AGING

This study tests whether 12 months of high-intensity strength training can reduce falls in people aged 80 and older who have sarcopenia (age-related muscle loss). About 241 participants will either do progressive resistance exercises or be in a control group. The goal is to see i…

This study tests whether a daily supplement called calcium alpha-ketoglutarate (CaAKG) can slow biological aging and improve physical health in adults aged 40 to 75. Participants take either CaAKG or a placebo for 12 weeks. Researchers measure changes in biological age, physical …

This study tests whether a low dose of everolimus, a drug that targets a key aging pathway, can safely improve how the body ages in people aged 55-80 with insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes i…

This study tests a three-drug combination (isatuximab, pomalidomide, and dexamethasone) at lower-than-standard doses in people with multiple myeloma that has returned or not responded to treatment. The goal is to see if the lower doses are both safe and effective for patients who…

This study tests whether intermittent doses of fisetin, a compound found in fruits and vegetables, can improve blood vessel function and reduce stiffness in adults aged 65 and older. Researchers will measure changes in artery health and look at how fisetin affects aging cells and…

This early-phase study tests whether a drug called rapamycin can reverse biological aging in 52 healthy adults aged 50 to 80. Participants take the drug for six months, and researchers measure changes in a DNA-based 'aging clock' that estimates biological age. The goal is to see …

This study tests three ways to help older adults (60+) with type 2 diabetes who live in nursing homes manage their blood sugar. One group uses gentle electrical pulses on leg muscles, another does supervised exercise, and a third gets health education. The goal is to see which ap…

This study tests whether a person's own stem cells, taken from fat tissue and returned through an IV, can safely improve quality of life and physical function in people with age-related frailty. About 200 adults aged 40 to 90 who have lost energy and exercise tolerance will take …

This study tests whether a combination of medications and supplements can improve healthspan in adults aged 60-80. Thirty participants will be split into three groups: one taking a mix of B12, naltrexone, metformin, and NAD+; another adding rapamycin, GSH, and a supplement; and a…

This study tests whether a daily MitoQ supplement can improve blood vessel function and reduce stiffness in adults aged 60 and older. Over 3 months, half the participants receive MitoQ and half a placebo. The goal is to see if targeting cell energy centers (mitochondria) can lowe…

This study looks at whether reducing the number and dose of medications can improve health for people aged 80 and older who take 6 or more daily pills. Doctors and nurse practitioners will work with patients to safely lower doses or stop unnecessary drugs. The goal is to see if t…

This study looks at whether eating wild blueberries can help lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. About 58 participants will eat blueberries and have their artery function and…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and possibly reduce the risk of dementia. It continues a previous 3-year trial where half the participants received hearing aids and the other half rec…

This study compares a new injectable filler, TEOSYAL® TPVM, to an existing one for improving chin shape and lower face aging. About 155 healthy adults with moderate to severe chin retrusion will receive treatment. The goal is to see if the new filler is as safe and effective as t…

This study tests whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo versi…

This study looks at whether taking creatine and HMB (a protein-like supplement) along with a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older …

This pilot study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with digital meditation can improve thinking skills and wellbeing in older adults with mild cognitive impairment (MCI). About 90 participants aged 60-85 will use a meditation app whi…

This study looks at whether a 12-week program of functional task training (like standing up, walking, and carrying objects) can improve muscle strength and daily function in older adults with sarcopenia. 30 people aged 60 and older will be randomly assigned to different exercise …

This study tests whether a nutritional product can help improve cognitive function, reduce brain fog, and ease fatigue in adults aged 40 and older. Over 650 participants in the US will take either the active supplement or a placebo for 8 weeks and complete surveys about their thi…

This study looks at whether 8 weeks of daily computer-based cognitive training, sometimes paired with a gentle brain stimulation technique called tDCS, can improve thinking, balance, and daily living skills in seniors aged 50+ with mental health conditions. Participants live in c…

This study tests whether adding low, horizontal and vertical lights around bathroom and entry doorframes can help reduce nighttime falls in people with Alzheimer's or related dementias. About 335 assisted living residents with dementia will take part, with each person experiencin…

This study tests a gentle ultrasound treatment aimed at a deep brain area (the hippocampus) to see if it can improve sleep and memory in older adults with early signs of Alzheimer's. Twenty participants aged 60-85 with mild memory issues and poor sleep will receive either real or…

This study looks at whether a fun social media game can help women aged 65-85 walk more. Participants will join a private Facebook group with weekly photo challenges and wear a step tracker. The goal is to see if this approach boosts daily steps compared to just using a tracker a…

This small pilot study tests whether a non-invasive brain stimulation technique called tDCS can improve both thinking and walking in older adults with mild Alzheimer's disease. Participants will receive 10 sessions of either real or sham stimulation targeting a key brain area. Th…

This study tests a painless, non-invasive brain stimulation method called RAVANS (a type of vagus nerve stimulation) to see if it can improve memory and thinking in healthy older adults. Researchers will measure changes in memory tasks and other cognitive tests. The goal is to un…

This study tests a simple checklist called CMOT to help ICU teams reduce distress when removing breathing machines from dying patients. About 184 patients and their care teams will take part across four ICUs. The goal is to see if this structured approach can make the process mor…

This study looks at whether adding cognitive exercises to physical training can help frail older adults feel better and move better. Forty-five people aged 65 or older who are frail or pre-frail will take part in an 8-week program. They will be split into three groups: one doing …

This pilot study is testing a program to help older adults improve their digital skills in their own homes. Participants receive a tablet, internet access, and several personalized coaching visits to learn how to use technology for health and communication. The goal is to see if …

This study looks at why being less active harms blood vessels and muscles, especially in people aged 65 to 85. Researchers want to understand the role of oxidative stress in these changes. The goal is to find ways to prevent damage and help older adults recover better after perio…

This study looks at whether taking a special morning and evening food supplement for 6 months can change certain blood markers linked to aging. It involves 60 healthy adults aged 50 to 70. Half take the supplement, half take a placebo. Researchers measure things like blood sugar,…

This study looks at how three types of protein drinks (casein, whey, and soy) change substances in the blood and urine of healthy older adults aged 60 to 80. Researchers also check thinking skills, mood, and appetite after drinking them. The goal is to learn more about how differ…

This study looks at how sleep and daily body rhythms impact memory and brain health in couples over age 50 where one partner has mild memory problems. Researchers will track sleep, daily activities, and thinking skills using smartphones and tests. The goal is to understand how sl…

This study looks at whether a gentle brain stimulation technique called tDCS can improve how well the brain's networks work together during walking and thinking tasks. Researchers will test 60 older adults with mild memory concerns, giving them either real or fake stimulation whi…

This study aimed to see if biofeedback-based trunk control training could improve walking in older adults with and without chronic low back pain. Researchers planned to compare 20 older adults with back pain and 20 healthy volunteers. The study was withdrawn before enrolling anyo…

This study looks at whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 people in Beijing will be randomly assigned to either the adaptive training or a placebo version. Th…

This study tests the safety and biological effects of dietary supplements, starting with spermidine, in healthy adults aged 18 to 75. Ten participants will take increasing doses over three months to see how the body responds. The goal is to gather information for future aging-tar…

This study was designed to see if eating blueberries (whole or as a powder) for 12 weeks could improve memory and thinking in adults aged 65 and older who have mild memory complaints. The study was withdrawn before any participants were enrolled, so no results are available. It w…

This study tests whether a 12-week program that combines brain training, social activities, and exercise can help seniors with mental health conditions living in community housing. The program involves 18 participants working in small groups with a support worker. The goal is to …

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty means losing strength and independence. The study will test if this eating pattern h…

This study looks at how skin around the eyes moves and changes as we age. Researchers will use motion capture technology to measure skin movement in 60 healthy women. The goal is to better understand skin dynamics and how treatments like creams or massages might affect them.

This study was designed to see if a drug called abatacept could improve blood vessel function in older adults by targeting immune cells called T cells. It planned to enroll people aged 55-75 without major health problems. However, the study was withdrawn before any volunteers wer…

This study tests whether a sex-specific food supplement can affect markers of biological aging in healthy adults aged 50 to 70. Over six months, 60 participants will take either the supplement or a placebo, and researchers will measure changes in blood biomarkers, DNA methylation…

This study looks at whether a 12-week indoor cycling program can improve blood flow and brain function in older veterans (ages 65-80) who don't currently exercise. Researchers will measure brain health before and after the program using special MRI scans. The goal is to learn how…

This study was designed to see how well compounds from a standardized ashwagandha supplement are absorbed in healthy adults aged 65 and older. Researchers planned to measure levels of active ingredients in the blood after taking the supplement. The study was withdrawn before any …

This study looks at how nutritional counseling and physical exercise affect cell aging in elderly women. Researchers will measure telomere length (a marker of cell age) and other aging-related markers in 60 women aged 60-75, some with obesity and some without. The goal is to unde…

This study looks back at the medical records of 2,500 people who had thinking and memory tests before and after hyperbaric oxygen therapy (HBOT). The goal is to see if HBOT is linked to improvements in cognitive function for patients with traumatic brain injury, stroke, fibromyal…

This study looks at whether a special health check for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with doctors about age-related concerns during cancer treatment. About 479 patients, caregivers, and clinic staff are takin…

This study looks at whether specially designed sports exercises can improve balance, physical abilities, and thinking skills in people aged 60 and older. About 140 participants will either join a 12-week adapted sports program or continue their normal routine. Researchers will me…

This study looks at whether doing computerized brain exercises in the morning or late afternoon works better for older adults who have been in the intensive care unit (ICU). Many ICU survivors have trouble thinking clearly and sleeping well. The goal is to see which time of day h…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…

This study explores whether older adults who have fallen recently can safely use a mild brain stimulation device at home, with help from a caregiver or spouse. The goal is to see if this approach can improve balance and mobility. About 72 pairs of older adults and their helpers w…

This study looks at whether a custom exercise, nutrition, and lifestyle program can improve muscle strength, immune health, and thinking skills in adults aged 50 to 85. Participants get a personalized plan for about 3 months and complete fitness and quality-of-life tests before a…

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a clear plan that other hospitals can u…

This study explores whether a simple, non-invasive test called passive leg movement can measure blood vessel health in older adults. Researchers will use ultrasound to see how blood flow changes when a person's leg is moved without their effort. The goal is to create a tool that …