University Hospital, Clermont-ferrand

This study tests whether a simple clinical score can help doctors decide the right time to remove breathing tubes in brain-injured patients. About 660 adults with acute brain injury who need a ventilator will take part. The goal is to reduce the number of patients who need to be …

This study tests whether a ketoanalogue supplement can help prevent muscle loss in people with stage 4 or 5 chronic kidney disease (CKD) who are not yet on dialysis. About 100 adults will take the supplement alongside a moderately low-protein diet. The goal is to see if this appr…

This study looks at two ways to fix a common problem after heart stent placement: when the stent doesn't fully expand. The trial will compare a new technique called intravascular lithotripsy (using sound waves) with standard high-pressure balloons. About 80 adults with narrowed s…

This study looks at whether raising carbon dioxide levels in the blood during general anesthesia can improve blood flow to the brain before removing a clot in stroke patients. About 50 adults with a major stroke will take part. The goal is to see if this simple technique helps pr…

This study tests whether the drug carvedilol can reduce high blood pressure in the liver's blood vessels, a common problem in people with cirrhosis. High pressure raises the risk of life-threatening bleeding. The trial will enroll 30 adults with cirrhosis and use a special ultras…

This study tests whether using a measure called the CO2 gap to guide early treatment of septic shock can reduce deaths more than the usual method of tracking lactate levels. Septic shock is a life-threatening condition where blood flow to tissues is poor. The trial will enroll 75…

This study looks at whether a heart procedure called left atrial occlusion can help people with atrial fibrillation and radiation cystitis (bladder inflammation from past cancer radiation) who are at risk of bleeding. The procedure involves placing a small device in the heart to …

This study looks at whether a special diet workshop held 15 days after bariatric surgery can help patients increase their protein intake over the next year. About 88 adults who are scheduled for sleeve gastrectomy or bypass surgery will take part. The goal is to improve protein l…

This study tests a drug called tislelizumab in people aged 70 and older with advanced esophageal cancer who cannot receive standard chemotherapy. The main goal is to see how many patients are alive after 6 months of treatment. The drug works by helping the immune system fight can…

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. By measuring a protein in stool (fecal calprotectin) three months after surgery, doctors can decide earlier whether to adjust treatment. The goal is to reduce the number of patients who…

This study tests an artificial intelligence tool that analyzes stool samples from premature babies to predict necrotizing enterocolitis (NEC), a severe and often fatal gut infection. Researchers will collect samples from 1,000 premature infants across several hospitals to see if …

This study tests if sophrology (a relaxation method using breathing and visualization) and neurolinguistic programming (NLP) can reduce stress and improve well-being in hospital workers. About 200 staff members who feel stressed will take part. The goal is to see if these techniq…

This study looks at whether doing light, adapted physical activity every day can improve sleep in children aged 5 to 16 who are being treated for blood cancer. Researchers will track sleep quality, night awakenings, and overall well-being in 30 participants. The goal is to find a…

This study tests a quick-dissolving tablet placed under the tongue (sublingual sufentanil) to relieve moderate to severe pain from a single injury in the emergency room. About 300 adults with arm or leg injuries will receive either the new tablet or standard pain treatment. The g…

This study looks at whether measuring certain proteins (cytokines) in the fluid from surgical drains can identify patients who are safe to start eating just 3-4 days after throat cancer surgery, instead of the usual 7 days. The goal is to reduce hospital stays and improve quality…

This study tests whether a single dose of misoprostol, a medication often used in gynecology, can reduce blood loss during surgery to remove uterine fibroids (myomectomy). About 80 women aged 18-43 with symptomatic fibroids will receive either misoprostol or a placebo before surg…

This study tests two throat sprays (CDN and CW) for adults with a cough from a viral cold or sore throat. About 58 people will use one of the sprays for 7 days and report side effects and symptom changes. The goal is to see if the sprays are safe and help ease coughing.

This study tests whether using virtual reality (VR) during needle placement can reduce pain and fear in children aged 6 to 16 with acute leukemia. About 120 participants will be randomly assigned to receive either standard care or VR during each needle stick over three months. Th…

This study tests a less invasive treatment for headaches that can happen after a spinal tap or epidural. Instead of the standard blood patch (injecting blood into the back), researchers will use a numbing block inside the nose. 80 adults with persistent headaches will be randomly…

This study looks at whether hypnosis can help reduce pain and stress when getting stitches in the emergency room. About 180 adults with skin wounds will be involved. Researchers will measure heart rate and ask patients about their pain and stress levels to see if hypnosis makes a…

This study compares two types of hamstring stretches—passive alone versus passive plus active—to see which better improves flexibility in people with chronic low back pain. About 90 adults aged 18 to 65 with long-term back pain and tight hamstrings will participate. Each person w…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a short-term anti-inflammatory drug only before planned walks to help with movement pain, while also learning about proper footwear and avoiding fear of movement. The goal is …

This study is testing a new tool called CANoPy that predicts the risk of developing nerve pain in cancer patients before they begin treatment. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer to see if the tool can accurately identify thos…

This study uses a powerful 7-Tesla MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's disease who have not yet started medication, and compares them to healthy volunteers. The goal is to understand how brain metabolism changes early in the disease, …

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study is looking for tiny molecules in the blood, called microRNAs, that might be linked to nerve damage caused by chemotherapy. Researchers will study 90 people with lung or colon cancer who are receiving specific chemo drugs. The goal is to see if these molecules can help …

This study looks at how special plant-protein foods and a 12-week exercise program change the way older adults digest and use protein. Researchers will measure how well the body absorbs amino acids and how muscles respond. The goal is to understand how to best support muscle heal…

This study aims to better understand chronic pain by following 5,000 patients through a smartphone app called e-DOL. Participants will regularly report their pain levels, treatments, and daily life events. The goal is to learn what factors influence pain over time and improve car…

This study looks at bile acid levels in the blood and tumor tissue of 20 men with testicular germ cell cancer. Researchers want to see if these levels can help predict how the disease will progress or how well treatment will work. The goal is to find new markers that could guide …

This study is for 700 people with chronic conditions like arthritis, diabetes, or heart disease. Researchers will use a small movement sensor worn for 5 days every 4 months to track physical activity and sitting time. The goal is to see if a person's unique activity pattern can p…

This study looks at how brain connections might be different in women with osteoporosis. Researchers will compare brain scans and health surveys from 66 postmenopausal women—some with osteoporosis and fractures, some without fractures, and some healthy. The goal is to understand …

This study looks at whether a set of computer tests can detect attention problems caused by concussions in young rugby players aged 11 to 25. Researchers will compare the test results of 30 players who have had a concussion with those of 60 athletes who have never had a concussio…

This study compares a new semi-automatic machine (GAVI®) to the standard manual method for freezing donor eggs. Researchers want to see if the machine can freeze eggs just as well, with the same survival rate after thawing. The study involves 50 egg donors and will also look at f…

This study looks at nerve-related issues like numbness, tingling, and pain in people who finished treatment for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 participants to map where these problems occur and how severe they are. The goal is to better unde…

This study aims to find out how many adults with Tourette syndrome have trouble being assertive and managing emotions. About 350 participants will fill out online surveys about their tics, quality of life, self-esteem, and mood. No treatment is given—the goal is simply to learn m…

This study is looking at whether a molecule in the blood called miR-1 can be used as a marker to track how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy progress. Researchers will compare miR-1 levels in 104 people, including healthy volunteers and patie…

This study follows 140 working-age stroke survivors in France to understand what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from …

This study looks at whether the size of a screen (like a phone or computer) affects how people rate their stress on a visual scale. Researchers will ask 200 healthy adults to complete stress, anxiety, and sleep quality scales on different devices. The goal is to make online surve…

This study looks at whether a mother's physical activity during pregnancy influences her newborn's heart rate variability—a measure of heart health. Researchers will track 100 babies born to moms in a larger exercise study, comparing activity levels with heart data and growth up …

This study looks at what motivates or prevents people with chronic low back pain from using a health app to stay physically active. Researchers will interview 25 patients to understand their needs and challenges. The goal is to design better digital tools that help patients maint…

This study looks at children with neuroblastoma or Ewing sarcoma who had ovarian or testicular tissue frozen to preserve their fertility before cancer treatment. The problem is that this tissue might contain hidden cancer cells that could cause the cancer to return if the tissue …

This study aims to understand why over 20% of people with migraine don't get relief from triptan medications. Researchers will compare levels of tryptophan and related substances in the blood of people who respond well to triptans versus those who don't. The study involves 144 ad…

This study looks at how sexuality and mental health are related in people aged 60 and older. Researchers will survey 200 volunteers about their sexual satisfaction, mood, and quality of life. The goal is to better understand these connections and support healthy aging.