Spinal zaps may steady blood pressure in spinal cord injury

NCT ID NCT05960448

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both active and sham stimulation while using an arm bike or sitting in a cool room, and researchers will measure exercise endurance, heart rate recovery, core temperature, and thermal comfort. The goal is to see if TSCS can improve autonomic function, which often becomes impaired after SCI, leading to issues like orthostatic hypotension.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcutaneous spinal cord stimulation (TSCS) — electrical stimulation delivered through the skin to the spinal cord, compared to a sham (placebo) version.
What this could lead to
If effective, TSCS could offer a non-invasive way to help people with spinal cord injuries maintain blood pressure and tolerate exercise and temperature changes better.
What could go wrong
This is a small early-stage crossover study with no expected long-term benefit. Results may not apply broadly, and the stimulation may not improve outcomes beyond placebo.

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Conditions

The condition(s) this trial relates to.

Hypotension, Orthostatic Motor Activity orthostatic hypotension spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • James J Peters VAMC

    The Bronx, New York, 10468, United States

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