SPINAL CORD INJURY

This early-stage study is testing whether gentle electrical stimulation applied to the skin over nerves and the spinal cord can help improve arm, hand, or leg movements in people with paralysis or weakness. Researchers are recruiting 64 adults with conditions like stroke or spina…

This early-stage trial is testing whether injecting lab-grown nerve cells into the spinal cord is safe for people with a recent spinal cord injury. Researchers will enroll 12 participants who were injured 2 to 8 weeks ago to receive the experimental cell therapy. The main goal is…

This study is testing whether electrical stimulation of the spinal cord can help people with spinal cord injuries regain the ability to stand and walk. Researchers will implant a stimulation device and combine it with rehabilitation training to see if it can improve leg movement,…

This study is testing whether combining two safe, non-invasive electrical stimulation techniques—one to the brain and one to the spinal cord—can work together to improve hand function and thinking skills after a stroke or spinal cord injury. Researchers will compare the combined …

This study is testing a new 'smart' bandage that delivers gentle electrical stimulation to help heal chronic, slow-healing wounds. It will involve 16 veterans with wounds related to diabetes or spinal cord injury. Researchers will compare the new bandage to standard wound care to…

This study is testing whether breathing brief, controlled amounts of low oxygen air can help stabilize blood pressure in people with chronic spinal cord injuries. Unstable blood pressure is a major problem after these injuries and significantly increases the risk of heart disease…

This study is testing whether adding gentle electrical stimulation to the lower back during robotic exoskeleton walking training helps people with spinal cord injuries walk better. Researchers will compare two groups: one using the exoskeleton with stimulation and one using the e…

This study is testing a brain implant system to help people with severe arm paralysis from spinal cord injury, stroke, or amputation. Researchers will implant tiny electrodes to read brain signals for controlling devices and to send artificial touch sensations back to the brain. …

This UCLA study is testing whether gentle electrical or magnetic stimulation of the spinal cord can help improve bladder function in men with spinal cord injuries. The research aims to see if this non-invasive approach can help people urinate more normally and reduce the need for…

This study is testing whether an implanted electrical stimulator on the spinal cord can help people with long-term, severe neck-level spinal injuries. Researchers want to see if the device can safely improve automatic body functions like blood pressure control, bladder and bowel …

This study aims to improve surgery for children with tight ankle muscles that limit their ability to walk properly. Researchers are testing if cutting a small, often-overlooked leg muscle (the plantaris) first, before the larger calf muscles, leads to better ankle movement and a …

This study is testing whether a brain stimulation training method can improve arm and hand movement in people with chronic cervical spinal cord injuries. Researchers will use a non-invasive magnetic brain stimulator to try to strengthen the weakened brain-to-muscle connections th…

This study aims to find better ways to control sleep-disordered breathing in people with chronic neck-level spinal cord injuries. Researchers are testing if giving supplemental oxygen or the medication trazodone can reduce breathing pauses and improve sleep quality. The study inv…

This study is testing if new 3D scanning and printing technology can make custom ankle braces as well as the old, slower plaster-cast method. Researchers will compare how well the braces work, how satisfied people are with them, and the cost for each type. The goal is to see if d…

This study is testing whether a non-invasive electrical stimulation on the neck, combined with physical training, can help people with spinal cord injuries regain the ability to reach and grasp with their hands. It will involve veterans with chronic neck-level injuries and health…

This study is testing if a procedure that freezes specific nerves in the shoulder works as well as standard Botox injections for reducing pain and improving movement. It involves 50 adults with shoulder pain and stiffness (spasticity) caused by conditions like stroke, multiple sc…

This early-stage study is testing the safety of a new device designed to deliver a cell therapy called LCTOPC1 directly to the spinal cord. It will enroll 10 people with recent (21-42 days) or older (1-5 years) spinal cord injuries in the neck or upper back. The main goal is to s…

This study is testing if gentle nerve stimulation can prevent serious bladder problems in people with recent spinal cord injuries. Researchers will compare two types of non-invasive stimulation (at the ankle or lower back) against standard care in 45 participants. The goal is to …

This is a small, early-stage study to see if stimulating the spinal cord and brain is safe and can help improve arm and hand function for people with neck-level spinal cord injuries. Researchers will temporarily implant small wires near the neck's spinal cord to deliver electrica…

This study is testing a new digital tool designed to prevent serious skin sores in veterans with spinal cord injuries. The tool asks veterans questions about their risks and gives their doctors a report with recommended actions. Researchers will see if using this tool in clinics …

This study is testing a new robotic exoskeleton designed to help people with spinal cord injury walk and move around more easily. The device is hands-free and self-balancing, aiming to improve stability during daily activities. Up to 12 participants will train with the exoskeleto…

This pilot study is testing whether a non-invasive electrical stimulation applied to the skin over the spine can help improve automatic body functions that are often disrupted after a spinal cord injury. Researchers are recruiting 30 adults with chronic spinal cord injuries to se…

This study is testing a new rehabilitation device called the SSMD to see if it helps improve arm and hand movement in adults recovering from a stroke or traumatic brain injury. About 150 participants will be randomly assigned to use either the new SSMD device or a standard electr…

This study is testing if a freezing treatment for nerves can better reduce pain caused by severe muscle stiffness (spasticity) in people with conditions like stroke, multiple sclerosis, or spinal cord injury. 50 participants will be randomly assigned to receive either the standar…

This small pilot study is testing whether a vibrating capsule, already approved for chronic constipation, is safe and helpful for people with spinal cord injuries who have severe bowel problems. Researchers will give the capsule to 12 participants to see if it can be used safely …

This study is testing whether a non-invasive brain stimulation technique can reduce severe, treatment-resistant nerve pain in people with spinal cord injuries. Researchers will compare stimulating two different brain areas to see which is more effective at lowering pain scores. T…

This study is testing a mobile health app designed to support the mental and emotional well-being of veterans with spinal cord injuries and their family caregivers. Researchers are working directly with 100 veterans and caregivers to adapt the app to their specific needs. The mai…

This study is testing whether a purified CBD medication (Epidiolex) can help reduce urinary incontinence and improve bladder symptoms in adults with recent spinal cord injuries. Twenty participants will take CBD twice daily for 90 days while tracking their symptoms. Researchers w…

This study is testing whether a wearable robotic exoskeleton helps people with recent spinal cord injuries walk better than standard physical therapy. Researchers will compare the two approaches in 80 participants over 8 weeks to see which improves walking ability, balance, and q…

This study is testing whether daily electrical stimulation on the skin near the pelvic area can help reduce bowel accidents in people living with spinal cord injuries. Twelve participants will use a small, at-home stimulation device for several hours a day over four weeks to see …

This study is testing whether adding robotic training with a device called Hunova® to standard physical therapy helps people with recent spinal cord injuries improve their trunk control and sitting balance. Researchers will compare two groups: one receiving standard rehab plus th…

This study is testing whether a special suit that uses mild electrical stimulation can help people walk farther and improve muscle strength after a major injury like a stroke, spinal cord injury, or amputation. Researchers will measure changes in walking distance, muscle performa…

This small, early-stage study is testing if a very low dose of the medication naltrexone can help reduce chronic nerve pain caused by a spinal cord injury. Ten adults with this type of pain will take a daily pill for 12 weeks to see if their pain levels go down and their quality …

This study is testing whether an online program called SCI&U, which connects people with recent spinal cord injuries to trained peer coaches, can help them better manage their health after leaving the hospital. Participants will have up to 14 online coaching sessions over 6 month…

This study is testing a lightweight, wearable robotic suit (an exoskeleton) designed to help people with leg stiffness (spasticity) from spinal cord injuries. The goal is to see if the device can safely stretch the legs and assist with walking, potentially improving movement and …

This study is testing which type of electrical stimulation leg exercise works better for people with spinal cord injuries. Researchers will compare short, intense workouts with longer, gentler sessions to see which improves leg fitness and strength more. Twenty participants will …

This study is testing whether combining leg nerve stimulation with standing therapy can improve bladder control and quality of life for people with chronic spinal cord injuries. Researchers will work with 12 participants to see if this 12-week program is practical and helps reduc…

This study is exploring whether a mindfulness program can be adapted and delivered using virtual reality (VR) to help veterans with spinal cord injuries manage chronic pain. Researchers will first work with a small group of veterans to identify needed changes to the program, then…

This study is testing a surgically implanted device that uses small electrical pulses to activate trunk and hip muscles in people with spinal cord injuries. The goal is to see if this 'neuroprosthesis' can improve seated posture, balance, breathing, and the ability to perform dai…

This study is testing whether daily probiotic or prebiotic supplements can help improve gut health and reduce digestive problems in people living with chronic spinal cord injury. Fifty participants will try each supplement for eight weeks to see if it eases their gastrointestinal…

This small pilot study is testing whether a combination of non-invasive electrical spinal stimulation and robot-assisted walking training can improve mobility and quality of life for people with chronic spinal cord injuries. Twelve participants will undergo two training phases: o…

This study aims to find out if surgery or Botox injections work better for improving arm and hand function in people with spasticity—a condition of stiff, tight muscles that often follows a stroke, spinal cord, or brain injury. Thirty participants will try both treatments, one af…

This small pilot study aims to understand if a single dose of testosterone given as a nasal spray can quickly improve nerve and heart function in male veterans with spinal cord injury. Researchers will measure muscle and heart rate responses in 15 men (10 with injury, 5 without) …

This study is checking if insulin, a diabetes medication, is safe when given as a nasal spray to people with spinal cord injuries. It's a small, early-stage trial with 12 participants who will use the spray or a placebo at home for up to 24 days. The main goal is to see if this a…

This study aims to find out if simple blood tests taken soon after a spinal cord injury can predict how much movement and function a person will recover six months later. Researchers will track 260 adults with new spinal injuries, taking blood samples frequently during the first …

This study aims to understand how robotic arm supports and other assistive devices affect the daily lives of people with movement impairments from conditions like stroke or spinal cord injury. Researchers will interview 150 people who already use these devices to learn about thei…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale. Researchers want to see if it's a reliable and useful tool for clinicians. The goal is to help clinicians give personalized advice to wheelchair users on how often they should shift their weight…

This large European study aims to understand how people naturally recover from spinal cord injuries. Researchers will follow 8,000 patients through rehabilitation, measuring their independence, movement, and nerve function. The data will create a detailed picture of recovery to h…

This study aims to create a standard test to measure how well different assistive technologies and brain-computer interfaces help people with severe motor impairments from spinal cord injury or ALS use computers and phones. Researchers will have 60 participants, including people …

This study aims to better understand how occupational therapists help adults recover arm and hand function after a stroke or spinal cord injury. Researchers will video record real outpatient therapy sessions to identify what makes treatments effective. The goal is to create a pra…