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Warm water soak could boost aging blood vessels, early study hints

NCT ID NCT06633198

Knowledge-focused Sponsor: William Hughes Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This early-phase study tests whether soaking the lower legs in warm water (42°C) for an hour can improve how small blood vessels widen in response to increased blood flow. Researchers will study 20 healthy adults aged 18-80 to see if this passive heating mimics some benefits of exercise. The goal is to understand the role of nitric oxide and cellular recycling processes in any observed improvements.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Passive heating (warm water immersion) and L-NAME (a drug used to test nitric oxide involvement)
What this could lead to
If successful, this study could point toward passive heat therapy as a way to improve blood vessel function in older adults, potentially reducing cardiovascular risk without requiring exercise.
What could go wrong
This is a very early, small study (20 participants) that only measures short-term effects. It may not translate into long-term benefits or apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must be between 18-80 yrs. of age * No more than 1 cardiovascular risk factor (see list in exclusion criteria) Exclusion Criteria: * Cardiovascular Risk Factors * Uncontrolled/unmanaged hypertension and/or use of current anti-hypertensive therapy * Current Tobacco product use or within last 6 months * BMI greater than 30 * Hyperlipidemia - diagnosed and/or taking medications to manage * Hypercholesterolemia - diagnosed and/or taking medications to manage (e.g. statins) * Type 1 or Type 2 Diabetes * Use of anti-coagulant or anti-platelet drugs * Use of beta blockers * Symptomatic coronary artery disease * Diagnosed Heart Failure (Any classification above Class I as defined by NY Heart Association) * Diagnosed renal impairment Renal impairment defined, according to National Kidney Foundation as abnormalities of kidney structure or function, present for greater than 3 months, including: * Albuminuria (ACR ≥ 30 mg/g) * Urine sediment abnormalities * Electrolyte and other abnormalities due to tubular disorders * Structural abnormalities detected by imaging * History of kidney transplantation * Decreased glomerular filtration rate (GFP \< 60 mL/min/1.73 m2) * Current Hormone Replacement Therapy Use * History of retinopathy * Documented neuromuscular disorders * Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity) * Pregnancy (Young Female subjects) * Allergies to povidone iodine * Tattoos on lower arm (forearm) * Use of erectile dysfunction medication in the past 6 months * Use of topical/non-topical steroids in last 6 months (e.g. cortisone cream) * Active anti-cancer treatment or treatment within last 12 months * Active COVID-19 or within the past 3 months * Gender Reassignment Therapy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

Contacts and locations

Locations

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

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