Blood test may spare kids from unneeded radiation after head bumps

NCT ID NCT02819778

Completed Diagnosis Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could safely cut down on CT scans, which expose children to radiation that may increase cancer risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: S100B blood test
What this could lead to: If successful, this blood test could become a standard tool to safely avoid many CT scans in children with mild head injuries, reducing radiation risks.
What could go wrong: The test may not be accurate enough to replace CT scans in all cases, and results might vary across different hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Craniocerebral Trauma disease traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRANIOCEREBRAL TRAUMA PEDIATRICS

Contacts and locations

Locations

Assistance Publique des Hôpitaux de Marseille

Marseille, 13385, France
CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France
Hospices Civils de LYON

Bron, 69677, France
Limoges Teaching hospital

Limoges, 87042, France
Montpellier Teaching hopsital

Montpellier, 34090, France
Nantes Teaching Hospital

Nantes, 44036, France
Nice Teaching Hospital

Nice, 06200, France
Nimes Teaching Hospital

Nîmes, 30900, France
Reims Teaching Hospital

Reims, 51092, France
Saint-Etienne Teaching Hospital

Saint-Etienne, 42055, France
Vichy Hospital Center

Vichy, 03200, France

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