National Institute Of Neurological Disorders And Stroke (ninds)

This study looks at deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve with other treatments. DBS uses a device like a pacemaker to send electrical signals to parts of the brain that control movement, helpi…

This study looks at whether removing a brain tumor and the nearby area where seizures start can reduce or stop seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery impr…

This study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with HAM/TSP, a rare progressive disease that causes leg weakness and other serious problems. About 24 adults with HAM/TSP will take the drug daily for 9 months. Researchers will c…

This study provides deep brain stimulation (DBS) therapy to 300 adults with Parkinson's disease, dystonia, or essential tremor. DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement, aiming to reduce symptoms like shaking and stiff…

This study tests brain surgery as a treatment for people with epilepsy that medication cannot control. It includes children and adults aged 8 and older who have partial seizures starting in one area of the brain. The goal is to remove or treat the seizure-causing brain area to st…

This study uses botulinum toxin (Botox) injections to treat movement disorders like dystonia, tremors, and spasms. It aims to improve symptoms and train doctors in injection techniques. Up to 2000 people aged 2 and older with these conditions can join. Treatment is ongoing and do…

This study aims to see if a PET scan after a drug called desmopressin can find tiny pituitary tumors in people with Cushing's disease that standard MRI scans miss. About 22 participants aged 8 and older with Cushing's disease and negative or unclear MRI results will receive the P…

This study looks at whether a short, high-dose course of corticosteroids can help heal a specific type of brain lesion in people with multiple sclerosis (MS). About 30 adults with MS who have a ring-enhancing lesion on their MRI will either receive the steroid treatment or no tre…

This study aims to understand how multiple sclerosis (MS) damages the brain and spinal cord over a person's lifetime. Researchers will follow 250 adults with MS or similar conditions, using yearly MRI scans, eye tests, and other exams. Participants agree to donate their brain and…

This study looks at whether giving magnetic pulses to the brain at the right moment in your natural brain wave cycle can make movement training more effective. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to understand how th…

This study is testing whether a special MRI dye called mangafodipir is safe and can show areas where the blood-brain barrier is broken in people with epilepsy that doesn't get better with medication. About 40 adults aged 18-60 will get the dye and have several MRI scans over a fe…

This study looks at why some people with HIV who have the virus well-controlled by medication still develop problems with memory, concentration, and thinking. Researchers will compare people with HIV and healthy volunteers over up to 10 years using brain scans, blood tests, and s…

This study tests a small MRI coil placed inside the nose during pituitary tumor surgery to get clearer images. It includes 70 adults with pituitary tumors who are already scheduled for surgery. The goal is to see if the coil is safe and helps doctors find small tumors that standa…

This study compares a new portable ultra-low field (ULF) MRI to standard MRI for detecting brain diseases like stroke, cancer, and epilepsy. About 200 people (ages 3 and older) with or without neurological symptoms will get both scans to see if the portable version works just as …

This study aims to improve MRI technology by scanning healthy volunteers. Researchers want to collect data to make MRI measurements more accurate and reliable. Participants must be 18 or older and in good health. They will have one or more MRI scans of the brain, liver, or other …

This study follows up to 1,590 adults who had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the different ways people recover and to design future studies on lo…

This study looks at whether brain activity can predict when someone will make a mistake during a typing task, up to 1 second before it occurs. Researchers will use brain scans (MRI and MEG) to compare brain patterns before errors versus correct actions. The goal is to understand …

This study aims to find better ways to measure how spinal and bulbar muscular atrophy (SBMA) progresses. Researchers will follow 70 men with and without SBMA for up to 2 years, using muscle tests, imaging scans, and lab tests. The goal is to identify reliable markers of disease c…

This study aims to improve how doctors locate the exact spot in the brain causing seizures in people with epilepsy that doesn't respond to medication. Researchers will use advanced MRI and other brain scans to create a detailed map of normal brains, then compare them to the brain…

This study is testing a new, painless technique called electrical impedance myography (EIM) to measure muscle health. Researchers will use a mild electric current on the skin to see how it travels through muscles in both healthy volunteers and people with neuromuscular diseases. …

This study aims to understand how the binding of RNA with DNA (called R-loops) is linked to amyotrophic lateral sclerosis type 4 (ALS4) and other inherited neurological disorders. Researchers will observe up to 330 people aged 5 and older, including those with ALS4, related condi…

This study aims to find out if brain and muscle sensors can tell the difference between organic tics (caused by a diagnosed disorder) and functional tics (caused by problems in how the brain and body communicate). Researchers will monitor 75 adults aged 18 to 80, including people…

This study gathers medical information from 200 adults with nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Researchers will perform standard tests like nerve conduction studies, muscle exams, and sweat tests to create a database for…

This study aims to better understand stroke and mini-strokes (TIAs) by observing up to 4,000 adults who have had or are at risk for these conditions. Researchers will collect data from standard medical tests and some extra research tests, like blood draws and brain scans, to trac…

This study aims to learn more about how infections and inflammation harm the brain and nervous system. Researchers will observe up to 1,000 people aged 2 and older who have or may have a nervous system infection or inflammation. By collecting samples and performing tests like MRI…

This study aims to improve how doctors observe nerves and muscles using ultrasound, a safe imaging technique. Researchers will collect normal measurements from healthy adults and compare them to people with neuromuscular disorders like muscular dystrophy or peripheral neuropathy.…

This study aims to develop better MRI methods for looking at the brain's structure and activity. Healthy adults aged 18 and older will have yearly MRI scans, sometimes while doing simple tasks like listening or tapping fingers. The goal is to improve imaging technology, not to tr…

This study uses MRI scans to watch how multiple sclerosis (MS) changes in the brain over time. Researchers will follow up to 3750 people, including those with MS, those starting new treatments, and healthy volunteers. The goal is to better understand how the disease progresses an…

This study aims to collect information from people with movement disorders (like tremors or Parkinson's disease) and their family members. Participants will have one visit at the NIH clinic for exams, tests, and questions. No new treatments are given, but the data will help resea…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen up to 360 adults with these conditions using tests like memory exams, movement assessments, MRI scans, and genetic tes…

This study gathers medical information and samples from people with neurosurgical disorders (like brain tumors, epilepsy, or Parkinson's) during their regular care. It aims to build a database for future research, not to test new treatments. Up to 5,000 participants aged 4 and ol…

This study follows people with HTLV-I-associated myelopathy (HAM/TSP), a rare spinal cord disorder, to learn how the disease changes over time. Up to 750 participants, including infected individuals, family members, and healthy volunteers, will provide blood and spinal fluid samp…

This study aims to understand Gulf War Illness (GWI), a condition affecting up to 210,000 veterans with symptoms like fatigue, pain, and memory problems. Researchers will compare 85 Gulf War veterans—some with GWI and some without—using extensive tests over a 2-week hospital stay…

This study follows 75 people with congenital myasthenic syndromes (CMS) for up to 5 years to see how the disease changes over time. Participants will have regular tests like heart and lung checks, muscle ultrasounds, and MRI scans. The goal is to better understand CMS and improve…

This study tests whether a special radioactive tracer can help PET scans find certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults will receive the tracer and u…

This study uses brain scans (MRI) to see which parts of the brain are active when people with chronic fatigue syndrome (ME/CFS) feel pain or physical effort. Researchers want to understand why these sensations may feel more unpleasant for some people. The study involves 47 adults…

This study follows 269 people aged 8 to 75 with neurofibromatosis type 2 (NF2) for up to 10 years. Researchers will track tumor growth, hearing, speech, and swallowing through yearly MRIs, hearing tests, and exams. The goal is to better understand how NF2 progresses, not to test …

This study looks at families with inherited movement disorders to find the genes responsible. Researchers will use advanced technology to make accurate diagnoses and understand the disease's root causes. Up to 2,500 people with movement disorders and their family members can join…

This study looks at why some people keep their thinking skills after a stroke while others don't. Researchers will interview 450 adults who had a stroke and had a brain scan. They want to see how things like education, race, and income affect memory and attention over time.

This study aims to learn more about epilepsy, especially in people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like EEGs, MRIs, and memory assessments. The goal is to better understand these se…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect medical images, blood, and spinal fluid over time to learn how the disease progresses and affects the immune system. No tre…

This study aims to understand how the brain responds to sounds during sleep using fMRI and EEG. Healthy volunteers aged 18-34 will sleep in an MRI scanner while their brain activity is recorded. Sounds will be played to see what brain patterns occur before waking up. The goal is …

This study looks at people with inherited neurological disorders to learn how these diseases develop and change over time. Researchers will collect medical history, do physical exams, and take blood or skin samples for genetic testing. Up to 3,500 children and adults with these r…

This study aims to find out if people with long COVID still have inactive pieces of the SARS-CoV-2 virus hiding in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long-term nerve symptoms and some without. The goal …