Scientists Fine-Tune diagnostic tools for autonomic nervous system disorders

NCT ID NCT03648905

Completed Knowledge-focused Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 12 times

Summary

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, multiple system atrophy, or related conditions. The goal is to make diagnoses more accurate and reliable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radioactive imaging agents (13N-Ammonia, 18F-DOPA, 11C-Methylreboxetine, 18F-Dopamine)
What this could lead to: If successful, this could lead to better diagnostic tests for autonomic failure, helping doctors identify and manage conditions like Parkinson's disease more accurately.
What could go wrong: This is an observational study focused on improving tests, not testing a new treatment. It is small (89 participants) and may not lead to immediate changes in patient care.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy orthostatic hypotension Parkinson disease primary orthostatic hypotension pure autonomic failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTONOMIC FAILURE MULTIPLE SYSTEM ATROPHY PARKINSON'S DISEASE

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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