AGING

This project adapted a program that helps nursing home residents with dementia get daily mouth care to reduce bacteria that can cause pneumonia. The goal was to make it work for assisted living residents with dementia. Over 1,400 residents took part, and the program was taught to…

This study looked at whether having a dental professional clean the teeth of older adults in their own homes can prevent root cavities. The researchers enrolled 194 people aged 65 and older who needed help with daily care. They compared those who got professional cleaning plus hi…

This study tested whether a 6-month program combining physical and mental exercises, special foods, and vaccines could improve the health of elderly people living in nursing homes. 90 residents aged 70 and older took part. The goal was to see if this combined approach was practic…

This study looked at whether a 10-week Taekwondo program could improve physical and mental function in adults aged 60 and older. Forty participants were split into a Taekwondo group (training twice a week) or a waiting-list group. Researchers measured balance, strength, fitness, …

This study tested whether rapamycin, a drug used to prevent transplant rejection, can improve heart function in healthy adults aged 70 to 95. Researchers used MRI scans to measure changes in heart pumping and blood vessel flexibility after 8 weeks of treatment. The goal was to se…

This study looked at whether hyperbaric oxygen therapy (HBOT) can improve blood flow and brain function in healthy older adults. 62 people aged 65 and older received HBOT sessions. Researchers measured changes in brain blood vessels, cognitive test scores, and exercise capacity. …

This pilot study tested whether a telehealth program combining strength training, balance exercises, and nutrition advice could help older men at high risk for falls and fractures. Forty-five men aged 60 and older participated. The goal was to see if the program was practical and…

This study tested a blood pressure monitoring system to help older adults (65+) stick to their hypertension medication. 200 participants used the system for 6 months, with one group also getting extra strategies. The goal was to see if the system improved how consistently they to…

This study tested a program of diet, exercise, and the diabetes drug metformin in 114 older veterans (ages 65-85) who were obese and frail. The goal was to see if this combination could improve their physical function, strength, and mobility better than lifestyle changes alone. T…

This study tested a personalized medication care plan for older adults (60+) living in rural areas. The goal was to reduce falls by safely stopping or lowering medications that increase fall risk. About 400 participants from primary care clinics took part, with some receiving the…

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 older adults living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the program m…

This study tested whether a daily chicken extract and peptide supplement could prevent or slow cognitive decline in older adults without dementia. Over 2 years, 276 participants aged 55-75 with normal cognition or mild memory issues took either the supplement or a placebo. The st…

This study looked at whether high-intensity interval training (HIIT) can help older adults stay fit and independent. 39 people aged 60 and older did a special HIIT program with short bursts of activity. The results showed improvements in muscle strength, flexibility, and enduranc…

This study looked at whether virtual reality (VR) experiences are practical and helpful for seriously ill older adults living in nursing homes. Researchers tested two types of VR—computer-generated and film-based—to see if they could improve relaxation and ease common symptoms li…

This study tested whether 20 hours of executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. 119 participants were split into a training group and a no-contact control group. The goal was to…

This study tested whether a gel filler called STYLAGE® XXL can restore lost volume in the mid-face (cheek area) better than no treatment. 90 adults aged 30 to 65 who wanted cheek correction took part. The main goal was to measure volume change 24 weeks after a single treatment.

This study tested whether a non-invasive brain stimulation technique called tDCS could improve balance and cognitive function in older adults who have fallen at least twice in the past year. 118 participants received either real or sham stimulation over 20 sessions. The goal was …

This study looked at whether gardening activities (horticultural therapy) can reduce loneliness and improve life satisfaction in elderly people living in nursing homes. 54 adults over age 60 took part, with some doing gardening and others not. The goal was to see if interacting w…

This study tested four topical creams and serums to see if they could improve skin longevity and reduce wrinkles over eight weeks. 132 healthy adults aged 40 to 65 used the products and had their skin measured with 3D imaging and questionnaires. The goal was to see if the product…

This study looked at whether remote hearing care (telehealth) works as well as in-person clinic visits for older adults who already use hearing aids. About 339 people aged 70-84 took part. The goal was to see if telehealth helps them use their hearing aids more and feel more sati…

This study looked at whether acupressure—a gentle, non-invasive technique—can improve sleep, quality of life, and feelings of hopelessness in older adults living in nursing homes. Fifty people aged 65 and older took part. One group received acupressure three times a week for four…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help them manage their pain and mood. The study measured changes in pain int…

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults with HIV. The program teaches skills to manage stress and adopt healthier habits. Fifty people aged 50 and older with well-controlled …

This study looked at whether an 8-week program of social video chats could help older adults (65+) with or without mild memory problems feel less isolated and lonely. About 99 participants were split into two groups: one started the video chats right away, and the other waited. T…

This study looked at whether a group Nordic walking program could improve the physical and mental health of older adults (65+) who were evacuated from their homes to Haifa. Twenty-four participants walked together twice a week for two months using special poles. Researchers measu…

This study looked at whether taking a daily high-dose vitamin D3 pill (10,000 IU) for 12 weeks could improve muscle strength and muscle mass in 29 older adults (60+) with obesity in southern Mexico. Participants had their grip strength, muscle mass, and physical performance measu…

This study looked at whether watching exercise videos before doing the exercises helps older adults think better, keep their balance, feel less tired, and move more easily. 162 people aged 65 and older took part. Some did regular exercise, some watched exercise videos then exerci…

This study looked at whether a year of special resistance training (focused on movement speed) could help older adults living in nursing homes. 27 people took part, doing exercises to improve muscle power, strength, and daily function. The goal was to see if this training could s…

This small study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with a history of depression. Sixteen people aged 60 and older with recurrent depression took part. The goal was to see…

This study tested whether a 4-week breathing exercise program (inspiratory muscle training) could improve diaphragm thickness, reduce fatty liver, and boost exercise capacity in 30 healthy men aged 60-80. Participants were split into a training group and a control group. Research…

This study tested a 12-week exercise program called Vivifrail in 80 elderly residents of long-term care facilities. Participants were randomly assigned to either the exercise group or a control group. The program aimed to improve physical performance, grip strength, and reduce fa…

This study tested whether an Apple Watch, a new app, and weekly health coaching could help dementia caregivers improve their sleep and mood. 21 caregivers wore the watch to track their activity and sleep patterns, and received personalized feedback and support for up to 6 weeks. …

This study tested a new hyaluronic acid gel called IPN-21-SENSE to see if it could restore lost volume in the mid-face area. 89 adults aged 30 to 84 who wanted mid-face correction took part. The gel was compared to no treatment, and the main goal was to measure volume change afte…

This study tested whether a fermented milk drink containing a specific probiotic (Lactobacillus casei Shirota) could help elderly Taiwanese people with sarcopenia, a condition of age-related muscle loss. Researchers measured changes in gut bacteria, muscle strength, and walking s…

This study tested a hyaluronic acid filler called RHA Redensity to improve fine lines on the cheeks. Twenty adults aged 31 and older with visible cheek lines received the treatment. The goal was to see if the filler could reduce the appearance of these lines after 8 weeks.

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older, as well as their caregivers. Researchers analyzed medical records and interviewed groups to understand new care needs. The goal is to improve healthcare servic…

This study looked at whether a gentle, non-invasive brain stimulation technique can help older adults learn and remember complex walking tasks, like stepping over obstacles. Researchers used MRI scans to see how the brain changes with practice. The goal is to find new ways to mak…

This study looked at how periods of reduced activity, like after surgery or injury, affect blood vessel function and muscle health in older adults. Researchers measured blood flow in the arm and leg to understand the role of oxidative stress. The goal is to find ways to prevent d…

This small pilot study looked at how well blueberry flavonoids are absorbed and whether they can lower inflammation in older adults (65+) who have mild depressive symptoms. Six participants took either a standard or higher dose of blueberry powder, and researchers measured change…

This study looked at how quickly cutting back on physical activity for just 3 days can harm blood vessel function and raise blood sugar after meals in active older adults (55+). Researchers compared them to younger adults (18-40) to see if age makes the effects worse. The goal is…

This study tested whether personalized electronic health record tools, powered by a smart computer program, could help primary care doctors reduce or stop risky medications in older adults aged 65 and over. The study involved 70 doctors and 1,249 patients over 30 weeks. The goal …

This study looked at 95 older adults to understand why muscle loss speeds up in people with type 2 diabetes or after a hospital stay. Researchers measured leg muscle and knee strength to find clues. The goal is to discover new targets for treatments that could help older people s…

This study looked at how emotional skills of young women (45 or younger) with non-metastatic breast cancer and their partners influence their ability to cope with the disease and treatment. About 391 couples participated, completing surveys during chemotherapy and follow-up. The …

This study looked at whether medications with a high 'atropine load' increase the risk of confusion after hip fracture or joint replacement surgery in older adults. Researchers tracked 161 patients, checking their drug use and confusion levels daily. The goal is to help doctors c…

This study tested whether having healthcare workers wear a special suit that mimics the physical challenges of aging (like stiff joints and blurred vision) could increase their empathy for elderly patients. 82 nurses, therapists, and other staff from four nursing homes took part.…

This study looked at how heat waves impact the heart and body temperature in older adults. Researchers measured changes in core body temperature and heart function in 59 healthy volunteers aged 18-35 and 65+. The goal was to understand the risks, not to test a treatment.

This study looked at how limiting eating to certain hours of the day (time-restricted eating) affects energy use and daily body rhythms in overweight adults aged 65 and older. Researchers used wearable rings and blood tests to track changes in metabolism, sleep, and activity. The…

This study looked at how a fiber supplement (inulin) changes gut health in people with COPD compared to healthy older and younger adults. Researchers measured short-chain fatty acids, which are made when gut bacteria break down fiber. The goal was to understand differences in gut…

This study looked at how short-term pain impacts the ability to learn and remember new walking patterns in 61 healthy young (18-35) and older (55-85) adults. Researchers measured how well participants learned and retained a new way of walking while experiencing pain, and compared…

This study looked at how the brains of younger (18-45) and older (60-85) adults process emotional images. Researchers used MRI scans to see which brain areas activate when people judge emotions or think about taking action. The goal was to understand normal changes in emotional p…

This study tested whether a drug called ivabradine, which lowers heart rate, can improve the flexibility of arteries in healthy people. 20 volunteers aged 25-65 with a resting heart rate of 70 or higher took either ivabradine or a placebo for 8 days. Researchers measured artery s…

This study tested whether imagining a finger movement (motor imagery) combined with a gentle electrical current to the brain (tDCS) could improve learning of a complex finger sequence. 64 healthy young and elderly adults participated. The goal was to see if this combination boost…

This study tested how a very low-carbohydrate ketogenic diet compares to a Mediterranean diet for bone health and muscle function in older adults. Researchers enrolled 12 postmenopausal men and women to see if the diets affect bone metabolism and muscle decline. The goal was to g…

This study looked at how eating more or fewer calories than normal affects muscle maintenance in healthy middle-aged adults during a short period of leg immobilization. Researchers measured daily muscle protein building rates and muscle size changes using MRI. The goal was to und…

This study tested whether drinking a ketone monoester improves how muscles work in healthy young (20-25) and older (65-85) men. Participants performed bike and strength tests while researchers used special imaging and tracer infusions to measure muscle efficiency. The goal was to…

This study looked at whether a 4-week moderate strength training program could help healthy men aged 60-75 by improving diaphragm thickness (a key breathing muscle), reducing liver fat, and enhancing quality of life. Thirty participants were split into an exercise group and a con…

This study looked at whether a supplement called COMP-4 can help blood vessels work better and reduce signs of aging in healthy adults aged 18-39. Researchers measured blood flow in the arm and checked for aging markers in the blood after 14 days of taking the supplement. The goa…

This study looked at how age changes brain wave patterns during anesthesia with desflurane. Researchers monitored 47 adults having surgery, measuring brain activity before, during, and after anesthesia. The goal was to understand aging's effect on brain signals, not to test a tre…

This study followed 81 adults who had stroke-like symptoms to see if damage to the blood-brain barrier is linked to white matter changes in the brain that can cause mental decline. Participants had MRI scans and thinking tests over 6 years. The goal was to learn more about how th…

This study tested whether a supplement called L-Citrulline can improve blood vessel function in the brain and body of healthy young and older adults. Twenty participants took the supplement and had their brain activity and blood flow measured using special scans. The goal was to …

This study tested whether a specially designed video game could help adults aged 45 and older stay healthy and active as they age. Over 500 people in Spain were randomly assigned to play the game or read online information about aging. Researchers measured their health and well-b…

This study looked at whether older adults who need to lose weight can follow either a reduced-calorie diet or a time-restricted eating plan (eating only within an 8.5-hour window each day) for 9 months. About 90 people took part, and researchers measured how well they stuck to th…

This study looked at whether a 12-week adapted CrossFit program could improve balance, mobility, and leg strength in older adults living in the community. Sixty participants were randomly assigned to either the exercise program or their usual routine. The main measure was the Tim…

This study looked at how one session of exercise affects the brain's ability to respond to insulin in adults aged 40 to 80 who are overweight or obese. Researchers measured brain blood flow and thinking skills before and after exercise. The goal is to understand how exercise migh…

This study tested a social robot that plays trivia and gives reminders to people with Alzheimer's or other dementias living in assisted care. The goal was to see if the robot helps improve engagement, mood, and quality of life. 26 residents, family members, and staff took part. T…

This study looked at how sleep affects balance and thinking in healthy adults aged 65 and older. Over six weeks, 18 participants wore an OURA ring and kept a sleep diary while doing balance and memory tests. The goal was to understand daily connections between sleep, mobility, an…

This study looked at fat tissue from 31 healthy adults (young and older) to see how blocking a protein called MetAP2 changes aging-related markers in the lab. No drugs were given to participants—only tissue samples were studied. The goal was to learn more about aging, not to trea…

This study tested a set of tablet games called VibrantMinds in 26 older adults with mild cognitive impairment or dementia. The games are designed to measure thinking skills like memory and attention in a fun, engaging way. Researchers want to see if these games can work as well a…

This study tested a plant-based supplement (LLP-01) in 32 healthy adults aged 50-75 to see if it changed blood markers related to inflammation and heart health. Participants took the supplement or a placebo for 2 months. The goal was to gather information, not to treat any diseas…

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults. Researchers compared these movements across different ages to see how brain pulsatility changes from adulthood to old age. The goal was to …

This study looked at whether training the muscles used for breathing can improve heart function and mood in women who have gone through menopause. Researchers measured how quickly the body adjusts to exercise and how far participants could walk in six minutes. The study involved …

This study looked at how menopause affects brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used brain scans and memory tests to see how the brain's cholinergic system responds to hormone changes. The goal is to identify which women are more…

This study looked at whether it's possible to collect blood, stool, and survey data from women aged 65 and older who are taking hormone therapy for breast cancer. The goal was to gather information on how this treatment might affect aging and gut bacteria. 94 women took part, and…

This pilot study tested whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune health in adults aged 50-70. The main goal was to see if the approach was feasible, not to prove it works. Only 23 people…

This study looked at whether easy-to-do bedside tests, like measuring muscle size and physical function, can predict how fit older adults (over 65) really are. Researchers tested 64 independent seniors using a special exercise bike to measure their maximum oxygen use. The goal wa…

This study looked at how cannabis affects thinking, balance, and walking in 25 older women, some with HIV and some without. Participants took either cannabis or a placebo, then did tests like walking while reciting letters and reaching forward without losing balance. The goal was…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild cognitive impairment. 53 participants aged 60+ with little to no music background took part. The goal was to see if improv training c…

This pilot study tested whether eating biscuits made with insect protein (from mealworms) along with a structured exercise program could improve heart health in older adults. 30 people aged 60 and older took part for 28 days. Researchers measured changes in cholesterol, blood pre…

This study looked at how regular Reformer Pilates affects flexibility, muscle strength, and posture in women aged 18 to 65. Researchers tested 38 women using simple exercises like the sit-and-reach test and a 3D body scanner. The goal was to see how these traits change with age, …

This study tested whether metformin, a common diabetes drug, can slow aging in healthy adults aged 40 to 75. Researchers gave metformin or a placebo to 101 participants for 12 weeks to see how it affected insulin sensitivity, blood sugar control, and mitochondrial function. The g…

This study tested whether time-restricted eating (eating only during certain hours) could improve blood vessel and brain function in adults aged 55 to 80. Researchers measured changes in brain blood flow and cognitive performance. The goal was to see if this eating pattern might …

This study looked at two methods to help emergency room doctors prescribe safer medications for older veterans. The goal was to reduce the use of drugs that can be harmful for people aged 65 and older. Researchers compared giving doctors simple reports versus more active feedback…

This study looked at 556 people to understand why some with early age-related macular degeneration (AMD) have trouble seeing in the dark. Researchers used advanced eye imaging to map how changes in the retina affect night vision recovery. The goal was to find better ways to measu…

This early-phase study looked at whether drinking beetroot juice (rich in natural nitrates) could improve artery stiffness and brain blood flow in adults aged 50-79. Sixteen participants were randomly given either nitrate-rich or nitrate-free beetroot juice. The goal was to see i…

This study looked at whether daily breathing exercises could influence memory, attention, and blood markers linked to Alzheimer's disease. Healthy adults aged 50-70 did memory training plus either relaxing or alertness-boosting breathing for 10 weeks. Researchers measured changes…

This study looked at how inflammation changes the brain's reward system in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure loss of pleasure and motivation after an inflammatory challenge. The goal was to understand the link betwe…

This study surveyed 47 older adults (65+) in France to understand how much they know about cannabidiol (CBD) and whether they use it. The goal was to gather information to help guide safe CBD use and prevent potential side effects in this age group. Participants completed a quest…

This study enrolled 1,000 adults aged 30 and older from North Carolina to track their physical and mental abilities over two years. Researchers collected biological samples and measured factors like physical activity and cognitive function. The goal is to better understand how ag…

This study aimed to create online, self-paced mindfulness and lifestyle education programs for adults aged 50 and older who have memory concerns but normal thinking skills. Researchers held focus groups with 23 participants to discuss healthy living, program content, and desired …

This study looked at how age and body fat affect inflammation in 100 veterans. Researchers wanted to see if losing a moderate amount of weight and increasing aerobic exercise could lower inflammation. The goal was to understand the link between body fat, aging, and health risks l…

This study looked at whether taking a beta glucan supplement (Beta Glucan 500) for 12 weeks could change markers of biological and immune age in healthy adults aged 40 and older. 60 participants took two capsules daily. The goal was to see if the supplement could slow down aging …

This study looked at whether high-intensity rehabilitation can improve recovery for older adults admitted to skilled nursing facilities after a hospital stay. Over 4,300 people took part. The goal was to see if this approach works and can be put into practice widely.

This study looked at how well people aged 60 and older recover physically and mentally after a planned knee replacement. Researchers measured things like daily steps, pain, thinking skills, and immune responses in 297 participants. The goal was to understand what helps some peopl…

This study aimed to understand how aging affects specific enzymes in the body that are needed to activate a common HIV prevention and treatment drug. Researchers collected blood and colon tissue samples from 21 adults of different ages, some taking the drug and some not, to measu…

This study aimed to measure how often older adults with diabetes living in nursing homes experience dangerously low blood sugar levels. Researchers used continuous glucose monitors on 86 residents for 10 days to track blood sugar patterns. The goal was to better understand this h…