ALZHEIMER DISEASE

This early-stage study tests a new drug called LY4006895 in healthy volunteers and people with early Alzheimer's. The main goal is to check if the drug is safe and how the body processes it. About 128 participants will take either the drug or a placebo, and the study lasts up to …

This study looks at whether adding the drug donanemab to standard care helps people with early Alzheimer's stay independent longer. About 6,250 participants will be followed for over 5 years in real-world clinics. The goal is to see if donanemab slows the need for daily help or n…

This study follows 120 people with early Alzheimer's or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets amyloid plaques in the brain. Researchers will track changes in thinking, daily function, and brain scans over 18 months, while also wa…

This study looks at whether people with mild Alzheimer's disease can learn skills to avoid falling after being purposely unbalanced in a safe lab setting. About 30 participants aged 65 and older will take part. The goal is to see if this training reduces real-life falls and impro…

This study will follow 400 people with early Alzheimer's disease who are taking lecanemab, a drug that removes amyloid plaques from the brain. Researchers want to see if simple blood tests can track the drug's effects as accurately as brain scans. The goal is to make monitoring e…

This early-stage study tests whether a combination of an anti-inflammatory drug (etanercept) and repeated ultrasound can safely open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more medication reach the brain. Only 5 participants will be en…

This study is testing an experimental drug called ARO-MAPT-SC in healthy volunteers and people with early Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it. The drug works by targeting a protein linked to Alzheimer's, with the hope of slowi…

This study tests whether fasudil, a drug that relaxes blood vessels, can improve memory and thinking in people with early Alzheimer's disease. About 200 participants will receive either fasudil or a placebo for 12 months. Researchers will measure changes in memory, brain activity…

This study tests a drug called sargramostim, already approved for bone marrow stimulation, in people with mild-to-moderate Alzheimer's disease. Over six months, 42 participants will receive either the drug or a placebo to see if it is safe and helps with thinking and memory. The …

This early-phase study tests whether adding near-infrared light therapy to the drug lecanemab can improve thinking and memory in people with mild Alzheimer's disease. About 20 participants will receive either the light therapy or a sham device, along with lecanemab, for 16 weeks,…

This early study tests whether a surgical bypass in the neck can help the brain drain harmful proteins linked to Alzheimer's. Ten people with mild-to-moderate Alzheimer's will receive the procedure and be followed for two years. The goal is to see if the surgery is safe and wheth…

This study tests whether a combination of supplements (CMA2) can improve brain function in people with Alzheimer's disease. About 845 adults aged 50 and older will take either the supplement or a placebo twice daily for 26 weeks. Researchers will measure changes in memory and thi…

This study tests a daily capsule called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a mouth infection (P. gingivalis). The drug targets the bacteria to see if it can slow memory and thinking decline. Participants and their caregivers will make regular cli…

This study tests bumetanide, a water pill used for high blood pressure, in 40 people with early Alzheimer's. Researchers want to see if it is safe and might help slow the disease. Participants must have mild cognitive impairment or mild dementia due to Alzheimer's.

This study tests whether siponimod, a drug already used for multiple sclerosis, can safely slow brain shrinkage in people with mild Alzheimer's disease. About 105 participants will receive either the drug or a placebo for 12 months, then be monitored for 6 more months. The main g…

This study tests whether a robotic device can safely perform microsurgery on deep neck lymph nodes in people with mild to moderate Alzheimer's disease. The goal is to see if this approach is feasible and safe, not yet to prove it works. Fifteen participants aged 50 and older with…

This early study is testing a combination of two drugs, parthenolide and ipriflavone (called NPC-1), in 40 adults aged 55 and older who have early Alzheimer's or memory concerns. The goal is to see if the treatment is safe and can improve blood markers linked to Alzheimer's brain…

This study tests whether the sleep aid lemborexant can lower levels of amyloid-beta and tau proteins in the blood—proteins linked to Alzheimer's disease. Researchers will enroll 201 healthy adults aged 65 and older. Participants will take either lemborexant or a placebo to see if…

This study is testing whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 people aged 55 to 89 will take rapamycin for 12 months. Researchers will monitor side effects and check if the drug reaches the…

This study is for people with Alzheimer's disease who have already taken part in a previous trial of the drug SNK01. It aims to check the long-term safety of SNK01 and see if it might help with memory and thinking. About 30 participants will receive the treatment and be monitored…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow the progression of early Alzheimer's symptoms. About 406 adults aged 50-89 with mild cognitive impairment or mild dementia will receive either the drug or a placebo for up to 72 weeks. Researchers will m…

This study tests an experimental drug called NIO752 in 10 people with mild to moderate Alzheimer's. The drug is given via a spinal injection to try to reduce the brain's production of tau, a protein that forms harmful tangles and damages nerve cells. The main goal is to see if th…

This study tests a device that uses sound waves to temporarily open the brain's protective barrier in people with Alzheimer's disease. The goal is to see if this is safe and can help clear harmful brain proteins. The study involves 50 participants aged 50 to 85 who have probable …

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study looks at how different types of exercise affect brain health and Alzheimer's risk in older African Americans. About 280 people aged 60 and older who are not very active will either take cardio-dance classes or strength, flexibility, and balance classes for 6 months. Re…

This study tests whether using a special device that flashes light and plays sound at 40 times per second can help people with mild Alzheimer's. Sixty participants will use the device at home for one hour each day for six months. Researchers will check brain activity, memory, and…

This study tests an experimental drug called senicapoc in people with mild or early Alzheimer's disease. The goal is to see if it can slow memory loss and reduce brain inflammation. About 55 participants will take either the drug or a placebo for one year. This is a small early-s…

This early-stage study is testing the safety of a new drug called LY3954068 for people with early Alzheimer's disease. The drug is injected into the spinal fluid. Researchers will measure how much of the drug gets into the body and check its effect on a brain protein linked to Al…

This study is testing whether proteins and fats found in tears can help diagnose Alzheimer's disease. Researchers will collect tear samples from 90 people (some with Alzheimer's, some healthy) and look for specific biomarkers. If successful, this could lead to a simple, painless …

This study tests whether smartphone usage patterns can serve as a diagnostic tool for Alzheimer's disease and memory problems. Researchers will collect data from 90 participants with memory complaints, mild cognitive decline, or Alzheimer's disease over three months. The goal is …

This study tests a new PET scan tracer, [18F]PI-2620, to see if it can accurately detect tau protein buildup in the brains of people with Alzheimer's disease. Researchers will compare the scan results to brain tissue analysis after participants pass away. The goal is to improve d…

This study looks at whether a newer type of brain scan (Tau-PET) helps doctors diagnose Alzheimer's disease more accurately than the standard scan (Amyloid-PET). Researchers will enroll 120 adults aged 50-85 with mild memory problems or early dementia. Participants will receive b…

This study is looking for early warning signs of Alzheimer's disease in 6,000 older adults in China. Researchers will collect samples of blood and other body fluids, along with genetic and brain scan data, to create a test that can diagnose Alzheimer's early. They also aim to bui…

This study is testing a new, non-invasive way to detect Alzheimer's disease by looking for specific proteins (amyloid and tau) in stool samples. Researchers believe these proteins may travel from the brain to the gut, offering a simple diagnostic tool. The study will involve 115 …

This study tests a new dye, AMDX-2011P, given through a vein to see if it can safely highlight Alzheimer's-related amyloid in the retina. 25 adults with confirmed Alzheimer's will receive one dose and have their eyes imaged. The goal is to develop a simpler, less invasive way to …

This study is building a digital platform that uses simple, non-invasive tools like brain wave sensors, eye-tracking, and blood flow monitors to catch early signs of Alzheimer's disease. Researchers will follow 100 adults aged 55–80 with mild memory problems and compare them to h…

This study tests whether a blood test (Quest AD-Detect) can help doctors identify Alzheimer's disease earlier in patients hospitalized with confusion or delirium. Researchers will follow up with participants six months later to discuss results and arrange further care if needed. …

This study tests a new MRI technique to measure how cerebrospinal fluid (CSF) flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understand…

This study tests a new, ultra-low radiation PET scan to detect Alzheimer's disease and other dementias. Researchers aim to reduce radiation exposure by 10 to 100 times compared to current scans. About 200 adults, including healthy volunteers and those with memory problems, will r…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with memory concerns but no dementia. Participants will either do aerobic …

This study tests whether a daily supplement of alpha-linolenic acid (ALA), a plant-based omega-3 found in flaxseed and walnuts, can prevent memory decline in older adults with mild cognitive impairment who carry the APOE4 gene (a strong risk factor for Alzheimer's). About 20 part…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study tests whether the sleep aid suvorexant can slow the buildup of a protein called amyloid in the brain, which is linked to Alzheimer's disease. About 200 healthy adults aged 65 and older will take either the drug or a placebo for a period of time. Researchers will measur…

This study is testing whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. Researchers will compare a weight loss program to general health education in 81 adults with Down syndrome who are overweight but do not have dementia. The stud…

This study tests whether intensive singing training can improve memory, mood, and brain function in people with early-stage Alzheimer's. Over 5 months, participants will take twice-weekly singing lessons with a personal teacher, followed by a period of once-monthly sessions. Rese…

This study tests whether eating only between 10 a.m. and 8 p.m. (14 hours of nightly fasting) can reduce sleep problems, memory loss, and disease markers in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try this eating sch…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve memory, thinking, and mood in people with mild cognitive impairment or early-stage dementia. Fifty participants will receive both real and placebo stimulation in …

This study tests an experimental drug called KarXT to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. About 406 adults aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychosis will take eit…

This study tests whether a new combination drug, KarXT + KarX-EC, can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 325 adults aged 55 to 90 with Alzheimer's and psychosis will receive either the drug or a placebo. The goal is to see if the …

This study tests a transitional care program for people with Alzheimer's or dementia who are leaving a skilled nursing facility to go home, to assisted living, or to long-term care. The program also supports their caregivers. The goal is to see if the program can reduce caregiver…

This study is testing a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease improve their ability to remember the date, month, year, and season. Twenty participants will use the tool during their hospital stay to see if it helps them stay orient…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests whether a telerehabilitation program using a virtual reality (VR) app can improve thinking skills and social abilities in people with mild memory problems. About 480 adults aged 40-80 with subjective cognitive decline or mild cognitive impairment will use VR exer…

This study tests whether a mobile app called Brain CareNotes can reduce stress and burden for people caring for a loved one with dementia in rural areas. About 60 unpaid caregivers will use the app or a basic education app for six months. The goal is to see if the app is easy to …

This study tests an oral medication called IGC-AD1, made from a THC compound, to see if it safely reduces agitation in people with mild to severe Alzheimer's dementia. About 164 participants will take the drug or a placebo twice daily for several weeks. The goal is to improve qua…

This pilot study tests a combination of two non-invasive brain stimulation methods—iTBS and tDCS—in 20 older veterans with mild to moderate Alzheimer's disease who also have mood or behavior symptoms like agitation or apathy. Participants will receive one week of in-clinic iTBS s…

This study tests a computer-based program (CAST) to reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and to ease the burden on their care partners. About 388 pairs (patient and care partner) will take part. The program involves two sessi…

This study tests whether 6 months of supervised aerobic exercise (like walking or cycling) can boost fitness, reduce brain damage, and improve memory in adults 65 and older with mild cognitive impairment or early Alzheimer's. Participants will exercise regularly, have memory test…

This study tests whether nabilone, a synthetic cannabinoid already approved for nausea, can safely reduce agitation in people with Alzheimer's disease. Agitation is common and distressing, and current treatments have limited effectiveness and side effects. About 112 participants …

This study tests whether a low-carbohydrate (ketogenic) diet or a low-fat diet can improve thinking and memory in people with mild cognitive impairment. About 120 volunteers will follow one of the two diets for 16 weeks, then return to their normal eating habits. Researchers will…

This study tests an experimental pill (BMS-986368) to see if it can safely reduce agitation in people with Alzheimer's disease. About 120 participants will receive either the drug or a placebo. The goal is to ease symptoms like restlessness and aggression, not to cure Alzheimer's…

This study tests whether adding acupuncture to standard Alzheimer's medication (Donepezil) can improve memory, thinking, and daily living skills. Researchers will compare two groups of 90 patients each over 12 weeks: one group gets acupuncture plus medication, the other gets medi…

This early study is testing whether a gentle form of ultrasound, called LIFU, can safely stimulate the brain in people with mild cognitive impairment caused by Alzheimer's disease. Fifteen volunteers aged 45-85 will receive the treatment and be monitored for side effects and any …

This study tests a non-invasive brain stimulation method called deep TMS in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. The treatment uses a special coil to stimulate deeper brain areas fo…

This study tests whether personalized, virtual music therapy sessions can boost memory, mood, and thinking skills in people with mild Alzheimer's or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will meas…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 participants will receive either caffeine pills or a placebo (fake pill) to see if caffeine helps keep their minds shar…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the study drug or a placebo. The main goal is to see if agitation scores…

This study tests whether cannabidiol (CBD) capsules can safely reduce agitation in people with Alzheimer's disease. About 40 participants aged 55 and older will receive either CBD or a placebo, then switch treatments to compare effects. The goal is to find a new way to ease distr…

This small pilot study will test whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. The study involves 5 participants and focuses on side effects, not on whether the supplement improves memory or thinki…

This study tests whether a gentle magnetic pulse to the cerebellum can improve memory and thinking in people with mild Alzheimer's disease. About 100 adults aged 50-85 will receive either real or fake stimulation over three months. The goal is to see if this safe, non-invasive tr…

This study tests a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) in 30 older adults aged 55-70 who have memory concerns and a family history of Alzheimer's. Participants will receive either real or sham dTMS combined with cognitive …

This study tests a text message program called CuidaTEXT for Latino caregivers of relatives with Alzheimer's. About 288 caregivers will receive educational and support texts or no texts. The goal is to see if the texts reduce depressive symptoms and stress over 6 months.

This small study tests a special supplement called SCV09, which combines probiotics and prebiotics, in 30 people with Alzheimer's disease. The goal is to see if it can improve troubling behaviors like agitation or mood changes. Participants take the supplement for a period while …

This study tests whether a common painkiller (oxycodone with acetaminophen) can safely ease moderate to severe chronic pain in people with Alzheimer's disease. Ten participants will take the medication once daily for 12 weeks, with doctors adjusting the dose as needed. The goal i…

This study tests whether listening to music with a strong beat helps older adults with mild memory problems exercise more and keep their minds sharp. Eighty volunteers aged 65 and older will do strength and aerobic training for 6 months, some with special music and some without. …

This study tests whether adding an antioxidant to an NMDA-enhancing drug can improve thinking and memory more than the NMDA drug alone. It involves 80 people with early Alzheimer's or mild cognitive impairment. Participants will be followed for 24 weeks to see changes in cognitiv…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug combination or a placebo. The main goal is to see if agitation …

This study tests a new drug called NSC001 in 90 people with mild to moderate Alzheimer's disease. The main goal is to see if the drug is safe and tolerable, and to explore whether it can improve thinking and memory. Participants will be randomly assigned to receive either NSC001 …

This study tests whether a non-invasive device that sends a mild electrical current to the brain (tDCS) can improve mood and reduce symptoms like apathy, irritability, and depression in people with Alzheimer's disease. Participants will use the device at home for 30-minute sessio…

This study tests a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) on people with mild-to-moderate Alzheimer's disease. The goal is to see if targeting a deep brain area (the precuneus) is safe and can help improve memory. Parti…

This early-stage study tests whether galcanezumab, a drug used for migraines, can help people with mild-to-moderate Alzheimer's disease. Ten participants will receive injections over 24 weeks, and researchers will measure changes in brain proteins and thinking skills. The goal is…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—a lack of interest or motivation—is common and disabling in these conditions. The study includes 10 participa…

This study tests a simple, non-invasive device that plays soft sounds during sleep to boost deep sleep and improve memory. Sixty older adults with mild memory problems will use the device at home for four weeks. Researchers will measure memory, brain activity, and blood markers t…

This study is testing whether a non-invasive brain stimulation technique called tACS can improve symptoms like memory and thinking in people with Alzheimer's disease, Lewy body dementia, frontotemporal dementia, and normal pressure hydrocephalus. About 200 participants will recei…

This study is for people with Alzheimer's disease who experience agitation and have already completed a related study. It tests the long-term safety of a drug called KarXT, which combines two medications to help calm agitation. About 600 participants will take the drug and be mon…

This study tests a remote education program called Tele-Savvy, designed specifically for Latino caregivers of people with Alzheimer's or related dementias. The program includes weekly group sessions and videos to help caregivers build skills and feel more confident. Researchers w…

This study tests a hearing care program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and distress, and also ease the burden on caregivers. 300 people a…

This study tests whether combining a medication (methylphenidate) with a non-invasive brain stimulation technique (iTBS) can reduce apathy in people with Alzheimer's or mixed dementia. Apathy, or lack of motivation, is common in these conditions. The trial involves 12 participant…

This study tests a new, non-invasive brain stimulation technique that combines magnetic and electrical pulses to target brain networks involved in memory. The goal is to see if it can slow cognitive decline and improve daily function in 60 people with mild Alzheimer's. Participan…

This study tests whether vestibular therapy—exercises that train the inner ear balance system—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild-to-moderate Alzheimer's and known balance problems will be randomly assigned to receive the therapy …

This small pilot study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people who have mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The study will measure change…

This study tests a mobile app called Brain CareNotes to see if it can reduce stress for unpaid caregivers of people with Alzheimer's or related dementias. Over 12 months, 184 caregivers will use either the app or a basic education app. The goal is to lessen caregiver burden and m…

This study tests a Zoom-based education and skill-training program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. The goal is to reduce stress, improve well-being, and help plan for the future. Researchers will gather feedback from 70 p…

This study tests whether daridorexant, a sleep medication, can safely improve sleep in older adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. About 62 participants will take the drug and have their sleep measured in a lab. The …

This study tests whether a gentle, non-invasive brain stimulation technique (called tES) can improve memory, thinking, and walking in older adults with mild cognitive impairment or mild dementia. Caregivers are trained to deliver the stimulation remotely under guidance. The goal …

This study is testing the safety of a treatment called Transcranial Pulse Wave Stimulation (TPS) for people with Alzheimer's disease. Researchers will monitor 100 participants for side effects and also check if the treatment helps with memory and daily function. The goal is to im…

This study is testing a new way to teach family members caring for someone with dementia. It compares a special learning method that uses practice quizzes and feedback to traditional reading materials. The goal is to see if this method helps caregivers remember information better…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study looks at how quickly people with stroke or memory problems can move. Researchers want to see if new, short tests can help diagnose diseases like Alzheimer's or predict recovery after a stroke. About 129 adults aged 40-85 will take these tests, and the results will be c…

This study looks at whether a common vitamin, niacin (nicotinic acid), can get into the brain fluid of people with Alzheimer's disease. Researchers will give 30 participants a single dose of extended-release niacin or a placebo and measure its levels in blood and spinal fluid. Th…

This study tests a new virtual care program for veterans with early Alzheimer's disease. The program uses telehealth and streamlined tests to quickly determine if a patient is eligible for new antibody treatments. About 30 veterans will take part, and researchers will compare how…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and patients with early Alzheimer's. They hope to find a comm…

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve memory and brain function in older adults with mild memory problems or early Alzheimer's. About 30 participants will receive daily stimulation sessions over two 10-day periods, wit…

This study aims to find new biological markers for diseases like Alzheimer's, Parkinson's, and ALS by analyzing the genes, proteins, and metabolism of 1,200 patients. Researchers will use advanced technology to look for patterns that could help with earlier diagnosis, better prog…

This study aims to measure levels of a protein called fibrin in the brains of people with Alzheimer's disease and related dementias, compared to healthy volunteers. Researchers will use a special PET scan to see if fibrin builds up differently in certain brain regions. The study …

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This early-stage study tests whether a new drug called J4 is safe for people. It involves 76 healthy adults aged 18 to 64 who will take either the drug or a placebo. The main goal is to check for side effects and how the drug moves through the body. This is a first step before te…

This study will follow 40,000 people from families with a history of Alzheimer's disease across China. Researchers will collect genetic, brain scan, and memory test information to understand how the disease runs in families and how it develops over time. The goal is to improve ea…

This study tests a 4-week training program for assisted living staff (nurses, administrators, and dementia care coordinators) to improve palliative care for residents with dementia. The goal is to increase advance care planning discussions and documentation, and to reduce caregiv…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis over time. The goal is to gather data, not to test a treatment, so there is no …

This study looks at whether people with Alzheimer's disease have more trouble swallowing than healthy older adults. Researchers will test swallowing, coughing, and muscle strength in 240 participants, and ask caregivers about their experiences. The goal is to better understand ho…

This study uses a special PET scan to measure a protein called tau in the brains of 160 people with Alzheimer's disease. The goal is to see how tau buildup relates to memory, thinking, race, and heart health risks. Participants are already part of a larger Alzheimer's research pr…

This study is observing 500 people with early Alzheimer's disease who are receiving anti-amyloid antibody treatments. Researchers want to see if these drugs slow down memory and thinking problems, and what side effects might occur. The goal is to learn more about how well these t…

This study looks at how being overweight or obese in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will use brain scans and blood tests to compare three groups: metabolically healthy lean people, metabolically healthy overweight/obese people, an…

This study follows 3,400 adults who report no memory problems for about 7 years. Researchers use blood tests and thinking exercises to see who shows early signs of Alzheimer's-related decline. The goal is to better understand how the disease progresses in people with and without …

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study follows 800 healthy adults aged 50 to 80 over four years to find early biological markers of Alzheimer's disease. Researchers will use blood tests, spinal fluid samples, and brain scans to track changes. The goal is to develop a screening tool for the general populatio…

This study uses two types of eye imaging (OCT-A and adaptive optics) to look for changes in the retina that might be linked to memory problems, including Alzheimer's and other dementias. Researchers will compare 450 people with and without memory complaints to see if these scans …

This study looks at whether treating depression with an FDA-approved antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memo…

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and vascular risk factors. Participants are already part of a larger Alzheimer's study at the University of…

This study collects blood or brain tissue from families where at least two members have Alzheimer's or dementia. The goal is to build a large DNA bank so scientists can find the genes that raise the risk of late-onset Alzheimer's. Participants do not receive treatment or test res…

This study is building a large group of 1,000 older adults (age 60+) in Tennessee to help researchers better understand Alzheimer's disease. Participants include people with normal memory, mild memory problems, or Alzheimer's. They will have yearly check-ups, brain scans, and blo…

This study tests whether daily mindfulness practice, combined with heart rate biofeedback, can improve attention and memory in adults aged 50-70. Participants will practice specific breathing patterns for 10 weeks. Researchers will measure changes in blood markers linked to Alzhe…

This study explores whether a non-invasive device using light and sound at a specific frequency (gamma) can change brain activity. Researchers will test 150 healthy adults and people with Alzheimer's during a one-day visit at MIT. The goal is to see if this stimulation is safe an…

This study looks at 244 people with mild Alzheimer's to find blood markers that might explain why some people handle the disease better than others. Participants will give blood samples and take memory tests over time. The goal is to learn more about the disease, not to test a ne…

This study collects information from 735 Alzheimer's patients aged 50-90 who are receiving FDA-approved anti-amyloid antibody treatments as part of their regular care. Researchers will track changes in memory, thinking, and daily living skills over time. The goal is to learn how …

This study looks at how a specific substance in the brain (the miR-342-5p/AnkG pathway) may be linked to early nerve cell problems in Alzheimer's disease. Researchers will measure this substance in blood and spinal fluid from 40 people with Alzheimer's and compare it to their mem…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to notice signs of pain and talk about it with doctors. The study …

This study aims to enroll up to 550 adults with Down syndrome, ages 25-55, into a 'trial-ready' group. Researchers will track memory, thinking, genetics, and brain changes over time to better understand Alzheimer's disease in this population. The goal is to prepare a group of vol…

This study looks at whether special eye scans can find early signs of Alzheimer's disease and other dementias. Researchers will check for changes in blood flow and protein buildup in the retinas of 20 older adults with mild dementia, compared to healthy volunteers. The goal is to…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study explores whether personalized brain stimulation can improve memory in people with mild Alzheimer's disease. Researchers will use non-invasive techniques to synchronize brain rhythms. The goal is to understand how Alzheimer's affects memory and to develop drug-free trea…

This study is looking at whether certain substances in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 adults aged 60 and older, including those with and without memory issues, to see how well these blood ma…

This study looks at a minor neck surgery (called LVA) that some doctors think might improve memory and thinking in people with Alzheimer's disease. Early results showed some short-term benefits, but it's not clear if the surgery itself or other parts of the procedure (like anesth…

This study tests a new method to help primary care doctors detect early signs of dementia or memory loss in underserved communities. Over 45,000 adults aged 65 and older without prior diagnosis will participate across 24 clinics. The goal is to see if using a quick cognitive test…

This study uses a special PET scan to measure tau protein buildup in the brains of people with frontotemporal lobar degeneration (FTLD), atypical Alzheimer's disease, and healthy volunteers. Researchers want to see if this scan can help tell these conditions apart. About 72 adult…

This study aims to understand why some people experience memory and thinking problems as they get older. Researchers will use brain scans and memory tests to detect early signs of Alzheimer's disease in 300 healthy adults aged 60 and older. Participants will undergo MRI and PET s…

This study looks at how sleep and exercise habits influence the risk of Alzheimer's and dementia. Researchers will track 30 adults who have mild memory or thinking problems. Participants will wear a headband and a Fitbit to measure sleep and heart health, and provide blood and ur…

This study aims to understand why some people with Alzheimer's disease develop psychotic symptoms like delusions. Researchers will use brain scans to measure tau protein buildup and brain network changes in 91 older adults with and without psychosis, plus healthy volunteers. The …

This study is following 10,000 people aged 50 and older living in Scotland over many years. Researchers are collecting information on memory, thinking, lifestyle, and health risks to learn how dementia develops. The goal is to build a detailed picture of the Scottish population t…

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will collect medical records and survey data over time to identify what factors lead to brain diseases. The goal is to find ways to keep br…

This study aims to better predict how dementia will progress in individuals with mild cognitive impairment or early dementia. Researchers will collect blood samples and use computer models to track changes in thinking and memory over time. The goal is to improve prognostic confid…

This study looks at whether ovarian hormones are linked to aging and Alzheimer's disease in women. Researchers will use brain scans to measure markers of aging and Alzheimer's in 614 women aged 60 and older. No treatment is given—the goal is to better understand how hormones may …

This study compares a new infection management approach to usual care in nursing homes for people with dementia. The goal is to see if the new method reduces antibiotic use and unnecessary hospital visits. About 750 residents aged 60 and older with dementia will take part.

This study looks at whether being bilingual helps people with primary progressive aphasia (PPA) respond better to speech therapy. Researchers will give tailored language treatment in both languages to 60 bilingual Spanish speakers and track their progress for a year. Another 30 p…

This study looks at how stress hormones and certain genes might speed up memory loss in older adults with mild cognitive impairment. Researchers will test memory and collect blood and saliva samples after a short stressful task. Participants return after two years to see if stres…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…

This study aims to help family doctors better detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using simple blood tests and brain scans. The goal is to make accurate diagnosis easier and faster in primary c…

This study tests a web-based tool called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life wishes with a care partner. The goal is to see if the tool improves decision-making confidence and reduces anxiety for both the…

This study is testing whether blood markers for Alzheimer's disease and brain injury can help predict which older hospital patients are at higher risk of dying or being readmitted. Researchers will follow 400 hospitalized older adults with neurological issues or dementia. The goa…

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. No treatm…

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…

This study is testing whether new blood tests can accurately diagnose the cause of memory problems, potentially replacing the need for more invasive spinal fluid tests. Researchers will compare blood test results with spinal fluid results in 1,200 people being evaluated at a memo…