Could your heart hold the key to Alzheimer's prevention?

NCT ID NCT05372159

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study follows 1,000 adults aged 50 and older to see how the health of their heart and blood vessels relates to early signs of Alzheimer's disease and brain aging. Researchers will use brain scans, memory tests, and blood or spinal fluid samples to look for connections between vascular health and markers of cognitive decline. The goal is to better understand whether keeping blood vessels healthy might protect the brain as we age.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If links between heart health and brain aging are confirmed, this could point toward lifestyle or medical strategies to preserve memory and delay cognitive decline.
What could go wrong: This is an observational study, so it cannot prove cause and effect. Results may be influenced by other factors and may not lead to direct treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease cognitive disorder Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGED, 80 AND OVER AGING ALZHEIMER DISEASE BIOMARKERS BRAIN CASE-CONTROL STUDIES COGNITIVE DYSFUNCTION NEUROPSYCHOLOGICAL TESTS

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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