AGING

This study tested whether telehealth can replace in-person clinic visits for older adults who already use hearing aids. 339 participants were randomly assigned to receive hearing care either through telehealth or traditional clinic visits. The goal was to see if telehealth could …

This study tested whether a 7-day routine of warm water baths could help older women handle indoor overheating better. Sixteen participants were exposed to a simulated 10-hour heat wave before and after the baths. The goal was to see if the baths reduced body temperature spikes a…

This study tested a medication care plan to reduce falls in adults aged 60 and older living in rural Iowa. Participants worked with a health coach to safely reduce or stop taking medications that increase fall risk. The study compared fall rates between those who received the pla…

This study tested whether one year of twice-weekly leg press exercises could help older adults living in nursing homes maintain muscle mass, strength, and thinking abilities. Twenty-seven residents aged 65 and older who could walk with or without help took part. The exercises wer…

This study looked at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve blood flow, brain function, and physical fitness in healthy adults aged 65 and older. Researchers measured changes in brain blood vessels, cognitive test scores, an…

This study adapted a proven mouth care program for nursing homes to work in assisted living facilities for people with dementia. Nursing assistants were trained to provide daily mouth care and given supplies. The goal was to reduce harmful mouth bacteria that can lead to pneumoni…

This study tested whether a 6-month program combining physical exercise, cognitive training, dietary changes, and vaccinations could improve the well-being of elderly people living in long-term care facilities. 90 residents aged 70 and older took part. The goal was to see if this…

This completed trial tested a computer program that learns which reminders work best for each doctor to help them reduce high-risk medications in older patients. The study involved 70 primary care providers and over 1,200 patients aged 65 and older. The program personalized elect…

This study tested two different blood pressure tracking systems on smartphones to see if they help older adults take their medication regularly. About 200 people aged 65 and older with high blood pressure used one of the systems for six months. The goal was to see if one system i…

This study tested whether a daily beta glucan supplement, taken for 12 weeks, could improve markers of biological and immune age in 60 healthy adults aged 40 and older. Participants took two capsules of Beta Glucan 500 each day. Researchers measured changes in epigenetic markers …

This study tested whether a fermented milk drink containing Lactobacillus casei strain Shirota (sold as Yakult) could improve gut health and slow muscle loss in 132 elderly Taiwanese adults with sarcopenia. Participants drank two bottles daily for 12 weeks. Researchers measured c…

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

This study looked at whether rapamycin, a drug used to prevent transplant rejection, can improve heart function in healthy adults aged 70-95. Researchers used MRI scans to measure changes in heart pumping and blood vessel flexibility after 8 weeks of treatment. The goal was to se…

This study tested whether a 4-week program of inspiratory muscle training (using a POWERbreathe® device) could improve diaphragm thickness, reduce fatty liver, and increase aerobic capacity in 30 healthy men aged 60-80. Participants were split into a training group and a control …

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether having a dental assistant visit older adults at home every three months for professional cleaning and high-fluoride toothpaste could prevent root cavities. 194 home-living adults aged 65+ who needed daily care took part. The goal was to see if this appro…

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 adults aged 65-80 living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the prog…

This study tested whether taking a daily chicken extract or a peptide supplement for two years could help prevent memory and thinking problems in healthy older adults aged 55 to 75. A total of 276 participants were randomly assigned to receive one of the two supplements or a plac…

This study tested an 8-month exercise program for 30 people aged 90 and older. The program included warm-up walks, strength exercises with light weights, games, and stretching. Researchers measured changes in body composition, muscle strength, and cardiorespiratory fitness. The g…

This study tested whether taking 1,000 mg of glycine daily for six months could improve memory and thinking in older adults. Fifty-nine participants took the supplement, and researchers measured changes in a brain health marker and cognitive test scores. The goal was to see if th…

This study tested whether a non-invasive brain stimulation technique called tDCS could improve balance and cognitive function in older adults who have fallen at least twice in the past year and are afraid of falling. Over 100 participants received either real or sham stimulation …

This study tests whether a fun social media game can help women aged 65-85 walk more. Participants join a private Facebook group with weekly photo challenges and wear an activity tracker. The goal is to see if the game boosts daily steps compared to just using the tracker alone.

This study tested whether adding core exercises and cognitive training to standard resistance training can improve quality of life in frail older adults. Thirty-two participants aged 65 and older completed 8 weeks of training. Researchers measured anxiety, depression, thinking sk…

This study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with recurrent depression. Sixteen people aged 60 and older took part. The goal was to see if this combination improved memor…

This study tested whether adding virtual reality (VR) to standard computer-based cognitive training could improve memory, attention, and thinking skills in older adults with mild cognitive impairment. 70 participants completed a 12-week program of cognitive exercises, with one gr…

This study tested a digitally enhanced nursing discharge program for older adults recovering from limb fractures. The program uses interactive digital content and phone follow-ups to teach pain management, coping, and recovery strategies. Researchers compared it to standard care …

This small pilot study tested a 12-week machine-based Pilates program in 16 active adults aged 55-75 with chronic low back pain. Participants did two 50-minute sessions per week using special equipment like the Reformer. The goal was to see if the program could improve quality of…

This study looked at whether an 8-week group exercise program could improve physical abilities and sleep in adults aged 65 to 90. Eighty participants from community centers in Taiwan either joined the exercise program or continued their usual activities. The program included aero…

This study tested whether an 8-week program of social video chats could improve quality of life and reduce loneliness in older adults, including those with mild memory problems. 99 participants aged 65 and older were randomly assigned to either start the video chats right away or…

This study tested whether 20 hours of computer-based executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. About 119 participants were split into a training group and a no-contact control g…

This study tested whether virtual reality (VR) experiences are practical and helpful for older adults with serious illnesses living in nursing homes. 52 participants tried computer-generated or film-based VR. Researchers measured symptoms like pain and anxiety, and how relaxed th…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested a 12-week exercise program called Vivifrail in 80 elderly residents of long-term care facilities. Participants did physical training five times a week for about an hour. Researchers measured changes in physical performance, fall risk, grip strength, and overall …

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep, quality of life, and reduce hopelessness in older adults living in a nursing home. Fifty people aged 65 and older took part, with half receiving acupressure three…

This study looked at whether watching exercise videos before doing the exercises helps older adults improve their thinking, balance, tiredness, and physical abilities. 162 people aged 65 and older took part. Some did regular exercises, some watched videos of the exercises first, …

This study looked at whether gardening activities (horticultural therapy) can reduce loneliness and improve life satisfaction in older adults living in nursing homes. 54 people aged 60 and older took part. The therapy involved hands-on gardening to encourage social interaction an…

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This pilot study tested whether a Nordic walking group program could improve the physical and mental health of older adults who were evacuated from their homes to Haifa. Twenty-four participants aged 65 and older took part in 16 guided walking sessions over two months. Researcher…

This study tested whether taking a high dose of vitamin D3 daily for 12 weeks could improve muscle strength and mass in older adults with obesity. Researchers enrolled 29 participants aged 60 and older in southern Mexico. They measured handgrip strength, muscle mass, and physical…

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults (50+) living with HIV. The program teaches skills to manage stress related to aging and HIV, and encourages healthy habits like physic…

This completed study tested four topical face care products to see if they could improve facial skin longevity over eight weeks. 132 healthy adults aged 40 to 65 used the products twice daily. Researchers measured skin wrinkles with 3D imaging and asked participants about product…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study aimed to see if the program could…

This study tested a hyaluronic acid filler called RHA Redensity to improve fine lines on the cheeks. Twenty adults aged 31 and older with visible cheek lines received the filler. The goal was to see if the lines looked better after 8 weeks and if participants felt happier with th…

This study compared a 12-week adapted CrossFit program to usual activity in 60 older adults living in the community. The goal was to see if the program improved balance, mobility, and lower-body strength. Participants did supervised, safe exercises focused on functional movements…

This study tested whether playing a specially designed online video game could help adults aged 45 and older stay healthy and active. Over 500 participants in Spain were randomly assigned to play the game or receive standard online information. The game included activities to pre…

This study looked at whether high-intensity interval training (HIIT) can improve physical fitness in older adults. Thirty-nine people aged 60 and older did HIIT three times a week for 60 minutes. After the program, they showed better strength, flexibility, aerobic endurance, and …

This study tested a hyaluronic acid filler called STYLAGE® XXL against no treatment in 90 adults aged 30–65 who wanted to correct mid-face volume loss. Participants received injections in the cheek area, and researchers measured volume changes over 24 weeks. The goal was to see i…

This study tested a new gel called IPN-21-SENSE, made from hyaluronic acid, to restore lost volume in the mid-face (cheeks). 89 adults aged 30-84 who wanted cheek volume correction were randomly assigned to get the gel or no treatment. The gel was injected into the cheek area, wi…

This study tested how willing healthy seniors aged 80 and older are to use connected health devices like scales, activity trackers, and blood pressure monitors at home. 34 participants used the devices while researchers measured their comfort and acceptance through questionnaires…

This completed study followed 81 adults who had stroke-like symptoms to see how damage to the blood-brain barrier relates to white matter changes in the brain. Over 6 years, participants had regular MRI scans and thinking tests. The goal was to better understand why some people d…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study looks at how older women (65+) handle extreme heat and humidity, which is important because they face higher risks during heatwaves. Researchers will test 12 women in a hot room, slowly increasing humidity to find the exact point where their bodies can no longer cool d…

This study looked at whether a 12-week indoor cycling program could improve brain blood flow and function in 37 older veterans (ages 65-80) who did not exercise regularly. Researchers measured brain health before and after the exercise program using MRI scans. The goal was to lea…

This study tested whether an educational video and action plan, called 'Prepare for Your Diabetes Care,' could help older adults (75+) with type 2 diabetes reduce their risk of dangerously low blood sugar. Over 12 months, 669 participants were randomly assigned to receive the int…

This study looked at why some older adults (age 50 and up) maintain flu-fighting antibodies longer after getting the flu vaccine. Researchers enrolled 510 people and measured their immune response over time. The goal was to understand factors that help maintain protection, not to…

This study looked at how eating more or fewer calories affects muscle protein production and muscle size in healthy middle-aged adults during a short period of leg immobilization. Twenty-three participants were monitored under different energy intake conditions. The goal is to un…

This pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune function in aging adults. 23 sedentary adults aged 50-70 took part. The main goal was to see if the study methods were …

This study looked at 161 older adults who had hip fracture or joint replacement surgery. Researchers checked if medications with a high 'atropine load' (a measure of anticholinergic effect) were linked to postoperative confusion. They used the Confusion Assessment Method daily an…

This study looked at whether the diabetes drug metformin can slow aging in people without diabetes. Researchers wanted to see if the drug's effects depend on whether a person is insulin sensitive or insulin resistant. Over 12 weeks, 101 adults aged 40-75 took either metformin or …

This study collected fat tissue samples from 31 healthy young (18–30) and older (65+) adults. Researchers then tested in the lab how blocking a protein called MetAP2 affects aging-related markers in the fat tissue. The goal was to gather basic knowledge, not to test a treatment.…

This study tested whether a heart-rate-lowering drug called ivabradine can improve the flexibility of arteries in healthy people. 20 volunteers with a resting heart rate of 70 or higher took either the drug or a placebo for 8 days. Researchers measured artery stiffness and other …

This study enrolled 1,000 adults aged 30 and older from North Carolina to track their physical fitness, thinking skills, and daily activity over two years. Participants provided blood samples and completed tests like walking speed and memory tasks. The goal was to learn what fact…

This study looked at whether limiting when you eat (time-restricted eating) can improve how the body uses fuel and regulates daily rhythms in overweight adults aged 65 and older. Fifteen participants followed a set eating and fasting schedule for 8 weeks while researchers tracked…

This completed study looked at how regular Reformer Pilates practice affects flexibility, muscle strength, and posture in women aged 18 to 65. Researchers measured endurance and body composition in 38 healthy women. The goal was to understand how these factors change with age, ev…

This completed study looked at how emotional skills affect the way young women (45 or younger) with non-metastatic breast cancer and their partners adjust to the disease. 391 couples filled out questionnaires at several points during treatment, from before chemotherapy to after r…

This completed Phase 1 study tested whether taking L-Citrulline, a dietary supplement, for one week can improve blood vessel function in the brain and eyes of healthy young and older adults. Researchers measured brain activity and blood flow using special imaging techniques. With…

This study tested whether a daily supplement called COMP-4 could improve blood vessel function and reduce markers of aging in 32 healthy adults aged 18-39. Participants took the supplement for 14 days, and researchers measured blood vessel dilation using ultrasound and checked bl…

This pilot study tested whether protein biscuits made from insect flour (Tenebrio molitor) could improve heart health in older adults when combined with exercise. Thirty people aged 60 and older ate either insect biscuits or regular biscuits after supervised workouts for 28 days.…

This study looked at what happens when active older adults (55+) reduce their physical activity for just 3 days. Researchers measured changes in blood sugar after meals and blood vessel function, comparing them to younger adults. The goal was to see how quickly inactivity can aff…

This small, early study tested whether drinking beetroot juice (which is rich in natural nitrates) could improve artery stiffness and brain blood vessel function in adults aged 50 to 79. Sixteen participants were randomly given either nitrate-rich or nitrate-depleted beetroot jui…

This study tested whether a ketone drink improves muscle function in 25 healthy men (12 young, 12 older). Participants drank a ketone monoester and underwent MRI scans, tracer infusions, and bike/dynamometer tests. Researchers compared results within and between age groups to see…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study looked at whether a 4-week moderate resistance training program could improve diaphragm thickness, liver fat, and quality of life in healthy men aged 60-75. Thirty participants were split into an exercise group or a control group that kept their normal routine. Researc…

This study looked at whether a 10-week Taekwondo program could improve physical and mental function in adults over 60. Forty participants either took Taekwondo classes twice a week or continued their normal routine. Researchers measured balance, strength, fitness, and thinking sk…

This observational study enrolled 94 women with breast cancer to see if it's possible to collect blood, stool, and survey data from older patients taking aromatase inhibitors (a type of hormone therapy). The main goal was to test the feasibility of gathering this information for …

This study looked at how to best help emergency room doctors avoid prescribing potentially harmful medications to older veterans. Researchers compared two methods: giving doctors regular reports on their prescribing habits (passive feedback) versus having them actively discuss an…

This study looked at 100 overweight veterans to see if losing weight and doing aerobic exercise could lower inflammation linked to aging. Researchers measured inflammatory chemicals from fat tissue and checked fitness, body composition, and blood sugar. The goal was to understand…

This study tested whether using a breathing training device (PrO2 Fit) four times a week for 8 weeks could improve cardiovascular health and mood in postmenopausal women aged 50-75. Researchers measured how quickly the women's oxygen use responded during exercise and how far they…

This study tested whether time-restricted eating (eating only during certain hours of the day) could improve blood vessel health and brain function in older adults at risk for age-related memory decline. Researchers measured changes in brain blood flow and electrical activity in …

This pilot study tested whether a very low carbohydrate ketogenic diet or a Mediterranean diet affects bone health and muscle function in older adults. Twelve postmenopausal adults followed each diet for six weeks. The goal was to see if these diets are safe and worth studying fu…

This study looked at how reducing daily steps by about 70% affects blood vessel function and muscle health in older adults. Researchers measured blood flow in arm and leg arteries to understand the role of oxidative stress. The goal is to learn why inactivity leads to muscle loss…

This study tested a plant-based supplement called LLP-01 in 32 healthy adults aged 50 to 75. Researchers measured changes in blood markers related to inflammation and heart health, as well as grip strength and well-being. The goal was to see if the supplement could improve these …

This study tested whether daily paced breathing combined with brain training games could improve attention, memory, and reduce Alzheimer's-related markers in healthy adults aged 50-70. Participants did brain training and paced breathing at home for 10 weeks, and provided blood an…

This study looked at whether a more intense physical therapy program helps older adults recover better after a hospital stay in skilled nursing facilities. Over 4,300 people took part. The goal was to see if this approach improves walking speed and overall physical function.

This study looked at how aging changes certain enzymes (proteins) in the blood and colon. Researchers collected blood and colon tissue samples from 21 healthy adults, both younger (18-50) and older (65-80). They also checked if the HIV medications tenofovir and emtricitabine affe…

This study surveyed 47 older adults (65+) at a frailty clinic in France to learn about their use and understanding of cannabidiol (CBD). The goal was to gather information to help guide safe CBD use and prevent potential side effects in this age group. No treatment was given; it …

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults aged 18 and older. Researchers aimed to see how these movements change from young adulthood to old age. The study involved 53 participants a…

This study looked at how the brain processes emotional images in healthy aging. Researchers used MRI scans to compare brain activity in younger adults (18-45) and older adults (60-85) while they judged emotions or imagined actions. The goal was to understand why older adults may …

This study worked with 23 adults aged 50 and older who have memory concerns to design online mindfulness and lifestyle education programs. Participants joined focus groups to share their views on healthy living and web-based interventions. Their feedback will help shape future cl…

This study tested whether having healthcare workers wear a special suit that mimics the physical challenges of aging could increase their empathy toward older adults. 82 nurses, therapists, and other staff from four nursing homes took part. Half wore the suit and did everyday tas…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild memory problems. Fifty-three volunteers aged 60 and over took part in the training. The goal was to see if this creative activity cou…

This pilot study tested whether freeze-dried blueberry powder can boost flavonoid levels and reduce inflammation in older adults with mild depressive symptoms. Six participants aged 65 and older consumed either a standard or higher dose of blueberry powder for three days. Researc…

This study looked at how short-term pain impacts the ability to learn and remember new walking patterns in 61 healthy young (18-35) and older (55-85) adults. Researchers measured how well participants learned and retained a new way of walking while experiencing acute pain. They a…

This study looked at how inflammation affects feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure reward responses. The goal was to better understand the link between anxiety, inflammation, and …

This completed study from Duke University looked at 297 older adults (60+) undergoing knee replacement surgery. Researchers measured physical activity, pain, thinking skills, and immune responses before and after surgery to understand what helps people recover well. The goal was …

This completed study looked at how muscle size and strength change in older adults with type 2 diabetes during bed rest and exercise. Researchers studied 95 participants to find targets for future treatments to prevent muscle loss and disability. The goal is to improve health and…

This study looks at how one session of moderate-to-hard walking or jogging changes the brain's response to insulin in adults aged 40 to 80 who are overweight or obese. Researchers will use MRI scans to measure brain insulin sensitivity and also test memory, thinking, and heart he…

This study used a wearable ring and sleep diaries to track sleep patterns in 18 healthy older adults over six weeks. Researchers also tested their balance and thinking skills to see how these factors relate. The goal was to better understand how sleep affects mobility and brain f…

This completed study looked at how brain wave patterns change with age during desflurane anesthesia. Researchers recorded brain activity from 47 adults and elderly patients undergoing surgery. They analyzed different brain wave features to understand how aging affects the brain's…

This pilot study tested whether older adults with extra weight could stick to either eating fewer calories or eating only within an 8-hour window for 9 months. About 90 people took part, with some getting in-person coaching and others doing it remotely. The goal was to see if the…

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study looked at how heat waves impact the heart and body temperature in healthy older adults (65+) compared to younger people. Researchers measured core body temperature and heart function during simulated heat wave conditions. The goal was to understand the risks so we can …

This study looked at how smoking cannabis affects balance, walking, and attention in 25 older women, some with HIV and some without. Participants smoked either a low-THC cannabis cigarette or a placebo, then did walking and thinking tests. The goal was to understand why cannabis …

This study tested whether a fiber supplement called inulin changes how the body processes certain fatty acids in people with chronic obstructive pulmonary disease (COPD). Researchers compared 87 participants, including COPD patients and healthy older and younger adults, over 7 da…

This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatm…

This study tested whether mild electrical brain stimulation (tDCS) could help 72 older adults (65+) learn and remember a complex walking task, like stepping over obstacles. Participants practiced walking while receiving either real or fake (sham) stimulation. The goal was to see …

This study tested whether mentally practicing finger movements (motor imagery) combined with a mild electrical brain stimulation (tDCS) could improve learning of a complex finger sequence in both young (20-35) and older (65-80) healthy adults. 64 participants were split into four…

This study looked at 64 adults over 65 to see if easy bedside tests—like measuring muscle size with ultrasound—can predict cardiorespiratory fitness. Participants did a cycling test to measure their maximum oxygen uptake. The goal is to find simpler ways to assess fitness without…

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older and their caregivers. Researchers analyzed medical records and interviewed participants to understand the impact of lockdowns, reduced physical activity, and so…