Could cannabis calm Alzheimer's agitation? new trial underway

NCT ID NCT05543681

Recruiting now Symptom relief Sponsor: IGC Pharma, LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether IGC-AD1, a THC-based oral medication, can safely reduce agitation in people with mild to severe Alzheimer's dementia. About 164 participants will receive either the drug or a placebo twice daily for several weeks. Researchers will measure changes in agitation using a standard scale, aiming to improve quality of life for patients and their caregivers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IGC-AD1 (a THC-based oral solution)
What this could lead to: If it works, this could offer a new way to calm agitation in people with Alzheimer's, potentially reducing caregiver burden.
What could go wrong: This is an early Phase 2 trial with only 164 participants, so results may not apply to everyone. The drug contains THC, which can cause side effects like dizziness or confusion.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Aggression Alzheimer disease anxiety disorder cannabis dependence Caregiver Burden dementia Depression nail-patella syndrome Psychomotor Agitation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGGRESSION AGITATION,PSYCHOMOTOR ALZHEIMER DISEASE CARE GIVING BURDEN NPS

Contacts and locations

Locations

BayCare Health System Inc.
RECRUITING

St. Petersburg, Florida, 33705, United States
Baycrest Academy for Research and Education , University of Toronto
RECRUITING

Toronto, Ontario, ON M6A 2E1, Canada
Baylor Scott and White Research Institute
RECRUITING

Dallas, Texas, 75231, United States
Butler Hospital, Brown University
RECRUITING

Providence, Rhode Island, 02906, United States
Central Miami Medical Institute
RECRUITING

Miami, Florida, 33125, United States
ClinCloud, LLC
ACTIVE_NOT_RECRUITING

Maitland, Florida, 32751, United States
ClinCloud, LLC
RECRUITING

Melbourne, Florida, 32940, United States
Dent Neurologic Institute
RECRUITING

Amherst, New York, 02459, United States
Dominion Medical Associates, Inc.
RECRUITING

Richmond, Virginia, 23219, United States
Douglas Hospital Research Center, McGill university
RECRUITING

Montreal, Quebec, H4H 1R3, Canada
Grupo de Neurociencias de Antioquia, Universidad de Antioquia
ACTIVE_NOT_RECRUITING

Medellín, Antioquia, Colombia
Hamilton Health Sciences , Mcmaster University
RECRUITING

Hamilton, Ontario, L8M 1W9, Canada
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Ichor Research
RECRUITING

Syracuse, New York, 13210, United States
Instituto Sanacoop
COMPLETED

Bayamón, Bayamón, 00961, Puerto Rico
Integrative Clinical Trials, LLC
RECRUITING

Brooklyn, New York, 11229, United States
Island Health Authorities
RECRUITING

Victoria, British Columbia, V8R 1J8, Canada
Kerwin Medical Center
RECRUITING

Dallas, Texas, 75231, United States
Lynn Health Science Institute (LHSI)
RECRUITING

Oklahoma City, Oklahoma, 73112, United States
MedStar Franklin Square Medical Center Neurology
RECRUITING

Baltimore, Maryland, 21237, United States
Medstar Montgomery Medical Center
RECRUITING

Olney, Maryland, 20832, United States
Medstar Southern Maryland Hospital Center
RECRUITING

Clinton, Maryland, 20735, United States
Miami Jewish Health
RECRUITING

Miami, Florida, 33137, United States
Neurostudies Inc.
RECRUITING

Port Charlotte, Florida, 33952, United States
SCB Research Center Corp
RECRUITING

Bayamón, 00961, Puerto Rico
Senior Adults Specialty Research
RECRUITING

Austin, Texas, 78757, United States
Tandem Clinical Research GI, LLC
RECRUITING

Metairie, Louisiana, 70006, United States
Tekton Research LLC
RECRUITING

St Louis, Missouri, 63128, United States
The Alliance, Medical Sciences Campus University of Puerto Rico
RECRUITING

Rio Piedras, 00935, Puerto Rico
University of South Florida Department of Psychiatry and Behavioral Neurosciences
RECRUITING

Tampa, Florida, 33613, United States
Visionary Investigators Network
RECRUITING

Miami, Florida, 33133, United States

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