Stroke study aims to unlock mystery of white matter brain changes

NCT ID NCT03366129

Completed Knowledge-focused Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study followed 81 adults who had stroke-like symptoms to see how damage to the blood-brain barrier relates to white matter changes in the brain. Over 6 years, participants had regular MRI scans and thinking tests. The goal was to better understand why some people develop mental decline after a stroke.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help explain why some stroke patients develop thinking problems, pointing toward ways to prevent or slow that decline.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to any direct medical benefit, and results may not apply to all stroke patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebrovascular disorder stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING CEREBROVASCULAR DISORDER STROKE

Contacts and locations

Locations

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Suburban Hospital - Johns Hopkins

Bethesda, Maryland, 20814, United States

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