AGING

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This study tests whether a daily supplement made from ginger, L-citrulline, and two herbs can improve blood vessel function and reduce markers of aging in healthy adults. Over six weeks, 35 participants will take the supplement and have blood drawn to measure changes in PAI-1, a …

This study tests a combination of three drugs—isatuximab, pomalidomide, and dexamethasone—at lower doses than usual. It includes 6 patients with multiple myeloma that has returned or not responded to treatment, who are also vulnerable due to age or other health problems. The goal…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving …

This study tests whether a personalized lifestyle plan—including exercise, nutrition, sleep, stress management, and social engagement—can improve muscle, immune, and cognitive function in adults aged 50 to 85. Twenty-five participants will follow their own plan for about three mo…

This study tests whether a combination of medications and supplements can improve healthspan in adults aged 60-80. Participants take either a control, a multi-therapy (including metformin and NAD+), or a comprehensive therapy (adding rapamycin) for 90 days. The goal is to see cha…

This study looks at whether 12 months of high-intensity strength training can reduce falls in people aged 80 and older who have sarcopenia (age-related muscle loss). About 241 older adults living at home or in independent senior housing took part. The goal is to see if regular, p…

This early-phase study tests whether a drug called rapamycin can reverse biological aging in 52 healthy adults aged 50-80. Researchers will use a special DNA test to measure changes in biological age over six months. The goal is to see if we can slow or reverse the aging process,…

This study looks at whether reducing the number or dose of medications in people aged 80 and older can improve their health and independence. Researchers will work with primary care providers to safely lower doses of common drugs like those for blood pressure or pain. The goal is…

This study tests whether a computerized brain-training program can improve thinking skills in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either adaptive cognitive training or a placebo version, both…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tests whether a dietary supplement called calcium alpha-ketoglutarate (CaAKG) can slow biological aging and improve physical performance and metabolic health in adults aged 40 to 75. Thirty participants will take either CaAKG or a placebo daily for 12 weeks. Researcher…

This study tests whether a daily supplement called MitoQ can improve blood vessel function in people aged 60 and older. Aging often leads to stiff arteries and poor blood vessel health, raising heart disease risk. The trial involves 112 participants taking either MitoQ or a place…

This study tests whether intermittent doses of fisetin, a compound found in fruits and vegetables, can improve blood vessel function and reduce stiffness in arteries of adults aged 65 and older. Researchers will measure changes in blood flow and artery stiffness after one month, …

This trial tests whether a person's own stem cells, taken from fat tissue and given back through an IV, can safely improve quality of life and physical function in people with aging frailty. The study plans to enroll 200 adults aged 40 to 90 who have lost energy and exercise tole…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study tests whether a non-invasive electrical stimulation of the vagus nerve in the ear (called RAVANS) can improve memory and thinking in 126 older adults. Participants receive either real or sham stimulation during short sessions, and their memory is tested. The goal is to…

This study tests a structured team checklist called CMOT for when breathing support is removed from dying ICU patients. The goal is to reduce distress, which occurs in 30-59% of cases. Researchers will enroll 184 patients and ICU staff across four ICUs to see if the checklist is …

This study tests whether 12 weeks of piano improvisation training can improve thinking skills and self-control in adults aged 60 and older, including those with mild cognitive impairment. Participants will either take piano improvisation lessons or listen to music with an instruc…

This study tests whether using a far red light device on the legs for 10 minutes twice a day can improve walking distance in people with peripheral artery disease (PAD). The trial involves 32 adults aged 50 and older with PAD. Participants use the light at home for four months, a…

This pilot study tested whether a non-invasive brain stimulation technique called tDCS could improve cognitive and motor functions in older adults with mild Alzheimer's disease living in supportive housing. Eleven participants received either real or sham stimulation over 10 sess…

This study explores whether older adults who have fallen recently can safely receive mild brain stimulation at home, given by a caregiver or spouse. The goal is to see if this approach can improve mobility and balance. The study involves up to 72 pairs of older adults and their h…

This study tests whether special lights placed over doorways can help reduce nighttime falls in assisted living residents with Alzheimer's or related dementias. The lights are low-intensity and outline the bathroom or entry door, providing visual cues to improve balance. Research…

This study looks at whether a 12-week program of functional task training (like standing up, walking, and carrying objects) can improve muscle strength and daily function in older adults with sarcopenia. 30 people aged 60 and older will be randomly assigned to different exercise …

This study tests whether a 12-week adapted sports program can improve balance, physical function, and thinking in adults aged 60 and older. 140 participants will be randomly assigned to either the exercise program or their usual routine. Researchers will measure balance and mobil…

This study tests a nutritional product called Radicle Clarity™ 25_RAM to see if it can improve thinking, memory, and reduce brain fog in adults aged 40 and older. About 650 people in the US will take either the supplement or a placebo for 8 weeks and answer surveys about their co…

This pilot study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with digital meditation can improve thinking skills and well-being in older adults with mild cognitive impairment (MCI). About 90 adults aged 60-85 with MCI will participate. The goa…

This study tests whether eating only within a 10-hour window each day can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty makes it harder to recover from stress and can lead to loss of independence. The trial will enroll 30 participa…

This study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…

This study tests a hyaluronic acid filler called TEOSYAL TPVM against another filler for improving chin shape and lower face aging. About 155 healthy adults with moderate to severe chin retrusion will receive injections, with an optional touch-up at 4 weeks. The main goal is to s…

This pilot study is testing whether a 14-day program combining personalized exercise, a Mediterranean diet, and several supplements (vitamin D, omega-3s, multivitamin, and a tomato extract) is feasible for adults aged 55-70 who are at risk for accelerated aging. Only 10 participa…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study tests a digital literacy program for adults aged 65 and older to help them better communicate with their healthcare team, manage health information, and feel more socially connected. Twenty participants will learn to use digital tools in their own homes. The goal is to…

This study looks at how different types of exercise affect aging and health in adults aged 60 and older. Researchers will measure changes in blood markers, body function, and quality of life to find the best exercise methods. The goal is to create simple, effective plans to help …

This study tests whether taking alpha-ketoglutarate (AKG), a natural substance in the body, can lower biological age in 120 middle-aged adults from Singapore. Participants must have a biological age older than their actual age. The study measures changes in DNA methylation (a mar…

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study follows 75 adults aged 65 and older over three to four flu seasons to learn why the flu vaccine becomes less effective as people age. Participants will receive a different FDA-approved flu vaccine each year, and researchers will collect blood, nasal swab, and stool sam…

This study looks at whether antioxidant supplements can prevent muscle loss and blood vessel problems in older adults (ages 65-85) during five days of bed rest. Participants take either a placebo or two antioxidants (MITO-AO and PB-125) while researchers measure changes in blood …

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study looks at whether a special health check-up for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with their doctors about age-related concerns. About 479 older cancer patients and their caregivers are taking part. The…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study looks at how nutritional counseling and exercise affect telomeres—the protective caps on our chromosomes that shorten as we age—in elderly women. Researchers will compare women with and without obesity, measuring changes in telomere length and other aging markers after…

This study looks at whether taking a special morning and evening food supplement for 6 months can improve blood markers linked to aging in healthy adults aged 50 to 70. Sixty participants will be randomly assigned to take either the supplement or a placebo. Researchers will measu…

This study tests whether a daily food supplement designed for men or women can slow aging in healthy adults aged 50-70. Over 6 months, 60 participants will take either the supplement or a placebo. Researchers will measure blood markers and DNA changes to see if the supplement aff…

This study looks at how different protein drinks (casein, whey, and soy) affect blood and urine markers in healthy older adults aged 60 to 80. Researchers will also check cognitive function, mood, and appetite after each drink. The goal is to understand how protein sources influe…

This study looks at how sleep and daily body rhythms impact memory and thinking skills in couples where one partner has mild memory problems. Researchers will track 340 couples over time using smartphone tests and surveys. The goal is to understand if poor sleep in one partner af…

This study looks at how to improve the pre-surgery checkup process for older adults having major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare providers to find what works well and what could be better. The goal is to…

This study uses motion capture technology to precisely measure how the skin around the eyes moves and changes with age. Researchers will compare 60 healthy women in two age groups (18-33 and 50-65) to understand skin dynamics during facial expressions and jumps. The goal is to va…

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study was designed to see if certain immune cells (T cells) contribute to age-related blood vessel problems that raise heart disease risk. It planned to give a single injection of abatacept to adults aged 55-75 and measure changes in artery function and inflammation. However…

This study was designed to see how well compounds from a standardized ashwagandha supplement are absorbed in healthy adults aged 65 and older. Researchers planned to measure levels of active ingredients in the blood after taking the supplement. The study was withdrawn before enro…

This study looks at whether a personalized brain-training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo version for 12 weeks. The …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve how the brain's vestibular network works, which may help with walking and navigation. Sixty older adults with memory concerns will receive either real or fake stimulation during three 20-mi…

This study tests the safety and biological effects of dietary supplements, starting with spermidine, in 10 healthy adults aged 18 to 75. Participants take increasing doses over three months while researchers monitor blood markers and side effects. The goal is to learn how these s…

This study was designed to test whether eating blueberries or taking blueberry powder every day for 12 weeks could improve memory and thinking in older adults with mild memory complaints. It planned to include people aged 65 and older who were overweight and had some memory conce…

This study aimed to see if a four-session biofeedback training program could improve trunk control and walking in older adults with and without chronic low back pain. Researchers planned to compare 20 older adults with back pain to 20 healthy volunteers, measuring walking biomech…