University Hospital, Clermont-ferrand

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will use a simple stool test at 3 months to decide if treatment needs to be stepped up earlier. The goal is to reduce the number o…

This study tests a drug called tislelizumab in people aged 70 and older with advanced esophageal cancer who are not healthy enough for standard chemotherapy. The drug is given through an IV and aims to help patients live longer and with better quality of life. Researchers will tr…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study tests whether a ketoanalogue supplement (Ketosteril) can prevent muscle loss in 100 adults with stage 4 or 5 chronic kidney disease who are on a moderately low-protein diet. Participants take the supplement daily for a period, and researchers measure changes in muscle …

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide…

This study tests whether taking misoprostol before myomectomy (surgery to remove uterine fibroids) can reduce blood loss during the operation. 80 women aged 18-43 with symptomatic fibroids will receive either misoprostol or a placebo before surgery. The goal is to see if this sim…

This study tests whether carvedilol, a beta-blocker, can reduce high blood pressure in the liver's portal vein in people with cirrhosis. High pressure can lead to dangerous bleeding. Researchers will use an endoscopic ultrasound to measure pressure before and after one month of t…

This study aims to refine a non-invasive hearing test called electrocochleography (EcoG) to better detect hidden hearing loss — a condition where standard hearing tests appear normal but auditory nerve fibers are damaged. Researchers will test 220 healthy volunteers aged 18-55 to…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study aims to see if an artificial intelligence tool can predict necrotizing enterocolitis (NEC) — a severe and often fatal gut infection — in premature babies by analyzing their stool samples. Researchers will collect stool from 1,000 premature babies across several hospita…

This study looks at two lab tests (RT-qPCR and ddPCR) to find leftover cancer cells in frozen ovarian or testicular tissue from children treated for neuroblastoma or Ewing sarcoma. The goal is to make it safer for these children to later use their stored tissue to have children o…

This study tests whether a fecal microbiota transplant (FMT) can prevent graft-versus-host disease (GvHD) in 150 adults with blood cancers who receive a stem cell transplant. Patients get a single FMT enema within four weeks of transplant. The main goal is to see if FMT improves …

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study tests whether hypnosis before getting stitches in the emergency room can lower pain and stress. 180 adults with stitchable wounds will either receive standard care or a short hypnosis session before the procedure. The main measure is heart rate variability, and patient…

This study tests two throat sprays (CDN and CW) for adults with a cough from a viral cold. About 58 people will use one of the sprays for 7 days and report how well it works and any side effects. The goal is to see if these sprays are safe and help ease cough symptoms.

This study tests a 30-microgram sublingual sufentanil tablet for treating moderate to severe pain from a single injury in the emergency department. 300 adults with pain scores of 4 or higher on a 0-10 scale will receive either the tablet or standard pain treatment. The goal is to…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests a nerve block (sphenopalatine ganglion block) against the standard blood patch for treating severe headaches that can happen after a spinal tap or epidural. The nerve block is less invasive and involves numbing the nose. The trial will enroll 80 adults and measur…

This study looks at whether a special diet workshop held 15 days after bariatric surgery can help patients increase their protein intake. About 88 adults who are scheduled for weight-loss surgery will take part. The goal is to improve protein levels and overall recovery over the …

This study looks at whether doing adapted physical activity every day can improve sleep quality in children aged 5 to 16 who are being treated for blood cancer. About 30 children will take part, with some exercising daily and others just once over four days. Parents will track sl…

This study tests whether using a virtual reality headset can reduce pain and anxiety in children aged 6 to 16 with leukemia when they get a needle placed into a port. About 120 kids will be randomly assigned to use either a hypnotic VR, an interactive VR, or standard care (numbin…

This study tests whether combining passive and active hamstring stretching improves flexibility more than passive stretching alone in people with chronic low back pain. Ninety adults with tight hamstrings will be randomly assigned to one of the two stretching groups. Flexibility,…

This study tests whether measuring certain immune markers (cytokines) in drainage fluid after throat cancer surgery can identify patients at low risk of developing a fistula (an abnormal opening). If the test shows low risk, patients may be allowed to start eating on day 3 or 4 i…

This study looks at how much physical activity a pregnant woman does and whether it changes a substance called calprotectin in her baby's cord blood. Calprotectin is linked to infection risk in newborns. The researchers will measure activity levels in 250 mothers and test cord bl…

This study tracks 30 eye doctors and residents in France to see how working up to 60 hours straight affects their stress levels, heart rate, and surgical skills. Researchers will measure heart rate variability, saliva stress markers, and sleep quality. The goal is to understand i…

This study compares two methods for guiding early treatment in people with septic shock, a severe infection that can cause organ failure. The standard approach uses blood lactate levels, but this trial tests whether using the CO2 gap (a measure of blood flow) is better at reducin…

This study looks at how a common blood thinner (LMWH) works in pregnant women. Pregnancy naturally makes blood clot more easily, which can be risky. Researchers will use a special test to measure clotting in 50 pregnant women across all trimesters and after birth, to find the bes…

This study looks at how different brain regions communicate in women with and without osteoporosis. Researchers will use MRI scans and blood tests to compare brain connectivity and bone markers in 60 postmenopausal women. The goal is to better understand the link between the brai…

This study compares a new semi-automatic machine (GAVI®) to the standard manual method for freezing donor eggs. Researchers want to see if the machine can freeze eggs just as well, with similar survival rates after thawing. The trial involves 50 egg donors and will also look at f…

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study looks at bile acid levels in the blood and tumor tissue of 20 men with testicular germ cell cancer. Researchers want to see if these levels can serve as markers to predict how the disease will progress and how well it responds to treatment. The goal is to improve monit…

This study looks at why over 20% of migraine patients don't respond well to triptans, a common migraine medication. Researchers will compare tryptophan and related substances in the blood of 144 people who either respond or don't respond to triptans. The goal is to understand the…

This study looks at how often people with Tourette syndrome have trouble being assertive and managing emotions. About 350 adults with Tourette syndrome will fill out online surveys about their symptoms, quality of life, and mood. The goal is to better understand these challenges,…

This study uses a powerful 7-Tesla MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's disease who have not yet started medication, and compares them to healthy volunteers. The goal is to better understand how brain metabolism changes early in the di…

This study is looking at whether a molecule in the blood called miR-1 can help doctors understand how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy are progressing. Researchers will compare miR-1 levels in 104 people, including patients with different mu…

This study looks at whether tiny molecules in the blood, called microRNAs, can help predict how often and how severely cancer patients develop nerve damage from chemotherapy. Researchers will study 90 people receiving specific chemo drugs for lung or colon cancer. The goal is to …

This study looks at whether the size of a screen (from a smartphone to a large monitor) affects how people answer stress questions on a visual scale. Two hundred healthy adults will rate their stress on different devices and on paper. Saliva samples and heart rate measurements wi…

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

This study looks at whether a mother's physical activity during pregnancy influences her newborn's heart rate variability and oxygen levels. Researchers will monitor 100 babies overnight with heart and oxygen sensors, then track their growth and development until age 2. The goal …

This study explores the link between sexuality and mental health in people aged 60 and older. Researchers will use questionnaires to measure anxiety, depression, quality of life, and sexual satisfaction. The goal is to better understand how these factors interact in older adults …

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …

This study looks at what motivates or prevents people with chronic low back pain from using a health app to stay physically active. Researchers will interview 25 patients to understand their needs and expectations. The goal is to learn how to design better digital tools that help…

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…