SPINAL CORD INJURY

This study tests a non-invasive spinal cord stimulation device in 30 people with chronic spinal cord injury. The goal is to see if it can help control blood pressure, bladder, bowel, and sexual function. Participants will receive stimulation over several weeks and be monitored fo…

This study tests whether an implanted spinal cord stimulator can safely improve blood pressure, heart rate, and overall function in people with chronic cervical spinal cord injury. It involves 36 adults with stable, motor-complete injuries between the C4 and C7 vertebrae. The mai…

This study tests a brain implant that records activity from the movement area of the brain and stimulates the sensory area. It is for people who have little or no use of their hands due to spinal cord injury, stroke, or amputation. The goal is to see if the implant is safe and ca…

This study tests whether a spinal cord stimulator can help people with spinal cord injury regain the ability to walk and reduce pain. Twelve adults with complete or incomplete spinal cord injury will receive the implant and undergo rehabilitation. The study will measure improveme…

This study tests a therapy called ARC-IM, which uses a device implanted near the spine to deliver mild electrical pulses. The goal is to help people with recent or long-term spinal cord injury regain the ability to walk. The study will enroll 12 adults aged 18 to 65 with injuries…

This early-stage study tests a new device that delivers special cells (LCTOPC1) directly to the spinal cord in people with traumatic spinal cord injury. The goal is to see if the device is safe and can help replace damaged cells, potentially improving movement and quality of life…

This study looks at whether adding a mild electrical stimulation to the lower back (transcutaneous lumbosacral stimulation) during exoskeleton-assisted walking helps people with spinal cord injury walk farther and faster compared to using the exoskeleton alone. The study involves…

This early-stage study tests whether a single injection of special stem cells (made from reprogrammed human cells) is safe for people with a recent spinal cord injury. About 12 adults with moderate to severe paralysis will receive the cells. The main goal is to check for side eff…

This study looks at ways to treat sleep-disordered breathing in adults with chronic cervical spinal cord injury (more than 6 months after injury). Researchers will measure changes in breathing, sleep apnea severity, and other breathing control signals. The goal is to find effecti…

This study compares two treatments for arm muscle tightness (spasticity) caused by stroke, spinal cord injury, or brain injury. Thirty adults will receive both surgery and botulinum toxin injections at different times, so each person acts as their own comparison. The goal is to s…

This study tests whether electrical stimulation of the spinal cord can improve arm and hand function in people with tetraplegia (paralysis from the neck down) due to a cervical spinal cord injury. Researchers will recruit 86 participants, including veterans and healthy volunteers…

This study tests if gentle electrical stimulation of leg or lower back nerves can prevent bladder overactivity in people with a recent spinal cord injury. About 45 adults with injuries above the T11 level and within 6 months of injury will be randomly assigned to receive tibial n…

This study tests a decision support tool called CAPP-FIT to prevent community-acquired pressure injuries in veterans with spinal cord injury. About 808 participants from seven VA clinics will use an automated survey and provider report to identify risks and take action. The goal …

This study is testing a wearable suit called Neuro20 that uses mild electrical pulses to help muscles work. Researchers want to see if it can improve walking, muscle strength, and heart rate in 30 people who have had a spinal cord injury, stroke, or amputation. Participants will …

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with recent spinal cord injuries will receive either calcitonin or a placebo, and their pain levels will be tracked for up to a year. The g…

This study tests whether adding robotic training with the Hunova device to standard rehabilitation improves trunk control in people with spinal cord injury. About 78 participants will be randomly assigned to standard rehab alone or standard rehab plus Hunova sessions. The goal is…

This study tests a treatment called cryoneurolysis, which uses controlled freezing to calm overactive nerves that cause pain and stiffness in people with brain or spinal cord conditions like stroke, multiple sclerosis, or injury. About 50 adults will be randomly assigned to get e…

This study tests an online program called SCI&U that pairs people with spinal cord injury (SCI) with trained peer health coaches. The goal is to help those recently discharged from the hospital feel less emotionally distressed and more confident in managing their health. Particip…

This study tests a device called SSMD to see if it can improve arm movement in adults who have had a stroke or traumatic brain injury within the past year. About 150 participants will either use the SSMD device or standard electrical stimulation, along with usual rehab, for 5-6 w…

This study tests whether gentle electrical stimulation of the spinal cord can help improve bladder function in men with spinal cord injury. The goal is to increase urine flow and volume, making catheterization easier. The trial involves 24 men who have been injured for at least a…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury (SCI) manage chronic pain. Researchers will first adapt an existing mindfulness course for SCI needs, then test 1-2 modules using VR in 10 veterans. The goal is to see…

This study is testing a robotic leg brace (exoskeleton) that also delivers small electrical pulses to muscles, to see if it is safe and helps people with brain injury, spinal cord injury, or multiple sclerosis walk better. About 15 adults aged 18-80 who are already in physical th…

This study looks at whether a 3-month pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Researchers will track how many people join, stick with the program, and report any problems. They will also explore if the tra…

This study tests a surgically implanted device that uses small electric currents to stimulate trunk and hip muscles in people with spinal cord injury. The goal is to improve seated posture, balance, breathing, reaching, and wheelchair mobility. Ten participants with injuries betw…

This early-stage study tests whether focused shockwave therapy can reduce arm and hand spasticity in people with spinal cord injury. Twelve participants will receive three weekly treatments, and researchers will measure changes in muscle stiffness, function, and quality of life. …

This study tests whether a purified form of CBD (Epidiolex) can reduce urinary incontinence in people who recently had a spinal cord injury. Twenty adults with at least two leaks per day will take CBD for 90 days and track their symptoms using a smartphone app. The goal is to see…

This study tests a new smart bandage called exciflex that delivers gentle electrical therapy to help heal chronic wounds that won't close on their own. The study involves 16 veterans with diabetes or spinal cord injury who have wounds on their lower legs. The bandage is designed …

This study is testing a portable, wearable leg exoskeleton to help people with spasticity (muscle stiffness) due to spinal cord injury. Ten veterans will use the device for leg stretching, treadmill walking, and overground walking to see if it improves joint motion, muscle activi…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Researchers will enroll 12 adults with paralysis to see if the device is safe and effective for everyday use. Participants will train and be assessed over sev…

This study tests whether psilocybin, the active ingredient in magic mushrooms, is safe and can ease depression in veterans with spinal cord injury. Thirty participants will receive low, medium, or high doses and be monitored for side effects and mood changes over 13 months. The g…

This study tests whether short sessions of breathing air with less oxygen (low oxygen therapy) can improve blood pressure stability over 24 hours in people with chronic cervical spinal cord injury. Ten adults aged 19-65 with a spinal injury at or above T1 will receive the therapy…

This study tests whether a remote training program can help manual wheelchair users improve their skills, confidence, and how often they perform key movements. About 132 adults with spinal cord injuries will take part, either receiving remote feedback or being placed on a waitlis…

This study tests whether a noninvasive brain stimulation technique, combined with hand exercises, can improve grasping ability in people with chronic cervical spinal cord injury. About 54 participants will receive either real or sham stimulation during training sessions. The goal…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce stubborn nerve pain in people with spinal cord injuries. Researchers will compare two brain areas—the motor cortex and the anterior cingulate cortex—to see which works better. The trial invo…

This study is the first to test whether insulin nasal spray is safe for people with a spinal cord injury. Up to 12 adults who had a spinal cord injury at least 4 months ago will use the spray or a placebo at home every day for up to 24 days. Researchers will track side effects an…

This small pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training helps improve trunk control and walking ability in people with chronic spinal cord injury. About 12 participants will first receive robotic training alone, then robo…

This study tests whether taking probiotics or prebiotics daily for eight weeks can reduce stomach and bowel problems in people with chronic spinal cord injury. Fifty participants will try both supplements at different times, with a break in between, to see which works better. The…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to s…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it can reduce pain and improve movement in people with spasticity (muscle tightness) after a stroke, brain injury, or other conditions. Half of the 50 particip…

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per …

This study tests whether a wearable robotic exoskeleton helps people with recent spinal cord injury regain walking ability better than standard physical therapy. Eighty participants will be randomly assigned to either robot-assisted or conventional gait training for 8 weeks. The …

This study tests a special capsule that vibrates to help people with spinal cord injury who have trouble controlling their bowels. The capsule is swallowed and aims to stimulate bowel movements without the need for manual stimulation or suppositories. The trial will check if the …

This study tests whether using a TENS device on the skin near the genitals can help people with spinal cord injury control bowel accidents. Twelve adults with a spinal injury at T12 or higher will use the device at home for 6-8 hours daily over 4 weeks. Researchers will compare a…

This is a small, early-stage study to see if a combination of electrical stimulation is safe and might help improve arm and hand function for people with neck-level spinal cord injuries. Researchers will temporarily place small wires near the spinal cord in the neck and use a mag…

This study is testing whether using two non-invasive stimulation methods together (one on the brain, one on the spinal cord) can improve movement, feeling, and thinking in people who have had a stroke or spinal cord injury. Researchers will also use MRI and other tests to underst…

This study is not testing a new treatment. Instead, it aims to carefully measure how people naturally recover after a spinal cord injury. By tracking 8,000 participants across Europe, researchers hope to create a detailed map of recovery that can be used as a baseline for future …

This study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and practical for adults with spinal cord injury. Six participants will exercise 8 times over 6 weeks while researchers monitor heart rate, blood pressure, and other health…

This study tests whether a brain stimulation training technique can improve the connection between the brain, spinal cord, and muscles in people with chronic cervical spinal cord injury. The goal is to see if this training can help restore some movement function. The study involv…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if this sensor can quickly detect dangerous drops in blood supply, which can cause paralysis. Researchers will study 120 adults…

This study is testing a mobile health app designed to help veterans with spinal cord injuries and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to adapt the app to their needs and see if it is easy to use. The goal is to…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study is creating a standard test to measure how well assistive technologies (ATs) and brain-computer interfaces (BCIs) help people with spinal cord injury or ALS use computers and phones. About 60 participants, including healthy volunteers and people with motor impairments,…

This study gathers feedback from 150 people who already use upper limb assistive devices (like robotic arm supports or grasping gloves) in their daily lives. Through interviews and questionnaires, researchers aim to understand how these devices affect independence, satisfaction, …

This study watches and analyzes video recordings of real occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to identify the key techniques therapists use to improve arm and hand function. The goal is to create a toolkit that he…

This study looks at two different ways of using electrical stimulation to exercise the legs of people with spinal cord injury. One group does short bursts of high-intensity exercise, while the other does longer, easier exercise. The goal is to see which method improves fitness an…

This study is looking at whether two proteins in the blood, called NF-L and GFAP, can help doctors predict how much a person will recover after a spinal cord injury. Researchers will take blood samples from 260 people with spinal cord injuries and compare the protein levels to th…

This study looks at how a single dose of testosterone given as a nasal spray affects nerve signals and automatic body functions like heart rate in men with spinal cord injury. Many men with this injury have low testosterone, which may worsen nerve problems. The study will test 15…

This small study is testing whether combining electrical stimulation of a nerve in the leg with standing therapy can improve pelvic floor muscle function in adults with chronic spinal cord injury. Twelve participants will undergo 12 weeks of combined therapy and complete question…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure. Rese…

This early-phase study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive b…