Injury

This trial tests a new approach to face transplantation that aims to reduce the need for lifelong, high-dose immunosuppressive drugs. The method combines a bone marrow cell infusion with a single low-dose immunosuppressant, potentially lowering the risk of infection, cancer, and …

This trial tests an engineered skin graft called denovoSkin™, made from a patient's own skin cells, for treating deep burns. It aims to see if this graft can close wounds and reduce scarring better than the standard split-thickness skin graft. The study includes adults and adoles…

This trial tests a lab-grown skin substitute made from a patient's own cells as a permanent replacement for severe burn wounds. It is for people with deep burns covering over half their body, where donor skin is scarce. The study compares how well this substitute grafts and heals…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This trial tests whether adding vestibulo-ocular reflex (VOR) exercises—which train the eye-movement system that keeps vision stable during head motion—to standard balance training improves reaction time and reduces fear of re-injury in amateur athletes with chronic ankle instabi…

This trial asks whether giving children a low-dose ketamine infusion after heart surgery can protect their brains from damage. Children aged 1 to 60 months undergoing surgery for certain congenital heart defects will receive either ketamine at one of two doses or no ketamine. Res…

This trial tests whether adding legal support to standard violence recovery care can lower stress and reduce repeat firearm injuries. People treated for violent injuries at a trauma center receive either standard support or additional help with legal issues like benefits and hous…

This study tests a new therapy that uses a brain-computer interface to detect when a person tries to move, then activates spinal cord stimulation to help them walk. It is for people with incomplete spinal cord injury who are at least 6 months post-injury. The goal is to see if it…

This trial compares two surgical techniques for repairing a broken shin bone (tibial shaft fracture) using a metal rod inside the bone. The two approaches—medial parapatellar and transpatellar—differ in how the surgeon reaches the bone. About 56 adults with acute tibial fractures…

This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…

This trial compares a new biodegradable wound dressing, SupraSDRM®, to standard care for full-thickness wounds—such as severe burns, surgical wounds, or traumatic injuries—that are not ready for immediate skin grafting. The goal is to see if SupraSDRM® helps wounds heal faster an…

This trial tests whether a 14-week, individually tailored home-based rehabilitation program called 'Stronger at Home' can improve functional recovery in older adults who have had a hip fracture. Participants will receive visits from a physical therapist, a self-directed toolkit w…

This trial asks whether giving severely injured patients whole blood (Low-Titer Group O) is better than giving them separate blood components (red cells, plasma, platelets, and cryoprecipitate) during emergency transfusions. It enrolls about 1,100 adults with major traumatic blee…

This trial tests whether Angiotensin (1-7), a synthetic version of a natural protein fragment, is safe and effective for people with moderate to severe traumatic brain injury (TBI). Participants receive a daily injection for 21 days, along with blood tests, MRI scans, and cogniti…

This study compares two common surgeries for a certain type of hip fracture in adults aged 60 and older: hip replacement (arthroplasty) versus internal fixation (using screws or pins). The goal is to see which approach helps people survive, walk independently, and spend more time…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This study tests a drug called vadadustat in 1,100 hospitalized adults with acute respiratory distress syndrome (ARDS) caused by infection. Participants take either a low or high dose of vadadustat or a placebo daily for up to 14 days. The goal is to see if the drug reduces death…

This trial compares two ways of treating a common ankle fracture in children: wearing a cast for six weeks versus using a boot and starting movement early. The goal is to see if the longer cast time helps the broken bone piece heal back together, preventing a small extra bone fro…

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This phase 2 trial tests a new approach for patients with a specific type of mid-low rectal cancer (pMMR/MSS). Participants receive a short course of radiation followed by six cycles of the immunotherapy drug ivonescimab. The goal is to see if this combination can make the cancer…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This trial investigates whether placing infants with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone positioning) after surfactant treatment can improve their oxygen levels. The study involves 14 mechanically ventilated infants, comparing oxygenation an…

This trial tests whether applying tranexamic acid (TXA) directly to the surgical site during hip fracture surgery can reduce the need for blood transfusions in elderly patients. Participants receive TXA either as an injection through a drain tube or as a topical soak, compared to…

This study is tracking 200 adults who receive the Ennovate Cervical Spinal System, a metal implant used to stabilize the neck and upper back after fractures, disc disease, or tumors. Researchers will measure changes in pain and quality of life over time. The goal is to confirm th…

This trial compares robot-assisted reduction with traditional manual methods for treating a common type of hip fracture in adults aged 18 to 80. The goal is to see if the robotic system can achieve more precise bone alignment, reduce radiation exposure, and improve long-term hip …

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This trial tests whether locking a metal nail only on one side of a broken upper arm bone (unipolar interlocking) works as well as locking it on both sides (bipolar interlocking). The simpler technique may lower the risk of nerve injury, infection, and radiation exposure. About 3…

This study tests whether a precise, individualized version of a common spinal surgery can safely improve function and reduce pain in people with cervical spinal stenosis. Researchers will compare outcomes in 500 patients who receive the standardized open-door procedure with a tit…

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This trial investigates whether a robotic system can improve the accuracy of bone realignment and fixation in orthopaedic trauma surgery. Adults with fractures will receive surgery assisted by the R-Universal® robot, which uses 3D navigation to guide precise movements. The goal i…

This trial tests whether an antibody called IC14 can reduce dangerous lung inflammation in people with acute respiratory distress syndrome (ARDS), a severe condition where the lungs fill with fluid. Hospitalized patients on a ventilator receive either IC14 or a placebo, and resea…

This trial compares robot-assisted surgery to traditional methods for fixing a specific type of broken ankle (distal tibial fracture). The robot uses artificial intelligence to plan and perform the bone realignment, aiming for more accurate placement and less radiation exposure. …

This study tests whether clemastine, an allergy medicine, is safe for premature babies with white matter injury—a common brain injury in infants born early. Researchers will give the drug by mouth to 24 babies born at or before 32 weeks and now between 35 and 41 weeks old. The go…

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This trial tests whether using a patient-specific 3D-printed model of the spine helps surgeons plan screw placement for thoracic or lumbar fractures. Sixteen people with a single broken vertebra will be split into two groups: one using standard CT scans for planning, the other us…

This trial investigates whether a surgically implanted device that delivers personalized electrical stimulation to the spinal cord can improve upper limb function in people with spinal cord injury. Twenty participants with injuries at or above the T4 level will receive the implan…

This trial tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical spinal cord injury breathe more independently. Twenty adults with a C1-C5 injury who need a ventilator will have electrodes implanted near the injury site and re…

This study tests a robot-assisted, gamified rehabilitation program for children aged 7-16 with acquired brain injury. The program combines 15 supervised hospital sessions with 15 home-based sessions on a tablet, guided by an interactive avatar. Researchers will measure improvemen…

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The c…

This trial compares two ways to manage the wound after surgical removal of a chronic pilonidal sinus. Half of the 200 participants will receive a negative pressure wound therapy (NPWT) dressing that applies gentle suction to the wound, while the other half will receive standard o…

This trial tests whether an implantable brain-computer interface (BCI) can help people with tetraplegia from spinal cord injury regain hand function. Participants receive a surgically implanted BCI that reads brain signals and controls pneumatic gloves to assist with grasping and…

This trial investigates whether a single-use negative pressure wound therapy (NPWT) device, which applies gentle suction to the closed incision, can reduce surgical site infections, wound complications, and improve scar appearance compared to standard dressings after major lower …

This study investigates whether combining electrical stimulation of the abdominal and back muscles with specific breathing exercises can improve the strength of an unaided cough in people with acute spinal cord injury. Participants will use a device called the Xcite system to del…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This trial investigates whether two special wound dressings—one made from donated amniotic membrane and another from a synthetic material—can help heal diabetic foot ulcers and venous leg ulcers that have not responded to standard care. Adults aged 18 and older with these hard-to…

This Phase 3 trial investigates whether a psychedelic drug, psilocybin, combined with a specialized trauma-focused therapy (SIRT), can improve depression and anxiety in people with trauma-related major depressive disorder. The study also looks at changes in gut-brain axis biomark…

This study compares a standard metal rod (nail) used to fix shinbone fractures with a new 'micromotion' nail that allows a tiny amount of movement at the break. Researchers want to see if the new nail helps bones heal faster and with fewer problems. About 100 adults with stable s…

This study investigates penile transplantation as a way to replace a severely damaged or missing penis with a donor organ, aiming to restore appearance, sensation, and sexual function. It includes men aged 18-69 who have lost their penis due to trauma, surgery, or birth defects. …

This study tests a new approach for liver transplantation: after keeping the donor liver warm on a machine, doctors skip the usual cold flush before implanting it. Instead, they use a room-temperature albumin rinse. The goal is to see if avoiding sudden temperature changes reduce…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This study looks at children under 18 who need emergency surgery for a type of brain bleed called an extradural hematoma after a head injury. Researchers will track their recovery using a standard scale for childhood head injuries. The goal is to understand which factors lead to …

This study tests whether a non-invasive technique called transcutaneous spinal electrical stimulation (TSES) can improve how well people with spinal cord injury respond to exercise. Participants will do cycling-like leg exercises with and without TSES to see if it boosts oxygen u…

This trial tests whether robot-assisted therapy using the ArmeoSpring exoskeleton improves arm and hand function more than conventional occupational therapy in people with cervical spinal cord injury. Each participant receives both therapies in random order, allowing direct compa…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spinal cord is safe and practical for people with spinal cord injury. It includes 30 adults with either non-traumatic spinal cord injury (from cervical myelopathy) or traumatic injur…

This study looks at how well a specific hip implant (CoCrMo LOCK bipolar femoral head) works for people who have had a hip fracture. Researchers will check how many patients need a second surgery or experience complications like dislocation within two years. The study includes 60…

This study investigates whether a home-based, telehealth-supported program combining blood flow restricted exercise and transspinal stimulation can improve hand and arm function in people with chronic, incomplete tetraplegia. Participants will perform task-specific activities whi…

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This trial looks at two approaches for treating displaced wrist fractures in children aged 4 to 10. One group gets the standard sedated reduction (where the bone is realigned under sedation) followed by a cast. The other group gets only a cast without any realignment. The study m…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This pilot study tests a new way to make a custom pressure orthosis for burn scars using 3D scanning and printing. About 25 adults with healing hypertrophic burn scars will get the device. The main goal is to see if the manufacturing process works and the orthosis fits safely.

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This study is following 35 adults who have received a Tipmed revision hip prosthesis during routine care. Researchers will track how well the hip works and any complications over 24 months. The goal is to see if the device performs safely and effectively in real-world use.

This trial investigates the safest time to restart direct oral anticoagulants (DOACs) after a traumatic brain bleed. Many older adults who fall and hit their head are on blood thinners for conditions like atrial fibrillation, and stopping them raises the risk of stroke or clots. …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This early-phase trial tests a single inhaled dose of a lab-made protein (Rh-KGF-2) in 24 adults with moderate to severe ARDS who are on ventilators. The goal is to see if the drug is safe and tolerable, and to find the right dose. Participants are split into three dose groups, w…

This study tests whether injecting a person's own skin cells from the palm or sole into their amputation stump can thicken the skin and reduce breakdown. Researchers will enroll 50 adults with below-knee amputations who use a prosthetic. The goal is to see if this treatment is sa…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This study tests a new 'nine-grid' method to guide needle placement during vertebroplasty, a procedure that stabilizes spine fractures caused by osteoporosis. Researchers will compare this technique to the standard approach in 68 adults with a single fractured vertebra. The goal …

This study tests whether a drug called 4-AP, taken twice daily, can boost recovery of leg movement in people with spinal cord injury. Participants also receive a type of brain stimulation and leg training. The goal is to improve walking and muscle strength. The study involves 27 …

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study tests two non-invasive therapies to help people with chronic cervical spinal cord injury regain arm and hand function. Ten participants will try both therapies, each for two months, combined with rehabilitation. The goal is to see which works best and tailor treatments…

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study is testing a wireless brain implant that lets people with severe spinal cord injuries control external devices just by thinking. The device is placed in the brain with a small surgery. Researchers will check how well participants can perform tasks using only their brai…

This study compares two surgical methods to treat chronic ankle instability in people who also have joint hypermobility (very flexible joints). One method adds a special tape for extra support. The goal is to see which surgery provides better stability and fewer repeat injuries. …

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study looks at whether having surgery sooner or later after a traumatic spinal cord injury leads to better recovery. Researchers will compare how much nerve function improves in 100 adults who get either early or delayed surgery. The goal is to find the best timing to help p…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, inst…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study tests whether a gel made from umbilical cord stem cells can help heal severe burns faster and more safely. About 90 adults with burns covering less than 30% of their body will receive either a low-dose, high-dose, or placebo gel on their donor skin site. The main goal …

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study compares two common surgeries for wrist fractures that involve the joint surface: a volar locking plate (a metal plate placed inside the wrist) and an external fixator (a frame outside the arm with pins into the bone). Researchers will measure how long the surgery take…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests whether a gel made from human umbilical cord stem cells and cow collagen can safely help third-degree burn wounds heal faster. About 108 adults with burns covering 1-5% of their body will receive the gel or a placebo. The main goal is to see how much and how quic…

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This study compares two types of zirconia materials used in full-mouth dental implants: monolithic zirconia (a single, solid ceramic) and zirconia-feldspathic (a ceramic with a porcelain veneer). Researchers will track complications like chipping, cracking, or other issues over a…

This early study tests a device called Mechanical Tissue Resuscitation (MTR) that is designed to drain excess fluid from the brain area after a person has had part of their skull removed or repaired. The trial will include 11 people who need a drain as part of their standard care…

This study tests whether pouring tranexamic acid (TXA), a drug that helps blood clot, directly into the surgical wound during spine surgery can reduce bleeding and the need for blood transfusions. About 252 adults with spinal injuries or deformities will be randomly assigned to r…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study follows over 1,000 people who receive a shoulder replacement with FX Shoulder Solutions systems. Researchers will track how often the implant needs to be replaced (revision) and measure pain, movement, and quality of life for up to 10 years after surgery. The goal is t…

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This study tests whether adding a piece of donated hip bone (femoral allograft) to standard plate surgery helps people aged 40-70 recover better from severe shoulder fractures. Half the participants will get the graft plus a plate, the other half just the plate. Researchers will …

This study compares two common surgical methods—cannulated screws and K-wires—for fixing broken wrists in adults aged 18-60. The goal is to see which approach leads to better bone healing and hand strength. About 34 participants will be assigned to one of the two treatments and f…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This phase 2 trial tests whether a 4-week course of an essential amino acid supplement can help older adults (65+) rebuild muscle after a hip fracture. Sixty participants will be randomly assigned to receive either the supplement or standard care alone. Researchers will measure m…

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding in the brain. About 100 adults will receive the drug or a placebo within 24 hours of injury. The main goal is to see if …

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study looks at whether a special vibrating device placed on the chest can improve breathing in older patients with a hip fracture who also have respiratory failure. 60 participants will receive the therapy for 5 days, and doctors will check their blood oxygen levels and lung…

This study tests whether a spinal cord stimulator — a device that sends mild electrical pulses to the spinal cord — can help people with long-term bladder and bowel problems after a spinal cord injury. Ten adults with injuries older than 6 months will have the device implanted an…

This study tests a custom 3D-printed plastic splint to fix broken jaws in children aged 6 to 12. The splint is designed from a child's own teeth to hold the jaw in place without surgery. Ten children will be treated, and doctors will check how well their bite heals and if pain an…

This study looks at whether giving a blood thinner called heparin through a vein can improve the chances that a reattached finger will survive after a traumatic amputation. About 188 adults who have had finger reattachment surgery will be split into two groups: one gets heparin, …

This study tests a new sliding compression locking plate for treating fresh femoral neck fractures (a type of hip fracture). The goal is to see if this plate is safer and works better than current methods. About 1,150 adults who need surgery for this fracture will take part. The …

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several ti…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether two proteins in the blood, GFAP and UCH-L1, can help identify children with traumatic brain injury after a head injury. Researchers will compare blood levels of these proteins in children with different severities of head injury and check whether they mat…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This trial is testing whether advanced PET-CT scans can spot early signs of heart damage caused by standard radiation therapy for locally advanced non-small cell lung cancer. Ten adults with stage III lung cancer will receive a special PET-CT scan before and three months after th…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study is testing a new device called Traq™ that measures how well both eyes work together, including fixation and eye movement speed. The goal is to see if these measurements can help tell apart people who have had a recent mild traumatic brain injury (concussion) from those…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study is testing whether a bedside ultrasound can accurately detect skull fractures in children aged 6 and under who have minor head injuries with a scalp bruise. Researchers will compare ultrasound results to a standard CT scan in 150 children. If ultrasound proves reliable…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study tests whether a very powerful 7 Tesla MRI can detect tiny brain injuries in people with post-concussion syndrome after a mild head trauma. Researchers will scan 100 patients one week after their injury and compare the results to standard tests. The goal is to see if th…

This study is testing a new device that scans the eyes to find signs of mild traumatic brain injury (TBI). The device looks at how the eyes move and focus, which can be affected by a brain injury. Researchers will scan 60 people with a recent head injury and 20 healthy volunteers…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study looks at whether a special ultrasound (CEUS) can find hidden bleeding pockets (pseudoaneurysms) in the liver, spleen, or kidneys after an injury, just as well as the standard CT scan. About 385 adults with abdominal trauma will be followed over time with both tests. If…

This study will test whether an AI program can find vertebral fractures (broken spine bones) that might be missed on CT scans done for other reasons. Researchers will look at scans from 250 men aged 50 or older to see how common these fractures are. The goal is to improve detecti…

This study is testing whether a simple saliva test can help detect concussions in professional rugby players. Researchers will measure specific proteins and genetic material in saliva before and after matches, and compare them with impact data from special mouthguards. The goal i…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This trial tests whether a non-invasive cooling device worn like a headband can protect the inner ear from noise-induced hearing loss. Firefighters will use the device for 30 minutes immediately after their shifts over a year. Researchers will compare hearing outcomes between tho…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study tests a community violence prevention program for adults who have been hospitalized with a gunshot wound in Central Arkansas. The program offers bedside support, peer mentoring, and case management to help people stay safe and address mental health needs. Researchers w…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests whether Botox injections in the forehead can reduce light sensitivity in people who have had a traumatic brain injury. Fifty adults with chronic light sensitivity will receive a single treatment. Researchers will measure changes in pain and visual function over t…

This trial tests whether teaching people how to do everyday tasks soon after wrist fracture surgery improves their recovery. Participants who had surgery for a broken wrist will either receive standard post-surgery instructions or additional guidance on performing daily activitie…

This trial tests whether adding rhythmic auditory stimulation — like a steady beat — to dynamic neuromuscular stability exercises improves balance, body awareness, and performance in badminton players recovering from a lateral ankle sprain. About 44 players aged 18 to 30 with a r…

This trial tests whether a more intensive exercise program with in-person follow-up and repeated treadmill tests helps people with post-concussion symptoms and headaches recover better than a program with only phone-based follow-up. Participants will exercise at a level just belo…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This trial tests whether adding vestibulo-ocular reflex (VOR) exercises—simple eye movements that help stabilize gaze during head motion—to standard balance training can improve dynamic balance, reduce ankle instability, and sharpen cognitive performance in amateur athletes with …

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This trial explores whether combining cognitive training with a gentle electrical brain stimulation technique, called tDCS, can help improve working memory in people who have had a moderate to severe head injury. Participants will go through a 5-month program that includes memory…

This study tests a special care program designed for older adults (65+) who live alone and have limb injuries. The program, led by a nurse practitioner, includes six educational units to support recovery. Researchers will measure whether it helps reduce pain, depression, and lone…

This study tests whether giving spine radiation in one session or two sessions better prevents bone fractures in people with cancer that has spread to the spine. About 130 adults with spine tumors will receive either one or two focused radiation treatments. The goal is to find wh…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This study tests an injection called IS-001 that makes ureters glow under special imaging during robotic colorectal surgery. The goal is to help surgeons see the ureters more clearly and avoid accidentally injuring them. About 146 adults having robotic-assisted colorectal surgery…

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This trial tests whether brief, controlled episodes of breathing lowered oxygen — similar to being on a tall mountain — can improve leg strength and reaction time in people with incomplete spinal cord injury. Participants will receive different doses of this low-oxygen therapy or…

This trial compares two types of nerve blocks—the newer PENG block and the traditional femoral nerve block—given before spinal anesthesia for hip fracture surgery. The goal is to see which one better reduces pain and helps patients sit comfortably for the spinal injection. Adults…

This study tests whether a specific nerve block, called the deep iliacus plane block, can reduce the amount of opioid pain medication needed after hip fracture surgery. Half of the participants receive the real block with bupivacaine, while the other half receive a sham (fake) bl…

This trial tests whether infrared laser therapy can relieve pain and speed healing in people with chronic venous leg ulcers — slow-healing wounds on the lower leg caused by poor blood flow. About 20 adults with ulcers lasting more than four weeks will receive either real laser tr…

This trial tests whether a 3-month, home-based walking program can improve thinking skills like memory and processing speed in adults with traumatic brain injury (TBI). Participants will either start walking right away or wait 3 months. The study focuses on safety and whether peo…

This study follows veterans who completed 40 sessions of hyperbaric oxygen therapy (HBOT) for traumatic brain injury, post-concussive symptoms, or PTSD. Researchers want to see if improvements in thinking, mood, and daily function persist or even grow after treatment stops. Parti…

This trial compares intravenous (IV) acetaminophen to oral acetaminophen for managing pain and preventing delirium in adults aged 60 and older after hip fracture surgery. Participants receive either IV acetaminophen plus a placebo pill, or IV placebo plus oral acetaminophen, ever…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study tests two types of ankle foot orthoses (AFOs) — advanced braces that store and release energy versus conventional ones — in veterans and warriors with lower limb injuries. Researchers will measure mobility, balance, and confidence in daily activities to see if the newe…

Some people with severe traumatic brain injury appear unresponsive but may still be aware—a hidden state called cognitive motor dissociation. This pilot trial tests whether gentle electrical pulses delivered through clips on the left ear, stimulating two nerves at once (the vagus…

This study looks at whether a special prosthetic ankle that reads muscle signals can help people with below-knee amputations improve their balance and stability. About 50 adults who have had an amputation for at least two years will train with this powered ankle and be compared t…

This trial tests whether adding a second nerve block to the standard one helps people with hip fractures feel less pain while being positioned for spinal anesthesia before surgery. The study compares the usual pericapsular nerve group (PENG) block alone versus the PENG block comb…

This study tests whether training the brain-to-muscle pathway using transcranial magnetic stimulation (TMS) can improve arm and hand movement in people with incomplete spinal cord injury. Participants will undergo 30 sessions where TMS is used to strengthen the connection between…

This study tests whether watching projected arm movements (visual illusion) combined with physical exercise can improve hand and arm function, sensation, and pain in people with incomplete cervical spinal cord injury. Participants will be assigned to one of four groups: visual il…

This study tests whether giving lidocaine through an IV during surgery can lower the amount of opioids needed for pain in children aged 3-18 having arm fracture repair. Half the children will get lidocaine, half a placebo, and researchers will compare opioid use and pain scores. …

This study tests whether a therapist-guided exercise program helps people aged 50 and older recover better from a wrist fracture compared to usual care advice. Participants will either receive supervised exercises or standard self-management advice. The main goal is to see if the…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether a device that delivers high-frequency radiofrequency electrical currents (called TECAR) can reduce pain and improve movement in people with muscle injuries or low back pain. Researchers will measure pain, flexibility, and function before and after a singl…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests the Point Mini, a mechanical finger prosthetic, in 14 children aged 3-17 with partial hand differences from amputation or birth. Each child uses their current device for one month, then the Point Mini for two months, to compare hand function, ease of use, and how…

This study tests whether taking creatine supplements after a concussion helps people recover faster. Twenty adults aged 18–35 with a recent concussion will either take creatine or follow their usual diet. Researchers will track how many days it takes to become symptom-free and co…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study compares two ways of delivering cognitive processing therapy (CPT) to pregnant women with posttraumatic stress disorder (PTSD). One group receives standard weekly therapy sessions for 12 weeks, while the other gets an intensive schedule of 10 sessions over just 5 days.…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests whether a low-volume nose resistance breathing exercise using an Acapella device plus an incentive spirometer can improve lung function and reduce shortness of breath, cough, and phlegm in people with cervical spinal cord injuries. Forty-two inpatients aged 18–38…

This study tests a silk-based wound dressing against a standard adhesive dressing in 50 adults undergoing double-incision mastectomy for female-to-male gender affirmation. Each patient serves as their own control, with one side of the chest getting the silk dressing and the other…

This study tests whether adding virtual reality (VR) exercises to standard physical therapy can improve hand function, reduce pain, and speed recovery in adults with traumatic wrist or hand injuries. About 40 participants will receive either usual rehab alone or usual rehab plus …

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This pilot study is testing whether a home-based virtual reality exercise program called VR-Move can improve fitness and quality of life in people with spinal cord injuries. Sixteen participants will use the VR system three times a week for 12 weeks. The goal is to provide an acc…

This study tests whether hypnosis before getting stitches in the emergency room can lower pain and stress. 180 adults with stitchable wounds will either receive standard care or a short hypnosis session before the procedure. The main measure is heart rate variability, and patient…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests two different therapies to help people with ongoing memory problems after a concussion. One is traditional cognitive rehabilitation, and the other is a new cognitive-behavioral therapy (CBT) approach. Researchers want to see which one works better for improving h…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study looks at how older adults (ages 65-74) who live alone and have limb injuries experience recovery. Researchers are testing a special "Geriatric Trauma Care Program" to see if it can improve pain, daily function, mood, and loneliness. About 110 participants will join for…

This study tests whether daily training with colored lights can reduce light sensitivity in people who have had a traumatic brain injury. Twenty participants will use a device at home for 20 minutes a day, first with a blue light and then with a red light, or vice versa. Research…

This study tests whether strengthening the ankle, the hip, or both together works best for people with chronic ankle instability. 45 participants aged 18-35 will do isometric exercises three times a week for four weeks. Researchers will measure improvements in stability, strength…

This study looks at whether a new type of nerve block, called the Quadro-Iliac Plane (QIP) block, helps people recover better after hip replacement surgery. Researchers will compare it to other standard blocks by measuring pain, how quickly people get up and move, and overall rec…

This study tests whether daily symptom tracking via smartphone can help teens with concussion get quicker access to specialty care. About 210 teens aged 13-18 who visit the emergency department with a concussion and are at high risk for long-term symptoms will report their sympto…

This study tests whether a week of accelerated brain stimulation (25 sessions over 5 days) can quickly reduce PTSD symptoms. It involves 132 adults with PTSD, including those with traumatic brain injury. The goal is to see if this fast-paced treatment works better than a placebo …

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study tests whether a special laser can make burn scars look and feel better. Researchers will treat mature burn scars on the body and measure changes in scar height, texture, color, and flexibility. The study involves 6 adults in Winnipeg with scars that are 6-12 months old…

This study tests whether a drug called phenylephrine can control bleeding during burn surgery as well as the standard drug epinephrine, but without causing unwanted changes in heart rate or blood pressure. About 24 adults with burns needing skin grafts will take part. The goal is…

This study tests a special gel dressing called Plurogel against standard burn dressings in people with partial thickness burns on the face or one limb. The goal is to see if Plurogel helps burns heal faster, reduces pain, and lowers the need for skin grafts. About 25 adults will …

This early-phase trial tests whether disposable nitrous oxide (laughing gas) canisters can reduce pain and anxiety during burn dressing changes. Thirty adult burn patients will try both the gas and a placebo in random order. The goal is to see if this offers a safer alternative t…

This study tests whether a structured prenatal yoga program can reduce how traumatic women perceive childbirth to be, and improve their self-image and delivery preferences. Forty-six pregnant women in their second trimester or later will attend eight yoga sessions over four weeks…

This pilot study tests whether a gel called PluroGel®, used with standard dressings, can help burn injuries heal better and reduce the need for skin grafting. Twenty adults with similar burns on both arms or legs will have one limb treated with the gel and the other with standard…

This study tests whether community health workers can help caregivers of people with traumatic brain injury (TBI) during the move from rehab to home. About 126 adult caregivers will get either standard support or extra help from a health worker starting before discharge. The goal…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study looks at whether pulsed dye laser therapy can make burn scars less red, softer, flatter, and more flexible. Researchers will treat people with burn scars that are 1 to 6 months old and living in Winnipeg. The goal is to see if the laser helps scars heal better.

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study tests whether a smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. About 50 participants will use either a basic or interactive app, and those who struggle may get extra coaching. The goal is to find the best way to boos…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests whether a 12-week pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Thirty participants will do exercises five times a week. Researchers will track how many people join, stick with the program, and …

This study tests a 3D-printed adapter that snaps onto an Xbox controller, allowing children aged 7 to 17 with a one-sided upper limb difference to use almost all buttons with one hand. Researchers want to see if it improves gaming performance and enjoyment. Twenty participants wi…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study looks at whether giving children a nerve block before elbow fracture surgery can help control pain afterward and reduce the need for strong painkillers like oxycodone. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either …

This study tests whether a short-arm fiberglass cast works as well as a long-arm cast for stabilizing certain forearm fractures in children aged 4 to 16. The goal is to see if the shorter cast provides enough support while being more comfortable. About 120 children with Salter Ha…

This study tests whether putting tranexamic acid (a medicine that helps blood clot) into the surgical wound before closing it can reduce pain and the need for painkillers after wrist fracture surgery. About 90 adults having surgery for a broken wrist will be randomly assigned to …

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study tests whether socks made with semiconductor fabric can improve healing and reduce symptoms after an ankle sprain. About 100 adults with ankle injuries will wear either the special socks or regular compression socks and report their pain and function over time. The goal…

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests whether a semi-elemental liquid diet (a pre-digested formula) reduces stomach and bowel issues like vomiting, diarrhea, and bloating in patients with severe traumatic brain injury. About 100 adults will receive either the special formula or standard liquid nutrit…

This study tests Emotional Freedom Techniques (EFT), a stress-reduction method that involves tapping on specific body points, in smokers who have failed standard quit programs. Researchers want to see if EFT can improve quit rates by reducing anxiety and cravings. The trial enrol…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether adding a lightweight SAM splint to usual pain relief helps adults with suspected wrist fractures feel less pain while waiting for X-rays in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a sp…

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study compares two types of nerve blocks—suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB)—for pain relief after hip fracture surgery. Researchers will enroll 70 adults undergoing hip fracture repair and measure pain scores and opioid use. The goal…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study tests a portable virtual reality system that guides eye exercises to help veterans with mild traumatic brain injury improve their eye coordination. About 80 veterans will be split into two groups: one receiving active therapy and the other a sham version. The goal is t…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

This study looks at whether pelvic floor muscle training is practical and helpful for people recovering from a spinal cord injury during inpatient rehab. Researchers will recruit 50 participants to do pelvic floor physiotherapy five times a week for six weeks. The goal is to see …

This study tests whether a 3D hologram can distract children aged 3 to 12 during painful burn dressing changes, reducing their pain, anxiety, and fear. About 70 children with second-degree burns covering less than 10% of their body will be randomly assigned to see a hologram or r…

This pilot study tests whether a topical diclofenac gel (Voltaren) works as well as oral ibuprofen for reducing pain in children aged 6-18 with ankle or knee sprains. Sixty participants will use either the gel or oral medicine three times a day for three days, then report their p…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study tests whether using a medical glue (cyanoacrylate bioadhesive) instead of stitches to close the wound on the roof of the mouth after gum graft surgery leads to less pain and faster healing. Sixty-six healthy adults will be randomly assigned to receive either stitches o…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study compares two sedation approaches—dormicum-ketamine versus dexmedetomidine—to see which better prevents emergence delirium (confusion and agitation) in children aged 3 to 16 with burns. Sixty kids undergoing burn dressing changes or minor procedures will be randomly ass…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study compares two types of nerve blocks—the PENG block and the Deep Iliacus Plane Block—for pain relief during spinal anesthesia positioning and after hip fracture surgery. 75 adults aged 30-85 will receive one of the blocks plus standard pain medication. The goal is to see…

This study tests whether giving children acetaminophen (Tylenol) with ibuprofen (Advil) works as well as acetaminophen with oxycodone for pain after elbow fracture surgery. About 90 children with a specific type of elbow fracture will be randomly assigned to one of the two combin…

This pilot study is testing whether a dual-screw nail (InterTAN) helps people recover better after a broken hip than a standard single-screw nail (TFNA). Thirty adults with unstable hip fractures will be randomly assigned to receive one of the two devices during surgery. The rese…

This study tests whether a brief behavioral treatment for insomnia (BBTi) — guided by a nurse or through a mobile app — can improve sleep, mood, and thinking in people recovering from traumatic brain injury (TBI). About 93 participants with chronic TBI and insomnia will be assign…

This study tests whether non-invasive spinal stimulation, used at home with exercise, can safely improve arm and hand function in people with recent cervical spinal cord injury. 46 participants will be randomly assigned to start the program immediately or after a 12-week delay. T…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether using mild electrical pulses on the belly muscles during a bowel program can cut down the time it takes. Fifteen adults with chronic spinal cord injury (above T11) will try the device at home and track their bowel routine times, quality of life, and any c…

This pilot study tests whether focused shockwave therapy can safely reduce arm spasticity in people with spinal cord injury. Twelve participants will receive three weekly sessions of sound waves applied to the forearm and elbow muscles. Researchers will measure changes in muscle …

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study tests whether an advanced balance perturbation training program can help warfighters with lower limb trauma—such as amputations or limb salvage—recover better. Researchers want to see if it increases weight-bearing on the injured limb and reduces stumbles and falls. Th…

This study aims to understand and improve fertility in men with spinal cord injury. Researchers will collect and analyze semen samples from participants to assess sperm count, motility, and other factors, and correlate these with patient characteristics. The goal is to help men w…

This study looks at whether the bacteria in your gut can help predict who might experience side effects from stereotactic radiosurgery (SRS), a precise type of radiation used to treat brain tumors. Researchers will collect stool and blood samples from 150 patients before and afte…

This study will follow 1,000 people receiving Medtronic spinal or cranial devices during routine surgery. Researchers will track outcomes like fusion success, pain relief, and device safety for up to two years. The goal is to gather real-world data on how these already-approved p…

This study tests a special method of removing the breathing tube after abdominal surgery to prevent lung problems. It involves 270 adults at moderate or high risk of lung complications. The goal is to see if a protective extubation approach is practical and followed correctly by …

This study aims to build a digital early-warning system that uses machine learning to predict acute lung injury (ALI) in patients undergoing major liver surgery. By analyzing cardiopulmonary interaction characteristics, the model could help doctors identify at-risk patients early…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This study is a large registry that tracks cancer patients who receive both radiotherapy and molecular therapies, such as immunotherapy. The goal is to better understand how these two treatments interact and to identify how often severe side effects occur. By collecting data from…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to learn about its safety and how it works in the body. Participants will help researchers understand if the device is promising for future use.

This study looks at whether certain X-ray and CT features can predict if a broken wrist (distal radius fracture) will stay in place without surgery after a doctor repositions the bone. Adults aged 18 to 65 with a specific type of fracture will get an extra X-ray at 3 months and a…

This study tests whether a simple blood test, taken within 24 hours of a severe burn injury, can help predict a patient's chances of surviving the next 30 days. The test measures the ratio of red cell distribution width to albumin levels, which may reflect inflammation and nutrit…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study looks at whether imagining certain movements or scenarios can trigger or worsen headaches and dizziness in people who have had a mild traumatic brain injury or concussion and still have symptoms months later. Researchers will ask 60 adults to imagine movements that usu…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study looks at whether stopping certain blood pressure medications (ACE inhibitors or ARBs) before colorectal cancer surgery can reduce the risk of heart injury. Researchers will monitor 156 adults for signs of heart damage after surgery. The goal is to find the safest way t…

This study explores whether two computer-based tasks can measure decision-making fatigue in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will compare results from TBI patients with those from healthy volunteers to see if the tasks are practical…

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response …

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study gathers information from trauma patients with a specific type of brain bleed called acute subdural hematoma. Researchers will look at standard surgeries and a newer procedure to see which works best. The goal is to learn from past cases to guide future treatment. No ne…

This study compares two types of numbing medicine for upper limb surgery: a standard one and a longer-acting version. Researchers want to see how quickly the diaphragm (the main breathing muscle) recovers after the nerve block. 120 adults having arm or hand surgery will be split …

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This study follows 100 people with advanced gum disease (Stage III or IV) who undergo regenerative periodontal surgery. Researchers track how the surgical site heals in the first one to two weeks and then check whether that early healing pattern relates to gum health and bone cha…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This observational study tracks 7,000 men and women with cancer to see how treatments like chemotherapy, radiation, and immunotherapy affect fertility. In women, researchers measure a hormone called AMH to gauge ovarian reserve; in men, they analyze sperm quality. The goal is to …

This study investigates how epidural spinal cord stimulation (EES) influences communication between the brain, spinal cord, and muscles in people with spinal cord injury. Researchers will record electrical signals from the spine, brain, and muscles during temporary stimulation to…

This study is creating and testing a Turkish version of a questionnaire that measures how people recover from ankle fractures. Researchers will ask 150 adults with ankle fractures to fill out the new Turkish questionnaire along with two other standard forms. The goal is to make s…

This study compares three ways to image the lungs of infants: CT scans, electrical impedance tomography (EIT), and lung ultrasound. The goal is to see how well the non-invasive methods (EIT and ultrasound) match up with CT in detecting collapsed or overinflated lung areas. Ten in…

This pilot study explores whether an electrical impedance tomography (EIT) device can detect soft tissue injury in adults who have suffered high-energy fractures of the arms or legs. Participants will undergo EIT imaging in the emergency department, operating room, clinic, and ho…

This study tests whether a light-based imaging tool called optical coherence tomography (OCT) can spot bacteria or biofilm on bone, tissue, and surgical hardware during open fracture or infected fracture surgery. Researchers will enroll 40 adults to see if the technique is practi…

This study monitors brain electrical activity and blood flow in critically ill patients with acute brain injury who are on a breathing machine. Researchers adjust the machine's pressure settings and perform lung reopening maneuvers, then use EEG and ultrasound to see how the brai…

This pilot study tests whether StimolIrpinia, a multimedia collection of local images, videos, and cultural information, can support cognitive rehabilitation in people with severe acquired brain injury. Ten hospitalized patients will use the tool in six 30-minute sessions over tw…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study compares two methods of training therapists to deliver an online emotion regulation program (Online EmReg) to people with traumatic brain injury (TBI). One group of therapists receives a 3-hour workshop only, while the other gets the workshop plus 3 months of bi-weekly…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study looks at two different methods for setting the pressure on a breathing machine (ventilator) in people with a serious lung condition called ARDS. The goal is to see which method improves oxygen levels better over 24 hours. About 52 adults with moderate to severe ARDS wi…

This study investigates how the community of bacteria in the mouth and gut changes after sepsis or severe trauma in people who have been in the intensive care unit. Researchers will compare these patients to healthy individuals to see if microbiome disruption is linked to ongoing…

This study follows 500 children aged 8-17 who have had a concussion within the past week. Researchers track their symptoms, fatigue, social interactions, thinking skills, school needs, and biological markers like saliva inflammation and puberty hormones over a year. The goal is t…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study collects and stores brain tissue from adults who have had a traumatic brain injury and require surgery to remove a bruise on the brain. Researchers will analyze the tissue to understand the molecular and cellular processes involved in brain damage and repair. The goal …

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study looks at whether two different training programs can improve emotional health in people who have had a moderate to severe traumatic brain injury. About 48 adults will take part in 8 one-on-one sessions over a month, learning either to recognize emotions or adopt health…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing diffe…

This study compares brain health in 300 former professional football players (ages 29-59) to a similar group of men who did not play football. Participants will undergo cognitive tests, balance and eye-movement exams, sleep assessments, and high-resolution MRI scans. The goal is …

This study looks at 200 children with minor head trauma to see if family education, income, and health literacy influence parents asking for a CT scan. Doctors already have a rule (PECARN) to decide when a CT is needed, but parents sometimes request one anyway. The goal is to und…

This study looks at whether a harmless thermal camera can help doctors see how surgical wounds are healing after skin surgery. About 120 adults having skin lesions removed will have their wounds photographed with the camera. The goal is to catch problems like infection or slow he…

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This study compares carbon dioxide emissions from orthopedic surgeries performed with different materials and setups. Researchers will track waste, energy use, and sterilization methods for procedures like carpal tunnel release or wound revision. The goal is to identify ways to r…

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at blood from people with ARDS, a severe lung condition with no specific medicines. Researchers will take immune cells from the blood and test a new blocking agent in the lab to see if it can reduce lung damage. The goal is to learn more about the disease and fin…

This study looks at whether starting physical therapy 2 weeks after reverse total shoulder replacement (for a broken upper arm bone) is better than waiting 6 weeks. Ten adults aged 50-85 will be randomly assigned to one of the two rehab schedules. The goal is to see which timing …

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study will use data from 1,200 hip fracture patients to build a machine learning model that predicts mobility and daily living independence three months after injury. The goal is to help patients and doctors set realistic expectations for recovery. No new treatments are bein…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study is observing nearly 2,700 active-duty service members to find out what makes them more likely to get muscle or bone injuries. Participants will do physical tests and answer questions to identify risk factors. The goal is to create better ways to prevent injuries and he…

This study tests whether keeping the thumb in a cast for four weeks after surgery reduces the risk of tendon rupture compared to the standard early active motion therapy. About 380 patients in Sweden will be randomly assigned to one of the two rehab programs. The goal is to find …

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study looks at whether a special mobility program, designed with input from patients and doctors, can help older adults move more after hip fracture surgery. About 25 participants will try the program during their hospital stay. Researchers will check if the program is pract…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study looks at whether surgery improves walking in older adults with pelvic ring fractures. Researchers will compare walking patterns and hospital outcomes between those who get surgery and those who don't. The goal is to see if surgery leads to better recovery and quality o…

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study looks at how doctors decide to use brain CT scans for people with mild head injuries in emergency rooms. Many CT scans come back normal, exposing patients to unnecessary radiation and increasing costs. Researchers will analyze data from 2,500 adults across Italy to und…

This study looks at whether a breathing technique called acute intermittent hypoxia (AIH) increases spasticity (muscle tightness) in people with chronic spinal cord injury. Ten adults with incomplete spinal cord injury will receive AIH and have their reflexes and muscle stiffness…

This study looks at why some infants develop lung injury after heart surgery that uses a heart-lung machine. Researchers will collect blood and fluid from the lungs of 56 babies under 1 year old to study how their immune cells (neutrophils) behave. The goal is to better understan…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study enrolls people who have already had a hand or arm transplant to collect information over time. Researchers will measure hand function, pain, quality of life, and mental well-being using questionnaires and tests. The goal is to better understand the long-term safety and…

This study follows 150 adults who need surgery for a broken upper arm bone (proximal humerus fracture) using the ALPS plating system. Researchers will measure shoulder strength, movement, and pain, and track any complications. The goal is to see how well this surgical tool perfor…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study is testing whether a non-invasive brain stimulation technique called iTBS, combined with computer-based attention training, can improve focus and daily functioning in people with persistent attention problems after a mild traumatic brain injury (mTBI), with or without …

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study tests a new computer system called SeeMe that can detect tiny movements in people with severe traumatic brain injury (TBI). Current exams may miss these movements, leading to misdiagnosis. The study will involve 60-80 TBI patients and aims to see if SeeMe can find sign…

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study looks at whether older adults who are frail before hip fracture surgery have higher levels of inflammation, measured by simple blood tests. Researchers will enroll 200 patients aged 65 and older and check their frailty using a standard questionnaire. The goal is to bet…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at how different laser energy levels affect skin damage and repair. Twenty healthy Chinese women will receive various laser doses on their forearms. Researchers will track changes in skin color, moisture, and healing over 10 days. The goal is to create a model fo…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study follows 300 people with a broken wrist (distal radius fracture) to understand their pain, hand function, and use of painkillers or splints during the first three months. Participants will fill out daily and weekly questionnaires. The goal is to learn what recovery real…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to mod…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study compares two recovery approaches after surgery for pelvic fractures: starting to put weight on the leg immediately versus waiting a while. Researchers will track 50 adults aged 18 to 55 to see which group has better function, less pain, and stronger muscles. The goal i…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This study exposes small areas of sun-damaged skin to simulated sunlight to see how proteins and genes change. Researchers will compare 46 adults—half with a history of skin cancer, half without—to find differences that might explain cancer risk. Participants will have four small…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study looks at whether wearing a rigid neck collar is needed for stable neck fractures. About 616 adults with these fractures will be treated either with a collar for 12 weeks or without one. The goal is to see if both approaches lead to similar healing, while avoiding colla…

This study looks at two types of spine surgery for people with broken back bones. One is a traditional open surgery, the other is a less invasive method. Researchers will use 3D walking analysis and muscle activity tests to see which approach helps patients recover better. The go…

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study looks at whether online driver training can help reduce crash risk for new teen drivers. Researchers will enroll 1,300 adolescents aged 16-17 in Pennsylvania who have a learner's permit. Participants will complete online safety education or skills training, and their d…

This study looks at whether a special test called ANKLE-GO, done 3 months after ankle ligament surgery, can predict if athletes will safely return to their sport. About 116 people who had surgery for chronic ankle instability will take the test and be followed for a year. The goa…

This study looks at how spinal cord stimulation combined with physical training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand if these changes lead to bette…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study looks at whether it's safe and satisfying to shower early after orthopedic fracture surgery, compared to waiting longer. About 56 adults with arm or leg fractures will be randomly assigned to bathe early or follow the traditional delayed approach. The goal is to see wh…

This study compares two types of spinal stimulation—transcutaneous (through the skin) and epidural (implanted via surgery)—to see how they help people with spinal cord injury generate leg force and stand with support. Sixty adults aged 22-75 who cannot stand independently will pa…

This study measures how loose the knee is during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. Researchers use a navigation system and a special device to track knee movement in real time. The goal is to gather data that may help improve surgical tech…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study looks at whether using a blood test (anti-Xa) to adjust the dose of a blood thinner (enoxaparin) works better than dosing based on weight alone for preventing dangerous blood clots in burn patients. About 25 adults with serious burns will be enrolled. The goal is to se…