National Institute Of Neurological Disorders And Stroke (ninds)

This study tests a new drug called LMP744 in people whose glioblastoma has come back after standard treatment. The drug is designed to kill cancer cells by blocking a key growth signal and interfering with DNA repair. Participants will receive the drug through a vein for 5 days e…

This study uses botulinum toxin (Botox) injections to treat movement disorders such as dystonia, tremor, and spasticity. Up to 2,000 participants aged 2 and older will receive tailored injections, with doctors trained in proper techniques. The goal is to manage symptoms and build…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This phase 2 trial tests the safety of brincidofovir, an antiviral drug, in 24 adults with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Participants receive the drug intravenously twice a week for up to 12 weeks, with follow-up …

This phase 2 trial tests whether a 3-day course of high-dose corticosteroids (methylprednisolone or prednisone) can help heal ring-enhancing brain lesions in people with multiple sclerosis. Thirty adults with MS and a specific type of active lesion will be randomly assigned to re…

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with a rare spinal cord disease called HAM/TSP caused by the HTLV-1 virus. About 24 adults will take the drug daily for 9 months to see if it reduces harmful immune activity and im…

This study tests brain surgery as a treatment for people whose epilepsy doesn't improve with medication. About 300 children and adults aged 8 and older will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, tho…

This study is testing deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve enough with medication. DBS uses a device like a pacemaker to send electrical pulses to specific brain areas that control movement. R…

This study tests whether a special PET scan, combined with a drug called desmopressin, can find tiny pituitary tumors that standard MRI scans miss in people with Cushing's disease. About 22 participants will receive the drug and a radioactive tracer, then undergo imaging. The goa…

This study follows people infected with HTLV-I virus, some of whom develop a rare spinal cord condition called HAM/TSP. Researchers will track changes in symptoms, immune system markers, and virus levels over time. The goal is to better understand why only a few infected people g…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This early-stage study is testing whether a contrast agent called mangafodipir can safely highlight areas where the blood-brain barrier is broken in people with drug-resistant epilepsy. Forty adults will undergo MRI scans with mangafodipir and gadolinium to see if these scans can…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study aims to understand Gulf War Illness (GWI), a condition affecting up to 210,000 veterans with symptoms like fatigue, pain, and memory problems. Researchers will compare 85 Gulf War veterans—some with GWI and some without—through extensive tests including blood draws, sc…

This study follows 75 people aged 6 months or older with congenital myasthenic syndromes (CMS), a group of inherited disorders that weaken communication between nerves and muscles. Over up to 7 visits in 5 years, researchers will use physical exams, heart and lung tests, MRIs, an…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study aims to understand the link between genes and symptoms in people with inherited movement disorders. Researchers will study up to 2,500 participants, including patients and their family members, to identify new disease-causing genes and improve diagnosis. The goal is to…

This study is testing a new, painless device called electrical impedance myography (EIM) to measure muscle health. Researchers will use it on healthy volunteers and people with neuromuscular diseases to see how well it works compared to standard tests like ultrasound and nerve st…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This study uses advanced brain scans (MRI and MEG) to better locate seizure-causing areas in people with epilepsy who are considering surgery. Researchers will also create a database of normal brain images from healthy volunteers. The goal is to improve surgical outcomes by compa…

This study follows 269 people with neurofibromatosis type 2 (NF2) for up to 10 years to learn how the disease progresses. Participants will have yearly exams, MRI scans, hearing tests, and blood draws. The goal is to understand tumor growth, hearing loss, and speech or swallowing…

This study looks at whether brain scans can detect when a person is about to make a mistake during a typing task, up to one second in advance. Researchers will use MRI and MEG to record brain activity in 40 healthy right-handed adults aged 18 to 35. The goal is to understand how …

This study aims to understand how the brain behaves during sleep by using fMRI and EEG to track brain activity while playing sounds. Healthy volunteers aged 18-34 will spend nights in an MRI scanner, wearing electrodes and headphones. The goal is to see how loud a sound needs to …

This study aims to learn more about how infections and inflammation harm the brain and nerves. Researchers will collect samples and perform tests on people aged 2 and older who have or may have these conditions. The goal is to better understand these diseases so that better tests…

This long-term observational study uses MRI scans to track how multiple sclerosis (MS) changes over time in up to 3750 people. Researchers will compare brain images and immune system markers in untreated patients, those on approved therapies, and healthy volunteers. The goal is t…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This study looks at how taking a nap helps the brain remember new motor skills, like typing a sequence. Researchers will use brain scans to see what happens during rest and sleep. The study includes adults who have had a stroke and healthy volunteers of different ages. The goal i…

This study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This pilot study tests whether a radioactive tracer called 89Zr-Df-crefmirlimab can help PET scans detect certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults w…

This study follows 250 adults with multiple sclerosis (or similar conditions) for years, using yearly MRI scans and other tests to track brain and spinal cord changes. After a participant passes away, researchers examine donated brain and spinal cord tissue to see how the MRI fin…

This study aims to find out whether people with long COVID still have inactive remnants of the SARS-CoV-2 virus in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long COVID symptoms and some without. The goal is to…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study aims to improve how MRI scans measure the body by collecting data from 200 healthy adults. Participants will have one or more MRI scans of the brain, liver, or other organs. The goal is to make these scans more consistent and useful for doctors, not to treat any diseas…

This study tests a small MRI coil placed inside the sphenoid sinus during pituitary tumor surgery. The goal is to see if it can provide clearer images of tiny tumors that standard MRI often misses. About 70 adults with pituitary tumors will take part. The coil is inserted through…

This study uses functional MRI to see how the brain processes unpleasant sensations like pain and physical effort in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy volunteers. Researchers will apply mild heat and ask participants to sq…

This study compares a new portable, ultra-low field MRI to standard hospital MRI for detecting brain diseases like stroke, tumors, and epilepsy. About 200 people (ages 3 and up) with neurological symptoms, plus healthy volunteers, will get both types of scans. The goal is to see …

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This study uses ultrasound, a safe imaging technique that uses sound waves, to get detailed pictures and measurements of nerves and muscles. Researchers aim to collect normal values from healthy adults and compare them with data from people who have neuromuscular disorders. The g…

This study aims to learn more about rare inherited disorders that affect the brain, spinal cord, muscles, and nerves. Researchers will collect medical history, perform exams, and run genetic tests on up to 3,500 participants. No new treatments are tested; the goal is to better un…

This observational study is looking at men with spinal and bulbar muscular atrophy (SBMA), a rare inherited disease that causes gradual muscle weakness. Researchers will track changes in muscle strength, imaging scans, and blood or spinal fluid markers over two years. The goal is…

This study follows 1,590 adults who have had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the range of recovery experiences and identify factors that lead to p…

This study gathers medical information from 200 adults with possible nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Participants undergo standard tests like nerve conduction studies, EMG, and physical exams. The data is stored anony…

This study aims to learn how the binding of RNA with DNA (called R-loops) is linked to amyotrophic lateral sclerosis type 4 (ALS4) and other inherited neurological disorders. Researchers will observe up to 330 people aged 5 and older, including those with ALS4, related conditions…