, and resear…

This study tested a program where a pharmacist works with people with dementia, their caregivers, and their doctor to review and safely stop medications that may no longer be helpful. The goal was to reduce the number of pills taken, making life simpler and safer. The study inclu…

This study tested whether wearable devices like Apple Watches could help reduce anxiety, burden, and loneliness in people caring for a spouse or family member with dementia or mild cognitive impairment. 63 caregivers in the U.S. used the technology for 6 months. The goal was to s…

This study looked at whether a specially designed light therapy can improve sleep, thinking, mood, and behavior in people with Alzheimer's disease or mild cognitive impairment. About 100 participants received either the active light or a placebo for 6 months. The goal was to see …

This study tested a new, drug-free approach to help older adults with mild cognitive impairment or Alzheimer's disease. The method combined mild electrical brain stimulation, cognitive training, and near-infrared light delivered through the nose. The goal was to see if this combi…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while undergoin…

This study looked at whether different types of exercise—aerobic (like walking) and resistance (like lifting weights)—can improve thinking and memory in older adults with mild cognitive impairment, a condition that can lead to dementia. Researchers enrolled 226 adults in Vancouve…

This study tested a non-invasive electrical stimulation technique on 80 people with mild cognitive impairment (MCI) to see if it could improve long-term memory. Participants learned word pairs and then received either real or fake (placebo) stimulation. Their memory was tested ri…

This study looked at over 6,000 Medicare patients with mild cognitive impairment or dementia to see how amyloid PET scans affect their care and health outcomes. Researchers compared results between different racial and ethnic groups to improve precision in diagnosis and treatment…

This study tested a simple idea: sending gentle reminders (nudges) to doctors and caregivers to help reduce or stop certain high-risk medications in people with dementia. Researchers worked with 250 patients aged 65 and older to see if this approach was practical and could be mea…

This study tested a program called Keeping on Course for people with mild cognitive impairment (MCI) and their care partners. The goal was to teach communication skills and strategies to help them feel more in control while coping with MCI. 29 dyads (pairs) participated in the pr…

This study tested a special device that delivers insulin through the nose to see how much gets into the brain. Insulin is a hormone that helps control blood sugar, but it may also affect memory. The study included 20 people with mild memory problems or normal cognition. Researche…

This study looked at 81 people with mild memory problems who were getting a heart valve replacement (TAVR). Researchers tested their thinking and memory before and after the procedure using a 5-minute quiz. The goal was to see if fixing the heart valve helps improve brain functio…

This study tested whether a simple brain wave test (EEG) can help diagnose Alzheimer's disease at different stages. Researchers collected EEG data from 29 people, including those with mild memory problems, Alzheimer's, Lewy body dementia, and healthy volunteers. The goal was to s…

This study tested a new online program called the Brain Health Support Program (BHSP) that teaches people about dementia and how to lower their risk through healthy habits like diet, exercise, and social connection. Twenty adults with mild memory concerns or a family history of d…

This study looked at whether people with mild cognitive impairment or Alzheimer's dementia can understand the risks and benefits of learning their PET scan results for amyloid and tau proteins, and then make an informed choice about it. Researchers also tracked how patients and t…

This study looked at 150 people with mild memory problems to see if a special MRI scan (pCASL) can give similar information to a standard PET scan. Participants had brain scans, spinal taps, and yearly memory tests for three years. The goal was to see if the MRI could help predic…

This study checked if a Spanish version of the Frail'BESTest, a balance test, is accurate and reliable for frail adults over 60 who also have mild memory issues. Researchers tested 83 people living in care homes. The goal is to help identify balance problems early so falls can be…

This study looked at the gut bacteria of 44 adults aged 50-90, including healthy volunteers, people with mild cognitive impairment, and those with early Alzheimer's disease. Researchers wanted to see if lifestyle changes could alter the gut microbiome and possibly slow memory dec…

This small study tested whether real-time neurofeedback could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see if brain training could help slow memory decline, but the study …

This study tested whether remote smartphone tests of thinking, memory, and motor skills can identify older adults who might develop confusion (delirium) after spine surgery. 34 participants completed the tests before their operation. The goal was to see if this approach could hel…

This study looked at blood and urine samples from 95 adults aged 40 and older to find chemical markers that could help detect Alzheimer's disease early. Researchers compared samples from people with normal aging, mild cognitive impairment, and different stages of Alzheimer's. The…

This study looked at whether certain hormone levels in the blood differ between people with Alzheimer's disease, those with mild memory problems, and healthy older adults. Researchers measured IGF-I and IGFBP-3 in 693 participants to see if these levels are linked to thinking and…

This completed study tested whether an AI platform can detect mild cognitive impairment and dementia by analyzing speech. Researchers compared language patterns from 196 older adults (55+) with standard cognitive tests. The goal was to see if speech changes can serve as a screeni…

This study tested a social robot that plays trivia and gives reminders to people with Alzheimer's or other dementias living in assisted care. The goal was to see if the robot helps improve engagement, mood, and quality of life. 26 residents, family members, and staff took part. T…

This study tested whether a personalized computer program that matches seniors' interests can improve their attitudes toward technology and make brain-training exercises more effective. 49 older adults with mild cognitive impairment from senior living communities took part. The g…

This study tested a set of tablet games called VibrantMinds in 26 older adults with mild cognitive impairment or dementia. The games are designed to measure thinking skills like memory and attention in a fun, engaging way. Researchers want to see if these games can work as well a…

This study looked at whether giving insulin through the nose can help people with mild memory problems. Researchers measured how much insulin reached the brain fluid and checked if it improved memory. The study involved 13 adults who were either healthy or had mild cognitive impa…

This study tested a program called Patient Priorities Care for 178 people with dementia or mild cognitive impairment. Participants received a packet before their doctor visit and could talk with a trained facilitator about their personal care goals. The study aimed to see if this…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild cognitive impairment. 53 participants aged 60+ with little to no music background took part. The goal was to see if improv training c…

This study looked at how older adults make decisions about where to live and what care they might need as they age, especially if they develop memory loss or Alzheimer's disease. Researchers followed 293 participants over three years, asking if they had decided on their living pr…

This study looked at whether limiting eating to a specific time each day (time-restricted feeding) is practical and acceptable for older adults (ages 65-80) who have mild cognitive impairment and are overweight. Over 12 weeks, 33 participants followed this eating pattern, and res…

This study looked at whether a simple home exercise program (the Otago Exercise Program) could reduce fall risk in older adults (65+) who have mild memory problems and recently broke a hip from a fall. About 60 participants were followed for 6 months. The goal was to see if the e…

This study tested a program called 'Tiempo Juntos para la Salud' (Time Together for Health) to encourage moderate physical activity in 234 Spanish-speaking Latinos aged 55 and older with mild cognitive impairment. Participants attended activity sessions and had their physical act…

This study looked at whether text message reminders help older adults follow a daily morning light routine designed to reset their internal body clock. Twenty healthy adults over age 55 took part. Researchers measured light exposure and sleep patterns to see if reminders improved…