Spinal cord injury

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests an implanted spinal cord stimulator (ARC-IM System) to help people with chronic spinal cord injury manage dangerously low blood pressure and fainting. Sixty participants will receive the implant and be randomly assigned to active or sham stimulation for 3 months,…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests whether a drug called 4-AP, taken twice daily, can boost recovery of leg movement in people with spinal cord injury. Participants also receive a type of brain stimulation and leg training. The goal is to improve walking and muscle strength. The study involves 27 …

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This study tests two non-invasive therapies to help people with chronic cervical spinal cord injury regain arm and hand function. Ten participants will try both therapies, each for two months, combined with rehabilitation. The goal is to see which works best and tailor treatments…

This study tests a device that sends electrical pulses to the spinal cord, combined with daily rehab, to help people with chronic spinal cord injury regain walking ability. Twelve participants will receive the implant and be followed for over a year. The goal is to see if the app…

This study is testing a wireless brain implant that lets people with severe spinal cord injuries control external devices just by thinking. The device is placed in the brain with a small surgery. Researchers will check how well participants can perform tasks using only their brai…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study looks at whether having surgery sooner or later after a traumatic spinal cord injury leads to better recovery. Researchers will compare how much nerve function improves in 100 adults who get either early or delayed surgery. The goal is to find the best timing to help p…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests a device that stimulates a nerve in the leg to help people with spinal cord injury manage their bladder function at home. About 21 adults with chronic spinal cord injury (at level T9 or above) will use the device and be monitored for safety, reliability, and ease…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests whether an implanted device that sends electrical pulses to the spinal cord can improve movement and feeling in people with chronic spinal cord injuries. Ten participants with injuries above the T10 level will receive the implant and undergo regular assessments o…

This early study is testing a device called ARC-IM Therapy, which delivers electrical impulses to the lower spinal cord, to see if it can help people with spinal cord injury regain the ability to walk. The trial will include 12 adults with recent or long-term injuries. The main g…

This study tests whether functional electrical stimulation (FES) can improve arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove device to stimulate muscles during short therapy sessions. The goal is to see if this appr…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether semaglutide (Ozempic), a drug used for type 2 diabetes, works well for people with spinal cord injury (SCI) who also have diabetes. SCI patients are at higher risk for diabetes, but it's unclear if standard treatments are effective. The trial will measure…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study tests whether a spinal cord stimulator — a device that sends mild electrical pulses to the spinal cord — can help people with long-term bladder and bowel problems after a spinal cord injury. Ten adults with injuries older than 6 months will have the device implanted an…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study tests whether an implanted spinal cord stimulator can improve autonomic functions like blood pressure and heart rate in people with chronic cervical spinal cord injury. The device delivers electrical pulses to the spinal cord to help regulate involuntary body processes…

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several ti…

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve nerve recovery. About 102 adults with recent spinal cord injuries will take part. The goal is to see if…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study combines non-invasive electrical stimulation of the spinal cord with treadmill step training to help people with incomplete spinal cord injury improve walking, posture, and bladder, bowel, and sexual function. About 36 participants will receive stimulation alone or wit…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This early study tests a device called the Bidirectional Neural Bypass System in up to 7 people with tetraplegia (paralysis from the neck down). The device is designed to let users move and feel their hand and wrist again by bypassing the damaged spinal cord. Researchers will mea…

This study looks at whether nerve transfer surgery can improve arm function and quality of life in people with high-level cervical spinal cord injuries (tetraplegia). Thirty participants will receive standard nerve transfer surgery and be followed for up to 4 years. The goal is t…

This study is testing a robotic exoskeleton called TWIICE Rise to see if it is safe and practical for people with spinal cord injury to use for walking. The trial involves 15 participants and will take place in clinics, homes, and community settings. The goal is to assess how wel…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans and adults in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab…

This pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training (RGT) can improve trunk control and walking in people with chronic spinal cord injury. Twelve participants will first receive RGT alone, then RGT plus tSCS, and their prog…

This study tests a personalized stepwise treatment for teens aged 12-16 with mild to moderate scoliosis (spine curve under 45 degrees). It compares two types of electroacupuncture and checks if a simpler screening method can replace X-rays. The goal is to improve spine curvature …

This study is testing a small device called KeyGrip that is implanted in the arm to help people with cervical spinal cord injury regain hand function. The device uses mild electrical pulses to activate paralyzed muscles, allowing hand opening and closing. Researchers will measure…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This study tests a new device called SSMD to help people with arm weakness after a stroke or traumatic brain injury. About 150 adults will use the device in supervised sessions over 5-6 weeks. The goal is to see if it improves arm movement better than standard electrical stimulat…

This early study tests whether a common diabetes pill, glyburide, can safely protect the spinal cord from further damage after a traumatic injury. Researchers will enroll 12 adults with acute spinal cord injury to check safety and see if the drug helps preserve nerve function. Th…

This early-stage trial tests a new device designed to deliver OPC1 cells directly into the spinal cord of people with traumatic spinal cord injuries. The study will enroll 10 participants with either recent or chronic injuries. The main goal is to see if the device and injection …

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study is testing a personal exoskeleton that lets people with spinal cord injury walk hands-free and stay balanced on their own. Twelve participants with injuries at or above the T6 level will train with the device over several sessions. The goal is to see if the exoskeleton…

This study tests a hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk and perform everyday activities. The trial will enroll 24 participants who will train with the device over several sessions. Researchers will measure how quickly they ca…

This study tests whether a wearable robotic exoskeleton helps people with recent spinal cord injury regain walking ability better than standard physical therapy. Eighty participants will be randomly assigned to either robot-assisted or conventional gait training for 8 weeks. Rese…

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compa…

This study is for adults over 21 with chronic spinal cord injury (more than a year) who have lost motor function. Researchers will implant a spinal cord stimulator and combine it with advanced robotic rehabilitation to see if it can improve movement, like walking. The main goal i…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This study tests whether a non-invasive device that sends small electrical pulses to the spine, combined with repetitive hand and arm exercises, can improve movement in people with chronic tetraplegia from a cervical spinal cord injury. Researchers will measure changes in muscle …

This early study tests the safety and function of a brain-computer interface (BCI) implanted by a robot in people with severe paralysis. The device aims to let users control external devices like computers or phones using their thoughts. The trial enrolls 15 adults with quadriple…

This study tests whether a combination of a wearable robot suit, electrical spinal stimulation, and muscle-strengthening exercises can help people with complete spinal cord injury walk on their own. Twenty adults with paralysis from the chest down will train for months to see if …

This early-stage study tests whether a harmless bacterium called Lactobacillus crispatus, when placed directly into the bladder, is safe and can help prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. Forty participants will receive two …

This study tests a new rehabilitation program for people with recent spinal cord injuries (within 1-5 months). Participants walk on a downhill treadmill while receiving electrical stimulation to their leg and trunk muscles. The goal is to improve walking and movement. Researchers…

This trial tests a device implanted in the arm that stimulates paralyzed muscles to help people with cervical spinal cord injury pick up and release objects. The study involves 13 participants and focuses on safety and how well the device improves hand function. It is an early-st…

This study tests a fully implanted neuroprosthetic device designed to improve hand, reach, and trunk function in people with cervical spinal cord injuries. Thirty participants will receive the device and be evaluated on their ability to perform daily activities with and without i…

This study tests a new spinal implant system (ARC-IM Lumbar) in 8 people with chronic spinal cord injury who already have a spinal implant. The goal is to improve walking, bladder, bowel, and sexual function, and make the system easier to use at home. Participants will be followe…

This study tests two surgical procedures to reduce further damage after a severe spinal cord injury. Ten adults with recent spinal cord injury will receive either a standard decompression surgery or that surgery plus a nerve graft. The goal is to see if these approaches are safe …

This pilot study tests a spinal cord stimulator implanted at both the injury site and the lower back to help people with chronic spinal cord injury stand and walk. Five participants will go through three phases of stimulation over 9 months, combined with physiotherapy. The goal i…

This study tests whether a fully implanted nerve stimulator can help people with incomplete spinal cord injury walk farther and more independently. Five participants will first be screened, then receive the implant and use it for up to two years. The device is turned on and off t…

This early-stage study tests a new treatment called XS228, made from special stem cells that can become nerve cells. The goal is to see if injecting these cells into the spine is safe and tolerable for people who had a spinal cord injury 2 to 8 weeks ago. Up to 12 adults with inj…

This study is testing whether cooling the body to 33°C (just below normal) for 48 hours soon after a cervical spinal cord injury can improve nerve recovery and function. Researchers will enroll 120 adults aged 18-70 with severe but non-penetrating injuries. The cooling is deliver…

This study tests whether short, controlled sessions of breathing lower oxygen (called low oxygen therapy) can help stabilize 24-hour blood pressure in people with chronic cervical spinal cord injury. Ten participants will undergo 4 days of treatment, with blood pressure and heart…

This early study tests whether a spinal cord stimulator can safely help people with cervical spinal cord injuries breathe without a ventilator. Twelve adults who have been injured for at least a year and rely on a breathing machine will receive an implant and attend weekly sessio…

Neuralink is testing a brain-computer interface called the N1 Implant, placed by a robot, to help people with severe paralysis communicate. The study will enroll 6 adults with conditions like ALS or spinal cord injury who cannot speak or use their hands well. The main goal is to …

This study tests a wearable robotic exoskeleton designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device fits on the legs and can assist or resist movement during walki…

This study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…

This study tests whether a device that sends electrical pulses to the spinal cord can help people with chronic spinal cord injuries regain movement and feeling. Ten participants with injuries between the T11 and L3 vertebrae will receive the implant and undergo rehabilitation. Re…

This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…

This study tests whether an implanted epidural electrical stimulator can help people with spinal cord injury move better. Twenty participants will receive the device and undergo physical rehabilitation. Researchers will measure brain activity, muscle signals, and joint movement t…

This study tests an implanted device that sends electrical pulses to the spinal cord to help people with spinal cord injury regain walking ability and reduce pain. Twelve adults with chronic spinal cord injury will receive the implant and then undergo physical therapy. The goal i…

This study compares two treatments for arm spasticity (stiff, tight muscles) caused by stroke, spinal cord injury, or brain injury. Thirty adults will first receive Botox injections, then undergo tendon-lengthening surgery a few months later. Researchers will measure how well eac…

This study tests whether adding Hunova® robotic rehabilitation to standard therapy improves trunk control in people with spinal cord injuries. 78 participants will receive either standard rehab alone or standard rehab plus Hunova® sessions. The goal is to see if the robotic devic…

This early study tests whether a brain-computer interface can detect a person's intention to move their hand and then trigger electrical stimulation in the spinal cord to help produce that movement. Three adults with chronic spinal cord injury will have temporary spinal electrode…

This study tests a new therapy that uses a brain-computer interface to detect when a person tries to move, then activates spinal cord stimulation to help them walk. It is for people with incomplete spinal cord injury who are at least 6 months post-injury. The goal is to see if it…

This study tests whether a migraine drug called Eletriptan (TZ-161) can help people with recent spinal cord injuries. 28 adults with thoracic spinal cord injury will receive either the drug or a placebo for 6 days, alongside standard care. The goal is to check safety and see if i…

This study is testing a new, 10-minute MRI sequence (3D FGAPSIR) to see if it can find more spinal cord lesions in people with multiple sclerosis than standard scans. Researchers will enroll 200 adults already scheduled for a spinal MRI. The goal is to improve detection of spinal…

This study tests a smartphone app designed to help people who use wheelchairs or scooters prevent and manage falls. Researchers will compare the app to standard fall prevention information in 120 adults with spinal cord injury or multiple sclerosis. The goal is to see which appro…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether gentle electrical stimulation of nerves in the leg or lower back can prevent the bladder from becoming overactive after a spinal cord injury. Researchers will compare two types of nerve stimulation against standard care in 45 adults who had a spinal injur…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study tests a smartwatch-based system that gives real-time tips and reminders to help people with spinal cord injury increase their physical activity. About 196 adults who use wheelchairs will be split into two groups: one gets a standard web-based exercise program, and the …

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study tests whether deep brain stimulation (DBS) can improve walking in people with incomplete spinal cord injury. Six adults who have had a spinal injury for at least one year will receive DBS to a brain area called the cuneiform nucleus. The goal is to see if it safely hel…

This study tests whether a low-volume nose resistance breathing exercise using an Acapella device plus an incentive spirometer can improve lung function and reduce shortness of breath, cough, and phlegm in people with cervical spinal cord injuries. Forty-two inpatients aged 18–38…

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a traumatic spinal cord injury, is safe and might help patients recover movement. Fifteen adults with acute spinal cord injury will receive either real or sham sti…

This study tests a live, group tele-exercise program (TEEMS) for people with spinal cord injury. Researchers want to see if it improves exercise confidence, physical activity, and quality of life compared to watching pre-recorded exercise videos. The program is fully virtual to m…

This pilot study is testing whether a home-based virtual reality exercise program called VR-Move can improve fitness and quality of life in people with spinal cord injuries. Sixteen participants will use the VR system three times a week for 12 weeks. The goal is to provide an acc…

This study is testing a wearable robotic exoskeleton called ABLE Daily to see if it is safe and works well for helping people with spinal cord injury walk in their home and community. Ten participants will train with the device at a clinic for three weeks, then use it on their ow…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This study tests whether a smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. About 50 participants will use either a basic or interactive app, and those who struggle may get extra coaching. The goal is to find the best way to boos…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests whether a 12-week pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Thirty participants will do exercises five times a week. Researchers will track how many people join, stick with the program, and …

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This pilot study is testing a special capsule that vibrates as it moves through the digestive system. The goal is to see if it is safe and helpful for people with spinal cord injuries who have bowel problems. Only 12 participants will be enrolled to check safety and how well they…

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study tests a new approach that combines magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation to improve hand, leg, and trunk function in people with spinal cord injury. Researchers will enroll 25 participants, including both injured and abl…

This study tests a new multi-speed ergonomic wheelchair designed to reduce shoulder overuse injuries common in manual wheelchair users. Thirty adults who use a manual wheelchair daily will try different gear ratios on various surfaces. The goal is to see if the design improves pr…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study looks at whether pelvic floor muscle training is practical and helpful for people recovering from a spinal cord injury during inpatient rehab. Researchers will recruit 50 participants to do pelvic floor physiotherapy five times a week for six weeks. The goal is to see …

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical (neck) spinal cord injury regain arm and hand function. The device, called the CoverEdgeX 32 Surgical Lead, is already approved for pain but is investigational f…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests whether non-invasive spinal stimulation, used at home with exercise, can safely improve arm and hand function in people with recent cervical spinal cord injury. 46 participants will be randomly assigned to start the program immediately or after a 12-week delay. T…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether using mild electrical pulses on the belly muscles during a bowel program can cut down the time it takes. Fifteen adults with chronic spinal cord injury (above T11) will try the device at home and track their bowel routine times, quality of life, and any c…

This pilot study tests whether focused shockwave therapy can safely reduce arm spasticity in people with spinal cord injury. Twelve participants will receive three weekly sessions of sound waves applied to the forearm and elbow muscles. Researchers will measure changes in muscle …

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This early-stage study is checking if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will monitor side effects and see if virtual training…

This study tests whether breathing low oxygen, along with spinal cord stimulation and walking practice, can improve walking for people with chronic spinal cord injury. About 60 adults with some walking ability will take part. The goal is to see if these combined treatments can he…

This study is for adults aged 18–80 with chronic spinal cord injury who can already walk a little. It combines short periods of breathing low oxygen, spinal cord stimulation, and walking practice to see if it helps them walk better. The goal is to improve walking speed and endura…

This study tests a brain implant that lets people with severe paralysis control a tablet computer using only their thoughts. The goal is to help them communicate, use apps, and control smart devices, improving their quality of life. Up to 5 participants will be implanted and foll…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with breathing exercises, can improve lung function in people with chronic spinal cord injury. About 36 adults will be split into three groups: breathing training alone, stimulation alone, or bo…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether a spinal cord stimulator, combined with breathing exercises, can improve respiratory function in people with chronic spinal cord injury. Thirty adults with neck-level injuries will undergo 16 weeks of training while using the device. Researchers will meas…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Sixty adults will receive either real or sham rTMS daily for 15 sessions while continuing their usual pain medications. Pain levels will be mea…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

This study is testing whether a slow, resistive yogic breathing technique called Ujjayi can improve breathing, lung function, and sleep in people with spinal cord injuries. Twenty adults aged 18 to 60 who use wheelchairs will practice Ujjayi breathing for six weeks. Before and af…

This study tests whether a gentle electrical current applied to the skin over the spinal cord (called transcutaneous spinal cord stimulation) can safely improve walking in children aged 3 to 16 with incomplete spinal cord injury. Twenty children will receive either real stimulati…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study is testing a wearable robotic hand orthosis called MyHand-SCI for people with C6-C7 spinal cord injury. The device is designed to assist with hand and finger movement. Researchers will enroll 40 participants to evaluate how usable and helpful the device is. The goal is…

This study is testing a wearable robotic exoskeleton that stretches the legs of people with spasticity caused by spinal cord injury. The device aims to mimic the stretching done by nurses or caregivers. Ten veterans will try the device during leg stretching, treadmill walking, an…

This study tests whether virtual reality exercises can reduce neck pain and disability better than standard physical therapy. Seventy-two adults with chronic neck pain or whiplash will do 12 sessions over six weeks. Half will use VR, the other half will do the same exercises with…

This small pilot study tests whether adding a gentle electrical stimulation to the spinal cord (tSCS) can make robotic arm training more effective for people with chronic tetraplegia from a spinal cord injury. Six to eight adults with neck-level injuries will first receive roboti…

This study tests whether magnetic pulses to the brain (TMS) can ease nerve pain that won't go away with standard drugs in people with spinal cord injury. 39 adults with pain for at least 6 months will receive either real or sham TMS to the motor cortex or the anterior cingulate c…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether electromagnetic stimulation can safely improve bladder function in people with spinal cord injury. Researchers will enroll 24 men with complete motor paralysis who have used catheters for at least a year. Participants will receive non-invasive stimulation…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study is testing a personal exoskeleton that helps people with spinal cord injury stand, walk, and move without using their hands. The device is self-balancing, so users don't need crutches or a walker. Researchers will see if 24 participants can complete walking tests and e…

This study tests whether a virtual walking therapy can reduce chronic nerve pain in people with spinal cord injury. Participants will watch a life-sized video of themselves walking through a forest while seated in a tilting wheelchair. The trial will enroll 40 adults and compare …

This study is testing whether adding a mild electrical stimulation to the lower back can boost the benefits of a robotic exoskeleton for people with chronic spinal cord injury. Twenty-four participants who cannot walk will receive either exoskeleton training alone or combined wit…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests a new rehab approach for people with incomplete spinal cord injury. It combines electrical muscle stimulation with augmented reality games during walking exercises. 70 adults aged 18-45 will be split into two groups: one gets the high-tech training, the other get…

This study tests whether a 10-week online expressive writing program can help adults with spinal cord injury work through feelings of grief and loss. Participants will write about their emotions with guidance from a coach and share reflections with others. The goal is to see if t…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This small early-stage study tests whether a device that combines augmented reality (AR) with functional electrical stimulation (FES) is safe and usable for people with cervical spinal cord injury. Seven participants will attend 20 one-hour sessions over 10 weeks, using the syste…

This study tests whether combining a powered exoskeleton (a robotic leg brace) with functional electrical stimulation (small muscle zaps) can improve walking speed in people with chronic spinal cord injury. About 34 participants with incomplete injuries will be randomly assigned …

This study tests whether playing a virtual reality walking game at home can help reduce neuropathic pain in adults with chronic spinal cord injury. 250 participants with complete injuries will use a VR headset to see virtual legs walking from a first-person view. They will play t…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether combining non-invasive spinal cord stimulation with walking rehabilitation can reduce muscle stiffness and improve leg strength and walking ability in people with incomplete spinal cord injury. Ten adults with stable, incomplete spinal cord injury who can…

This study tests whether sildenafil (the drug in Revatio, similar to Viagra) can reduce urine leakage in people with spinal cord injuries. Twenty-four adults who have at least three leaks per week will take either sildenafil or a placebo for four weeks. Researchers will track how…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. About 18 adults with cervical-level injuries will receive either real or sham stimulati…

This study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …

This study tests whether using a small electrical stimulation device on the skin near the genitals can help people with spinal cord injury control bowel accidents. Twelve participants will use the device at home for 6-8 hours daily over 4 weeks. The goal is to see if this approac…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests whether gentle electrical stimulation of a nerve in the genital area can improve bowel control in people with spinal cord injury. Researchers will measure how the rectum and anus respond to the stimulation using a small balloon. The goal is to see if this non-inv…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests whether a powered arm brace called MyoPro can help people with incomplete spinal cord injury improve arm and hand function. Sixty adults aged 18-80 with specific injury levels will either use the device or receive standard therapy. Researchers will measure streng…

This study tests whether combining bodily illusions (like the rubber hand illusion) with mild brain stimulation (tDCS) can reduce neuropathic pain in people with spinal cord injury. Thirty participants will undergo 10 sessions over 2-4 weeks. The goal is to see if these technique…

This study tests whether ankle braces made with 3D scanning and printing work as well as those made the old-fashioned way with plaster casts. About 50 people aged 8 and older with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury will try both types …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study is testing a special suit called the Neuro20 that uses mild electrical pulses to stimulate muscles in the arms, legs, chest, and back. Researchers want to see if wearing it during therapy sessions can improve walking ability, muscle performance, and heart health in peo…

This study tests whether a noninvasive electrical stimulation applied to the lower back can reduce spasticity (involuntary muscle activity), improve muscle strength, and lessen pain in people with spinal cord injury. Thirty-six participants will receive the stimulation over sever…

This study tests whether pairing brain stimulation with spinal cord stimulation can make hand exercises more effective for people with chronic cervical spinal cord injury. The idea is that synchronized stimulation strengthens nerve circuits, improving hand muscle responses. Up to…

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation…

This study tests whether taking probiotics or prebiotics daily for eight weeks can ease stomach and bowel problems in people with chronic spinal cord injury. Fifty participants will try both supplements in a crossover design, with a four-week break in between. The researchers wil…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) is safe and practical when used during arm and hand therapy for people with chronic incomplete cervical spinal cord injury. Twelve adults will receive 18 therapy sessions over six weeks, followed …

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This study tests whether an online program called SCI&U, which pairs people with trained peer health coaches, can help those recently discharged from inpatient rehab after a spinal cord injury. Participants will have up to 14 one-hour video sessions covering health topics like bl…

This study tests a wearable robotic arm exoskeleton to help people with spinal cord injuries improve arm and hand function. Nine tetraplegic inpatients will use the device for 12 weeks alongside standard rehab. Researchers will measure changes in arm strength, movement, and daily…

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study looks at how blood pressure changes in the first year after a spinal cord injury and whether a device that stimulates the spine through the skin can help. Five people with recent injuries will be followed for a year, testing the stimulation during sessions to see if it…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study from Mayo Clinic looks at how the body manages blood pressure after a spinal cord injury and whether those changes can predict future health problems. Researchers will test 18 people with spinal cord injuries (either recent or long-term) using simple procedures like co…

This Mayo Clinic study is looking at how spinal cord stimulation affects blood pressure, heart rate, and immune function in people with spinal cord injuries. Researchers will test how the body handles changes in blood pressure using simple tasks like hand cold pressor tests and b…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study looks at whether a breathing technique called acute intermittent hypoxia (AIH) increases spasticity (muscle tightness) in people with chronic spinal cord injury. Ten adults with incomplete spinal cord injury will receive AIH and have their reflexes and muscle stiffness…

This study looks at why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks in 300 participants to understand the underlying causes. The goal is to better classify pain types, not to test a new trea…

This study will video-record occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to understand exactly what therapists do to help patients improve arm and hand movement. The goal is to create a toolkit that makes rehabilitation …

This study is developing a standard test to measure how well assistive technologies (like eye trackers) and brain-computer interfaces help people with spinal cord injury or ALS use computers and phones. Researchers will test 60 participants, including healthy volunteers and peopl…

This study is looking at whether measuring two proteins in the blood (NF-L and GFAP) soon after a spinal cord injury can help doctors predict how severe the injury is and how much recovery a person might have 6 months later. Researchers will enroll 260 adults with traumatic spina…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study looks at how different meals affect energy use and appetite in men with high spinal cord injury (T6 and above) compared to able-bodied men. Participants will eat standardized meals and have their metabolism measured. The goal is to understand how food impacts cardiovas…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This small study tests whether combining standing therapy with mild electrical stimulation of a nerve in the leg can improve pelvic floor muscle function in adults with chronic spinal cord injury. Twelve participants will undergo 12 weeks of treatment, three times per week. Resea…

This study looks at how spinal cord stimulation combined with physical training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand if these changes lead to bette…

This study compares two types of spinal stimulation—transcutaneous (through the skin) and epidural (implanted via surgery)—to see how they help people with spinal cord injury generate leg force and stand with support. Sixty adults aged 22-75 who cannot stand independently will pa…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study tests whether breathing low oxygen for short periods (called intermittent hypoxia) can improve walking and strength in people with chronic spinal cord injury. Researchers want to understand how this affects the nervous system. The trial involves 44 participants who wil…

This study looks at how eating a high-fat meal affects pain sensitivity and inflammation in people with chronic spinal cord injury. Researchers will compare a high-fat meal to a moderate-fat meal in 40 adults. They aim to understand links between body composition, diet, and pain.

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage common health problems like pain, bladder issues, and stress. About 40 adults with spinal cord injury will receive texts with tips and support, and researchers will see…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study looks at whether starting body-weight-supported treadmill training (BWSTT) at different times within the first 6 months after a spinal cord injury affects walking ability. 108 participants will be randomly assigned to start therapy within 60 days, 3 months, 6 months, o…

This study aims to understand how upper-limb assistive devices—like grasping gloves, mealtime aids, and robotic arms—impact the daily lives of people with motor impairments. Researchers will interview and survey 150 regular users (including those with stroke, spinal cord injury, …

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how small electrical pulses to the brain or arm nerves can help restore sensation in people with spinal cord injuries. Participants already have tiny electrodes implanted as part of a larger study. Researchers will test different stimulation patterns to see wh…

This study is testing a non-surgical method of spinal cord stimulation to help people with spinal cord injury regain movement. Researchers want to see if adjusting the timing and strength of electrical pulses can target specific muscles more precisely. The study involves 48 adult…

This study interviews 60 adults with spinal cord injuries and neurogenic bladder, plus their caregivers, to learn about their experiences with different types of bladder washes (gentamicin, lactobacillus, or both). The goal is to understand what they like, dislike, and find helpf…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study uses ultrasound to measure the thickness of ankle cartilage in people with spinal cord injuries and compares it to healthy individuals. The goal is to see if cartilage damage starts early, which could help prevent osteoarthritis. Researchers will also assess participan…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study aims to create a Turkish version of a questionnaire that measures how environmental factors affect people with spinal cord injuries. Researchers will work with experts and adults living with spinal cord injury in Turkey to make sure the questions are clear, relevant, a…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at whether training physical and occupational therapists in motivational interviewing (a supportive communication style) helps people with spinal cord injuries or disorders engage more actively in their rehab sessions. About 180 patients will take part across thr…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how fast the bladder is filled during a urodynamic test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will test two different filling speeds in 30 participants to see which one ca…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study tests whether combining non-invasive brain and spinal cord stimulation during a movement task can improve hand function and thinking in people with stroke or spinal cord injury. 45 participants will receive both types of stimulation separately and together to see if th…

This early-phase study looks at how a single dose of intranasal testosterone affects nerve and autonomic function in 15 male veterans with spinal cord injury who have low testosterone. Researchers will measure muscle responses and heart rate changes before and after the dose. The…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study uses advanced MRI scans to look at changes in the spinal cord and fluid around it in people with spinal cord injuries. The goal is to see if these changes relate to a person's symptoms and nerve function. Researchers hope this will lead to earlier diagnosis and better …

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure to pr…

This study is gathering information on how people naturally recover from spinal cord injuries. Researchers will follow 8000 participants across Europe, measuring their independence, movement, and nerve function over time. The goal is to create a detailed baseline of recovery, whi…

This study uses MRI scans to observe how the brain and spinal cord change after a spinal cord injury. Researchers will compare 450 patients (from recent to long-term injury) with healthy volunteers. The goal is to find imaging markers that can predict recovery and guide rehabilit…

This study will follow 35 people who recently had a spinal cord injury to see how their gut bacteria change over the first year. Researchers will collect blood, stool samples, and bowel function surveys at the start, 6 months, and 12 months. The goal is to understand how the gut …

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study looks at whether intensive upper-limb training, started within 13 weeks of a cervical spinal cord injury, can trigger changes in the brain and nerves that improve arm and hand function. Researchers will measure brain activity, nerve signals, and motor skills in 44 part…

This study tests two types of brief, low-oxygen breathing treatments in 18 adults with recent spinal cord injury (2 weeks to 6 months after injury). The goal is to see which treatment better improves breathing strength and cough function. Researchers will also look at genetic dif…

This study is checking if it's possible to give gabapentin, a nerve pain medication, within the first few days after a spinal cord injury. The goal is to see if a larger study on nerve recovery can be done. About 42 adults with any level or severity of spinal cord injury will tak…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study tests whether a brain stimulation training can strengthen the connections between the brain, spinal cord, and muscles in people with chronic cervical spinal cord injury. Researchers will enroll 15 adults with incomplete injuries at or above C6 who are at least one year…

This study tests two different ways of using electrical stimulation to exercise the legs of people with spinal cord injury. One group does short, intense bursts of exercise, while the other does longer, easier sessions. Researchers want to see which method better improves fitness…

This study explores how electrical stimulation of the spinal cord can help people with cervical spinal cord injury regain arm and hand function. Researchers will place electrodes on the spinal cord during surgery and test different stimulation patterns. The goal is to find the be…

This study looks at how food changes the connection between the brain and stomach in people with and without spinal cord injury. Researchers will measure brain and stomach signals in 28 adults to understand gut-brain communication. The goal is to learn more about how spinal cord …

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study looks at why men with spinal cord injury often have low testosterone and how that might damage blood vessels, raising the risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury and low testosterone. They …

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study checks if a pressure-sensitive insole (Ceriter Stride One) can accurately measure walking patterns in people with stroke, brain injury, or spinal cord injury. About 30 participants will wear the insole while walking on a high-tech treadmill (GRAIL) to compare results. …

This study looks at why blood vessels may not work as well after a spinal cord injury, which can raise the risk of heart attacks and strokes. Researchers will measure blood flow and study tiny particles from blood vessel cells in 40 adults with and without spinal cord injuries. T…

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which w…

This study is testing whether a combination of spinal cord stimulation and brain stimulation can safely improve arm and hand function in people with cervical spinal cord injury. Twenty adults with incomplete injuries will receive temporary spinal implants and brain stimulation ov…

This study tests whether ultrasound can measure muscle activation caused by two types of stimulation: non-invasive spinal cord stimulation and functional electrical stimulation. Researchers will apply these stimulations to the ankle muscles of 30 healthy adults and compare the re…

This study looks at how spinal cord injury (SCI) affects a person's sense of their own body, known as embodiment. Researchers will use questionnaires and brain scans (fMRI) to compare 80 people with and without SCI. The goal is to understand why some people with SCI feel disconne…

This study investigates the reticulospinal system, an ancient part of the brain that controls posture, walking, and reaching. Researchers will use loud sounds and brain stimulation to test how this system works in healthy people and those with spinal cord injury. The goal is to u…

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…