AGING

This study tests whether a daily supplement called nicotinamide mononucleotide (NMN) can reduce biological age in healthy middle-aged and older adults (ages 40-70). Participants will take NMN or a placebo for 12 months, and researchers will measure aging using DNA, protein, and o…

This study looks at whether taking a natural supplement and doing moderate exercise twice a week can improve immune function and reduce stress on the body in adults aged 65 and older. Sixty participants will take either the supplement or a placebo for six months while following t…

This study tests a daily oral supplement designed to boost nitric oxide levels, which helps blood vessels relax and reduces clotting risk. Researchers want to see if it lowers PAI-1, a protein linked to aging and heart disease. About 35 healthy adults will take the supplement for…

This study tests whether a traditional Chinese medicine (TCM) formula can improve muscle strength and bone health in older adults who are starting to become frail. 90 people aged 65 and older who are pre-frail will be randomly assigned to take either the TCM formula or a nutritio…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems take their blood pressure medication more consistently. About 100 participants will use either the full app or just an education portal for 16 weeks. T…

This study tests whether brief, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and thinking skills in older adults with type 2 diabetes. Researchers will compare the training against a placebo in 80 people aged 60-85. The goal is to f…

This study tests whether a ketone supplement can reduce the harmful effects of a high-salt diet in adults aged 60-85. Researchers will measure changes in blood pressure, blood vessel function, and kidney health. The goal is to find a simple way to protect older adults from salt-r…

This study is testing whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve overall health in people aged 70-85. The goal is to see if restoring a healthy mix of gut bacteria can slow aging and lower the risk of age-related diseases. The…

This study tests two ways to help people with peripheral artery disease (PAD) walk farther and with less pain. It compares supervised treadmill exercise versus home walking, with or without nitrate-rich beetroot juice. The goal is to find a more convenient and effective treatment…

This study tests two drugs, sirolimus and everolimus, that may slow the aging process. Healthy adults aged 55-89 take a low weekly dose for 6 weeks to find the safest amount. The goal is to reduce side effects while still getting anti-aging benefits.

This study tests whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older who speak English or Spanish will take part. The program incl…

This study is testing whether a 12-week program combining a special nutritional supplement (with synbiotics) and supervised exercise can improve muscle strength, gut health, immune function, and thinking skills in people aged 50-80 who are showing early signs of frailty. The goal…

This study looks at whether combining physical exercise with cognitive training (like brain games) can improve thinking and memory in people with chronic heart failure. Researchers will also see if the effects differ between men and women. About 216 adults aged 50 and older with …

This study tests whether the drug sirolimus can slow down aging in adults aged 65 to 80. Researchers will measure changes in aging-related blood markers and physical abilities like walking speed over one year. The goal is to see if sirolimus can reduce age-related decline and pre…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older. Researchers will compare this time-saving method to the standard recomme…

This study tests whether the weight-loss drug tirzepatide can slow biological aging in 90 adults aged 55-70. Participants will receive weekly injections or no drug for 24 weeks, then be followed for 12 more weeks. The focus is on changes in DNA-based aging markers, not weight los…

This study looks at whether a type of dietary fiber (soluble corn fiber) can help older men absorb more calcium and improve bone health. Researchers think fiber changes gut bacteria, which may boost calcium absorption. Thirty male Veterans aged 60 and older will take part in this…

This study tests a prehabilitation program for adults aged 65 and older with breast cancer. The program includes exercise, nutrition advice, and a health assessment before surgery. The goal is to see if it helps maintain physical function and reduce complications. Researchers wil…

This study tests whether a special food containing probiotics and prebiotics can help manage bone loss in women aged 60 and older. Over 18 months, researchers will measure bone density and strength in 220 participants. The goal is to see if this dietary approach can slow or impro…

This study looks at whether a combination of physical exercise and a thermogenic nutritional supplement can improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of mild metabolic …

This study tests whether a daily pill called empagliflozin (a type of SGLT2 inhibitor) can reduce stiffening of arteries that happens with age. The trial will include 80 healthy adults aged 60-80 who have some artery stiffness but no diabetes. Participants will take the drug or a…

This study looks at how different types of exercise affect brain health and Alzheimer's risk in older African Americans. About 280 people aged 60 and older who are not very active will either take cardio-dance classes or strength, flexibility, and balance classes for 6 months. Re…

This study tests a new program called Cafe Move that aims to help older adults prevent age-related physical frailty. The program is designed to be easy to access and lets participants take charge of their own health. Researchers will enroll 36 independently living adults to see i…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study is testing two injectable products, INNEA and INNEA AQUA, to see how well they reduce wrinkles on the cheeks and décolletage (upper chest). About 55 women aged 35 to 65 with at least mild wrinkles will receive the injections and be followed for one month after the last…

This study tests a device called Walkasins that provides gentle vibrations to the legs to replace lost foot sensation in older adults. Researchers want to see if it helps people aged 65-95 with slow walking speed walk more automatically and with less mental effort. The study invo…

This study is testing whether nicotine gum can reverse age-related hearing problems. Researchers will give nicotine gum to healthy adults aged 18 to 85 and measure their hearing and brain responses. The goal is to see if nicotine can improve how the brain processes sound, which c…

This study looks at whether adding simple mental tasks (like memory games) to water aerobics can boost thinking skills in older women more than water exercise alone. About 98 inactive women aged 60-75 will take part in a 12-week program. Researchers will measure memory, attention…

This study is testing whether a precise vibration system can improve muscle strength, coordination, and movement, and reduce pain in older adults and stroke survivors. Researchers will recruit 80 participants to try the vibration exercises and measure changes in strength, balance…

This study tests whether two natural substances, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in adults aged 30 to 75. Eighty participants will take daily capsules for 12 weeks and undergo sleep tests, blood work, and other health checks. The goal …

This study tests whether fisetin, a natural substance found in strawberries, can reduce aging cells in the body and help people with peripheral artery disease (PAD) walk longer distances. About 34 adults aged 50 and older with PAD will receive either fisetin or a placebo for 4 mo…

This study tests whether a topical cosmetic product can improve skin hydration and reduce wrinkles in adults aged 45 to 65. About 30 healthy volunteers with visible facial wrinkles will apply the product and be compared to an untreated group. Researchers will measure skin moistur…

This study tests whether a special video-based game can help adults aged 60 and older improve their balance, thinking skills, and confidence. Participants will play the game twice a week for 6 weeks, while a comparison group does nothing new. The goal is to see if this fun, low-c…

This study tests whether a daily ketone drink can help adults aged 65 and older who are starting to lose strength and mobility. Over 20 weeks, 180 participants will either take the ketone supplement or a placebo. Researchers will measure changes in physical function, immune healt…

This study looks at whether a simple, home-based exercise program can help older adults (60+) undergoing cancer treatment maintain their strength, mobility, and quality of life. About 180 participants will be randomly assigned to either a one-year exercise program or usual care. …

This study tests a program called SickleFit that combines exercise and nutrition coaching for adults aged 35 and older with sickle cell disease. The goal is to see if the program is safe, doable, and liked by participants. About 40 people will take part, with some getting the pro…

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults (60+) who have had lasting cognitive symptoms after COVID-19. 75 participants will either use the brain-training program or do other computer activities for about 6 week…

This study tests a friendly AI chatbot that guides people through telling their life stories to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and healthy seniors. The chatbot is not a treatment but…

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood assessments at the start and end. The goal is to …

This study tests three types of leg exercises (leg press, vibration, or mixed) to see which best improves blood flow and walking ability in older adults with poor circulation or chronic wounds. 425 participants will exercise 3 times a week for 12 weeks. The goal is to find a safe…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests whether a personalized digital meditation program (MediTrain) can improve sleep, reduce stress, and boost thinking skills in older adults with mild cognitive impairment (MCI). Researchers will enroll 90 participants aged 60-85, comparing those with MCI to healthy…

This study compares three exercise programs to see which best improves balance in healthy adults aged 65 and older. Participants will do core stabilization exercises, amplitude-based exercises, or a combination of both. The goal is to reduce fall risk and improve mobility and qua…

This study tests whether a natural supplement combined with a supervised exercise program can improve mood, sleep, thinking, and physical function in women going through menopause. Researchers will compare the supplement to a placebo, with all participants doing the same exercise…

This study tests whether using mild electrical pulses on the thigh muscle can help people regain strength and movement faster after total knee replacement. Many patients have long-term weakness after surgery, and this treatment is rarely used in rehab. The trial will include abou…

This study tests whether doing exercises that challenge both the mind and body at the same time—like walking while counting backwards—can improve balance, reduce falls, and enhance sleep in older adults. The exercises are done at home through video calls, making them easy to acce…

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking-pole exercise can help older adults feel better physically and mentally. About 1,500 people aged 55 and older will take part. Researchers will measure changes in strength, mood, slee…

This study tests whether a special type of tai ji quan that combines physical movement with mental tasks can reduce falls in older adults with mild cognitive impairment (MCI). Researchers will enroll 336 people aged 65 and older who have memory complaints and a history of falls o…

This study tests whether a supplement called EGA® can help healthy adults aged 60 to 80 exercise longer. Participants will take either EGA® or a standard NMN supplement, then switch after a break. The main goal is to see how long they can cycle before getting tired, along with ot…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study tests whether shining a specific red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to narrowed arteries. The trial will involve 32 adults aged 50 and…

This study explores whether taking a daily polyphenol supplement (natural compounds found in plants) alongside a 12-week exercise program can help older adults build strength and physical function better than exercise alone. Researchers will recruit 40 people over 60 to test if t…

This study tests a small, TENS-like device that gives mild electrical stimulation to see if it can improve balance and walking in older adults. About 120 people aged 60 and older will do tasks like walking for 6 minutes and standing on foam while wearing the device. The goal is t…

This study looks at whether whole body vibration therapy, when added to usual care, can improve muscle mass, strength, and function in older adults. Forty people aged 65 and older with mild frailty will be randomly assigned to receive vibration therapy plus usual care or usual ca…

This study tests whether a daily vitamin B3 supplement called Nicotinamide Riboside (NR) can improve brain blood flow and memory in healthy adults aged 60 to 85. Participants will take NR or a placebo for a period and undergo brain scans and memory tests. The goal is to see if NR…

This study tests whether a technology-assisted block training program can improve cognitive function, hand dexterity, and grip strength in adults aged 65 and older. Forty participants will use the program and be assessed on thinking, hand skills, and well-being. The goal is to se…

This study looks at how a single dose of psilocybin, the active ingredient in magic mushrooms, might change the brain's structure and function in healthy older adults. Forty volunteers aged 60 to 85 will receive either a tiny or a moderate-to-high dose and undergo MRI scans to me…

This study tests two drugs, rapamycin and everolimus, in healthy adults aged 65-90 to find doses that safely reduce age-related cell changes. Researchers will measure drug levels and activity in blood, fat, and muscle. The goal is to learn how to mimic younger cellular function, …

This pilot study looks at whether reducing alcohol and taking probiotics can improve thinking skills and brain energy use in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to drink less and take either a probiotic or a placebo pill. The goal…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will test healthy adults of different ages and people with Parkinson's disease. The goal is to understand why falls happen more often as we age or wit…

This study tests a special toolkit designed to help primary care doctors have better conversations about future medical care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolk…

This study aims to understand why some people age healthily while others face physical and mental decline. Researchers will measure how the body uses protein, sugar, and fat in 100 adults of different ages. The goal is to learn more about the aging process, not to test a treatmen…

This study uses yearly PET scans to track amyloid proteins in the brains of 400 adults aged 55 and older over 5 years. The goal is to see how these proteins relate to memory loss and other thinking problems as people age. Participants also complete memory tests and questionnaires…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will use a new, non-invasive method to measure artery stiffness and see if genetics play a role. The goal is to find the best way to …

This study looks at healthy adults over 60 to see if brain scans and eye-tracking tests can predict whether thinking skills will stay sharp or decline over time. Researchers will use MRI to examine a small brain area called the locus coeruleus, which is linked to memory, and trac…

This study looks for the temperature and humidity limits where older adults can no longer keep their body cool during exercise. Researchers will have 190 participants exercise in different conditions to find the point where heat stress becomes dangerous. The goal is to better und…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and test memory and physical function in 150 participants. The goal is to find factor…

This study aims to understand how obesity and aging interact by analyzing blood samples from 650 adults of different ages and weights. Researchers will measure biological age using DNA markers to see if obesity makes people age faster. The goal is to lay the groundwork for future…

This study looks at how small blood vessels in frail older adults (ages 65-85) handle the stress of intense exercise. Researchers want to see if a simple, safe technique called ischemic conditioning—using a blood pressure cuff to briefly restrict blood flow—can protect those vess…

This study looks at how well different cooling methods (like fans or cold water) reduce heart strain in healthy adults aged 65 and older during simulated heat waves. Researchers will measure body temperature and heart function. The goal is to find simple ways to keep older people…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in normal aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and patients with early-stage Alzheimer's. They aim to…

This study tests whether a natural supplement from brown seaweed (fucoidan) can slow or reverse biological aging in 60 pre-frail men aged 50-80. Researchers will measure changes in DNA methylation (a marker of biological age) and inflammation. The goal is to see if activating a l…

This study looks at how the brain changes as we age, using EEG scans to find new markers of healthy aging. Researchers will also test whether tiny particles from stem cells (called exosomes) can help rejuvenate the aging brain in mice. The goal is to better understand brain aging…

This study looks at how blood vessels in the arm respond to low oxygen in women at different stages of menopause. Researchers will measure blood flow in 75 healthy women who are premenopausal, perimenopausal, or postmenopausal. No treatments or drugs are tested—the goal is simply…

This study looks at how older adults with hearing loss understand speech in noisy settings, like a crowded room. Researchers will test 121 people—young and older with normal hearing, plus older adults with hearing loss—using listening tasks and brain wave measurements. The goal i…

This study looks at how estrogen levels affect the way women's bodies handle heat, comparing women before and after menopause. Researchers will measure skin blood flow, sweating, and core temperature during controlled heat exposure. The goal is to understand why older women are m…

This study explores how binge drinking affects blood pressure and small blood vessels in adults aged 50-64. It compares binge drinkers to non-drinkers and moderate drinkers. The second part tests whether 8 weeks of aerobic exercise can improve blood pressure and blood vessel func…

This study looks at how older women (65+) handle extreme heat and humidity. Researchers will expose 12 women to increasing humidity in a hot room to find the exact point where their bodies can no longer keep cool. The goal is to better understand heat risks for this group as clim…

This study tests whether a digital intervention can improve working memory and self-control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home brain training, with a fol…

This study looks at how two mTOR inhibitor drugs (sirolimus and everolimus) behave in healthy adults aged 65 and older. Researchers will measure drug levels, inflammation markers, and physical function like walking speed. The goal is to gather information for future trials on agi…

This study tests a new system that continuously monitors vital signs like heart rate and oxygen levels in older adults, both in the hospital and at home. Researchers want to see if the device is easy to use and if it helps doctors get the right information at the right time. The …

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help reduce the risk of elder fraud.

This study aims to identify frailty and pre-frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. About 100 participants from a specialty clinic w…

This study is testing a digital meditation program to see if it can improve thinking and reduce stress in adults aged 60 and older. Researchers will enroll 4,000 participants to find the best amount of meditation needed for brain health. The goal is to create a personalized appro…

This study tests three approaches to help older adults with HIV become more physically active: coaching, cognitive behavioral therapy for barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit to track steps. The…

This pilot study is testing whether a 14-day program combining exercise, mindfulness, sleep tips, a Mediterranean diet, and supplements is practical for adults aged 55-70 who are at risk for faster aging. Only 10 people will take part, and the main goal is to see if the study pro…

This study aims to gather health information, brain scans, and blood or spinal fluid samples from 1,000 older adults—some healthy, some with mild memory issues, and some with Alzheimer's. Researchers will track changes over time to better understand the disease. No treatments or …

This study looks at bone marrow from 24 adults aged 65 and older who are having hip surgery. Researchers will analyze the samples to see how metabolism and gene activity differ in stem cells with certain age-related mutations. The goal is to better understand clonal hematopoiesis…

This study explores whether hypoxic conditioning—breathing air with less oxygen—can improve blood flow in the brains of inactive adults aged 60 to 80. Researchers will test this approach alone and combined with exercise training. The goal is to find new ways to preserve brain hea…

This study looks at how long-term inflammation impacts muscle function and how older adults respond to exercise. Researchers will measure muscle protein building rates in 120 older participants. The goal is to better understand age-related muscle decline, not to test a treatment.

This study looks at why some older adults get more benefits from exercise than others. Researchers will have 250 people aged 60+ follow a combined endurance and resistance training program. The goal is to understand the differences in how people respond, so that in the future exe…

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a hormone infusion. The goal is to underst…

This study looks at how past sports injuries and sitting too much can affect the long-term health of former athletes. Researchers will compare strength, physical activity, and overall health in 450 current and former athletes, as well as non-athletes, to understand why some peopl…

This study tests whether an online program that teaches positive emotion skills can improve mental well-being and slow biological aging. Researchers will measure changes in mood, purpose, and biological age markers in 80 adults aged 40-70 from the Chicago area. The program is sel…

This study looks at how short-term pain, created with a capsaicin heat patch, changes the way older adults (ages 55-90) learn and remember new walking patterns. Researchers will measure how well participants adjust their step symmetry on a split-belt treadmill and whether they re…

This study looks at whether giving magnetic pulses to the brain at the right moment in your natural brain wave cycle can make movement training more effective. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to understand how th…

This study looks at how different amounts of resistance (strength) training affect inflammation in adults aged 60-75. Participants will be placed into one of three training groups (low, medium, or high volume) or a non-exercise group for 4 weeks, followed by 4 weeks of rest. The …

This study aims to learn why our bodies and minds change as we get older. Researchers will use brain scans, fitness tests, and wearable devices to track health in 770 adults. The goal is to understand aging better, not to test a treatment.

This study tests whether drinking cold water (4°C) four times a day for six months can lower body fat and slow aging in healthy adults aged 50–65. Participants are split into two groups: one drinks cold water, the other drinks room-temperature water (37°C). Researchers will measu…

This study is following 10,000 adults aged 18 and older to learn how muscle loss (sarcopenia), metabolic diseases, and aging are connected. Researchers will collect health data, lifestyle info, and biosamples over time. The goal is to understand what leads to earlier death and po…

This early-phase study tests whether passive heat exposure (raising body temperature by about 1°C) can improve how small blood vessels widen and respond to blood flow demands in 20 healthy adults aged 18-80. Researchers aim to understand if heat can mimic some benefits of exercis…

This study looks at how the nervous system and blood vessels change as women age. Researchers will measure blood flow in the forearm of 64 women aged 18 to 70. The goal is to better understand early signs of aging in the body's blood vessels.

This study looks at whether blood flow in fat tissue changes as we age. Researchers will compare healthy younger adults (18-35) and older adults (65-80) by measuring blood flow, taking small fat samples, and having them drink a sugary drink. The goal is to learn more about aging,…

This study looks at whether relaxing in a low-frequency ultrasound bath can help older adults stay stronger and sharper. Twenty volunteers aged 70 and older will take 45-minute baths three times a week for 8 weeks. Some will get the ultrasound, others just a regular bath. Researc…

This study looks at whether using simple moisturizers like Vaseline or CeraVe can lower inflammation in adults aged 70 and older with dry skin. Participants apply a moisturizer daily for 4 weeks and go without it for another 4 weeks, acting as their own control. Researchers will …

This study looks at whether a blood test can estimate how fit you are, as measured by your VO₂max (a key fitness indicator). Researchers will collect blood samples and fitness data from 250 healthy adults. The goal is to find blood markers that predict fitness, which could lead t…

This study looks at how mild dehydration (losing 2-3% of body weight) and then rehydrating affects inflammation, blood sugar, sleep, and strength in healthy adults aged 45-65. Researchers will measure changes in cells and body functions over 12 days. The goal is to understand if …

This study aims to understand why older adults lose important immune cells (T cells) from their nose, which may explain why they get more respiratory infections. Researchers will compare young adults, healthy older adults, and frail older adults using gentle nose swabs and blood …

This study tests whether combining fasting with exercise can slow the aging process in healthy adults over 65. Two hundred forty participants will be split into four groups: exercise only, fasting only, both, or neither. Researchers will measure biological age using DNA markers a…

This small pilot study tests whether whole-body electrical muscle stimulation combined with exercise can improve the way nerves activate muscles in healthy older adults (65+). Participants will do supervised sessions twice a week for four weeks, with before-and-after tests of mus…

This study compares two online training programs for staff who care for people with dementia in assisted living facilities. About 1,764 staff and family members will take part to see if the training improves staff knowledge, attitudes, and care practices. The goal is to find the …

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study looks at muscle and heart health in people over 60 with multiple sclerosis (MS) compared to those without MS. Participants will do a 4-month exercise program to see how their bodies adapt. The goal is to understand how MS and aging together affect muscle function and f…

This study looks at whether common blood pressure drugs (beta blockers) cause older adults to get hotter during extreme heat. Researchers will measure body temperature and sweating in 22 healthy people aged 65+ while they are exposed to heat for 3 hours. The goal is to understand…

This study looks at why older adults respond differently to strength training. Researchers will track 300 people aged 65 and older who are at risk for mobility problems. Participants will do progressive resistance training, and scientists will measure changes in physical function…

This study tests whether guided imagery—creating mental pictures of future rewards—can help mid-life adults stay motivated to exercise. 160 physically inactive adults will complete an exercise program and undergo MRI scans, questionnaires, and blood tests to see if this technique…

This study looks at how different types of dietary fats affect brain function in healthy adults aged 65 to 75. Participants will follow two one-week diets: one similar to a typical North American diet and one similar to a Mediterranean diet. Researchers will measure memory and br…

This study aims to understand how people age by following healthy volunteers for life. Participants aged 20 and older undergo physical and mental tests every few years. The goal is to learn how people can adapt to aging successfully.

This study looks at why older adults may not respond as strongly to the pneumonia vaccine as younger people. Researchers will compare blood samples from 60 healthy volunteers aged 21-40 and 65+ before and after receiving the Prevnar-13 vaccine. The goal is to understand how aging…

This study aims to understand how aging changes the brain and kidneys in healthy adults. Researchers will use advanced MRI scans and thinking tests to measure blood flow and brain function. The goal is to learn more about normal aging, not to treat any disease. About 120 healthy …

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers. Researchers will use tiny needles and various stimuli to learn how the skin and nerves send touch information to the brain. The goal is to use this knowledge to create pro…

This study looks at how getting older and having tired muscles change the way people balance and walk. Researchers will test 140 adults, both young (20-40) and older (60-85), by having them do exercises that tire out their arms or legs. The goal is to better understand these effe…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study looks at how the changing seasons—summer to winter—might affect your biological age, which is a measure of how well your body is aging compared to your actual age. Researchers will track 60 healthy adults over 40 for one year, using blood or saliva samples to measure a…

This study looks at how getting older and feeling stressed can change the way we remember and find our way around. Researchers will have 85 adults aged 65-80 do a virtual navigation task while their brains are scanned. Some will be put under mild stress to see if it makes them re…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild memory problems. Researchers want to see how tau relates to thinking skills, brain activity, and the risk of future decline. About 105 people aged 55–90 who …