National Institute Of Neurological Disorders And Stroke (ninds)

This study tested a treatment for progressive multifocal leukoencephalopathy (PML), a serious brain infection that strikes people with weak immune systems. Researchers took blood cells from a healthy relative, grew them in a lab to boost their ability to fight the virus, and then…

This early-stage study tested a gene therapy that delivers a protective protein called GDNF directly to the brain in 25 people with advanced Parkinson's disease. The goal was to see if it is safe and if it might help protect dopamine-producing brain cells. Participants received t…

This study tested a gene transfer treatment for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and affects movement, breathing, and other functions. Fourteen people aged 3 and older with GAN received the treatment through a spinal tap. The main goal was…

This study tested a drug called NT-I7 in 12 adults with progressive multifocal leukoencephalopathy (PML), a rare and serious brain infection caused by a virus. People with PML often have low levels of immune cells (lymphopenia), making it hard to fight the infection. The goal was…

This study tested different types of noninvasive brain and nerve stimulation in up to 1,500 healthy adults to see how they affect movement and brain activity. The goal was to find the best settings for these techniques, which may one day help people with conditions like stroke. N…

This study tested a special risk score that combines genetic and environmental factors to see if it can predict who might develop multiple sclerosis (MS). Researchers studied 181 people, including those with MS and their close relatives. The goal was to improve understanding of M…

This early study tested whether a single dose of the cancer drug pembrolizumab is safe for people with well-controlled HIV. Researchers wanted to see if the drug could help reveal HIV that may be hiding in the brain. Thirteen adults with HIV took part, and the main goal was to ch…

This study examined 328 people who were children during the Ebola outbreak in Liberia. Researchers wanted to understand long-term brain and nerve problems in survivors compared to close contacts who never got sick. Participants had a neurological exam, memory and thinking tests, …

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study looked at the genetic causes of Chiari I malformation, a condition where part of the brain pushes into the spinal canal. Researchers studied 152 people with the condition and their family members. They used MRI scans and blood tests to find genes that may be responsibl…

This study looked at whether ferumoxytol, an iron-based contrast agent, can help spot inflammation in the brains of people with multiple sclerosis (MS) using a powerful 7 Tesla MRI. Fourteen participants (some with MS, some healthy) received ferumoxytol and had multiple MRI scans…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, like family history or loss of smell. Participants underwent tests such as brain scans, blood draws, and spinal taps, and were followed for several years. The go…

This study followed 81 adults who had stroke-like symptoms to see if damage to the blood-brain barrier is linked to white matter changes in the brain that can cause mental decline. Participants had MRI scans and thinking tests over 6 years. The goal was to learn more about how th…

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with tremor conditions like Parkinson's disease or essential tremor, as well as healthy volunteers. Participants underwent tests such as MRI scans, brain wave record…

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or nerve problems after recovery. Researchers used brain scans, memory tests, and other exams to find possible changes in the nervous system. The goal was to better understand long-term effects of …

This study used brain scans to learn why a brain chemical called acetylcholine doesn't work properly in people with dystonia, a condition that causes muscles to twist or turn on their own. Researchers compared 31 adults with dystonia to healthy volunteers using MRI and PET scans.…

This study looked at people who had a recent head injury to learn more about how traumatic brain injury (TBI) affects the brain over time. Researchers used MRI scans and thinking tests to track changes for up to three months after the injury. The goal was to find better ways to d…

This study used brain imaging to track changes in people with Parkinson disease over up to 9 years. Researchers compared brain scans of people with definite or possible Parkinson to healthy volunteers. The goal was to better understand why dopamine-producing brain cells stop work…

This study looked at 78 women to understand why standard treatments for endometriosis often fail to relieve chronic pelvic pain. Researchers examined the roles of hormones, immune chemicals, stress, and genetics, and how nerves and muscles contribute to pain. The goal was to gath…

This study aimed to understand how symptoms develop and change over time in people who have a specific genetic mutation (C9ORF72) that causes ALS (Lou Gehrig's disease) and frontotemporal dementia. Researchers followed 50 adults with this mutation for 3 years, measuring their str…

This study aimed to screen and observe people with neurological conditions and healthy volunteers to better understand these diseases. It enrolled over 3,800 participants to collect data and identify candidates for future research studies. No experimental treatments were tested—r…

This study aims to understand how different layers of the brain help us learn and remember new movement skills. Healthy participants will practice typing sequences with their left hand while having their brains scanned with MRI. Researchers want to see which specific brain layers…