Could freezing nerves beat botox for spasticity pain?
NCT ID NCT07303582
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to receive either cryoneurolysis or Botox, and researchers will track pain, goal achievement, and side effects over 24 weeks. The goal is to see if cryoneurolysis is a safe and effective option that might require fewer repeat treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cryoneurolysis (nerve freezing procedure)
What this could lead to
If it works, this could offer a new, longer-lasting option for managing pain and stiffness from spasticity, reducing the need for frequent repeat treatments.
What could go wrong
This is a small pilot study with only 50 people, so results may not apply to everyone. The freezing procedure may cause temporary numbness or other side effects, and it may not work better than existing treatments.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Oxford Centre for Enablement (OUH NHS-FT)
RECRUITINGOxford, OX3 7HE, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact