Could freezing nerves beat botox for spasticity pain?

NCT ID NCT07303582

Recruiting now Symptom relief Sponsor: Oxford University Hospitals NHS Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to receive either cryoneurolysis or Botox, and researchers will track pain, goal achievement, and side effects over 24 weeks. The goal is to see if cryoneurolysis is a safe and effective option that might require fewer repeat treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoneurolysis (nerve freezing procedure)
What this could lead to: If it works, this could offer a new, longer-lasting option for managing pain and stiffness from spasticity, reducing the need for frequent repeat treatments.
What could go wrong: This is a small pilot study with only 50 people, so results may not apply to everyone. The freezing procedure may cause temporary numbness or other side effects, and it may not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

brain injury central nervous system disorder multiple sclerosis Muscle Spasticity Pain spinal cord injury stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED BRAIN INJURY (INCLUDING STROKE) CENTREAL NEUROLOGICAL CONDITION MULTIPLE SCLEROSIS SPINAL CORD INJURY

Contacts and locations

Locations

Oxford Centre for Enablement (OUH NHS-FT)
RECRUITING

Oxford, OX3 7HE, United Kingdom

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