Can a nasal spray and diabetes pill boost brain power?

NCT ID NCT05081219

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether a nasal insulin spray and a diabetes pill called empagliflozin, alone or together, could improve memory and brain function in 47 adults aged 55-85 with mild cognitive impairment or early Alzheimer's disease. The goal was to see if these treatments are safe and help correct energy problems in the brain. Participants were already showing signs of Alzheimer's-related brain changes.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Wake Forest University Health Sciences / Wake Forest School of Medicine

    Winston-Salem, North Carolina, 27157, United States