AGING

This study is testing whether eating wild blueberries daily can help lower blood pressure and improve artery function in middle-aged and older adults with mildly elevated blood pressure. Researchers are enrolling 58 men and postmenopausal women aged 45-70 to measure changes in bl…

This study is testing whether a special brain training program on tablets can help improve thinking skills in older adults who have high blood pressure and are at risk for memory problems. 120 participants aged 60+ will be randomly assigned to either the active brain training pro…

This study is testing whether a gentle, non-invasive ultrasound treatment aimed at a deep brain area can help improve sleep problems and mild memory issues in older adults showing early signs of Alzheimer's disease. Participants will receive either the real ultrasound treatment o…

This is a small, 90-day pilot study testing whether combinations of existing drugs and supplements can improve health and slow aging in older adults. It will enroll 30 people aged 60-80 to measure changes in fitness, thinking skills, body composition, and blood markers. Participa…

This study is testing a combination of three drugs for multiple myeloma that has returned or stopped responding to prior treatments. It specifically aims to see if using lower doses of two of the drugs is safe and effective for older patients or those who are too frail for standa…

This study is testing whether a 3-month course of a supplement called MitoQ can improve blood vessel function and reduce artery stiffness in healthy adults aged 60 and over. The goal is to see if reducing cellular stress in blood vessels can lower the risk of age-related heart di…

This study is testing whether a personalized brain training program on a tablet can help improve thinking skills in older adults with diabetes, who are at higher risk for memory problems. 120 participants aged 60+ will be randomly assigned to use either the active training progra…

This study is testing whether a dietary supplement called calcium alpha-ketoglutarate (CaAKG) can help slow biological aging and improve health in middle-aged and older adults. For 12 weeks, 30 generally healthy participants aged 45-75 will take either the supplement or a placebo…

This study is testing whether a year of supervised strength training can help prevent falls in adults aged 80 and older who have age-related muscle loss (sarcopenia). Researchers are comparing the fall rates of 241 participants who either do the strength training program or recei…

This study is testing whether a gentle, non-invasive electrical stimulation of a neck nerve (called the vagus nerve) can improve memory and thinking skills in older adults. Researchers will give the stimulation to about 140 participants and measure changes in their ability to rem…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and reduce the risk of developing dementia. It builds on a previous 3-year trial and involves about 629 participants aged 70-84 who have untreated hear…

This study is testing whether a low dose of a drug called everolimus, taken daily or weekly for 24 weeks, can safely improve signs of aging in older adults who have insulin resistance (a pre-diabetic condition). Researchers will measure changes in metabolism, heart health, brain …

This small, early-stage study is testing whether a combination of a monthly fasting-mimicking diet and a low weekly dose of the drug rapamycin can slow down or even reverse biological aging. It will enroll 52 healthy adults aged 50-80. Researchers will use a new blood test that m…

This study aimed to see if eating blueberries for 12 weeks could improve memory and thinking skills in older adults with mild memory complaints. It planned to compare whole blueberries, blueberry powder, and a placebo pill. However, the study was withdrawn before any participants…

This study is testing if carefully lowering the doses of many common medications helps people aged 80 and older stay healthier. Doctors will work with 1,800 patients who take six or more daily pills to find the lowest effective dose for each one. The goal is to see if this approa…

This study is testing if a natural compound called fisetin, found in fruits and vegetables, can improve blood vessel function and reduce artery stiffness in adults aged 65 and older. Researchers want to see if short-term, intermittent treatment is safe and if it works by reducing…

This study is testing a simple, non-invasive method to check blood vessel health in aging Veterans. Researchers move a participant's leg gently while using an ultrasound to measure blood flow, which indicates how well the blood vessels are working. The goal is to see if this test…

This study is testing if a specific eating pattern can help prevent frailty in older men undergoing hormone therapy for prostate cancer. Researchers will compare a 12-week program of time-restricted eating (eating all meals within a set daily window) to a regular diet. The goal i…

This study is testing if a fun, year-long social media game can help older women become more active. About 300 sedentary women aged 65-85 will either just wear a Fitbit or also play a weekly photo challenge game in a private Facebook group. Researchers want to see if the game mak…

This small pilot study is testing whether a non-invasive brain stimulation technique can help improve symptoms in people with mild Alzheimer's disease. Researchers are giving 10 sessions of personalized electrical stimulation to the forehead area of older adults to see if it make…

This study is testing whether a special exercise program using adapted sports can help older adults improve their balance, physical ability, and thinking skills. About 140 participants aged 60 and older were randomly assigned to either join the sports program or continue their us…

This study is testing a new team checklist called the Comfort Measures Only Time Out (CMOT). It aims to reduce distress for patients and improve the process when life support is being withdrawn in the intensive care unit. The research involves ICU teams using the checklist during…

This study is testing whether a new nutritional supplement can improve thinking skills like memory and focus, and reduce feelings of 'brain fog' and fatigue in adults over 40. About 650 participants in the U.S. will take either the real product or a placebo (a look-alike with no …

This pilot study is testing whether combining a gentle, non-invasive brain stimulation technique with a digital meditation program can improve thinking skills and well-being in older adults with mild cognitive impairment (MCI). Researchers will measure changes in attention, react…

This small pilot study is testing whether a personalized coaching program can help older adults feel more confident using technology like tablets and the internet. Researchers from Johns Hopkins will provide devices and home visits to 20 participants to see if improving digital s…

This study aimed to see if a special training program could help older adults walk better and manage chronic low back pain. Researchers planned to compare 20 seniors with back pain to 20 without, measuring their posture and walking before and after a four-week training course. Th…

This study is testing whether doing computerized brain training exercises in the morning or late afternoon works better for older adults recovering from a stay in the intensive care unit (ICU). Researchers want to see if the timing of these exercises can help improve thinking ski…

This study tests whether stem cells taken from a person's own fat tissue can safely improve quality of life and physical function in older adults experiencing frailty. Researchers will remove a small amount of fat, isolate specific cells, and return them via an IV drip. The goal …

This study is testing whether TEOSYAL® TPVM works as well as another product for improving the appearance of receding chins. Researchers are comparing safety and effectiveness in 155 adults who want chin enhancement. Doctors will inject the products, and independent experts will …

This study aims to improve conversations between doctors, older cancer patients, and their caregivers. Researchers are testing a special health assessment tool to help doctors better address age-related concerns when discussing chemotherapy. The goal is to see if using this tool …

This study is testing whether spermidine, a dietary supplement, affects biological markers related to aging in healthy adults. Ten participants will take increasing doses over three months while researchers monitor safety and measure changes in immune and metabolic markers. The g…

This study aims to see if taking specific morning and evening food supplements for six months changes blood markers associated with aging and longevity. It involves 60 healthy adults aged 50 to 70, with half taking the supplements and half taking a placebo. Researchers will measu…

This study is testing whether taking music improvisation classes can help improve thinking skills and self-control in older adults. Researchers want to see if this fun, creative training can help people stay mentally engaged, especially those with mild memory concerns. The study …

This study is testing whether a 12-week aerobic exercise program can improve blood flow and blood vessel function in the brains of older veterans. Researchers are comparing a spin class group to a stretching group to see if exercise causes measurable changes in brain health. The …

This study aims to develop new, less invasive ways to measure how the body uses energy and maintains its daily rhythms. Researchers are enrolling 15 overweight adults aged 65+ to follow a time-restricted eating pattern. They will use smart rings and blood tests to see if this eat…

This study was designed to understand how the bodies of healthy older adults absorb and process a specific ashwagandha (Withania somnifera) supplement. It planned to measure the levels of the supplement's compounds in the blood and urine over time and check for any side effects. …

This study aimed to understand if a specific type of immune cell (T cells) causes arteries to stiffen and function poorly as people age. Researchers planned to test this by giving an existing arthritis drug, Abatacept, to healthy older adults to see if it improved artery health. …

This study aims to understand how the skin around our eyes changes with age and movement. Researchers will use motion capture technology, like in movies, to precisely measure skin movement in 60 healthy women. They will compare this new method to older tools and test if it can de…

This study aims to see if taking sex-specific food supplements for six months changes blood and saliva markers linked to aging and longevity. It will involve 60 healthy adults aged 50-70, who will take either the supplement or a placebo. Researchers will measure various health in…

This study aims to understand how nutritional counseling and combined exercise training affect markers of cellular aging in older women. It will involve 80 women aged 60-75, comparing those with normal weight and obesity. Researchers will measure changes in cell health, inflammat…

This study is exploring how different protein drinks (from milk or soy) affect chemicals in the blood and urine, as well as thinking skills and mood, in healthy older adults. Researchers are comparing drinks containing casein, whey, and soy protein in 32 participants aged 60-80. …

This study is exploring whether a gentle, non-invasive form of brain stimulation can improve walking and navigation skills in older adults who have noticed some memory changes. Researchers will use a technique called tDCS on 60 participants while they walk and do thinking tasks. …

This study aims to understand and improve the process of checking older adults' overall health before major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare staff to create a detailed map of the current system. Then, the…

This study aims to understand how sleep and daily routines affect the health of couples where one partner has mild memory problems. Researchers are observing 170 couples over time to see if sleep patterns influence memory changes and well-being in both partners. The goal is to le…