National Institute Of Neurological Disorders And Stroke (ninds)

This study is testing a surgical procedure called deep brain stimulation (DBS) to help people with severe, untreatable hand dystonia—a condition causing painful, involuntary muscle cramps and movements. Five adults who have not been helped by standard treatments will have a small…

This is a first-in-human safety study testing a new gene therapy for Giant Axonal Neuropathy (GAN), a rare and fatal genetic disorder that damages nerves. Researchers are giving a single spinal injection that delivers a working copy of the faulty gene to the brain and spinal cord…

This study is testing if a drug called acamprosate is safe and might help slow the progression of ALS (amyotrophic lateral sclerosis) in people who have a specific genetic change (C9orf72 mutation). It involves 30 participants who will take the drug for 24 weeks while researchers…

This study is testing if a treatment called intravenous immunoglobulin (IVIG) can help reduce neurological symptoms in people with Long COVID, such as brain fog, dizziness, and fatigue. About 45 adults who had COVID-19 at least 12 weeks ago and still have these symptoms will rece…

This study aims to improve the tests used to diagnose chronic autonomic failure, a condition where the body's automatic functions like blood pressure control stop working properly. Researchers will enroll about 89 adults with conditions like Parkinson's disease, multiple system a…

This study aims to learn more about syringomyelia, a condition where a fluid-filled cyst forms in the spinal cord, often causing pain, weakness, and paralysis. Researchers will follow 180 adults with this condition for five years, tracking their symptoms, physical function, and M…

This study aims to learn how memory works by recording brain activity in epilepsy patients who already have electrodes implanted for their medical care. Researchers will have participants play memory games on a computer while monitoring their brain signals, and may gently stimula…

This study aims to understand how brain and spinal cord tumors grow in people with von Hippel-Lindau (VHL) disease, a rare genetic condition. Researchers will follow 250 participants aged 8-75 for five years, using regular MRI scans and blood tests to track tumor growth and ident…