Antioxidant cocktail may shield seniors from bed rest damage

NCT ID NCT04351113

Ongoing Knowledge-focused Sponsor: Joel Trinity Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether antioxidant supplements can prevent muscle loss and blood vessel problems in older adults (ages 65-85) during five days of bed rest. Participants take either a placebo or two antioxidants (MITO-AO and PB-125) while researchers measure changes in blood flow and muscle function. The goal is to understand how inactivity harms the body and find ways to protect it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MITO-AO and PB-125 (dietary supplements)
What this could lead to: If successful, this could point toward a simple supplement strategy to protect older adults from muscle loss and blood vessel problems during hospital stays or bed rest.
What could go wrong: This is an early-stage study with only 82 participants, so results may not apply to everyone. The supplements may not work as hoped, and the study focuses on short-term bed rest, not long-term inactivity.

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Conditions

The condition(s) this trial relates to.

muscular atrophy skeletal muscle disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING ANTIOXIDANTS OXIDATIVE STRESS SKELETAL MUSCLE VASCULAR ENDOTHELIUM

Contacts and locations

Locations

VA Medical Center

Salt Lake City, Utah, 84148, United States

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