University Hospital, Clermont-ferrand

This study is testing if carefully raising the level of carbon dioxide (CO2) in a patient's blood during emergency stroke surgery can improve blood flow to the endangered parts of the brain. It will compare two groups of 50 patients having surgery to remove a blood clot: one grou…

This study aims to find out if getting immediate advice from a blood clotting specialist improves emergency care for patients who experience severe bleeding while taking blood-thinning medications. It will compare standard emergency care against care guided by an expert's opinion…

This study is testing a simple 4-point clinical checklist to help doctors decide when it's safe to remove breathing tubes from brain-injured patients who are still unconscious. The goal is to reduce the risk of failed tube removal, which can lead to pneumonia and other complicati…

This study is testing a drug called tislelizumab for elderly patients (70+) with advanced esophageal cancer who are too frail for standard chemotherapy. The main goal is to see how many patients are still alive 6 months after starting treatment. Researchers will also monitor safe…

This study is testing if a single diet workshop given 15 days after weight loss surgery helps patients eat enough protein over the next year. It aims to prevent muscle loss and undernutrition, which are common problems after these operations. Researchers will follow 88 patients f…

This study aims to find the best way to fix a heart stent that has re-narrowed because it didn't fully expand during the original procedure. Researchers will compare a newer method using sound waves (intravascular lithotripsy) against the standard method of using high-pressure ba…

This study is testing a new strategy to prevent Crohn's disease from returning after intestinal surgery. It involves checking a simple stool test 3 months after surgery and starting stronger medication right away if the test suggests inflammation, instead of waiting 6 months. The…

This study is testing if measuring inflammation in surgical drain fluid can help doctors decide when it's safe for patients to start eating after throat cancer surgery. The goal is to see if patients with low inflammation can safely start eating much sooner, which may help them l…

This study is testing if a pill called misoprostol can reduce bleeding during surgery to remove uterine fibroids. It will involve 80 women in France who are having this surgery. Researchers will compare blood loss in women who take misoprostol versus a placebo pill before their o…

This study is observing how well the medication risankizumab (SKYRIZI) heals the full thickness of the bowel wall in adults with Crohn's disease. Researchers will use intestinal ultrasound scans, which are easier for patients than repeated colonoscopies, to measure healing at 4 a…

This study is testing if a nutritional supplement called ketoanalogues can help prevent muscle loss in people with advanced chronic kidney disease (CKD). Participants will follow a moderate protein diet while taking the supplement. The goal is to see if this approach helps mainta…

This study is testing if a heart medication called carvedilol can safely lower high blood pressure in the liver's portal vein (portal hypertension) in people with cirrhosis. The goal is to see if this reduces the risk of dangerous digestive bleeding. Researchers will measure the …

This study tests a walking program designed to help people with painful hip or knee osteoarthritis become more active. Participants take common anti-inflammatory pain medication only before planned walks, combined with proper footwear and education, to reduce pain during movement…

This study is testing whether using virtual reality (VR) headsets can help children and teenagers with leukemia feel less pain and anxiety when they need repeated needle insertions into their chest port for treatment. Over 3 months, researchers will compare VR distraction to stan…

This study is testing if a small heart implant can safely replace blood thinners to reduce severe, recurring bladder bleeding. It focuses on prostate cancer survivors who have a heart rhythm problem (atrial fibrillation) and suffer from bleeding caused by past radiation therapy. …

This study is testing if a less invasive nerve block procedure, given through the nose, works as well as the current standard treatment (an epidural blood patch) for severe headaches that can occur after a spinal tap or epidural. It will involve 80 adults whose headaches have not…

This study is testing whether relaxation and mental training techniques can reduce stress and improve well-being for hospital workers. It will enroll 200 staff members who report feeling stressed. Participants will learn methods like controlled breathing and visualization, and re…

This study is testing whether doing a special, adapted physical activity every day can improve sleep for children and teenagers (ages 5-16) who are being treated for blood cancer. Researchers will compare the effects of daily activity to doing it just once over a four-day period.…

This study aims to find out if combining passive and active hamstring stretching works better than passive stretching alone for improving flexibility in people with chronic low back pain. Researchers will enroll 90 participants with low back pain lasting at least 3 months and mea…

This study aims to improve the safety of fertility preservation for children with neuroblastoma or Ewing's sarcoma. Before cancer treatment, children can have ovarian or testicular tissue frozen to preserve future fertility, but there's a risk the tissue contains hidden cancer ce…

This study aims to understand how plant-based proteins and a physical activity program affect muscle health and protein use in the body. It will involve 12 inactive older men, comparing plant protein to whey protein in meals and measuring body responses before and after a 12-week…

This study aims to understand what motivates or stops people with chronic low back pain from staying physically active using a smartphone app. Researchers will interview 25 patients to learn about their experiences, expectations, and challenges. The goal is to gather information …

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to understand why some migraine patients do not get relief from common triptan medications. Researchers will compare blood levels of tryptophan, a dietary nutrient, and related substances in patients who respond well to triptans versus those who do not. The goal i…

This study aims to find out if patterns of physical activity and sedentary time, measured by wearable sensors, can predict when a person with one chronic disease might develop another. Researchers will follow 700 people with conditions like arthritis, diabetes, or COPD for four y…

This study aims to understand if the amount of physical activity a woman gets during pregnancy is linked to her newborn's heart rate patterns and early growth. Researchers will monitor the heart rates and oxygen levels of 100 newborns and track their height, weight, and developme…

This study aims to discover if bile acid levels in the blood and tumor tissue can act as markers for testicular germ cell cancer. Researchers will compare levels in healthy and cancerous tissue from 20 male patients to see if they correlate with disease stage and predict how well…

This study aims to understand if leg muscle strength is linked to frailty and malnutrition in people with liver cirrhosis. Researchers will measure the leg strength of 60 patients and compare it to healthy volunteers. The goal is to see if a simple strength test could be a useful…

This study aims to better understand the brain chemistry of Parkinson's disease in its earliest stages. Researchers will use a powerful, specialized MRI scanner to measure levels of specific chemicals in the brains of people who have been recently diagnosed and are not yet on med…

This study aims to validate a new scoring tool designed to predict which cancer patients are most likely to develop long-term nerve pain as a result of their treatments, like surgery or chemotherapy. Researchers will enroll 625 participants, including cancer patients and healthy …

This study aims to understand how often adults with Tourette's syndrome experience difficulties with assertiveness and managing their emotions. 350 participants will complete a series of online questionnaires about their confidence, tic severity, quality of life, and mental healt…

This study aims to understand what helps or hinders people returning to work after their first stroke. Researchers will follow 140 stroke survivors of working age to identify key factors—like stroke severity, independence, job type, and mental health—that predict a successful ret…

This study aims to understand if the size of the screen you use (like a phone, tablet, or computer) changes how you answer common stress and anxiety questionnaires. Researchers will have 200 volunteers answer the same questions on different devices and on paper. They will also me…

This study aims to see if a specific molecule in the blood, called miR-1, can be used as a marker to track the progression of muscle-wasting diseases. Researchers will compare miR-1 levels in people with Duchenne/Becker muscular dystrophy, myotonic dystrophy, and congenital myopa…

This study aims to map and understand nerve-related issues like numbness, tingling, and pain in patients who were treated for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 patients during their regular follow-up visits to document these sensations and thei…

This study aims to discover if tiny molecules in the blood can predict who will develop nerve damage from chemotherapy. Researchers will follow 90 patients with lung or colon cancer receiving specific drugs known to cause this side effect. The goal is to find a blood test that co…

This study aims to understand the connection between sexual activity and mental health in people aged 60 and older. Researchers will survey 200 older adults about their sexual satisfaction, anxiety, depression, and quality of life. The goal is to gather information about how main…