Can a 'Smart Bridge' in the spine help paralyzed patients walk again?
NCT ID NCT04302259
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to understand how nerve signals travel and to see if this approach can help patients regain lower limb function. The study involves surgical implantation, imaging, and rehabilitation, with a focus on safety and feasibility.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Intelligent Spine Interface (ISI-C), an implanted epidural electrical stimulation device
- What this could lead to
- If successful, this device could help people with spinal cord injuries regain movement and function in their lower limbs.
- What could go wrong
- This is an early, small study focused on safety and feasibility. The device requires surgery, and it's uncertain if it will provide meaningful functional improvement.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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