Blood test may spare kids from unneeded radiation after head bumps

NCT ID NCT02819778

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could safely cut down on CT scans, which expose children to radiation that may increase cancer risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

S100B blood test

What this could lead to

If successful, this blood test could become a standard tool to safely avoid many CT scans in children with mild head injuries, reducing radiation risks.

What could go wrong

The test may not be accurate enough to replace CT scans in all cases, and results might vary across different hospitals or patient groups.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Craniocerebral Trauma disease traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Assistance Publique des Hôpitaux de Marseille

    Marseille, 13385, France

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France

  • Hospices Civils de LYON

    Bron, 69677, France

  • Limoges Teaching hospital

    Limoges, 87042, France

  • Montpellier Teaching hopsital

    Montpellier, 34090, France

  • Nantes Teaching Hospital

    Nantes, 44036, France

  • Nice Teaching Hospital

    Nice, 06200, France

  • Nimes Teaching Hospital

    Nîmes, 30900, France

  • Reims Teaching Hospital

    Reims, 51092, France

  • Saint-Etienne Teaching Hospital

    Saint-Etienne, 42055, France

  • Vichy Hospital Center

    Vichy, 03200, France