AGING

This study tests whether fisetin, a natural compound, can reduce aging cells in the body and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will take fisetin or a placebo for 4 months. The main goal is to see if fisetin helps them…

This study tests two drugs, sirolimus and everolimus, that may slow the aging process. Healthy adults aged 55-89 take a low weekly dose for 6 weeks to find the safest amount. The goal is to reduce side effects while still getting anti-aging benefits.

This study tests whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older who speak English or Spanish will take part. The program incl…

This study is testing whether a 12-week program combining a special nutritional supplement (with synbiotics) and supervised exercise can improve muscle strength, gut health, immune function, and thinking skills in people aged 50-80 who are showing early signs of frailty. The goal…

This study tests a daily oral supplement made from natural ingredients and L-citrulline to see if it can improve blood vessel function and reduce markers of aging and heart disease risk. Healthy adults aged 18 and older will take the supplement for 6 weeks. Researchers will measu…

This study looks at whether combining physical exercise with cognitive training (like brain games) can improve thinking and memory in people with chronic heart failure. Researchers will also see if the effects differ between men and women. About 216 adults aged 50 and older with …

This study tests whether sirolimus, a drug that affects cell growth and metabolism, can slow aging in healthy adults aged 65 to 80. Ten participants will take sirolimus for one year, and researchers will measure changes in aging-related blood markers and physical abilities like w…

This study tests whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve overall health in people aged 70-85. The researchers believe that restoring a healthy gut microbiome may slow aging and lower the risk of age-related diseases. The tr…

This study tests whether the weight-loss drug tirzepatide can slow biological aging in 90 adults aged 55-70. Participants will receive weekly injections or no drug for 24 weeks, then be followed for 12 more weeks. The focus is on changes in DNA-based aging markers, not weight los…

This study looks at whether a type of dietary fiber (soluble corn fiber) can help older men absorb more calcium and improve bone health. Researchers think fiber changes gut bacteria, which may boost calcium absorption. Thirty male Veterans aged 60 and older will take part in this…

This study tests a prehabilitation program for adults aged 65 and older with breast cancer. The program includes exercise, nutrition advice, and a health assessment before surgery. The goal is to see if it helps maintain physical function and reduce complications. Researchers wil…

This study tests whether short, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and thinking skills in adults aged 60-85 with type 2 diabetes. Researchers will compare the effects of this training against a placebo in 80 participants. …

This study looks at whether taking ketone supplements can help older adults (ages 60-85) avoid the negative effects of a high-salt diet, such as higher blood pressure, blood vessel problems, and kidney stress. Researchers will give 30 healthy volunteers a high-salt diet with or w…

This study tests whether a natural supplement from brown seaweed, called fucoidan, can slow or reverse biological aging in 60 pre-frail men aged 50-80. Researchers will measure changes in DNA methylation (a marker of biological age) and inflammation levels. The goal is to see if …

This study tests whether a daily natural supplement combined with a twice-weekly exercise program can improve immune function and reduce inflammation in adults aged 65 and older. Sixty participants will take either the supplement or a placebo for six months while following the sa…

This study tests whether a special food containing probiotics and prebiotics can help manage bone loss in women aged 60 and older. Over 18 months, researchers will measure bone density and strength in 220 participants. The goal is to see if this dietary approach can slow or impro…

This study tests whether adding nitrate-rich beetroot juice to exercise (either supervised treadmill sessions or home walking) improves walking distance more than exercise alone in people with peripheral artery disease (PAD). About 210 adults aged 50 and older with PAD will be ra…

This study looks at whether a combination of physical exercise and a thermogenic nutritional supplement can improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of mild metabolic …

This study tests whether a daily pill called empagliflozin (a type of SGLT2 inhibitor) can reduce stiffening of arteries that happens with age. The trial will include 80 healthy adults aged 60-80 who have some artery stiffness but no diabetes. Participants will take the drug or a…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication. About 100 participants will use either the full app with reminders or just an education portal for 16 weeks. …

This study looks at how different types of exercise affect brain health and Alzheimer's risk in older African Americans. About 280 people aged 60 and older who are not very active will either take cardio-dance classes or strength, flexibility, and balance classes for 6 months. Re…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this breathing exercise to standard…

This study tests a new program called Cafe Move that aims to help older adults prevent age-related physical frailty. The program is designed to be easy to access and lets participants take charge of their own health. Researchers will enroll 36 independently living adults to see i…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking-pole exercise can help older adults feel better physically and mentally. About 1,500 people aged 55 and older will take part. Researchers will measure changes in strength, mood, slee…

This study tests whether a special type of tai ji quan that combines physical movement with mental tasks can reduce falls in older adults with mild cognitive impairment (MCI). Researchers will enroll 336 people aged 65 and older who have memory complaints and a history of falls o…

This study tests three types of leg exercises (leg press, vibration, or mixed) to see which best improves blood flow and walking ability in older adults with poor circulation or chronic wounds. 425 participants will exercise 3 times a week for 12 weeks. The goal is to find a safe…

This study tests whether a daily ketone supplement can improve strength, mobility, and immune function in adults 65 and older who are starting to feel weaker. Over 20 weeks, 180 participants will either take the ketone drink or a placebo and complete physical tests, blood draws, …

This study tests a friendly AI chatbot that guides people through telling their life stories to boost emotional well-being. It includes healthy adults, older adults aged 65+, and adults with mental health conditions living in care homes. The chatbot helps create a personal "life …

This study tests whether two natural substances, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in adults aged 30 to 75 with poor sleep. Eighty participants will take daily capsules of one or both compounds, or a placebo, for 12 weeks. Researchers wi…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests whether a personalized digital meditation program (MediTrain) can improve sleep, reduce stress, and boost thinking skills in older adults with mild cognitive impairment (MCI). Researchers will enroll 90 participants aged 60-85, comparing those with MCI to healthy…

This study tests whether a cosmetic cream can improve skin hydration and reduce wrinkles in adults aged 45 to 65. Researchers will measure skin moisture and wrinkle depth around the eyes after 2 and 8 weeks of use. The goal is to see if the product visibly slows signs of aging.

This study tests two injectable products, INNEA and INNEA AQUA, to see how well they reduce wrinkles on the cheeks and décolletage (upper chest). About 55 women aged 35 to 65 with at least mild wrinkles will receive up to three injections. Doctors will rate wrinkle improvement on…

This study compares three exercise programs to see which best improves balance in healthy adults aged 65 and older. Participants will do core stabilization exercises, amplitude-based exercises, or a combination of both. The goal is to reduce fall risk and improve mobility and qua…

This study tests whether a natural supplement combined with a supervised exercise program can improve mood, sleep, thinking, and physical function in women going through menopause. Researchers will compare the supplement to a placebo, with all participants doing the same exercise…

This study tests a device called Walkasins, worn on the legs, that provides gentle vibrations to replace lost foot sensation in older adults. Researchers want to see if it helps people aged 65-95 with numb feet walk more automatically and with less mental effort. The study involv…

This study explores whether nicotine gum can improve how well older adults process sounds. Researchers will give nicotine gum to 48 non-smokers aged 18-85 and measure hearing sensitivity and brain responses. The goal is to see if nicotine can reverse some age-related hearing decl…

This study tests whether a digital intervention can improve working memory and inhibitory control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home training, with a fol…

This study looks at whether a one-year, home-based exercise program can help older adults (60+) undergoing cancer treatment improve their strength, balance, and quality of life. About 180 participants will be split into two groups: one doing guided exercises at home and the other…

This study tests whether a supplement called EGA® can help healthy adults aged 60 to 80 exercise longer. Participants will take either EGA® or a standard NMN supplement, then switch after a break. The main goal is to see how long they can cycle before getting tired, along with ot…

This study looks at whether adding simple mental tasks (like memory games) to water aerobics can boost thinking skills in older women more than water aerobics alone. About 98 inactive women aged 60-75 will do a 12-week program with two sessions per week. Researchers will measure …

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study tests whether shining a specific red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to narrowed arteries. The trial will involve 32 adults aged 50 and…

This study tests a program called SickleFit that combines exercise and nutrition advice for adults aged 35 and older with sickle cell disease. The goal is to see if the program is safe, doable, and helpful for improving health and quality of life. About 40 participants will be ra…

This study tests whether a neuroscience-based computer brain training program can improve memory and thinking in older adults (60+) who have had cognitive problems for at least 12 weeks after a confirmed COVID-19 infection. Researchers will compare the brain training to other com…

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study looks at whether doing exercises that challenge both the mind and body at the same time—like walking while counting backwards—can help older adults (ages 65-74) with balance, fear of falling, thinking skills, and sleep quality. The exercises are done at home through vi…

This study explores whether taking a daily polyphenol supplement (natural compounds found in plants) alongside a 12-week exercise program can help older adults build strength and physical function better than exercise alone. Researchers will recruit 40 people over 60 to test if t…

This study tests a small, TENS-like device that gives mild electrical stimulation to see if it can improve balance and walking in older adults. About 120 people aged 60 and older will do tasks like walking for 6 minutes and standing on foam while wearing the device. The goal is t…

This study looks at whether whole body vibration therapy, when added to usual care, can improve muscle mass, strength, and function in older adults. Forty people aged 65 and older with mild frailty will be randomly assigned to receive vibration therapy plus usual care or usual ca…

This study looks at whether a special video-based game program can help adults aged 60 and older improve their balance, thinking skills, and self-confidence. Thirty-two participants will either play the games twice a week for six weeks or receive no extra activity. Researchers wi…

This study is testing whether a special vibration system can help older adults and stroke survivors improve muscle strength, balance, and movement, while also reducing pain. Researchers will recruit 80 participants to try the vibration exercises and measure changes in strength, w…

This study tests whether using gentle electrical pulses on the thigh muscle can help people regain leg strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus el…

This study tests whether a daily vitamin B3 supplement called Nicotinamide Riboside (NR) can improve brain blood flow and memory in healthy adults aged 60 to 85. Participants will take NR or a placebo for a period and undergo brain scans and memory tests. The goal is to see if NR…

This study tests whether a technology-assisted block training program can improve cognitive function, hand dexterity, and grip strength in adults aged 65 and older. Forty participants will use the program and be assessed on thinking, hand skills, and well-being. The goal is to se…

This study looks at how older adults with hearing loss understand speech in noisy environments, and how hearing aids can help. Researchers will test 121 people with normal hearing and hearing loss using listening tasks and brain wave measurements. The goal is to find out which he…

This study looks at how aging changes the way our bodies use energy and how our physical and mental abilities decline. Researchers will study 100 healthy adults to understand why some people stay healthy longer. The goal is to learn more about aging to help prevent disease in lat…

This study looks at why some older adults get more benefits from exercise than others. Researchers will have 250 people aged 60+ follow a combined endurance and resistance training program. The goal is to understand the differences in how people respond, so that in the future exe…

This study aims to understand how obesity and aging are connected by looking at blood-based aging markers in 650 adults. Participants include young (18-35) and older (60+) people who are either lean or overweight. The goal is to find clues that could lead to future treatments or …

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a hormone infusion. The goal is to underst…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will use a new, non-invasive method to measure stiffness caused by blood pressure itself versus long-term changes in the artery wall.…

This study looks at how past sports injuries and sitting too much can affect the long-term health of former athletes. Researchers will compare strength, physical activity, and overall health in 450 current and former athletes, as well as non-athletes, to understand why some peopl…

This study aims to understand how two drugs, sirolimus and everolimus, behave in the bodies of adults aged 65 and older. Researchers will measure drug levels and biological markers related to aging and inflammation. The goal is to gather essential data for designing future trials…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and patients with early Alzheimer's. They hope to find a comm…

This study tests whether an online program that teaches positive emotion skills can improve mental well-being and slow biological aging. Researchers will measure changes in mood, purpose, and biological age markers in 80 adults aged 40-70 from the Chicago area. The program is sel…

This study looks at how estrogen levels affect the way women's bodies handle heat. Researchers will compare premenopausal and postmenopausal women aged 42 to 64 to see if lower estrogen after menopause makes it harder to cool down. Participants will be exposed to mild heat while …

This study looks at how short-term pain, created with a capsaicin heat patch, changes the way older adults (ages 55-90) learn and remember new walking patterns. Researchers will measure how well participants adjust their step symmetry on a split-belt treadmill and whether they re…

This study looks at whether giving magnetic pulses to the brain at the right moment in your natural brain wave cycle can make movement training more effective. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to understand how th…

This study looks at how different amounts of resistance (strength) training affect inflammation in adults aged 60-75. Participants will be placed into one of three training groups (low, medium, or high volume) or a non-exercise group for 4 weeks, followed by 4 weeks of rest. The …

This study explores how binge drinking affects blood pressure and small blood vessels in adults aged 50-64. Researchers will compare binge drinkers to non-drinkers and moderate drinkers. Then, they will test whether 8 weeks of aerobic exercise can improve blood pressure and blood…

This study uses yearly PET scans to track amyloid proteins in the brains of 400 adults aged 55 and older over 5 years. Researchers aim to understand how these proteins build up with age and whether they are linked to memory loss or other thinking problems. Participants also take …

This study aims to understand how the brain changes as we age and to find new ways to measure healthy brain aging. Researchers will study brain activity in healthy adults and in mice, looking for patterns that change with age. They will also test whether stem cell-derived exosome…

This study aims to learn why our bodies and minds change as we get older. Researchers will use brain scans, fitness tests, and wearable devices to track health in 770 adults. The goal is to understand aging better, not to test a treatment.

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand which muscle factors …

This study tests whether drinking cold water (4°C) four times a day for six months can lower body fat and slow aging in healthy adults aged 50–65. Participants are split into two groups: one drinks cold water, the other drinks room-temperature water (37°C). Researchers will measu…

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand what leads to earlier death and po…

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess memory with thinking tasks. The goal is to find factors that can improve s…

This study aims to find the temperature and humidity limits that are safe for older adults during exercise. Researchers will have 190 participants exercise in different conditions to see when their body can no longer cool itself, increasing the risk of heat illness. The goal is t…

This study aims to find the best amount of a digital meditation program to improve thinking skills and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. Participants will use a meditation app, and their cognitive…

This study tests a new system that continuously tracks vital signs like heart rate and oxygen levels in older adults, both in the hospital and at home. Researchers want to see if the device is easy to use and helpful for patients and doctors. The study involves 15 older adults an…

This study tests three approaches to increase physical activity in older adults with HIV: coaching, cognitive behavioral therapy for barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear Fitbits to track steps. The goal …

This study looks at how mild dehydration (losing 2-3% of body weight) and then rehydrating affects inflammation, blood sugar, sleep, and strength in healthy adults aged 45-65. Researchers will measure changes in cells and body functions over 12 days. The goal is to understand if …

This study aims to understand why older adults lose important immune cells (T cells) from their nose, which may explain why they get more respiratory infections. Researchers will compare young adults, healthy older adults, and frail older adults using gentle nose swabs and blood …

This study tests whether combining fasting with exercise can slow the aging process in healthy adults over 65. Two hundred forty participants will be split into four groups: exercise only, fasting only, both, or neither. Researchers will measure biological age using DNA markers a…

This small pilot study tests whether whole-body electrical muscle stimulation combined with exercise can improve the way nerves activate muscles in healthy older adults (65+). Participants will do supervised sessions twice a week for four weeks, with before-and-after tests of mus…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This early-phase study looks at how short-term heat exposure affects small blood vessel function in healthy adults aged 18 to 80. Researchers want to see if passive heating can mimic some benefits of exercise for blood vessel health. The study involves 20 participants and uses a …

This study collects bone marrow samples from 24 adults aged 65 and older during hip surgery. Researchers will analyze the cells' metabolism and look for specific genetic changes linked to clonal hematopoiesis (CHIP). The goal is to understand how these changes affect stem cell fu…

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study looks at how well different cooling methods (like fans or cool cloths) can reduce heart strain in healthy older adults during extreme heat. About 100 people aged 65 and older will be tested in a controlled warm environment. The goal is to learn which cooling strategies…

This study looks at muscle and heart health in people over 60 with multiple sclerosis (MS) compared to those without MS. Participants will do a 4-month exercise program to see how their bodies adapt. The goal is to understand how MS and aging together affect muscle function and f…

This pilot study tests whether a 14-day program combining physical activity, mindfulness, sleep tips, a Mediterranean diet, and supplements is practical for adults aged 55-70 who are at risk for faster aging. Only 10 participants will be enrolled to see if people stick with the p…

This study tests whether a supplement called nicotinamide mononucleotide (NMN) can slow or reverse aging in healthy adults aged 40-50 and 60-70. Over 12 months, researchers will measure changes in biological age using advanced tests like DNA and protein markers. The goal is to se…

This study is building a large group of 1,000 older adults (age 60+) in Tennessee to help researchers better understand Alzheimer's disease. Participants include people with normal memory, mild memory problems, or Alzheimer's. They will have yearly check-ups, brain scans, and blo…

This study looks at whether common blood pressure drugs (beta blockers) cause older adults to get hotter during extreme heat. Researchers will measure body temperature and sweating in 22 healthy people aged 65+ while they are exposed to heat for 3 hours. The goal is to understand…

This study looks at why older adults respond differently to strength training. Researchers will track 300 people aged 65 and older who are at risk for mobility problems. Participants will do progressive resistance training, and scientists will measure changes in physical function…

This study looks at how long-term inflammation impacts muscle function and how older adults respond to exercise. Researchers will measure muscle protein building in 120 older adults. The goal is to better understand age-related muscle loss, not to test a new treatment.

This study tests whether guided imagery—creating mental pictures of future rewards—can help mid-life adults stay motivated to exercise. 160 physically inactive adults will complete an exercise program and undergo MRI scans, questionnaires, and blood tests to see if this technique…

This study looks at how different types of dietary fats affect brain function in healthy adults aged 65 to 75. Participants will follow two one-week diets: one similar to a typical North American diet and one similar to a Mediterranean diet. Researchers will measure memory and br…

This study looks at whether breathing low-oxygen air (hypoxic conditioning), either by itself or combined with exercise, can improve blood vessel health in the brains of older adults. Researchers will enroll 64 inactive people aged 60 to 80 to test this approach. The goal is to f…

This study looks at how aging affects blood flow and the nervous system in women. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand early changes in blood vessels as women age.

This study aims to understand how people age by following healthy volunteers for life. Participants aged 20 and older undergo physical and mental tests every few years. The goal is to learn how people can adapt to aging successfully.

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help older adults make smarter decisions about whom to trust.

This study looks at how well blood tests can measure fitness in healthy adults. Researchers will measure participants' maximum exercise capacity and collect blood samples to find connections. The goal is to develop a blood-based way to estimate fitness without needing a treadmill…

This study looks at why older adults may not respond as strongly to the pneumonia vaccine as younger people. Researchers will compare blood samples from 60 healthy volunteers aged 21-40 and 65+ before and after receiving the Prevnar-13 vaccine. The goal is to understand how aging…

This study aims to identify frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. No treatment or medication is given; the goal is simply to gathe…

This study aims to understand how aging changes the brain and kidneys in healthy adults. Researchers will use advanced MRI scans and thinking tests to measure blood flow and brain function. The goal is to learn more about normal aging, not to treat any disease. About 120 healthy …

This study looks at whether low-frequency ultrasound baths can improve muscle strength, thinking skills, and immune health in healthy older adults. Twenty people aged 70 and older will either get ultrasound baths or plain baths three times a week for eight weeks. The goal is to s…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers. Researchers will use tiny needles and various stimuli to learn how the skin and nerves send touch information to the brain. The goal is to use this knowledge to create pro…

This study tests two drugs, Rapamycin and Everolimus, in healthy adults aged 65-90 to find a safe dose that may slow aging at the cellular level. Researchers will measure drug levels and biological markers in blood, fat, and muscle. The goal is not to cure a disease but to unders…

This study looks at whether a simple technique called ischemic conditioning can protect small blood vessels in frail older adults during intense exercise. Sixty people aged 65 to 85 will use a blood pressure cuff at home for two weeks. Researchers will measure blood vessel functi…

This study looks at whether daily use of simple moisturizers like Vaseline or CeraVe can lower inflammation in older adults with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The goal is to see if a larger trial is pos…

This study looks at how getting older and having tired muscles change the way people balance and walk. Researchers will test 140 adults, both young (20-40) and older (60-85), by having them do exercises that tire out their arms or legs. The goal is to better understand these effe…

This study looks at whether blood flow in fat tissue changes as we age. Healthy adults aged 18-35 or 65-80 will have their fat blood flow measured, provide two small fat samples, and drink a sugary drink. The goal is to understand basic aging processes, not to treat any disease.

This pilot study looks at whether reducing alcohol and taking probiotics can boost memory and brain function in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to cut back on drinking and will take either a probiotic or a placebo pill. The st…

This study looks at healthy adults aged 60 and older to see if brain MRI scans and eye-tracking tests can predict whether thinking skills stay sharp or decline over time. Researchers will measure a small brain area called the locus coeruleus, which is linked to memory and attenti…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study looks at how blood vessels widen in response to low oxygen in women who are premenopausal, perimenopausal, or postmenopausal. Researchers will measure blood flow in the forearm to understand the role of certain receptors. The goal is to learn more about vascular change…

This study looks at how the changing seasons—summer to winter—might affect your biological age, which is a measure of how well your body is aging compared to your actual age. Researchers will track 60 healthy adults over 40 for one year, using blood or saliva samples to measure a…

This study looks at how older women (65+) handle extreme heat and humidity. As climate change brings more heat waves, researchers want to find the exact point where the body can no longer cool itself, which can lead to heat stroke. Twelve women will rest in a hot room while humid…

This study looks at how a single dose of psilocybin, the active ingredient in magic mushrooms, affects brain structure and function in healthy adults aged 60 to 85. Participants will take a dose ranging from micro to moderate-high and undergo MRI scans to measure changes. The goa…

This study looks at how getting older and feeling stressed can change the way we remember and find our way around. Researchers will have 85 adults aged 65-80 do a virtual navigation task while their brains are scanned. Some will be put under mild stress to see if it makes them re…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild memory problems. Researchers want to see how tau relates to thinking skills, brain activity, and the risk of future decline. About 105 people aged 55–90 who …