Injury

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This trial tests whether deliberately cooling the body to 34-35°C for five days after a severe traumatic brain injury improves neurological recovery at six months, compared with standard care that keeps temperature normal. Adults aged 18-65 with a closed head injury and high pres…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This study tests a new lab-grown skin substitute (EHSG-KF) for treating deep burns in adults and teens. It compares the substitute to standard skin grafts to see if it covers wounds better and is safer. The goal is to improve healing and reduce the need for large skin donations f…

This study compares two approaches to surgery for facial fractures: operating within 72 hours of injury versus waiting longer. It will track how well patients heal, including bone healing, function, and appearance. The goal is to see if earlier surgery leads to better outcomes fo…

This trial tests whether injecting bone cement into a recently fractured vertebra (vertebroplasty) reduces disability better than wearing a brace. Adults aged 18–70 with a traumatic spinal fracture (within 15 days) are randomly assigned to one of the two treatments. The study mea…

This trial tests whether a spinal implant that delivers electrical stimulation, combined with robot-assisted rehabilitation, can improve walking ability in people with chronic spinal cord injury. Participants will have a device implanted and then undergo months of training. The g…

This trial tests whether coating a dental implant with a gel made from fucoidan — a compound from brown seaweed — can improve wound healing and bone regrowth compared to standard implant placement. Twenty adults with early-stage gum disease who need a tooth replaced will receive …

This trial compares a new type of titanium bone plate, called a pin buckle plate, with standard miniplates for fixing fractures in the front of the lower jaw. Twenty adults with simple, single fractures will be randomly assigned to receive one of the two plates during surgery. Re…

This trial is testing whether a lab-grown blood vessel made from human collagen can safely replace damaged arteries in people with life- or limb-threatening vascular injuries below the neck. Participants receive the artificial vessel as a bypass or replacement during emergency su…

This trial tests whether adding supervised exercise to standard care can improve wound healing in people with diabetic foot ulcers. Participants are randomly assigned to aerobic exercise, a structured exercise protocol, or standard care alone for 12 weeks. Researchers track ulcer…

This trial tests whether a comprehensive hand and arm strength training program, which includes using an upper-limb treadmill, can improve range of motion and function in children aged 6 to 16 who have elbow stiffness after a fracture. The study measures elbow movement with a gon…

This trial tests whether using a piezoelectric device (which uses ultrasonic vibrations) to cut bone during Le Fort I osteotomy reduces surgery time and blood loss compared to the conventional method using a mallet and chisel. The study includes 60 adults with old, improperly hea…

This study tested whether a cream called Nefopam can prevent or reduce scarring in burn patients. Fifty adult burn patients had small, controlled scratches made on their hips. One scratch was treated with the Nefopam cream and the other with a placebo cream. Researchers measured …

Osteoporosis weakens bones and raises fracture risk, but the best exercise for building bone is unclear. This trial tests two supervised strength-training programs in adults aged 50 and older with low bone density. One group lifts at a moderate intensity (70% of their max), the o…

This study tested whether adding tobramycin powder to the standard vancomycin powder in the wound during surgery reduces infections after high-risk leg fracture repair. About 1,550 adults with tibial plateau or pilon fractures at high infection risk took part. The main goal was t…

This study tests whether epidural electrical stimulation, combined with a structured rehabilitation program, can improve functional independence in people with spinal cord injury affecting the conus region. Participants receive an implanted stimulator and undergo task-oriented ex…

This trial investigates whether high-dose vitamin E (alpha-tocopherol) can reduce oxidative stress and improve outcomes in adults with severe burns covering at least 40% of their body. Participants receive vitamin E drops after surgery, and researchers measure vitamin levels, lun…

This study compares two surgical methods for fixing a broken hip bone (femoral neck fracture): a newer plate-and-screw system called the Femoral Neck System (FNS) versus the traditional approach using multiple cancellous screws (MCS). Researchers will track about 290 adults over …

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in …

This study tests whether using real-time measurements of oxygen levels in the brain and carbon dioxide in the breath can guide CPR more effectively than standard audiovisual feedback. Adults who have a cardiac arrest in the hospital and need CPR for at least five minutes may join…

This study compares two rehabilitation techniques—myofascial release and hand mobilization—after surgery to repair a flexor tendon injury in the hand. Thirty adults who had tendon repair surgery 2 to 4 weeks earlier are randomly assigned to one of the two therapy groups. Research…

This study tests a new device called the Photodynamic Bone Stabilization System for treating fractures of the humerus (the upper arm bone). The device is inserted into the bone and hardened with light to hold the broken pieces in place. Researchers are checking how well it helps …

This trial compares two casting strategies for adults with a broken wrist (distal radius fracture) that was set without surgery. One group wears a below-elbow cast from the start, while the other wears an above-elbow cast for two weeks before switching to a below-elbow cast. Rese…

This trial looks at two non-surgical approaches for treating a broken wrist (distal radius fracture). One group receives finger-trap traction followed by a cast, while the other gets a local anesthetic injection into the fracture site, then traction and manual realignment before …

This trial compares two approaches for a specific type of pelvic fracture (LC1) in people aged 60 and older. One group receives a minimally invasive surgery to place screws that stabilize the bone, while the other group gets pain management and physical therapy without surgery. T…

This study tests whether watching a video of someone walking, projected below a mirror, can help people with incomplete spinal cord injury improve their walking, strength, and sensation. The idea is that mirror neurons in the brain may be activated by seeing the movement, promoti…

This early-phase study tests whether a combination of two medications (neostigmine and glycopyrrolate) can be delivered through the skin using a mild electric current to help people with spinal cord injury have a bowel movement. Participants first receive the medication intraveno…

This trial investigates whether nerve transfer surgery can restore hand function in people with cervical spinal cord injury. Participants undergo a personalized nerve transfer procedure to reconnect nerves and improve arm and hand strength. Researchers track changes in motor stre…

This study tests whether a personalized training program guided by machine learning can reduce time-loss injuries and improve performance in elite track and field athletes. Over a 9-month season, 120 athletes aged 18–35 will either follow the adaptive, data-driven plan or a stand…

This study tests whether adding Nintendo Switch active video games to standard occupational therapy can reduce fall risk and improve balance in adults with weakness on one side of the body (hemiparesis) after a stroke or other brain injury. Participants play games like Ring Fit A…

This trial investigates whether placing vancomycin antibiotic powder directly into the wound during surgery can reduce deep surgical site infections in people with severe tibial plateau fractures. Participants are adults with high-energy fractures requiring plate and screw fixati…

This study tests whether a smartphone app can help people with diabetic foot ulcers monitor their wounds from home. Participants use the app to take weekly photos of their wound, which are reviewed remotely by medical professionals. The goal is to see if this approach is as effec…

This study tests whether a custom-designed brace called the IDEO, combined with a physical therapy program called Return to Run, can improve physical function in people with traumatic leg injuries. Participants are adults aged 18 to 60 who are at least two years past a leg injury…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study compares two physical therapy approaches—Cyriax mobilization and muscle energy techniques—to see which better improves hand and wrist function in people who have had surgery for a broken wrist. Seventy-six adults aged 18 to 40 with post-surgery stiffness will receive o…

This study tested two different thicknesses of 3D titanium plates used to fix broken jawbones (mandibular body fractures). The goal was to see which thickness leads to less pain and fewer complications like infection or bite problems. The trial involved 18 adults aged 20-60 who n…

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study tested two different thicknesses of 3D-printed titanium plates used to fix broken jawbones. 18 adults with jaw fractures received one of the two plate types during surgery. The goal was to see if one thickness led to less pain or fewer complications like infection or b…

This trial investigates whether a single 4 mg dose of the steroid dexamethasone, given intravenously before hip fracture surgery, can lower the risk and severity of postoperative delirium in adults aged 60 and older. Delirium is a sudden state of confusion that often occurs after…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This study looked at using bioabsorbable (dissolvable) screws instead of metal screws to fix a specific type of ankle injury called syndesmosis disruption. The goal was to see if these screws could hold the bones in place while they heal, then naturally dissolve, avoiding the nee…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study looked at whether giving tranexamic acid before surgery can reduce blood loss in people with broken thigh or shin bones. Fifty-four patients received either the drug or a placebo before their operation. Researchers measured blood loss during and after surgery, as well …

This study tested a new way to monitor blood flow to the brain during heart surgery to prevent brain injury. It included 460 high-risk patients having heart surgery with a heart-lung machine. The goal was to see if this monitoring could reduce strokes, new brain lesions, or memor…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This study looked at 442 people with severe open fractures of the shin bone (tibia). It compared two surgical approaches: using a modern ring external fixator (a frame outside the leg) versus internal fixation (a metal rod or plate placed inside the bone). The main goal was to se…

This study tracked 61 patients who received the ExploR Modular Radial Head implant to repair elbow fractures. Researchers measured pain, motion, and function using standard elbow scores and X-rays. The goal was to see how well the implant performs in everyday use.

This study looked at a special metal nail used to fix broken hip and thigh bones. The nail has a coating to help prevent infection. Researchers followed 149 adults for 12 months to see how well the bone healed and if there were any problems. The goal was to confirm the nail is sa…

This study tested whether adding albumin (a protein) to standard IV fluids helps adults with severe burns covering at least 25% of their body. 101 participants were randomly assigned to receive either standard fluids alone or standard fluids plus albumin during the first 24-48 ho…

This study tested a special bandage (dressing) that contains a germ-killing ingredient called chlorhexidine for IV tubes placed in the arm. The goal was to see if it reduces infections and other complications compared to the standard bandage. About 300 patients in Australia and F…

This study compared two ways to cover deep wounds on the lower leg, ankle, or foot: a synthetic skin patch called Integra versus traditional flap surgery (moving skin from another body part). 72 patients with traumatic skin loss were enrolled. The goal was to see which method lea…

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The procedure involves steps like deflating the tube cuff and using a speaking valve, with a team of doctors and nurses monitoring stability. The goal …

This study tested a new type of metal plate for fixing broken jawbones in the front and side areas. The plate is designed to be strong but low-profile, and to avoid damaging a key nerve in the chin. Twenty-two adults with recent jaw fractures were randomly assigned to get either …

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This study tested whether filling the bladder with a blue dye before surgery helps surgeons avoid accidentally injuring the bladder or ureters during a cesarean hysterectomy for placenta accreta. Sixty women were randomly assigned to receive the dye or standard care. The goal was…

This study tested a new injectable material called acellular adipose tissue (AAT) to repair modest soft tissue defects on the trunk, such as those from injury or surgery. Fifteen adults received one or more injections of AAT, which is made from donated fat cells stripped of their…

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This study looked at whether a menstrual cup can help women with vesicovaginal fistula (VVF) manage urine leakage while waiting for surgery. Eleven women in Ghana tested the cup, and researchers measured how much urine leaked with and without it. They also asked about comfort and…

This study tested a new surgical device called the Femoral Neck System (FNS) for fixing a common type of hip fracture. Researchers wanted to see how often patients needed another surgery after the implant. The study included 43 adults with hip fractures and followed them for one …

This study tested whether a gel made from chitosan (a natural substance) can better preserve the jawbone after a tooth is pulled, compared to letting the socket heal on its own. Twenty-six adults with at least one hopeless tooth in the back of the jaw participated. Researchers us…

This study looked at whether a one-day course of antibiotics is as good as a three-day course at preventing infections after femur or tibia fracture surgery with a metal rod (intramedullary nailing). Fifty-six adults were randomly assigned to receive either three or nine doses of…

This study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …

This study tested whether an online screening tool (mISP) alone or combined with a mental health skills program (MINDBODYSTRONG) can reduce suicide risk and depression in nurses. About 849 nurses who were at moderate to high risk for suicide took part. The program teaches coping …

This study tested whether giving patients extra oxygen (80% FiO2) during surgery could reduce surgical site infections after severe tibial plateau or pilon fractures. Over 1,100 patients were randomly assigned to receive either supplemental oxygen or standard care. The main goal …

This study tested a mixture of the patient's own bone, artificial bone substitute, antibiotic, and fresh blood to help heal leg fractures that had not joined properly. Twenty-five adults with broken thigh or shin bones that failed to heal after initial surgery received this compo…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study looked at how well the Gamma4 nail system works for fixing thigh bone fractures. 100 adults who needed this surgery were followed for a year to see if their bones healed and to check for any problems. The goal was to see if the nail helps bones heal properly without ca…

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…

This study looked at 91 people who had a metal frame (XtraFix®) placed outside their body to hold broken wrist or shoulder bones in place. The goal was to see if the frame helps bones heal safely and works as intended. Researchers checked X-rays and tracked any problems, like inf…

This study tested whether giving a clotting factor concentrate (4F-PCC) early to people with severe traumatic bleeding could reduce organ failure and death. 380 patients were randomly assigned to receive either standard care or standard care plus 4F-PCC within 2 hours of hospital…

This study tested a device called ExaStim that uses mild electrical stimulation on the skin over the spinal cord to help people with chronic cervical spinal cord injury improve arm and hand function. Thirty-three participants used the device at home for 4 weeks after a training p…

This study tested whether custom 3D-printed plastic (PEEK) plates work better than standard titanium plates for fixing fractures at the angle of the jaw. Twenty-two adults with this type of break were treated and followed to see how well their bite and jaw joint healed. The goal …

This study tested a custom 3D-printed guide and plate for repairing broken jaw bones (mandibular angle fractures) in 24 adults. The new method was compared to the standard technique using a single miniplate. The goal was to see if the custom device helps align the broken pieces m…

This study followed 148 people who had a procedure called Subchondroplasty® for stress fractures or bone defects in the foot or ankle. Researchers tracked pain, function, and satisfaction for up to 24 months after surgery. The goal was to see how well the procedure helps patients…

This study tested whether custom 3D-printed surgical guides and titanium plates can help surgeons fix broken jawbones more accurately. Six adults with jaw fractures received the personalized tools. The goal was to see if this approach leads to better bone alignment and faster sur…

This study tested a special balance training program for people with incomplete spinal cord injury who are at high risk of falling. The training involved unexpected pushes or pulls to trigger a stepping response, with some participants also receiving electrical stimulation to hel…

This study tested a new type of prosthetic leg for people who have lost a leg below or above the knee. The smart leg uses sensors to detect muscle signals and provides gentle vibrations to help the user feel the leg's position. It also has powered knee and ankle joints that activ…

This study tested whether giving a single, strong dose of steroids to people right after a major heart attack (STEMI) could reduce the amount of heart muscle that gets permanently damaged. The steroid was given before the standard emergency procedure to open the blocked artery. T…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIC) could improve blood flow and reduce tissue damage in women undergoing breast reconstruction with a free flap. RIC involves using a blood pressure cuff on the upper arm to create short …

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a new therapy that combines two types of electrical stimulation with balance training (like video games) to help people with incomplete spinal cord injury improve their standing balance. Seventeen participants completed 12 sessions over 4 weeks. The goal was to …

This study tested a closed-loop ventilation system (INTELLiVENT-ASV) in 20 adults with acute brain injury who needed a breathing machine. The goal was to see if this smart system could provide safer, more effective breathing support compared to standard ventilation. Researchers m…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested whether putting antibiotic powder (vancomycin or tobramycin) directly into open fracture wounds right after injury can prevent infections. Twenty adults with severe open fractures of the arm or leg took part. The goal was to see if this simple step reduces surgi…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study tests whether artificial intelligence (AI) can help emergency room doctors find broken bones, dislocations, and other bone problems more quickly and accurately. About 4,800 patients with arm or leg injuries will have their X-rays reviewed either with or without AI assi…

This study tests a device called HITT that scans the eyes to look for changes in eye movement that may occur after a mild traumatic brain injury (TBI). Participants who have had head trauma within the past two weeks will have their eyes scanned briefly, and their results will be …

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

After a severe open fracture, surgeons must remove dead or damaged tissue to prevent infection, but it can be hard to tell what is healthy. This study tests whether injecting a fluorescent dye (ICG) and using a special camera during surgery can show blood flow in real time, helpi…

This trial tests whether a portable ultrasound device, used at the patient's bedside, can accurately detect hip fractures after a fall or injury. Researchers will compare ultrasound findings with standard X-rays in 146 adults with suspected hip fractures. If proven reliable, ultr…

This study investigates whether dynamic vision testing can reveal vision impairments that standard concussion checks miss. Researchers will test college athletes who have had a concussion, using computerized vision and balance assessments. The goal is to see if these tests detect…

This study tests a handheld device that uses special light to measure oxygen levels, detect bacteria, and check temperature in wounds. Doctors will use the images to guide cleaning procedures. The goal is to see if this extra information helps them decide how much tissue to remov…

This study tested a special camera called the MolecuLight DX that uses fluorescence to measure the size of skin wounds. 34 adults with various types of wounds (like diabetic foot ulcers) took part. The goal was to see if the device measures wound area more accurately than a stand…

This study tested a new imaging method called 3D-DXA to measure bone density in the spine, comparing it to standard CT scans. Researchers enrolled 120 adults who already needed a CT scan. The goal was to see if the 3D-DXA technique, which uses less radiation, could give equally a…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can help doctors safely avoid CT scans in children with mild traumatic brain injury. Over 1,500 children across Europe participated. The goal was to see if these blood tests are accurate enough to …

This study tested whether a bedside ultrasound (POCUS) can accurately detect skull fractures in children aged 2-18 with mild closed head injuries. Researchers enrolled 95 children in the emergency department and compared ultrasound results to CT scans. If effective, this approach…

This study tested a new, rapid MRI method in 102 infants with brachial plexus birth palsy (nerve damage from birth). The goal was to see if the MRI could help doctors decide earlier and more accurately whether the baby needs nerve surgery. The MRI was done without anesthesia, and…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study compared the accuracy of bedside ultrasound (POCUS) with standard X-rays for diagnosing elbow fractures in 90 adults with indirect elbow trauma. Using CT scans as the gold standard, researchers aimed to see if ultrasound could be a reliable first-line tool. If proven a…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study tested a blood test called VIDAS TBI on 903 adults with mild head injuries in the emergency room. The test measures two brain proteins to see if it can reliably rule out brain damage. If it works well, it could help doctors decide who truly needs a CT scan, saving time…

This study tested a handheld device that uses near-infrared light to quickly detect bleeding inside the skull after a head injury. Researchers compared the device's results to CT scans in 180 patients in Uganda. The goal was to see if this portable tool could help diagnose brain …

This study tests whether taking a daily blueberry powder supplement for 24 weeks can improve memory and other thinking skills in adults aged 65 to 99. Participants will be randomly assigned to receive either the blueberry powder or a placebo, and researchers will measure changes …

This trial tests whether a mobile app can improve burn prevention and first aid knowledge among families living in tent cities and container houses after an earthquake. Sixty families will be randomly assigned to either receive standard training plus the app or standard training …

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested a program called Family Safety Net in rural Alaska. It aimed to help families store firearms safely to prevent suicide and accidental injuries. 58 adults who lived with guns took part. Some received a counseling session, others a scripted talk, and all got free …

This study tested two approaches to prevent serious fall injuries in older adults (65+) who had a prior bone fracture. One group received enhanced usual care, while the other received exercise coaching. Researchers tracked serious fall injuries, falls, and overall health over 36 …

This study looked at whether the Functional Movement Screen™ (FMS™) can predict injuries in amateur rugby players. Twenty healthy adult players from Normandy were tested at the start and end of the season, and their injuries were tracked. The goal was to see if a low FMS™ score c…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study looked at whether taking vitamin C can prevent Complex Regional Pain Syndrome (CRPS), a painful condition that can develop after a wrist fracture. Researchers enrolled 220 adults with specific types of wrist fractures and gave them vitamin C to see if it reduced their …

This study tests whether low-cost virtual reality (VR) tools, like 360° video and a new VR Photoscan process, can help people with post-traumatic stress disorder (PTSD) engage more easily with trauma-focused therapy. Participants will receive standard therapy (TF-CBT) either alon…

This study compares two types of nerve blocks—pericapsular nerve block and anterior quadratus lumborum block—for reducing pain during spinal anesthesia positioning and after surgery in people with hip fractures. Researchers will enroll 64 adults aged 30-85 scheduled for hip fract…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests a new nerve block called FRONT for pain relief after hip nail surgery in adults aged 60 and older. The block uses one needle to target two nerves, aiming to reduce pain while preserving leg movement so patients can get up and walk sooner. 60 participants will be …

This study looked at 300 adults having hip fracture surgery to compare two numbing methods: a lumbar plexus block (injecting medicine near nerves in the back) and unilateral spinal anesthesia (numbing one side of the spine). The goal was to see which method keeps blood pressure m…

This study tested whether giving lidocaine as a mist before suctioning the breathing tube can prevent dangerous spikes in brain pressure in children with severe traumatic brain injury. Ten children in the pediatric ICU received either nebulized lidocaine, lidocaine dripped into t…

This trial tests whether giving a steroid injection just before surgery for a broken leg can reduce swelling and pain compared to a placebo. Adults with certain leg fractures who need surgery within 72 hours are randomly assigned to receive either the steroid or a saline injectio…

This study tests whether adding a structured exercise program to standard ergonomics training can reduce work-related pain and improve quality of life in female dairy farmers. Sixty women who have been farming for at least 5 years will be split into two groups: one gets only ergo…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This trial tests whether an ultrasound-guided nerve block or an intravenous painkiller provides better pain relief when positioning patients with a broken femur for spinal anesthesia. Moving the leg into the correct position can be very painful. The study includes 64 adults aged …

This trial tests whether a group-based memory training program, called the modified Story Memory Technique (mSMT), can improve memory and everyday functioning in people with traumatic brain injury (TBI). Participants attend twice-weekly sessions for five weeks, working on memory …

This trial compares two ultrasound-guided nerve blocks—fascia iliaca block and femoral nerve block—for controlling pain in people with a broken hip (proximal femur fracture) before they receive spinal anesthesia. The goal is to see which block provides better pain relief, helping…

This trial tests whether adding a topical gel containing naproxen and lidocaine to standard intravenous pain medication improves pain relief for adults with isolated rib fractures from blunt chest trauma. Participants receive either the standard IV painkiller alone or the IV pain…

This study tests whether a six-week program of eye exercises delivered through virtual reality can help adults aged 18 to 42 who have vision problems after a concussion. Participants are randomly assigned to either the eye exercise program or usual care (education and symptom man…

This study tests whether a water-based barrier tape or a hydrocolloid barrier tape better protects the skin of babies aged 4–6 weeks who need a nasogastric tube. Researchers compare skin integrity after removing the tape, aiming to find which product causes less irritation. The t…

This study compares two ways of numbing the arm for wrist fracture surgery. One group receives a standard axillary block with a long-lasting anesthetic, while the other gets a short-acting axillary block plus separate long-acting blocks at the elbow for the median and radial nerv…

This pilot study tests whether two types of gentle brain stimulation—transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS)—can reduce chronic neuropathic eye pain and related symptoms like brain fatigue, migraine, and light sensiti…

This pilot study tests whether a 3-week knee exercise program with visual and audio feedback can improve joint awareness (proprioception) and movement quality in adults aged 18–64 who had a knee injury at least a year ago. Participants complete both a supervised lab-based biofeed…

This trial tests whether a very low dose of two drugs—dexmedetomidine and esketamine—given at night can improve sleep quality in older adults (65-89 years) undergoing knee or hip replacement. Poor sleep after surgery is common and linked to worse recovery. The study compares the …

This trial investigates whether acupuncture can reduce pain and improve function in people with spinal cord injury. Participants receive either acupuncture with electrical stimulation plus ear acupuncture, or standard care alone, for eight weeks. The study measures pain levels, q…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tested whether a natural enzyme-containing mouthwash (ORAL7) helps wounds heal better and reduces pain after impacted wisdom tooth removal, compared to a standard antiseptic mouthwash. 58 adults used either the enzyme mouthwash or chlorhexidine mouthwash for one week a…

This study tested whether adding perturbation-based training (unexpected movements) to standard foot-intensive rehabilitation helps people recover from ankle sprains. 36 adults aged 18-35 with recent ankle sprains were split into two groups and treated for 6 weeks. Researchers me…

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tested whether a guided, telehealth-based aerobic walking program could improve thinking, mood, and quality of life in people who had a traumatic brain injury (TBI). Researchers enrolled 112 participants and measured changes in brain blood flow, walking ability, and me…

This study looked at 111 people having arm surgery to see if a drug called dexmedetomidine or dexamethasone could prevent severe pain when the numbing shot wears off. Participants got one of the two drugs or a saltwater placebo. The goal was to see which drug reduces the chance o…

This study tested whether adding whole-body vibration training to standard physical therapy helps children aged 10-16 recover from severe burns on their legs and trunk. 60 children participated, half receiving vibration therapy plus exercise, and half receiving exercise alone. Th…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tested whether taking fish oil supplements (EPA and DHA) could help heal chronic venous leg ulcers in adults aged 55 and older. The idea was that fish oil might reduce inflammation at the wound site, allowing the ulcer to heal. Researchers measured changes in blood mar…

This study tested whether hypnotic suggestion can improve working memory in adults who had a brain injury at least a year earlier. 90 participants received either four weekly sessions of hypnosis or mindfulness. The goal was to see if hypnosis could unlock hidden memory capacity …

This study tests whether dantrolene, a non-sedating muscle relaxant, can improve pain control and reduce agitation in adults undergoing lumbar fusion surgery. Participants receive either dantrolene or a placebo pill before and after surgery. The goal is to see if dantrolene impro…

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested three different treatment approaches for teens aged 13-19 who had a concussion within the past three weeks and were still experiencing moderate to severe symptoms like headaches, dizziness, and neck pain. The goal was to see if early, symptom-specific treatments…

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

This study tested a new way to numb only the front part of the foot for surgery, leaving the heel sensation intact. The goal was to see if this approach could provide good pain relief while allowing patients to walk earlier. Twenty-seven adults having foot surgery received a targ…

This study tested whether changing how fast pressure increases during hyperbaric oxygen therapy (HBOT) can lower the chance of ear pain and injury. Over 1,500 people receiving HBOT were randomly assigned to one of two compression schedules. The goal was to see if a non-linear (sl…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This study tested whether a vacuum dressing (negative pressure wound therapy) helps skin graft donor sites heal faster than a regular bandage. Twelve people who needed a skin graft had both types of dressings applied to different donor sites. The researchers measured how long it …

This study tested whether guided emotional and sensory stimulation from family members could help coma patients with traumatic brain injury recover. 120 patients were split into two groups: one received standard care, the other added structured family interaction like talking, ge…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested whether adding traditional Chinese medicine (TCM) — like herbs, acupuncture, and massage — to standard care helps people with mild to moderate burns recover faster. Twenty adults received either TCM plus usual care or usual care alone. Researchers measured pain,…

This study compared a nerve block (interscalene brachial plexus block) to general anesthesia in 34 adults having open rotator cuff repair. The nerve block group reported fewer wound-related symptoms and used less pain medication after surgery. Researchers also measured changes in…

This study compared two ways to numb the wrist before setting a broken bone: a hematoma block (injecting anesthetic into the fracture site) and a brachial plexus block (numbing the arm nerves with ultrasound guidance). Researchers enrolled 90 adults with displaced wrist fractures…

This small pilot study looked at whether a single yoga-based physical therapy session could improve heart rate variability (a measure of stress resilience) in people with traumatic brain injury. Thirteen adults participated in three different activities on separate days: yoga the…

This study tested whether a procedure called vertebroplasty (injecting cement into a broken spine bone) relieves pain better than a sham (fake) procedure in people with osteoporosis. 52 adults aged 50 and older with recent spine fractures took part. The main goal was to measure p…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This study tested whether briefly restricting blood flow to the leg during physical therapy could help people regain strength and muscle after a broken femur (thigh bone). 219 adults aged 18-55 with a closed femur fracture took part. The approach uses a special tourniquet system …

This study compared four minimally invasive procedures—vertebroplasty, kyphoplasty, stentoplasty, and thermal facet ablation—for treating pain from vertebral compression fractures. Researchers enrolled 1000 adults with chronic back pain due to these fractures. The goal was to see…

This study tested whether puncturing the RP6 acupuncture point during the pushing phase of labor could reduce perineal tears and increase the chance of an intact perineum after childbirth. 350 women who had never given birth vaginally were randomly assigned to receive either real…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This study tested a digitally enhanced nursing discharge program for older adults recovering from limb fractures. The program uses interactive digital content and phone follow-ups to teach pain management, coping, and recovery strategies. Researchers compared it to standard care …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study looked at two types of nerve blocks—fascia iliaca block and femoral nerve block—to see which one works better for pain control in people having hip fracture surgery. 80 adults were randomly assigned to receive one of the two blocks before spinal anesthesia. The main go…

This study tested whether a nerve block (fascia iliaca block) given before spinal anesthesia helps patients with hip or upper thigh fractures get into a comfortable position. Forty patients were randomly assigned to receive either the nerve block with bupivacaine or a placebo (sa…

This study tested two methods of pain relief after shoulder fracture surgery: a single injection of a long-acting drug (liposomal bupivacaine) versus a continuous drip of standard painkiller through a small tube. 78 adults aged 18-80 who had shoulder fracture repair took part. Th…

This study tested whether giving fluoxetine (Prozac) to people with serious bone fractures could prevent or reduce depression, anxiety, and other mental health issues that often follow such injuries. 55 adults with broken bones requiring surgery were randomly assigned to take eit…

This study tested a personalized treatment plan for 3 mothers and their young children (ages 4-6) who experienced domestic violence and were living in a shelter. The plan included trauma therapy (EMDR) for the parent and child, plus attachment-based therapy, in an order tailored …

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether a 12-week program of supervised jumping and plyometric exercises could help children aged 10-18 recover leg strength and power after severe burns. 62 participants were split into two groups: one did the plyometric program, the other did standard exercise…

This study tested whether applying timolol gel (a drug usually used for glaucoma) to small surgical wounds after skin cancer removal helps them heal faster and look better. Researchers compared timolol gel to plain Vaseline in 87 adults with wounds up to 1.5 cm. The main goal was…

This study tested whether interpersonal psychotherapy (IPT) works as well as two established treatments for chronic post-traumatic stress disorder (PTSD): prolonged exposure therapy and relaxation therapy. 110 adults with chronic PTSD took part, receiving weekly sessions over 14 …

This study tested whether adding a special nerve stimulation treatment to standard exercise could improve neck disability in people with whiplash from a car accident. 44 adults with recent whiplash were split into two groups: one did only exercises, the other did exercises plus t…

This completed study tested two common PTSD treatments head-to-head: EMDR therapy (a talking therapy with eye movements) and SSRI antidepressants. Sixty adults with PTSD were randomly assigned to one treatment for six weeks. Researchers measured how many people achieved symptom r…

This study tested whether shining a red laser on the roof of the mouth after a gum graft procedure could reduce pain and help the area heal faster. Thirty adults who needed gum grafts took part. Half received laser treatment on the donor site, while the other half received standa…

This study tested whether giving N-Acetylcysteine (a supplement) along with multivitamins and minerals can help older adults (60+) recover from a traumatic brain injury. The goal was to see if it reduces thinking, emotional, and physical symptoms like headaches or memory problems…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested a low-cost elastic band device designed to help therapists assist people with spinal cord injury while walking on a treadmill. The device uses rubber bands to help move the legs forward during walking. Nineteen participants with spinal cord injury tried the devi…

This study looked at whether a nerve block given before spinal anesthesia can reduce pain when positioning hip fracture patients for surgery. 132 older adults took part, with half receiving the block and half not. Researchers measured pain levels at rest, during positioning, and …

This study tested whether a long-acting painkiller called Exparel (liposomal bupivacaine) works better than the standard version for numbing the foot and ankle during and after surgery. About 248 adults having elective foot or ankle surgery received either Exparel or standard bup…

This study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…

This study compared two types of nerve blocks—rhomboid intercostal and sub-serratus block versus thoracic paravertebral block—for pain relief and lung function in 50 adults with multiple rib fractures. The goal was to see which block better improves breathing and reduces pain. Re…

This study looked at whether a special nerve block called PENG can help people who have partial hip replacement surgery feel less pain and need fewer painkillers. 48 adults having this surgery were split into two groups: one got the nerve block plus usual care, the other got usua…

This study tested two different treatments for healing scars after a cesarean section: a special gel and a plant-based ointment. 117 women who had a C-section used one of the two treatments. Nurses checked their scars for redness, color, and texture, and women also reported pain …

This study looked at 80 adults having wrist fracture surgery to see if a lower concentration of the local anesthetic ropivacaine (3.75 mg/ml vs. 7.5 mg/ml) in a nerve block affects the severity of pain when the block wears off. Participants were randomly assigned to one of the tw…

This study looked at whether a Quadro-Iliac nerve block can reduce pain after hip surgery. Researchers reviewed 60 patients who had hip surgery, comparing those who got the block plus standard pain relief to those who only used standard pain relief. They measured opioid use, pain…

This study tested whether placing platelet-rich fibrin (PRF) made from the patient's own blood or an absorbable collagen sponge into the socket after wisdom tooth removal improves healing. Twenty-nine healthy adults with impacted lower wisdom teeth on both sides took part. Each s…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested whether adding TECAR therapy (a device that uses electrical currents) to standard exercises improves balance, pain, and daily function after an acute ankle sprain. 42 adults with grade I or II sprains were split into two groups: one did exercises alone, the othe…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested a new hollow cusp fracture reducer for fixing broken thigh and kneecap bones. 142 patients were split into two groups: one got the new device, the other had standard manual reduction. The new tool shortened surgery time, reduced X-ray use, and improved accuracy …

This study tested a new device called Intensive Neurowave Emotional Stimulation (INES) in 40 people with disorders of consciousness after severe brain injury. The experimental group received multisensory stimulation with emotionally meaningful audio-visual content, while the cont…

This study tested whether a sponge containing carvacrol (a natural compound) could reduce pain after a gum graft procedure. Thirty healthy adults scheduled for gum graft surgery received the sponge on their palate. The main goal was to measure pain levels using a standard pain sc…

This study tested a special nursing approach, called the Tidal Model, to help caregivers of people with traumatic brain injury. 18 caregivers took part and the program aimed to reduce their anxiety, depression, and burnout. The approach focused on understanding each caregiver's p…

This study tested whether giving numbing medicine through a thin tube (catheter) placed in the spine provides better pain relief after hip surgery than a single injection. 105 patients over age 60 were randomly assigned to one of three groups: continuous spinal anesthesia, single…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study tested whether a long-acting numbing drug called liposomal bupivacaine (Exparel) can reduce pain and opioid use after skin graft harvesting in burn patients. 74 adults with small burns received either Exparel, lidocaine, or a nerve block. Researchers measured pain scor…

This study tested whether teaching children the rock-paper-scissors game before elbow surgery makes nerve exams faster and easier afterward. About 100 children aged 4 to 10 years participated. The goal was to see if using a familiar game could help doctors check nerve function mo…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether combining ketamine with propofol reduces agitation during recovery from sedation, compared to ketamine alone. 150 adults needing sedation for a broken bone or dislocation were randomly assigned to one of the two drug combinations. The main goal was to se…

This study tested whether a nerve block called an erector spinae plane (ESP) block is practical to use in trauma patients with broken ribs. It included 27 adults with rib fractures and moderate to severe pain. The goal was to see if a larger trial is possible, not to prove the bl…

This pilot study tested two ways to manage pain in patients aged 70 and older who had a hip fracture and were waiting for surgery. One method used a continuous pulling technique on the skin, and the other used a pillow placed between the legs. The goal was to see which approach c…

This study tested whether a drug called dexmedetomidine can help control pain and reduce the need for strong painkillers (opioids) in people with three or more broken ribs from blunt chest injuries. 41 adults in the ICU took part. The goal was to see if the drug could lower pain …

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This study tested a computer-controlled method of giving propofol sedation to 45 adults in the emergency department. The goal was to find the right brain concentration needed for deep sedation during painful procedures like fixing a broken bone or putting a dislocated joint back …

This study tested a procedure called cryoanalgesia, which uses cold to numb nerves, for treating pain from broken ribs. Five adults with rib fractures received the treatment to see if it could improve pain control and reduce the need for strong painkillers. The goal was to find a…

This study looked at whether serial casting (applying a cast that is changed weekly) can improve arm and hand movement in adults who have stiff joints from burn scars. Twelve burn survivors with limited range of motion received one week of usual care, then serial casting if neede…

This study looked at whether a home-based rehabilitation program helps older adults (65+) recover walking ability after hip fracture surgery. Instead of staying in the hospital, participants received hospital-level care at home, including physical therapy and wound care. The goal…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested whether a gel (LAT gel) applied to cuts can numb them as well as the standard numbing shots (lidocaine) before getting stitches. 70 adults with simple cuts in the emergency department took part. The goal was to see if the gel causes less pain during application …

This study tested a device that combines mild electrical muscle stimulation with a balance-board video game to help people with spinal cord injury or stroke improve their balance and reduce fall risk. 18 adults who were at least one year past their injury took part. The goal was …

This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …

This study tested a gel made from cross-linked hyaluronic acid to see if it helps gums heal after a gum graft. Twenty healthy adults took part. Half received the gel on the wound, while the other half did not. Participants rated their pain and healing over two weeks, with checkup…

This study looked at whether a treatment called percutaneous electrolysis (using a tiny electric current through a needle) can help people with calf muscle tears feel better and move more easily. About 75 adults with a torn medial gastrocnemius muscle were split into three groups…

This pilot study tested whether a high-density sit-to-stand exercise program is feasible for older adults recovering from a hip fracture. Thirty patients aged 60 and older performed supervised chair rise exercises twice a week for 8 weeks. The goal was to see if the training coul…

This study looked at two types of ultrasound-guided nerve blocks for pain after hip replacement surgery in 62 patients aged 65 and older. One group got a PENG block plus a lateral femoral cutaneous nerve block, the other got a PENG block plus a lumbar erector spinae plane block. …

This study looked at whether different exercise programs could help children aged 10 to 17 who had severe burns on their legs. 84 children were split into three groups: balance training, jump-based (plyometric) training, or a mix of both. They exercised three times a week for eig…

This study tested whether an ultrasound-guided femoral nerve block (using bupivacaine) works as well as standard opioid painkillers (like morphine) for people with hip fractures in the emergency department. 44 adults with moderate to severe pain were enrolled. The goal was to see…

This study looked at whether a program called Hyperarch Fascia Training (HFT) can reduce ankle pain and improve jumping ability in active adults aged 20-45 who have had ankle sprains. 62 participants were split into two groups: one did HFT exercises remotely for 12 weeks, while t…

This study compared two ultrasound-guided nerve blocks—pericapsular nerve group block and quadratus lumborum block—for pain relief when positioning hip fracture patients for spinal anesthesia. 42 adults were randomly assigned to one block. Researchers measured pain scores, need f…

This study did not test any treatment. Instead, it screened over 1,300 adults with traumatic brain injury (TBI) or post-concussive symptoms to create a database for future research. Participants provided medical history, blood samples, MRI scans, and brain function tests. The goa…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study compares virtual reality (VR) training to mannequin training for teaching medical students how to manage airway injuries. Forty medical students will be randomly assigned to learn using VR or a mannequin, then tested a week later. The goal is to see if VR can provide e…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study looks at trauma patients with severe bleeding to understand how early blood transfusions affect their chances of survival and blood clotting. Researchers will compare patients who receive a transfusion within two hours of arrival to those who do not, and also examine t…

This observational study tests whether a bispectral index (BIS) monitor, which tracks brain activity, can reliably measure how deeply sedated patients with traumatic brain injury are in the intensive care unit. Researchers will compare BIS readings with other measures like pressu…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This trial investigates how the body handles sevoflurane, an inhaled anesthetic used for short-term sedation, in burn patients in the intensive care unit (ICU). It compares drug levels in burn patients with those in other ICU patients to see if dosing needs adjustment. The study …

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This study investigates how often adults remember events during procedural sedation with propofol in the emergency department, specifically for fracture or joint dislocation reduction. About 250 participants will be asked a questionnaire the day after sedation to check for any re…

This study reviews medical records of adults treated at a wound care clinic to see how many also have signs of depression, using a standard questionnaire called the PHQ-9. The goal is to measure how common depression is in this group and identify factors linked to it. The finding…

This study asks whether a routine blood test measure called the neutrophil-lymphocyte ratio (NLR) can help predict delirium—a state of sudden confusion—in older adults after hip fracture surgery. Delirium is a common and serious complication in elderly patients, and inflammation …

This observational study looks at how people with spinal cord injuries maintain balance while performing a stationary wheelchair wheelie. Participants will be asked to hold a wheelie for at least 20 seconds while sensors track their body movements and balance. The goal is to unde…

This study looks at whether the steep head-down position used during robot-assisted prostate surgery can cause subtle brain injury. Researchers measure three brain-specific proteins (S100B, GFAP, and NSE) in the blood before and after surgery, along with simple cognitive tests. T…

Osteoporosis is a common complication after spinal cord injury, raising the risk of broken bones. This study surveys 94 adults with chronic traumatic spinal cord injury to measure their awareness of osteoporosis and identify factors — such as education level or healthcare visits …

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This study investigates whether the hormone estradiol influences PTSD symptoms and brain activity related to fear and stress in women. Researchers will give some participants an estradiol patch and others a placebo before MRI scans that measure brain responses to threatening cues…

This study explores whether an enhanced rehabilitation program (ERP) is practical for people recovering from major trauma, such as severe leg injuries or multiple injuries. Participants receive at least two sessions per week of therapies like exercise, manual therapy, and cogniti…

This study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…

This study explores whether electrically stimulating the leg muscles of people with spinal cord injury can improve cognitive function. Participants will receive 12 weeks of neuromuscular electrical stimulation (NMES) to their quadriceps, three times a week. Researchers will measu…

This study follows 3,000 people who received stitches for traumatic wounds in an emergency department. Researchers track how the wounds heal and look for factors that lead to complications like infection or stitches coming apart. The goal is to identify what makes some wounds hea…

This pilot study tests whether a 15-minute animated video can help scrub nurse students perform better during dynamic hip screw surgery. Thirty operating room technology students are randomly assigned to receive either standard clinical training alone or standard training plus th…

This study looks at whether water polo players have different shoulder flexibility, strength, and core stability compared to non-players. Researchers measure shoulder rotation, muscle tightness, and trunk endurance in both groups. The goal is to understand what might lead to shou…

This study examines how different regional anesthesia techniques affect blood loss during surgery for a broken hip (femoral neck fracture). Researchers will compare patients who received a lumbar plexus block, spinal anesthesia, or general anesthesia, all of whom also received a …

This study looks at how the thigh muscles (quadriceps and hamstrings) turn on during movement in people who have had ACL knee surgery. Researchers want to understand if muscle timing problems remain even after standard rehab. The study involves 25 men aged 18-45 who are 6 months …

This study looks at children with broken wrists who are treated with a cast. Sometimes the cast is split along its length to relieve swelling, but this might weaken the cast and let the bones move out of place. Researchers will take X-rays before and after splitting the cast to s…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study compares dynamic vision—the ability to see clearly while moving—between college athletes and non-athletes, including those with a history of concussion. Participants undergo tests of dynamic visual acuity and gaze stabilization using a computerized system. The goal is …

This study looks at whether people who have had a Prineo dressing before are more likely to develop an allergic skin reaction when it is used again after joint replacement surgery. Researchers will compare first-time users with those who have had the dressing in the past, trackin…

This study looks back at medical records of over 1,000 people hospitalized for burns to see which of three scoring systems—ABSI, Revised Baux, or Modified Ryan—best predicts whether a patient will survive. The goal is to find the most accurate tool for doctors to use when making …

This study looks at how pain, tiredness, muscle strength, balance, and quality of life are connected to injury risk in volleyball players. Researchers will test 28 professional players using movement screens and surveys. The goal is to understand which factors make players more l…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study investigates whether a non-invasive brain monitoring tool can predict brain injury in extremely low birth weight infants (≤1000 grams) during their first week of life. Researchers will measure brain blood flow using ultrasound and other sensors to see if changes in per…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This completed study tested whether brain wave recordings (event-related potentials) can detect cognitive processing in people with brain injuries, including those with altered consciousness. Researchers compared 320 patients and healthy adults using high-density EEG. The goal wa…

This study looked back at 134 patients under 75 who had a partial hip replacement after a broken hip. The goal was to see how often the hip socket wears down over time and how often that leads to a second surgery. Researchers also checked if a common way to measure socket erosion…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study investigates whether a specific ultrasound measurement—called maximal diaphragm thickening fraction—can accurately assess diaphragm function in patients who are on mechanical ventilation. Researchers will compare this ultrasound technique to a standard method (phrenic …

This study looked at whether a 12-hour online training course in psychological first aid (based on the RAPID model) could improve people's communication and listening skills. Ten participants completed the training and were tested before and after. The goal was to see if such tra…

This study looked at whether spraying water on the skin can help burn survivors keep their body temperature down during exercise in hot conditions. Researchers compared core and skin temperature changes in 31 participants (burn survivors and healthy controls) while they exercised…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study looked at whether the ratio of urea to creatinine in urine can help identify malnutrition in intensive care patients with brain injury. Malnutrition is common in the ICU and raises the risk of infections. Researchers measured this ratio in 309 adults and tracked six ty…

This study looked at how receiving rehabilitation services at home (telerehabilitation) versus in a clinic affects the well-being and quality of life of people recovering from a traumatic brain injury. Five participants were followed for four months, completing questionnaires abo…

This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal …

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This study tested whether doing nerve stretches on one leg can improve flexibility in the opposite leg. Twenty healthy young adults performed a specific nerve glide on their right leg, while the left leg's range of motion was measured before and after. The same participants also …

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study looked at blood and saliva samples from 260 people, including those with traumatic brain injuries, to find protein markers that appear before dangerous pressure builds up inside the skull. The goal is to see if a simple blood test could warn doctors early. No treatment…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study looked at 1,286 older adults or those with heart risks undergoing major liver surgery. It compared two methods of controlling blood flow to the liver to see which one causes less heart injury after surgery. The goal is to find safer surgical approaches and identify ris…

This study tested whether a simple procedure called remote ischemic preconditioning (RIPC) could improve healing of tissue flaps in head and neck cancer patients who had prior radiotherapy. RIPC involves briefly inflating a blood pressure cuff on the arm to create short periods o…

This study looked at whether giving antibiotics for 3 days instead of 5 days after facial fracture surgery makes a difference in preventing infections. Researchers enrolled 143 trauma patients to compare the two durations. The goal is to find the shortest effective antibiotic cou…

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

Researchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…

This study looked at how different amounts of mannitol, a medicine used to reduce brain swelling, change blood osmolarity (a measure of blood thickness) in people with traumatic brain injury. Researchers observed 64 patients aged 18-40 with mild to moderate head injuries. The goa…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at whether a simple score called mREMS can predict how trauma patients will do in a hospital in Baghdad. Researchers checked 292 patients with road traffic injuries. They want to see if the score can help doctors in places with limited resources make better deci…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This study looked at two methods for healing skin wounds below the knee after surgery: closing the wound with stitches (complex linear closure) or letting it heal naturally (second intention). The goal was to see which method gives a better-looking scar and improves quality of li…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at how heading a soccer ball changes the brain and whether wearing a mouthguard makes a difference. Twenty-one male soccer players did 10 headers in two sessions—once with a mouthguard and once without. Before and after, they had brain scans, cognitive tests, an…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This completed study looked at 60 adults having leg surgery with a tourniquet to see if spinal or general anesthesia better maintains blood flow in the leg. Researchers used a light-based sensor to measure tissue oxygen levels. The goal was to understand which method might reduce…

This study tested a wearable device called the MOX activity monitor in 40 older adults (70+) recovering from hip fracture, stroke, or frailty in a hospital rehab ward. The goal was to measure how much they walk, stand, or sit during the day and see if that data helps track recove…

This study looked at how anaesthesia residents improve their non-technical skills—like communication, leadership, and decision-making—when treating patients with multiple serious injuries. Sixteen residents were interviewed about their experiences. The goal was to understand how …

This study looked at whether starting to put weight on your leg early after ankle fracture surgery helps you recover better than waiting longer. 435 adults who had surgery for certain types of ankle fractures took part. Researchers tracked complications and how quickly people ret…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study tested whether an online education and skill-building program is practical and helpful for family caregivers of older adults recovering from hip fracture surgery. Eight caregivers and health providers gave feedback on the program's ease of use, usefulness, and satisfac…

This study looked at 184 adults who had emergency belly surgery to see if the way doctors stitch the wound back up affects healing. They compared two methods: interrupted sutures (each stitch tied separately) and continuous sutures (one long stitch). The goal was to see which met…

This study collected X-ray images from 32 head and neck cancer patients during their radiation therapy sessions. The goal was to measure how much the head moves or changes shape between treatments. Researchers also used the images to create realistic artificial X-rays for future …

This study looked at whether vitamin D levels affect how well broken bones heal in young adults aged 18 to 25. Researchers measured vitamin D at the time of injury and tracked healing for up to a year. The goal was to understand if low vitamin D is linked to slower healing or com…

This study looked at 85 adults who had a burn injury to understand how fatigue affects their daily activities, quality of life, and ability to return to work. Participants filled out questionnaires 6 and 12 months after their injury. The goal is to identify problems early and imp…

This study looked at 59 people who came to the emergency room with eye injuries from fireworks during festivals in Upper Egypt in 2024. Researchers recorded the type and severity of each injury, along with complications and final eyesight. The goal was to better understand how th…

This study looked back at medical records of 397 patients who had surgery for a broken shinbone (tibia) using either an antibiotic-coated or a standard uncoated titanium nail. The goal was to see if the coated nail reduced infections and improved bone healing. Researchers also ch…

This completed study exposed 27 healthy young adults to either high heat (35°C) or moderate temperature (24°C) for three hours. Researchers measured changes in blood pressure, heart function, and lung capacity to understand how heat stress affects the body. The goal was to uncove…

This study checks whether a simple six-minute pegboard and ring test is a valid and reliable way to measure upper body exercise capacity in people with spinal cord injury. Researchers will compare the pegboard results with standard strength and function tests in 34 adults who use…

This pilot study tested whether offering secure storage devices (like lock boxes and cable locks) along with brief counseling to families of children hospitalized for mental health crises is feasible and acceptable. Only 2 families participated, and the goal was to see if they wo…

This study looked at whether resetting a broken wrist in the emergency room helps reduce pain while waiting for surgery. 147 adults with a displaced distal radius fracture took part. Researchers measured daily pain and hand function to see if the reset made a difference.

This study developed and tested a program to help nurses better support relatives of patients with acquired brain injury or malignant brain tumors. The program included nurse training, a dialog tool, a peer support list, videos, and documentation guidelines. Researchers tested it…

This completed study compared two anesthesia methods—general anesthesia and infraclavicular block—in 106 adults undergoing upper arm surgery with a tourniquet. Researchers measured markers of oxidative stress and blood vessel function to see which method causes less damage. The g…

This study tested whether a nurse-led education program could improve mothers' knowledge and attitudes about preventing and treating early childhood injuries at home. Four hundred mothers of children under 6 years old in rural Egypt took part. The program focused on first aid and…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and …

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This study examined bacteria in severe leg wounds of 646 adults (ages 18-64) with open tibia fractures or traumatic amputations. Researchers took samples at the time of wound closure to see if certain bacteria led to deep infections within 30 days to one year. The goal was to bet…

This study followed 53 older adults (65+) who had hip fracture surgery to see how well they recovered over a year. Researchers tracked their mobility and asked about their rehab experience. The goal was to understand the recovery process, not to test a new treatment.

This study tested whether a special 3D X-ray done in the operating room can replace standard CT scans after repairing an abdominal aortic aneurysm. 427 patients were randomly assigned to either the new 3D scan or the usual approach. The goal was to see if the new method reduces r…

This study looked at whether exercise training can improve physical capacity and heart function in adults who survived Hodgkin lymphoma after chemotherapy and chest radiation. Forty survivors took part in fitness tests and heart monitoring. The goal was to see if exercise could r…

This study looked at 100 patients who had a new, less invasive surgery to fix an unstable chest wall after a serious injury. The surgery uses smaller cuts and spares the muscles. The goal was to see how well their lungs worked and how they recovered, compared to patients who had …

This study looked back at medical records of nearly 1,000 patients who had surgery for a broken hip. Researchers checked how often patients needed medicine to raise their blood pressure during surgery and then tracked survival for up to one year. The goal was to understand if usi…

This study tested whether a digital symptom checker could work as well as a traditional phone call for guiding patients to the right level of care. Researchers planned to include 120 adults from a primary care center, but only 22 took part. The main goal was to see if a larger tr…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study looked at over 1,000 patients with multiple rib fractures to see how age and injury severity affect hospital outcomes after surgical repair. Researchers compared those who had surgery with those who did not, tracking deaths, time on a ventilator, and length of hospital…

This study looked at 161 older adults who had hip fracture or joint replacement surgery. Researchers checked if medications with a high 'atropine load' (a measure of anticholinergic effect) were linked to postoperative confusion. They used the Confusion Assessment Method daily an…

This completed study looked at hand and wrist injuries in professional hockey players in the Swedish Hockey League over three seasons. Researchers analyzed injury data from about 2,300 games to understand what types of injuries happen, when they occur, and which players are most …

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study tested whether small body-worn sensors can predict if a soldier might get a leg injury during military training. Over 1,800 active-duty soldiers took part. The sensors measured balance and agility to see if they could spot who is at higher risk.

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study looked at 165 trauma patients to see how often they had low blood oxygen (hypoxemia) during their first 24 hours in the hospital. Researchers used a special finger clip to track oxygen levels and compared daytime vs. nighttime episodes. The goal was to understand when …

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study looked at whether tiny molecules in the blood, called microRNAs, can help tell if someone with a mild head injury has actual brain damage visible on a CT scan. Researchers took blood samples from 155 people with mild traumatic brain injury and compared those with and w…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study looked at 73 trauma patients in the ICU to see if brainwave (EEG) patterns could predict delirium before it happens. Researchers recorded brain activity over several days and used machine learning to find early warning signs. The goal is to help doctors spot brain prob…

This study looked at three different ways to close surgical wounds after spine surgery. Researchers measured blood flow around the wound to see if one method was better. The study involved 50 adults with spinal stenosis who had back surgery at Mayo Clinic.

This completed study looked at how re-irradiation affects the quality of life and symptoms of 20 children with diffuse intrinsic pontine glioma (DIPG) or recurrent brain tumors, as well as their caregivers. Researchers used surveys to track physical, emotional, and social well-be…

This study involved over 22,000 children who experienced blunt trauma (like car crashes or falls) to develop a tool that helps doctors decide which kids truly need neck immobilization and imaging. The goal is to avoid unnecessary X-rays and CT scans, which expose children to radi…

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation, such as l…

This study looked back at the medical records of 465 adults admitted to the ICU for burns. Researchers wanted to see if existing scoring systems can accurately predict which patients are most at risk of dying. The goal is to help doctors make better decisions and improve care for…

This study looked at whether a low-field MRI (0.23-T) is safe and practical for patients who are on a heart-lung machine after a cardiac arrest. The goal was to see if doctors could use this MRI to find brain injuries early without causing harm. 36 unconscious patients took part,…

This study looked at whether waiting two minutes before lying flat after receiving spinal anesthesia could prevent dangerous drops in blood pressure in elderly patients having hip fracture surgery. Ninety patients aged 65 and older were split into two groups: one waited two minut…

This completed study looked at 86 patients who had a fracture possibly due to weak bones (osteoporosis). Researchers wanted to see if the calcium supplements patients were prescribed matched what they actually got from food. Many patients get calcium pills even if their diet alre…

This study tested a new breathing machine mode called NAVA in 15 patients recovering from acute lung injury. The goal was to see how their bodies responded to different levels of support from the machine. The study did not aim to treat or cure the lung injury, but to gather infor…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at whether a portable brain scanner called fNIRS can safely and effectively measure brain activity in people with chronic traumatic brain injury while they walk on a treadmill with virtual reality. Eight participants completed the session, and researchers checke…

This study tested a simple tool to help family doctors better manage mental health problems after a mild traumatic brain injury (concussion). Over 500 adults who visited an emergency department were enrolled. Doctors received a letter with their patient's mental health screening …

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study looked at whether using regular CT scans (already done for other reasons) can better predict the risk of spine fractures in people over 50, compared to the standard FRAX risk score. Researchers analyzed CT images from nearly 2,800 adults taken five years apart. The goa…

This completed study used artificial intelligence to predict the risk of death within 30 days and 1 year after hip fracture surgery. Researchers analyzed data from 1000 patients, including age, health conditions, and lab results. The goal was to see if AI could better identify hi…

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study tracked 69 older adults (age 40 and up) with traumatic brain injury to learn more about their health, frailty, and recovery. Researchers collected data on medications, injuries, and outcomes to find better ways to manage care. No new treatments were tested—the goal was…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study created a database of information from nearly 1,000 adult trauma patients with serious arm or leg injuries. Researchers collected details like injury type, treatments, and outcomes to help doctors improve how they save both life and limb. The goal was to learn from pas…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study looks at whether a set of steps to prevent urinary tract infections and bladder swelling in older hip fracture patients still works 9 years after it was first put in place. Researchers will compare infection and bladder problem rates from year 9 to earlier years in 750…

This study looked at whether a blended learning approach (online plus in-person) for first aid training helps adults in Rwanda learn and act better than traditional face-to-face classes or no training at all. Over 500 adults were randomly assigned to one of three groups. Research…

This study looked at what resilience means for people living with a spinal cord injury. Researchers interviewed 28 adults who had their injury at least one year ago, asking about their experiences and having them fill out surveys. The goal was to find common themes among people a…

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This study tested five different ways to ask caregivers about firearm access in a pediatric emergency department. Over 780 caregivers participated, and the goal was to see which question got the most honest answers about gun ownership and storage. The hope is that better screenin…

This study looked at 77 adults with a specific type of knee fracture (Schatzker IV) to see if MRI and CT scans could predict which fractures also involve a dislocation. Researchers compared imaging features between those with and without dislocation. The goal was to help surgeons…

This completed study surveyed 200 nurses at Parc Taulí University Hospital to find out what they know about treating complex wounds and what training they need. Nurses answered questionnaires and open-ended questions about wound care knowledge and challenges. The goal is to ident…

This study tested two types of robot-assisted training for people recovering from a severe brain injury. Ten participants were randomly assigned to either five days of robot-assisted walking training or five days of robot-assisted stepping training, then switched to the other. Th…

This study tested a program called TEaM to improve how doctors and schools support children after a mild traumatic brain injury (concussion). The program included training for doctors and tools to help them communicate with schools and families. Researchers enrolled 101 children …

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study looked at whether people with sensory modulation problems (like being overly sensitive to sounds or touch) are more likely to develop PTSD after a traumatic event. Researchers showed 248 healthy adults a stressful film and tracked their memories, pain sensitivity, and …

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose, since burns can change how drugs work. Only 2 people took part, so the results are very limited.

This study looked at 46 people having arm surgery with a nerve block to see if their emotional personality type affected pain and anesthesia success. Researchers found that anxious patients were more likely to need extra sedation or general anesthesia and reported higher pain aft…

This study looked back at medical records and conducted phone surveys of 70 patients who were treated for vertebral compression fractures with integrative Korean medicine at four hospitals. The goal was to see how well the treatment worked for pain and disability, both during the…

This study looked at 40 adults who had to wear a splint or cast on their dominant hand for 6 weeks after an injury. The goal was to see if being forced to use the non-dominant hand actually improves its function. Researchers measured hand skills and disability levels to understan…

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily t…

This study looked at 79 older adults with hip fractures to see if the balance of specific muscles around the hip affects the type of fracture. Researchers used CT scans to measure muscle areas and found that regional muscle balance may be more important than overall muscle loss. …

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked whether early signs of Alzheimer's in spinal fluid or cognitive tests were linked to how long patients lived. The goal is to understand if hidden Alzheimer's changes affect long-term…

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This study looked at whether giving spinal anesthesia quickly (15 seconds) or slowly (90 seconds) changes blood pressure and heart function in elderly patients with hip fractures. Eighty-four patients were randomly assigned to one of the two speeds. The researchers measured blood…

This study looked at how the war in Ukraine has impacted the mental health of 123 Ukrainian refugees living in Tarragona, Spain. Researchers used surveys and interviews to measure symptoms of depression and anxiety. The goal is to understand these challenges and help improve supp…

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Rese…